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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:INPP5B-TRIT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: INPP5B-TRIT1
	FusionPDB ID: 39825
	FusionGDB2.0 ID: 39825
		Hgene	Tgene
	Gene symbol	INPP5B	TRIT1
	Gene ID	3633	54802
	Gene name	inositol polyphosphate-5-phosphatase B	tRNA isopentenyltransferase 1
	Synonyms	5PTase	COXPD35\|GRO1\|IPPT\|IPT\|IPTase\|MOD5\|hGRO1
	Cytomap	1p34.3	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	type II inositol 1,4,5-trisphosphate 5-phosphataseinositol polyphosphate-5-phosphatase, 75kDaphosphoinositide 5-phosphatase	tRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferase
	Modification date	20200313	20200313
	UniProtAcc	P32019	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000373023, ENST00000373024, ENST00000373026, ENST00000373027, ENST00000373021, ENST00000458109, ENST00000467066,	ENST00000491865, ENST00000537223, ENST00000537440, ENST00000541099, ENST00000544981, ENST00000545233, ENST00000316891, ENST00000372818, ENST00000441669,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 8 X 4=192	5 X 5 X 3=75
	# samples	9	6
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: INPP5B [Title/Abstract] AND TRIT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	INPP5B(38351310)-TRIT1(40313332), # samples:2
Anticipated loss of major functional domain due to fusion event.	INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. INPP5B-TRIT1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	INPP5B	GO:0046856	phosphatidylinositol dephosphorylation	7721860

Fusion gene breakpoints across INPP5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRIT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-25-1633-01A	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-
ChimerDB4	OV	TCGA-25-1633	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000373026	INPP5B	chr1	38351310	-	ENST00000441669	TRIT1	chr1	40313332	-	2842	1560	1	2148	715
ENST00000373026	INPP5B	chr1	38351310	-	ENST00000316891	TRIT1	chr1	40313332	-	2842	1560	1	2148	715
ENST00000373026	INPP5B	chr1	38351310	-	ENST00000372818	TRIT1	chr1	40313332	-	2764	1560	1	2070	689
ENST00000373027	INPP5B	chr1	38351310	-	ENST00000441669	TRIT1	chr1	40313332	-	2146	864	37	1452	471
ENST00000373027	INPP5B	chr1	38351310	-	ENST00000316891	TRIT1	chr1	40313332	-	2146	864	37	1452	471
ENST00000373027	INPP5B	chr1	38351310	-	ENST00000372818	TRIT1	chr1	40313332	-	2068	864	37	1374	445
ENST00000373026	INPP5B	chr1	38351309	-	ENST00000441669	TRIT1	chr1	40313332	-	2842	1560	1	2148	715
ENST00000373026	INPP5B	chr1	38351309	-	ENST00000316891	TRIT1	chr1	40313332	-	2842	1560	1	2148	715
ENST00000373026	INPP5B	chr1	38351309	-	ENST00000372818	TRIT1	chr1	40313332	-	2764	1560	1	2070	689
ENST00000373027	INPP5B	chr1	38351309	-	ENST00000441669	TRIT1	chr1	40313332	-	2146	864	37	1452	471
ENST00000373027	INPP5B	chr1	38351309	-	ENST00000316891	TRIT1	chr1	40313332	-	2146	864	37	1452	471
ENST00000373027	INPP5B	chr1	38351309	-	ENST00000372818	TRIT1	chr1	40313332	-	2068	864	37	1374	445

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373026	ENST00000441669	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.001011846	0.9989881
ENST00000373026	ENST00000316891	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.001011846	0.9989881
ENST00000373026	ENST00000372818	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.001139978	0.99886
ENST00000373027	ENST00000441669	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.000712551	0.9992874
ENST00000373027	ENST00000316891	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.000712551	0.9992874
ENST00000373027	ENST00000372818	INPP5B	chr1	38351310	-	TRIT1	chr1	40313332	-	0.000764735	0.9992353
ENST00000373026	ENST00000441669	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.001011846	0.9989881
ENST00000373026	ENST00000316891	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.001011846	0.9989881
ENST00000373026	ENST00000372818	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.001139978	0.99886
ENST00000373027	ENST00000441669	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.000712551	0.9992874
ENST00000373027	ENST00000316891	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.000712551	0.9992874
ENST00000373027	ENST00000372818	INPP5B	chr1	38351309	-	TRIT1	chr1	40313332	-	0.000764735	0.9992353

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39825_39825_1_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373026_TRIT1_chr1_40313332_ENST00000316891_length(amino acids)=715AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_2_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373026_TRIT1_chr1_40313332_ENST00000372818_length(amino acids)=689AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDR

--------------------------------------------------------------

>39825_39825_3_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373026_TRIT1_chr1_40313332_ENST00000441669_length(amino acids)=715AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_4_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373027_TRIT1_chr1_40313332_ENST00000316891_length(amino acids)=471AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWE
ESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDH

--------------------------------------------------------------

>39825_39825_5_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373027_TRIT1_chr1_40313332_ENST00000372818_length(amino acids)=445AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_6_INPP5B-TRIT1_INPP5B_chr1_38351309_ENST00000373027_TRIT1_chr1_40313332_ENST00000441669_length(amino acids)=471AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWE
ESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDH

--------------------------------------------------------------

>39825_39825_7_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373026_TRIT1_chr1_40313332_ENST00000316891_length(amino acids)=715AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_8_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373026_TRIT1_chr1_40313332_ENST00000372818_length(amino acids)=689AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDR

--------------------------------------------------------------

>39825_39825_9_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373026_TRIT1_chr1_40313332_ENST00000441669_length(amino acids)=715AA_BP=520
MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRMAITGDDVSLDQIVPVSRDFTLEEVSPDGEL
YILGSDVTVQLDTAELSLVFQLPFGSQTRMFLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEEAGREMSAAAGSRERNTAGGSNFDGLRPNGK
GVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG
TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDQDYQHGIFQSIGFKEFHEYL
ITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_10_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373027_TRIT1_chr1_40313332_ENST00000316891_length(amino acids)=471AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWE
ESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDH

--------------------------------------------------------------

>39825_39825_11_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373027_TRIT1_chr1_40313332_ENST00000372818_length(amino acids)=445AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIK

--------------------------------------------------------------

>39825_39825_12_INPP5B-TRIT1_INPP5B_chr1_38351310_ENST00000373027_TRIT1_chr1_40313332_ENST00000441669_length(amino acids)=471AA_BP=276
MSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQ
KEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRL
VGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPL
TISNHDQDYQHGIFQSIGFKEFHEYLITEGKCTLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWE
ESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHIKSKSHLNQLKKRRRLDSDAVNTIESQSVSPDH

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:38351310/chr1:40313332)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INPP5B P32019	.
FUNCTION: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events. {ECO:0000269\|PubMed:7721860}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

22_148

519.6666666666666

994.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

22_148

439.6666666666667

914.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

22_148

519.6666666666666

994.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

22_148

275.6666666666667

750.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

22_148

519.6666666666666

994.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

22_148

439.6666666666667

914.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

22_148

519.6666666666666

994.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

22_148

275.6666666666667

750.0

Domain

Note=PH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

459_460

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

459_460

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

459_460

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

459_460

519.6666666666666

994.0

Region

Note=Substrate binding

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000316891

395_425

271.6666666666667

468.0

Zinc finger

Note=Matrin-type

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000372818

395_425

271.6666666666667

442.0

Zinc finger

Note=Matrin-type

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000441669

395_425

189.66666666666666

386.0

Zinc finger

Note=Matrin-type

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000316891

395_425

271.6666666666667

468.0

Zinc finger

Note=Matrin-type

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000372818

395_425

271.6666666666667

442.0

Zinc finger

Note=Matrin-type

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000441669

395_425

189.66666666666666

386.0

Zinc finger

Note=Matrin-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

821_993

519.6666666666666

994.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

821_993

439.6666666666667

914.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

821_993

519.6666666666666

994.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

821_993

275.6666666666667

750.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

821_993

519.6666666666666

994.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

821_993

439.6666666666667

914.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

821_993

519.6666666666666

994.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

821_993

275.6666666666667

750.0

Domain

Rho-GAP

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

342_668

519.6666666666666

994.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

582_583

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

596_598

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373023

669_782

519.6666666666666

994.0

Region

ASH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

342_668

439.6666666666667

914.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

459_460

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

582_583

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

596_598

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373024

669_782

439.6666666666667

914.0

Region

ASH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

342_668

519.6666666666666

994.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

582_583

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

596_598

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373026

669_782

519.6666666666666

994.0

Region

ASH

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

342_668

275.6666666666667

750.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

459_460

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

582_583

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

596_598

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351309

chr1:40313332

ENST00000373027

669_782

275.6666666666667

750.0

Region

ASH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

342_668

519.6666666666666

994.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

582_583

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

596_598

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373023

669_782

519.6666666666666

994.0

Region

ASH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

342_668

439.6666666666667

914.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

459_460

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

582_583

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

596_598

439.6666666666667

914.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373024

669_782

439.6666666666667

914.0

Region

ASH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

342_668

519.6666666666666

994.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

582_583

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

596_598

519.6666666666666

994.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373026

669_782

519.6666666666666

994.0

Region

ASH

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

342_668

275.6666666666667

750.0

Region

5-phosphatase

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

459_460

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

582_583

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

596_598

275.6666666666667

750.0

Region

Note=Substrate binding

Hgene

INPP5B

chr1:38351310

chr1:40313332

ENST00000373027

669_782

275.6666666666667

750.0

Region

ASH

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000316891

32_37

271.6666666666667

468.0

Region

Substrate binding

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000372818

32_37

271.6666666666667

442.0

Region

Substrate binding

Tgene

TRIT1

chr1:38351309

chr1:40313332

ENST00000441669

32_37

189.66666666666666

386.0

Region

Substrate binding

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000316891

32_37

271.6666666666667

468.0

Region

Substrate binding

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000372818

32_37

271.6666666666667

442.0

Region

Substrate binding

Tgene

TRIT1

chr1:38351310

chr1:40313332

ENST00000441669

32_37

189.66666666666666

386.0

Region

Substrate binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
INPP5B
TRIT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000316891		5	11	233_255	271.6666666666667	468.0	isopentenylpyrophosphate transferase
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000372818		5	10	233_255	271.6666666666667	442.0	isopentenylpyrophosphate transferase
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000316891		5	11	233_255	271.6666666666667	468.0	isopentenylpyrophosphate transferase
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000372818		5	10	233_255	271.6666666666667	442.0	isopentenylpyrophosphate transferase
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000316891		5	11	183_187	271.6666666666667	468.0	substrate tRNA
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000316891		5	11	55_58	271.6666666666667	468.0	substrate tRNA
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000372818		5	10	183_187	271.6666666666667	442.0	substrate tRNA
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000372818		5	10	55_58	271.6666666666667	442.0	substrate tRNA
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000441669		3	9	183_187	189.66666666666666	386.0	substrate tRNA
Tgene	TRIT1	chr1:38351309	chr1:40313332	ENST00000441669		3	9	55_58	189.66666666666666	386.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000316891		5	11	183_187	271.6666666666667	468.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000316891		5	11	55_58	271.6666666666667	468.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000372818		5	10	183_187	271.6666666666667	442.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000372818		5	10	55_58	271.6666666666667	442.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000441669		3	9	183_187	189.66666666666666	386.0	substrate tRNA
Tgene	TRIT1	chr1:38351310	chr1:40313332	ENST00000441669		3	9	55_58	189.66666666666666	386.0	substrate tRNA

Top

Related Drugs to INPP5B-TRIT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to INPP5B-TRIT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source