UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ITGA6-RAPGEF4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITGA6-RAPGEF4
FusionPDB ID: 40446
FusionGDB2.0 ID: 40446
HgeneTgene
Gene symbol

ITGA6

RAPGEF4

Gene ID

3655

11069

Gene nameintegrin subunit alpha 6Rap guanine nucleotide exchange factor 4
SynonymsCD49f|ITGA6B|VLA-6CAMP-GEFII|CGEF2|EPAC|EPAC 2|EPAC2|Nbla00496
Cytomap

2q31.1

2q31.1

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-6CD49 antigen-like family member Fintegrin alpha6Bintegrin, alpha 6rap guanine nucleotide exchange factor 4RAP guanine-nucleotide-exchange factor (GEF) 4Rap guanine nucleotide exchange factor (GEF) 4cAMP-regulated guanine nucleotide exchange factor IIexchange factor directly activated by cAMP 2exchange protein direc
Modification date2020032920200313
UniProtAcc

P23229

.
Ensembl transtripts involved in fusion geneENST idsENST00000264106, ENST00000264107, 
ENST00000343713, ENST00000375221, 
ENST00000409080, ENST00000409532, 
ENST00000397087, ENST00000409036, 
ENST00000473043, ENST00000535187, 
ENST00000538974, ENST00000539331, 
ENST00000540783, ENST00000264111, 
ENST00000397081, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 6=48017 X 18 X 9=2754
# samples 1219
** MAII scorelog2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2754*10)=-3.85745723580402
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITGA6 [Title/Abstract] AND RAPGEF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITGA6(173356251)-RAPGEF4(173898642), # samples:2
Anticipated loss of major functional domain due to fusion event.ITGA6-RAPGEF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGA6-RAPGEF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGA6-RAPGEF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGA6-RAPGEF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ITGA6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAPGEF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4YY-01AITGA6chr2

173356251

+RAPGEF4chr2

173898642

+
ChimerDB4STADTCGA-D7-A4YYITGA6chr2

173356251

+RAPGEF4chr2

173898641

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409532ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+434928445432301058
ENST00000409532ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+435128445432301058
ENST00000264107ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+47273222036081202
ENST00000264107ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+47293222036081202
ENST00000343713ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+4681317616735621131
ENST00000343713ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+4683317616735621131
ENST00000264106ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+4813330816736941175
ENST00000264106ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+4815330816736941175
ENST00000375221ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+4813330816736941175
ENST00000375221ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+4815330816736941175
ENST00000409080ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898642+44932988033741124
ENST00000409080ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898642+44952988033741124
ENST00000409532ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+434928445432301058
ENST00000409532ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+435128445432301058
ENST00000264107ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+47273222036081202
ENST00000264107ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+47293222036081202
ENST00000343713ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+4681317616735621131
ENST00000343713ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+4683317616735621131
ENST00000264106ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+4813330816736941175
ENST00000264106ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+4815330816736941175
ENST00000375221ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+4813330816736941175
ENST00000375221ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+4815330816736941175
ENST00000409080ITGA6chr2173356251+ENST00000264111RAPGEF4chr2173898641+44932988033741124
ENST00000409080ITGA6chr2173356251+ENST00000397081RAPGEF4chr2173898641+44952988033741124

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409532ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001470730.9998529
ENST00000409532ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001474810.99985254
ENST00000264107ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0004217960.9995782
ENST00000264107ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0004245540.99957544
ENST00000343713ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001883050.9998117
ENST00000343713ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001894820.9998105
ENST00000264106ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001873190.99981266
ENST00000264106ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001881680.9998118
ENST00000375221ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001873190.99981266
ENST00000375221ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0001881680.9998118
ENST00000409080ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898642+0.0002819910.999718
ENST00000409080ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898642+0.0002832080.9997168
ENST00000409532ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001470730.9998529
ENST00000409532ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001474810.99985254
ENST00000264107ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0004217960.9995782
ENST00000264107ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0004245540.99957544
ENST00000343713ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001883050.9998117
ENST00000343713ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001894820.9998105
ENST00000264106ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001873190.99981266
ENST00000264106ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001881680.9998118
ENST00000375221ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001873190.99981266
ENST00000375221ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0001881680.9998118
ENST00000409080ENST00000264111ITGA6chr2173356251+RAPGEF4chr2173898641+0.0002819910.999718
ENST00000409080ENST00000397081ITGA6chr2173356251+RAPGEF4chr2173898641+0.0002832080.9997168

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40446_40446_1_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264106_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_2_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264106_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_3_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264106_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_4_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264106_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_5_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264107_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1202AA_BP=0
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDND
ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGV
AATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPR
ANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGT
KDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIF
RSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQEL
TLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKF
CTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNG
SQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKS
EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDN
RKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKF
KKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN

--------------------------------------------------------------

>40446_40446_6_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264107_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1202AA_BP=0
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDND
ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGV
AATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPR
ANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGT
KDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIF
RSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQEL
TLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKF
CTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNG
SQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKS
EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDN
RKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKF
KKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN

--------------------------------------------------------------

>40446_40446_7_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264107_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1202AA_BP=0
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDND
ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGV
AATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPR
ANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGT
KDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIF
RSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQEL
TLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKF
CTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNG
SQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKS
EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDN
RKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKF
KKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN

--------------------------------------------------------------

>40446_40446_8_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000264107_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1202AA_BP=0
LIKRLRVSREQRAHSAVASCPRGGAAGRRARPVPGVGPGAAARGGEGGCGSSSAAASDPARSAGRPLQVPAPLPVRPPMAAAGQLCLLYL
SAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDND
ADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGV
AATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPR
ANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGT
KDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIF
RSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQEL
TLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKF
CTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNG
SQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKS
EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDN
RKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKF
KKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKN

--------------------------------------------------------------

>40446_40446_9_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000343713_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1131AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLD
SGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYV
YMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLD
RNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGL
SSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLK
EGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAY
RELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVA
KPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLT
ESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTA
AAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART

--------------------------------------------------------------

>40446_40446_10_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000343713_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1131AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLD
SGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYV
YMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLD
RNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGL
SSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLK
EGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAY
RELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVA
KPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLT
ESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTA
AAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART

--------------------------------------------------------------

>40446_40446_11_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000343713_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1131AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLD
SGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYV
YMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLD
RNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGL
SSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLK
EGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAY
RELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVA
KPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLT
ESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTA
AAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART

--------------------------------------------------------------

>40446_40446_12_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000343713_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1131AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLD
SGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYV
YMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLD
RNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGL
SSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLK
EGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAY
RELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVA
KPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLT
ESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTA
AAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART

--------------------------------------------------------------

>40446_40446_13_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000375221_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_14_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000375221_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_15_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000375221_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_16_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000375221_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1175AA_BP=1
MQVPAPLPVRPPMAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRAN
RTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMD
GGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYL
GLLFLTSVSYTDPDQFVYKTRPPREQPDTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDG
EGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGA
PYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTAC
GAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRP
IPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQ
KDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTE
VTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTA
TLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRC
PLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKL
EPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRL

--------------------------------------------------------------

>40446_40446_17_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409080_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1124AA_BP=0
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITA
RGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVS
KDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGR
WNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFR
NQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDN
VCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFP
EKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYF
GGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRK
KREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRL
PNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ

--------------------------------------------------------------

>40446_40446_18_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409080_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1124AA_BP=0
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITA
RGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVS
KDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGR
WNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFR
NQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDN
VCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFP
EKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYF
GGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRK
KREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRL
PNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ

--------------------------------------------------------------

>40446_40446_19_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409080_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1124AA_BP=0
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITA
RGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVS
KDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGR
WNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFR
NQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDN
VCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFP
EKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYF
GGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRK
KREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRL
PNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ

--------------------------------------------------------------

>40446_40446_20_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409080_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1124AA_BP=0
MAAAGQLCLLYLSAGLLSRLGAAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITA
RGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLR
GHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETEHDESLVPVPANSYLGFSLDSGKGIVS
KDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIGAPQYFDRDGEVGGAVYVYMNQQGR
WNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLKGISPYFGYSIAGNMDLDRNSYPDV
AVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSISIVGTLEAEKERRKSGLSSRVQFR
NQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSDEPKTAHIDVHFLKEGCGDDN
VCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAHEAKLIATFPDTLTYSAYRELRAFP
EKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYF
GGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGLEKVTCEPQKEINSLNLTESHNSRK
KREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAAENIRL
PNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQ

--------------------------------------------------------------

>40446_40446_21_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409532_RAPGEF4_chr2_173898641_ENST00000264111_length(amino acids)=1058AA_BP=1
MLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIF
GRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQP
DTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIG
APQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLK
GISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSI
SIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPI
LNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAH
EAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPIT
AKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGL
EKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYS
KLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFID

--------------------------------------------------------------

>40446_40446_22_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409532_RAPGEF4_chr2_173898641_ENST00000397081_length(amino acids)=1058AA_BP=1
MLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIF
GRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQP
DTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIG
APQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLK
GISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSI
SIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPI
LNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAH
EAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPIT
AKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGL
EKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYS
KLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFID

--------------------------------------------------------------

>40446_40446_23_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409532_RAPGEF4_chr2_173898642_ENST00000264111_length(amino acids)=1058AA_BP=1
MLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIF
GRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQP
DTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIG
APQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLK
GISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSI
SIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPI
LNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAH
EAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPIT
AKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGL
EKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYS
KLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFID

--------------------------------------------------------------

>40446_40446_24_ITGA6-RAPGEF4_ITGA6_chr2_173356251_ENST00000409532_RAPGEF4_chr2_173898642_ENST00000397081_length(amino acids)=1058AA_BP=1
MLVGAPRAEALPLQRANRTGGLYSCDITARGPCTRIEFDNDADPTSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIF
GRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGLLFLTSVSYTDPDQFVYKTRPPREQP
DTFPDVMMNSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLLPEHIFDGEGLASSFGYDVAVVDLNKDGWQDIVIG
APQYFDRDGEVGGAVYVYMNQQGRWNNVKPIRLNGTKDSMFGIAVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSANGINTKPTQVLK
GISPYFGYSIAGNMDLDRNSYPDVAVGSLSDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVKSCFEYTANPAGYNPSI
SIVGTLEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLKRQKQKVCMEETLWLQDNIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPI
LNSDEPKTAHIDVHFLKEGCGDDNVCNSNLKLEYKFCTREGNQDKFSYLPIQKGVPELVLKDQKDIALEITVTNSPSNPRNPTKDGDDAH
EAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSNVTFYLVLSTTEVTFDTPDLDINLKLETTSNQDNLAPIT
AKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKGL
EKVTCEPQKEINSLNLTESHNSRKKREITEKQIDDNRKFSLFAERKYQTLNCSVNVNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYS
KLNYLDILMRAFIDVTAAAENIRLPNAGTQKLPSKFKKFYAEFESLMDPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFID

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:173356251/chr2:173898642)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGA6

P23229

.
FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000250|UniProtKB:Q61739, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426363_3711035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426425_4331035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426480_4881035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326363_371996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326425_433996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326480_488996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326363_371991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326425_433991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326480_488991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427363_3711035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427425_4331035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427480_4881035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325363_371996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325425_433996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325480_488996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326363_371877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326425_433877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326480_488877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426363_3711035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426425_4331035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426480_4881035.01131.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326363_371996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326425_433996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326480_488996.01648.6666666666667Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326363_371991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326425_433991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326480_488991.01728.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427363_3711035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427425_4331035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427480_4881035.01772.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325363_371996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325425_433996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325480_488996.01092.0Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326363_371877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326425_433877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326480_488877.01085.3333333333333Calcium bindingOntology_term=ECO:0000255
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426101_1661035.01131.0RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426176_2291035.01131.0RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426283_3391035.01131.0RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+242630_951035.01131.0RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426340_4021035.01131.0RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426403_4581035.01131.0RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+2426459_5181035.01131.0RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326101_166996.01648.6666666666667RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326176_229996.01648.6666666666667RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326283_339996.01648.6666666666667RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+232630_95996.01648.6666666666667RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326340_402996.01648.6666666666667RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326403_458996.01648.6666666666667RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+2326459_518996.01648.6666666666667RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326101_166991.01728.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326176_229991.01728.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326283_339991.01728.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+232630_95991.01728.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326340_402991.01728.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326403_458991.01728.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+2326459_518991.01728.3333333333333RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427101_1661035.01772.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427176_2291035.01772.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427283_3391035.01772.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+242730_951035.01772.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427340_4021035.01772.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427403_4581035.01772.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+2427459_5181035.01772.3333333333333RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325101_166996.01092.0RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325176_229996.01092.0RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325283_339996.01092.0RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+232530_95996.01092.0RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325340_402996.01092.0RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325403_458996.01092.0RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+2325459_518996.01092.0RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326101_166877.01085.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326176_229877.01085.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326283_339877.01085.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+232630_95877.01085.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326340_402877.01085.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326403_458877.01085.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+2326459_518877.01085.3333333333333RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426101_1661035.01131.0RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426176_2291035.01131.0RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426283_3391035.01131.0RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+242630_951035.01131.0RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426340_4021035.01131.0RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426403_4581035.01131.0RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+2426459_5181035.01131.0RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326101_166996.01648.6666666666667RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326176_229996.01648.6666666666667RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326283_339996.01648.6666666666667RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+232630_95996.01648.6666666666667RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326340_402996.01648.6666666666667RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326403_458996.01648.6666666666667RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+2326459_518996.01648.6666666666667RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326101_166991.01728.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326176_229991.01728.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326283_339991.01728.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+232630_95991.01728.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326340_402991.01728.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326403_458991.01728.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+2326459_518991.01728.3333333333333RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427101_1661035.01772.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427176_2291035.01772.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427283_3391035.01772.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+242730_951035.01772.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427340_4021035.01772.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427403_4581035.01772.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+2427459_5181035.01772.3333333333333RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325101_166996.01092.0RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325176_229996.01092.0RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325283_339996.01092.0RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+232530_95996.01092.0RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325340_402996.01092.0RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325403_458996.01092.0RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+2325459_518996.01092.0RepeatFG-GAP 7
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326101_166877.01085.3333333333333RepeatFG-GAP 2
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326176_229877.01085.3333333333333RepeatFG-GAP 3
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326283_339877.01085.3333333333333RepeatFG-GAP 4
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+232630_95877.01085.3333333333333RepeatFG-GAP 1
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326340_402877.01085.3333333333333RepeatFG-GAP 5
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326403_458877.01085.3333333333333RepeatFG-GAP 6
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+2326459_518877.01085.3333333333333RepeatFG-GAP 7
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970872228772_1009739.0868.0DomainRas-GEF
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970872228772_1009739.0868.0DomainRas-GEF

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+24261079_10831035.01131.0MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+23261079_1083996.01648.6666666666667MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+23261079_1083991.01728.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+24271079_10831035.01772.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+23251079_1083996.01092.0MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+23261079_1083877.01085.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+24261079_10831035.01131.0MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+23261079_1083996.01648.6666666666667MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+23261079_1083991.01728.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+24271079_10831035.01772.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+23251079_1083996.01092.0MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+23261079_1083877.01085.3333333333333MotifNote=GFFKR motif
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+24261077_11301035.01131.0Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+242624_10501035.01131.0Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+23261077_1130996.01648.6666666666667Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+232624_1050996.01648.6666666666667Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+23261077_1130991.01728.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+232624_1050991.01728.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+24271077_11301035.01772.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+242724_10501035.01772.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+23251077_1130996.01092.0Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+232524_1050996.01092.0Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+23261077_1130877.01085.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+232624_1050877.01085.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+24261077_11301035.01131.0Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+242624_10501035.01131.0Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+23261077_1130996.01648.6666666666667Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+232624_1050996.01648.6666666666667Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+23261077_1130991.01728.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+232624_1050991.01728.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+24271077_11301035.01772.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+242724_10501035.01772.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+23251077_1130996.01092.0Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+232524_1050996.01092.0Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+23261077_1130877.01085.3333333333333Topological domainCytoplasmic
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+232624_1050877.01085.3333333333333Topological domainExtracellular
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+24261051_10761035.01131.0TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+23261051_1076996.01648.6666666666667TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+23261051_1076991.01728.3333333333333TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+24271051_10761035.01772.3333333333333TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+23251051_1076996.01092.0TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+23261051_1076877.01085.3333333333333TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+24261051_10761035.01131.0TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+23261051_1076996.01648.6666666666667TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+23261051_1076991.01728.3333333333333TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+24271051_10761035.01772.3333333333333TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+23251051_1076996.01092.0TransmembraneHelical
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+23261051_1076877.01085.3333333333333TransmembraneHelical
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970812531216_291883.01012.0DomainDEP
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970812531496_634883.01012.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970812531772_1009883.01012.0DomainRas-GEF
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970872228216_291739.0868.0DomainDEP
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970872228496_634739.0868.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970812531216_291883.01012.0DomainDEP
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970812531496_634883.01012.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970812531772_1009883.01012.0DomainRas-GEF
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970872228216_291739.0868.0DomainDEP
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970872228496_634739.0868.0DomainN-terminal Ras-GEF
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970812531356_476883.01012.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173356251chr2:173898641ENST00000397081253143_166883.01012.0Nucleotide bindingNote=cAMP 1
TgeneRAPGEF4chr2:173356251chr2:173898641ENST000003970872228356_476739.0868.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173356251chr2:173898641ENST00000397087222843_166739.0868.0Nucleotide bindingNote=cAMP 1
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970812531356_476883.01012.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173356251chr2:173898642ENST00000397081253143_166883.01012.0Nucleotide bindingNote=cAMP 1
TgeneRAPGEF4chr2:173356251chr2:173898642ENST000003970872228356_476739.0868.0Nucleotide bindingNote=cAMP 2
TgeneRAPGEF4chr2:173356251chr2:173898642ENST00000397087222843_166739.0868.0Nucleotide bindingNote=cAMP 1


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITGA6
RAPGEF4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneITGA6chr2:173356251chr2:173898641ENST00000264106+24261077_10831035.01131.0HPS5
HgeneITGA6chr2:173356251chr2:173898641ENST00000264107+23261077_1083996.01648.6666666666667HPS5
HgeneITGA6chr2:173356251chr2:173898641ENST00000343713+23261077_1083991.01728.3333333333333HPS5
HgeneITGA6chr2:173356251chr2:173898641ENST00000375221+24271077_10831035.01772.3333333333333HPS5
HgeneITGA6chr2:173356251chr2:173898641ENST00000409080+23251077_1083996.01092.0HPS5
HgeneITGA6chr2:173356251chr2:173898641ENST00000409532+23261077_1083877.01085.3333333333333HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000264106+24261077_10831035.01131.0HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000264107+23261077_1083996.01648.6666666666667HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000343713+23261077_1083991.01728.3333333333333HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000375221+24271077_10831035.01772.3333333333333HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000409080+23251077_1083996.01092.0HPS5
HgeneITGA6chr2:173356251chr2:173898642ENST00000409532+23261077_1083877.01085.3333333333333HPS5


Top

Related Drugs to ITGA6-RAPGEF4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ITGA6-RAPGEF4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource