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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ITGAV-FARP2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ITGAV-FARP2
FusionPDB ID: 40490
FusionGDB2.0 ID: 40490
HgeneTgene
Gene symbol

ITGAV

FARP2

Gene ID

3685

9855

Gene nameintegrin subunit alpha VFERM, ARH/RhoGEF and pleckstrin domain protein 2
SynonymsCD51|MSK8|VNRA|VTNRFIR|FRG|PLEKHC3
Cytomap

2q32.1

2q37.3

Type of geneprotein-codingprotein-coding
Descriptionintegrin alpha-Vantigen identified by monoclonal antibody L230integrin alphaVbeta3integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)vitronectin receptor subunit alphaFERM, ARHGEF and pleckstrin domain-containing protein 2FERM domain including RhoGEFFERM, RhoGEF and pleckstrin domain protein 2FERM, RhoGEF and pleckstrin domain-containing protein 2FGD1-related Cdc42-GEFPH domain-containing family C member 3pleckst
Modification date2020031320200313
UniProtAcc

P06756

O94887

Ensembl transtripts involved in fusion geneENST idsENST00000474571, ENST00000261023, 
ENST00000374907, ENST00000433736, 
ENST00000264042, ENST00000373287, 
ENST00000479427, ENST00000545004, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 9 X 8=7925 X 5 X 4=100
# samples 135
** MAII scorelog2(13/792*10)=-2.60698880705116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ITGAV [Title/Abstract] AND FARP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ITGAV(187534541)-FARP2(242429377), # samples:3
Anticipated loss of major functional domain due to fusion event.ITGAV-FARP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGAV-FARP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGAV-FARP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ITGAV-FARP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneITGAV

GO:0007155

cell adhesion

10218736

HgeneITGAV

GO:0008284

positive regulation of cell proliferation

19578119

HgeneITGAV

GO:0033627

cell adhesion mediated by integrin

12807887|17158881

HgeneITGAV

GO:0034446

substrate adhesion-dependent cell spreading

24658351

HgeneITGAV

GO:0045785

positive regulation of cell adhesion

10708943

HgeneITGAV

GO:0050764

regulation of phagocytosis

10570297

HgeneITGAV

GO:0070588

calcium ion transmembrane transport

18395422

HgeneITGAV

GO:1901388

regulation of transforming growth factor beta activation

22278742

HgeneITGAV

GO:2000536

negative regulation of entry of bacterium into host cell

10570297

TgeneFARP2

GO:0016322

neuron remodeling

12351724

TgeneFARP2

GO:0016601

Rac protein signal transduction

12351724


check buttonFusion gene breakpoints across ITGAV (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FARP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-43-2578-01AITGAVchr2

187534541

-FARP2chr2

242429377

+
ChimerDB4LUSCTCGA-43-2578-01AITGAVchr2

187534541

+FARP2chr2

242429377

+
ChimerDB4LUSCTCGA-43-2578ITGAVchr2

187534541

+FARP2chr2

242429377

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261023ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+444029804937231224
ENST00000374907ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+431728573436001188
ENST00000433736ITGAVchr2187534541+ENST00000264042FARP2chr2242429377+4158269813034411103

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261023ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.0008091750.99919087
ENST00000374907ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.0008200810.9991799
ENST00000433736ENST00000264042ITGAVchr2187534541+FARP2chr2242429377+0.000749320.9992507

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40490_40490_1_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000261023_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1224AA_BP=977
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTK
ADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYI
YDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIA
PLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILY
RARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNM
TISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQK
KIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQS
EMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAML
HLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHC
FTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMH
VCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFK

--------------------------------------------------------------

>40490_40490_2_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000374907_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1188AA_BP=941
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSRQLISDQVAEIVSKYDPNVYS
IKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYA
DVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRST
GLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVS
CFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEY
RLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQA
DFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAA
VEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPL
RIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKS
GGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGW
QKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRAPSIVQ

--------------------------------------------------------------

>40490_40490_3_ITGAV-FARP2_ITGAV_chr2_187534541_ENST00000433736_FARP2_chr2_242429377_ENST00000264042_length(amino acids)=1103AA_BP=856
MLLGTLLLILYILMLCRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKIL
ACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYD
PNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDIN
GDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIF
NGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGT
ALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPIT
IFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVS
IPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDL
AVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDM
EINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAI
QAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFK
NSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGASSSAGRA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:187534541/chr2:242429377)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITGAV

P06756

FARP2

O94887

FUNCTION: The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). Integrin alpha-V/beta-6 or alpha-V/beta-8 (ITGAV:ITGB6 or ITGAV:ITGB8) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). ITGAV:ITGB3 act as a receptor for CD40LG (PubMed:31331973). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:15184403, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22278742, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:28117447, ECO:0000269|PubMed:28302677, ECO:0000269|PubMed:28873464, ECO:0000269|PubMed:29030430, ECO:0000269|PubMed:31331973}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C. {ECO:0000269|PubMed:20615244}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8. {ECO:0000269|PubMed:18045938}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.FUNCTION: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630260_268902.01049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630314_322902.01049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630379_387902.01049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630443_451902.01049.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428260_268866.01013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428314_322866.01013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428379_387866.01013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428443_451866.01013.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630260_268856.01003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630314_322856.01003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630379_387856.01003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630443_451856.01003.0Calcium bindingOntology_term=ECO:0000255,ECO:0000269
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630109_170902.01049.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630173_225902.01049.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630237_291902.01049.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630292_357902.01049.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+263032_98902.01049.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630358_415902.01049.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630419_482902.01049.0RepeatFG-GAP 7
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428109_170866.01013.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428173_225866.01013.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428237_291866.01013.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428292_357866.01013.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+242832_98866.01013.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428358_415866.01013.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428419_482866.01013.0RepeatFG-GAP 7
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630109_170856.01003.0RepeatFG-GAP 2
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630173_225856.01003.0RepeatFG-GAP 3
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630237_291856.01003.0RepeatFG-GAP 4
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630292_357856.01003.0RepeatFG-GAP 5
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+263032_98856.01003.0RepeatFG-GAP 1
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630358_415856.01003.0RepeatFG-GAP 6
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630419_482856.01003.0RepeatFG-GAP 7
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018425_4280648.0Compositional biasNote=Poly-Ser
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018453_5110648.0Compositional biasNote=Pro-rich
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027929_1026807.01055.0DomainPH 2
TgeneFARP2chr2:187534541chr2:242429377ENST0000037328701844_3240648.0DomainFERM
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018535_7260648.0DomainDH
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018755_8520648.0DomainPH 1
TgeneFARP2chr2:187534541chr2:242429377ENST00000373287018929_10260648.0DomainPH 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+26301019_1023902.01049.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+24281019_1023866.01013.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+26301019_1023856.01003.0MotifNote=GFFKR motif
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+26301017_1048902.01049.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+263031_992902.01049.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+24281017_1048866.01013.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+242831_992866.01013.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+26301017_1048856.01003.0Topological domainCytoplasmic
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+263031_992856.01003.0Topological domainExtracellular
HgeneITGAVchr2:187534541chr2:242429377ENST00000261023+2630993_1016902.01049.0TransmembraneHelical
HgeneITGAVchr2:187534541chr2:242429377ENST00000374907+2428993_1016866.01013.0TransmembraneHelical
HgeneITGAVchr2:187534541chr2:242429377ENST00000433736+2630993_1016856.01003.0TransmembraneHelical
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027425_428807.01055.0Compositional biasNote=Poly-Ser
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027453_511807.01055.0Compositional biasNote=Pro-rich
TgeneFARP2chr2:187534541chr2:242429377ENST00000264042202744_324807.01055.0DomainFERM
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027535_726807.01055.0DomainDH
TgeneFARP2chr2:187534541chr2:242429377ENST000002640422027755_852807.01055.0DomainPH 1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1946_ITGAV_187534541_FARP2_242429377_ranked_0.pdbITGAV187534541187534541ENST00000264042FARP2chr2242429377+
MRCCPRPARSAPLVPGGRSEAQPSCLPRSCPGLAEKRAAGKFGRAQAAGRGHWAPRWGGGRWLPLPAWRPARTSAMAFPPRRRLRLGPRG
LPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDAT
GNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTK
ADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYI
YDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIA
PLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILY
RARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNM
TISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQK
KIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQS
EMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAML
HLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLVEESDNEWSVPHC
FTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQAAKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVRSSLEGHGQHRANTTMH
VCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSHGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSIPREADGIHKDYVFKLQFK
1224


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ITGAV_pLDDT.png
all structure
all structure
FARP2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ITGAV
FARP2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ITGAV-FARP2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ITGAV-FARP2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource