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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KAT6A-NCOA2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6A-NCOA2
FusionPDB ID: 41213
FusionGDB2.0 ID: 41213
HgeneTgene
Gene symbol

KAT6A

NCOA2

Gene ID

7994

10499

Gene namelysine acetyltransferase 6Anuclear receptor coactivator 2
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220GRIP1|KAT13C|NCoA-2|SRC2|TIF2|bHLHe75
Cytomap

8p11.21

8q13.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptionnuclear receptor coactivator 2class E basic helix-loop-helix protein 75glucocorticoid receptor-interacting protein-1p160 steroid receptor coactivator 2transcriptional intermediary factor 2
Modification date2020031320200313
UniProtAcc

Q92794

Q15596

Ensembl transtripts involved in fusion geneENST idsENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000267974, ENST00000524223, 
ENST00000452400, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 32 X 13=1081619 X 24 X 6=2736
# samples 4212
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/2736*10)=-4.51096191927738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KAT6A [Title/Abstract] AND NCOA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6A(41794848)-NCOA2(71053441), # samples:1
KAT6A(41794774)-NCOA2(71057084), # samples:1
Anticipated loss of major functional domain due to fusion event.KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-NCOA2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NCOA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4biphenotypic leukemia;acute lymphoblastic leukemia;lymphoblastic lymphomaEF374064KAT6Achr8

41794848

NCOA2chr8

71053441
ChimerKB3..KAT6Achr8

41914005

NCOA2chr8

71215994

-
ChiTaRS5.0N/AEF374064KAT6Achr8

41794774

-NCOA2chr8

71057084

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265713KAT6Achr841794774-ENST00000452400NCOA2chr871057084-9424376441255531713
ENST00000396930KAT6Achr841794774-ENST00000452400NCOA2chr871057084-9556389654456851713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000452400KAT6Achr841794774-NCOA2chr871057084-0.0001909150.9998091
ENST00000396930ENST00000452400KAT6Achr841794774-NCOA2chr871057084-0.0002205140.9997795

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41213_41213_1_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000265713_NCOA2_chr8_71057084_ENST00000452400_length(amino acids)=1713AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMG
NQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGP
SELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALG
IPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRL
QLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSG
MPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQS
PPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTR

--------------------------------------------------------------

>41213_41213_2_KAT6A-NCOA2_KAT6A_chr8_41794774_ENST00000396930_NCOA2_chr8_71057084_ENST00000452400_length(amino acids)=1713AA_BP=1117
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS
DWPTDNQDGWDGKQENEERLFGSQEIMTEKDMELFRDIQEQALQKVGVTGPPDPQVRCPSVIEFGKYEIHTWYSSPYPQEYSRLPKLYLC
EFCLKYMKSRTILQQHMKKCGWFHPPANEIYRKNNISVFEVDGNVSTIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVLTQNDVKGCHLVG
YFSKEKHCQQKYNVSCIMILPQYQRKGYGRFLIDFSYLLSKREGQAGSPEKPLSDLGRLSYMAYWKSVILECLYHQNDKQISIKKLSKLT
GICPQDITSTLHHLRMLDFRSDQFVIIRREKLIQDHMAKLQLNLRPVDVDPECLRWTPVIVSNSVVSEEEEEEAEEGENEEPQCQERELE
ISVGKSVSHENKEQDSYSVESEKKPEVMAPVSSTRLSKQVLPHDSLPANSQPSRRGRWGRKNRKTQERFGDKDSKLLLEETSSAPQEQYG
ECGEKSEATQEQYTESEEQLVASEEQPSQDGKPDLPKRRLSEGVEPWRGQLKKSPEALKCRLTEGSERLPRRYSEGDRAVLRGFSESSEE
EEEPESPRSSSPPILTKPTLKRKKPFLHRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDENELF
PREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADAFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMG
NQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGP
SELEMNMGGPQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALG
IPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRL
QLQHRLQAQQNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSG
MPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQS
PPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDTTR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41794848/chr8:71053441)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

NCOA2

Q15596

FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). {ECO:0000250|UniProtKB:Q61026, ECO:0000269|PubMed:23508108, ECO:0000269|PubMed:9430642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181019_10261117.33333333333332005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181069_10781117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718371_3791117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718788_8011117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718989_9951117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-161795_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718504_7781117.33333333333332005.0DomainMYST-type HAT
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-171895_1711117.33333333333332005.0DomainH15
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-161752_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181_1441117.33333333333332005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718488_7781117.33333333333332005.0RegionNote=Catalytic
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-171852_1661117.33333333333332005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718645_6491117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718654_6601117.33333333333332005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-1617537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718206_2651117.33333333333332005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718259_3131117.33333333333332005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-1718537_5621117.33333333333332005.0Zinc fingerC2HC MYST-type
TgeneNCOA2chr8:41794774chr8:71057084ENST0000045240011231254_1260868.33333333333341465.0Compositional biasNote=Poly-Gln
TgeneNCOA2chr8:41794774chr8:71057084ENST0000045240011231079_1087868.33333333333341465.0MotifNote=LLXXLXXXL motif
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123878_882868.33333333333341465.0MotifNote=LXXLL motif 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181147_11501117.33333333333332005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181221_12421117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181267_13021117.33333333333332005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181411_14141117.33333333333332005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181593_15971117.33333333333332005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181643_17041117.33333333333332005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181897_19771117.33333333333332005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181913_19481117.33333333333332005.0RegionNote=Required for activation of RUNX1-2
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123119_183868.33333333333341465.0DomainPAS
TgeneNCOA2chr8:41794774chr8:71057084ENST00000452400112326_83868.33333333333341465.0DomainbHLH
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123641_645868.33333333333341465.0MotifNote=LXXLL motif 1
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123690_694868.33333333333341465.0MotifNote=LXXLL motif 2
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123745_749868.33333333333341465.0MotifNote=LXXLL motif 3
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123691_743868.33333333333341465.0RegionCASP8AP2-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KAT6AING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, Myo1c, Rpl35, Tpx2, Srsf1, Tubgcp6, HEMGN, HNRNPL, KIAA1429, RANGAP1, BRD1, BRPF3, ING4, KAT7, JADE3, KAT6B, JADE2, JADE1, HIST1H2BO, HRG, CSNK2A2, APEX1, CENPA, DANCR, ZBTB2, CSNK2B, CSNK2A1, RFWD2, HSPD1, CMAS, HIST2H2BF, CASP2, TRIM65, HGH1, TTC4, PPP2R5C, OTUD3, DBNL, PIP4K2C, ATIC, NUDT12, B3GALTL, ATG4B, PABPN1, DEK, SF3A3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KAT6Aall structure
NCOA2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181517_17411117.33333333333332005.0PML
HgeneKAT6Achr8:41794774chr8:71057084ENST00000265713-16171517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000396930-17181517_16421117.33333333333332005.0RUNX1-2
HgeneKAT6Achr8:41794774chr8:71057084ENST00000406337-17181517_16421117.33333333333332005.0RUNX1-2
TgeneNCOA2chr8:41794774chr8:71057084ENST000004524001123730_1121868.33333333333341465.0ARNTL


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Related Drugs to KAT6A-NCOA2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6A-NCOA2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC4225396MENTAL RETARDATION, AUTOSOMAL DOMINANT 323CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKAT6AC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human
HgeneKAT6AC0033578Prostatic Neoplasms1CTD_human
HgeneKAT6AC0205833Medullomyoblastoma1CTD_human
HgeneKAT6AC0278510Childhood Medulloblastoma1CTD_human
HgeneKAT6AC0278876Adult Medulloblastoma1CTD_human
HgeneKAT6AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKAT6AC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneKAT6AC1275668Melanotic medulloblastoma1CTD_human
TgeneNCOA2C0006142Malignant neoplasm of breast1CTD_human
TgeneNCOA2C0033578Prostatic Neoplasms1CTD_human
TgeneNCOA2C0376358Malignant neoplasm of prostate1CTD_human
TgeneNCOA2C0678222Breast Carcinoma1CTD_human
TgeneNCOA2C1257931Mammary Neoplasms, Human1CTD_human
TgeneNCOA2C1458155Mammary Neoplasms1CTD_human
TgeneNCOA2C4704874Mammary Carcinoma, Human1CTD_human