UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:KATNA1-PPP2R1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KATNA1-PPP2R1A
FusionPDB ID: 41258
FusionGDB2.0 ID: 41258
HgeneTgene
Gene symbol

KATNA1

PPP2R1A

Gene ID

11104

5518

Gene namekatanin catalytic subunit A1protein phosphatase 2 scaffold subunit Aalpha
Synonyms-MRD36|PP2A-Aalpha|PP2AA|PP2AAALPHA|PR65A
Cytomap

6q25.1

19q13.41

Type of geneprotein-codingprotein-coding
Descriptionkatanin p60 ATPase-containing subunit A1katanin p60 (ATPase containing) subunit A 1katanin p60 subunit A1p60 kataninserine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformPP2A subunit A isoform PR65-alphaPP2A subunit A isoform R1-alphamedium tumor antigen-associated 61 KDA proteinprotein phosphatase 2 (formerly 2A), regulatory subunit A (P
Modification date2020031520200313
UniProtAcc

O75449

.
Ensembl transtripts involved in fusion geneENST idsENST00000335643, ENST00000335647, 
ENST00000367411, ENST00000494504, 
ENST00000462990, ENST00000473455, 
ENST00000477989, ENST00000322088, 
ENST00000444322, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 6 X 2=3610 X 12 X 4=480
# samples 412
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/480*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KATNA1 [Title/Abstract] AND PPP2R1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KATNA1(149922730)-PPP2R1A(52719782), # samples:3
Anticipated loss of major functional domain due to fusion event.KATNA1-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KATNA1-PPP2R1A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPP2R1A

GO:0007059

chromosome segregation

16580887


check buttonFusion gene breakpoints across KATNA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PPP2R1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08I-01AKATNA1chr6

149922730

-PPP2R1Achr19

52719782

+
ChimerDB4BRCATCGA-A8-A08I-01AKATNA1chr6

149924404

-PPP2R1Achr19

52719782

+
ChimerDB4BRCATCGA-A8-A08IKATNA1chr6

149922729

-PPP2R1Achr19

52719781

+
ChimerDB4BRCATCGA-A8-A08IKATNA1chr6

149924403

-PPP2R1Achr19

52719781

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000335647KATNA1chr6149922730-ENST00000322088PPP2R1Achr1952719782+3163933391709556
ENST00000335647KATNA1chr6149922730-ENST00000444322PPP2R1Achr1952719782+1965933391709556
ENST00000335647KATNA1chr6149922729-ENST00000322088PPP2R1Achr1952719781+3163933391709556
ENST00000335647KATNA1chr6149922729-ENST00000444322PPP2R1Achr1952719781+1965933391709556
ENST00000335647KATNA1chr6149924403-ENST00000322088PPP2R1Achr1952719781+3004774391550503
ENST00000335647KATNA1chr6149924403-ENST00000444322PPP2R1Achr1952719781+1806774391550503
ENST00000335647KATNA1chr6149924404-ENST00000322088PPP2R1Achr1952719782+3004774391550503
ENST00000335647KATNA1chr6149924404-ENST00000444322PPP2R1Achr1952719782+1806774391550503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000335647ENST00000322088KATNA1chr6149922730-PPP2R1Achr1952719782+0.0005375870.9994624
ENST00000335647ENST00000444322KATNA1chr6149922730-PPP2R1Achr1952719782+0.0009279820.99907196
ENST00000335647ENST00000322088KATNA1chr6149922729-PPP2R1Achr1952719781+0.0005375870.9994624
ENST00000335647ENST00000444322KATNA1chr6149922729-PPP2R1Achr1952719781+0.0009279820.99907196
ENST00000335647ENST00000322088KATNA1chr6149924403-PPP2R1Achr1952719781+0.0003945520.9996055
ENST00000335647ENST00000444322KATNA1chr6149924403-PPP2R1Achr1952719781+0.0006758040.9993242
ENST00000335647ENST00000322088KATNA1chr6149924404-PPP2R1Achr1952719782+0.0003945520.9996055
ENST00000335647ENST00000444322KATNA1chr6149924404-PPP2R1Achr1952719782+0.0006758040.9993242

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41258_41258_1_KATNA1-PPP2R1A_KATNA1_chr6_149922729_ENST00000335647_PPP2R1A_chr19_52719781_ENST00000322088_length(amino acids)=556AA_BP=298
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKT
TFFNVSSSTLTSKYRGESEKLVRLLFEMELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNE
VIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATII
PKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDV

--------------------------------------------------------------

>41258_41258_2_KATNA1-PPP2R1A_KATNA1_chr6_149922729_ENST00000335647_PPP2R1A_chr19_52719781_ENST00000444322_length(amino acids)=556AA_BP=298
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKT
TFFNVSSSTLTSKYRGESEKLVRLLFEMELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNE
VIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATII
PKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDV

--------------------------------------------------------------

>41258_41258_3_KATNA1-PPP2R1A_KATNA1_chr6_149922730_ENST00000335647_PPP2R1A_chr19_52719782_ENST00000322088_length(amino acids)=556AA_BP=298
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKT
TFFNVSSSTLTSKYRGESEKLVRLLFEMELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNE
VIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATII
PKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDV

--------------------------------------------------------------

>41258_41258_4_KATNA1-PPP2R1A_KATNA1_chr6_149922730_ENST00000335647_PPP2R1A_chr19_52719782_ENST00000444322_length(amino acids)=556AA_BP=298
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKT
TFFNVSSSTLTSKYRGESEKLVRLLFEMELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNE
VIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATII
PKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDV

--------------------------------------------------------------

>41258_41258_5_KATNA1-PPP2R1A_KATNA1_chr6_149924403_ENST00000335647_PPP2R1A_chr19_52719781_ENST00000322088_length(amino acids)=503AA_BP=245
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKELVSDANQHVKSALASVIMGLSPIL
GKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSL
CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV

--------------------------------------------------------------

>41258_41258_6_KATNA1-PPP2R1A_KATNA1_chr6_149924403_ENST00000335647_PPP2R1A_chr19_52719781_ENST00000444322_length(amino acids)=503AA_BP=245
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKELVSDANQHVKSALASVIMGLSPIL
GKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSL
CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV

--------------------------------------------------------------

>41258_41258_7_KATNA1-PPP2R1A_KATNA1_chr6_149924404_ENST00000335647_PPP2R1A_chr19_52719782_ENST00000322088_length(amino acids)=503AA_BP=245
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKELVSDANQHVKSALASVIMGLSPIL
GKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSL
CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV

--------------------------------------------------------------

>41258_41258_8_KATNA1-PPP2R1A_KATNA1_chr6_149924404_ENST00000335647_PPP2R1A_chr19_52719782_ENST00000444322_length(amino acids)=503AA_BP=245
MNMSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQH
DLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPE
TNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKELVSDANQHVKSALASVIMGLSPIL
GKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSL
CMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:149922730/chr19:52719782)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KATNA1

O75449

.
FUNCTION: Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023, ECO:0000269|PubMed:10751153, ECO:0000269|PubMed:11870226, ECO:0000269|PubMed:19287380}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKATNA1chr6:149922729chr19:52719781ENST00000335647-610249_256296.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149922729chr19:52719781ENST00000367411-711249_256296.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149922730chr19:52719782ENST00000335647-610249_256296.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149922730chr19:52719782ENST00000367411-711249_256296.0492.0Nucleotide bindingATP
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715400_589331.0590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715400_589331.0590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715400_589331.0590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715400_589331.0590.0RegionNote=PP2A subunit C binding
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715361_399331.0590.0RepeatNote=HEAT 10
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715400_438331.0590.0RepeatNote=HEAT 11
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715439_477331.0590.0RepeatNote=HEAT 12
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715478_516331.0590.0RepeatNote=HEAT 13
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715517_555331.0590.0RepeatNote=HEAT 14
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715556_589331.0590.0RepeatNote=HEAT 15
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715361_399331.0590.0RepeatNote=HEAT 10
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715400_438331.0590.0RepeatNote=HEAT 11
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715439_477331.0590.0RepeatNote=HEAT 12
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715478_516331.0590.0RepeatNote=HEAT 13
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715517_555331.0590.0RepeatNote=HEAT 14
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715556_589331.0590.0RepeatNote=HEAT 15
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715361_399331.0590.0RepeatNote=HEAT 10
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715400_438331.0590.0RepeatNote=HEAT 11
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715439_477331.0590.0RepeatNote=HEAT 12
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715478_516331.0590.0RepeatNote=HEAT 13
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715517_555331.0590.0RepeatNote=HEAT 14
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715556_589331.0590.0RepeatNote=HEAT 15
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715361_399331.0590.0RepeatNote=HEAT 10
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715400_438331.0590.0RepeatNote=HEAT 11
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715439_477331.0590.0RepeatNote=HEAT 12
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715478_516331.0590.0RepeatNote=HEAT 13
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715517_555331.0590.0RepeatNote=HEAT 14
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715556_589331.0590.0RepeatNote=HEAT 15

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKATNA1chr6:149922729chr19:52719781ENST00000335643-58249_256220.0312.0Nucleotide bindingATP
HgeneKATNA1chr6:149922730chr19:52719782ENST00000335643-58249_256220.0312.0Nucleotide bindingATP
HgeneKATNA1chr6:149924403chr19:52719781ENST00000335643-18249_2560312.0Nucleotide bindingATP
HgeneKATNA1chr6:149924403chr19:52719781ENST00000335647-510249_256243.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149924403chr19:52719781ENST00000367411-611249_256243.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149924404chr19:52719782ENST00000335643-18249_2560312.0Nucleotide bindingATP
HgeneKATNA1chr6:149924404chr19:52719782ENST00000335647-510249_256243.0492.0Nucleotide bindingATP
HgeneKATNA1chr6:149924404chr19:52719782ENST00000367411-611249_256243.0492.0Nucleotide bindingATP
TgenePPP2R1Achr6:149922729chr19:52719781ENST0000032208871547_321331.0590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr6:149922729chr19:52719781ENST0000032208871585_239331.0590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr6:149922729chr19:52719781ENST000003220887158_399331.0590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr6:149922730chr19:52719782ENST0000032208871547_321331.0590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr6:149922730chr19:52719782ENST0000032208871585_239331.0590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr6:149922730chr19:52719782ENST000003220887158_399331.0590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr6:149924403chr19:52719781ENST0000032208871547_321331.0590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr6:149924403chr19:52719781ENST0000032208871585_239331.0590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr6:149924403chr19:52719781ENST000003220887158_399331.0590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr6:149924404chr19:52719782ENST0000032208871547_321331.0590.0RegionNote=Polyoma small and medium T antigens Binding
TgenePPP2R1Achr6:149924404chr19:52719782ENST0000032208871585_239331.0590.0RegionNote=SV40 small T antigen binding
TgenePPP2R1Achr6:149924404chr19:52719782ENST000003220887158_399331.0590.0RegionNote=PP2A subunit B binding
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715124_161331.0590.0RepeatNote=HEAT 4
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715162_200331.0590.0RepeatNote=HEAT 5
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715201_239331.0590.0RepeatNote=HEAT 6
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715240_278331.0590.0RepeatNote=HEAT 7
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715279_321331.0590.0RepeatNote=HEAT 8
TgenePPP2R1Achr6:149922729chr19:52719781ENST00000322088715322_360331.0590.0RepeatNote=HEAT 9
TgenePPP2R1Achr6:149922729chr19:52719781ENST0000032208871547_84331.0590.0RepeatNote=HEAT 2
TgenePPP2R1Achr6:149922729chr19:52719781ENST0000032208871585_123331.0590.0RepeatNote=HEAT 3
TgenePPP2R1Achr6:149922729chr19:52719781ENST000003220887158_46331.0590.0RepeatNote=HEAT 1
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715124_161331.0590.0RepeatNote=HEAT 4
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715162_200331.0590.0RepeatNote=HEAT 5
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715201_239331.0590.0RepeatNote=HEAT 6
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715240_278331.0590.0RepeatNote=HEAT 7
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715279_321331.0590.0RepeatNote=HEAT 8
TgenePPP2R1Achr6:149922730chr19:52719782ENST00000322088715322_360331.0590.0RepeatNote=HEAT 9
TgenePPP2R1Achr6:149922730chr19:52719782ENST0000032208871547_84331.0590.0RepeatNote=HEAT 2
TgenePPP2R1Achr6:149922730chr19:52719782ENST0000032208871585_123331.0590.0RepeatNote=HEAT 3
TgenePPP2R1Achr6:149922730chr19:52719782ENST000003220887158_46331.0590.0RepeatNote=HEAT 1
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715124_161331.0590.0RepeatNote=HEAT 4
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715162_200331.0590.0RepeatNote=HEAT 5
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715201_239331.0590.0RepeatNote=HEAT 6
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715240_278331.0590.0RepeatNote=HEAT 7
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715279_321331.0590.0RepeatNote=HEAT 8
TgenePPP2R1Achr6:149924403chr19:52719781ENST00000322088715322_360331.0590.0RepeatNote=HEAT 9
TgenePPP2R1Achr6:149924403chr19:52719781ENST0000032208871547_84331.0590.0RepeatNote=HEAT 2
TgenePPP2R1Achr6:149924403chr19:52719781ENST0000032208871585_123331.0590.0RepeatNote=HEAT 3
TgenePPP2R1Achr6:149924403chr19:52719781ENST000003220887158_46331.0590.0RepeatNote=HEAT 1
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715124_161331.0590.0RepeatNote=HEAT 4
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715162_200331.0590.0RepeatNote=HEAT 5
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715201_239331.0590.0RepeatNote=HEAT 6
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715240_278331.0590.0RepeatNote=HEAT 7
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715279_321331.0590.0RepeatNote=HEAT 8
TgenePPP2R1Achr6:149924404chr19:52719782ENST00000322088715322_360331.0590.0RepeatNote=HEAT 9
TgenePPP2R1Achr6:149924404chr19:52719782ENST0000032208871547_84331.0590.0RepeatNote=HEAT 2
TgenePPP2R1Achr6:149924404chr19:52719782ENST0000032208871585_123331.0590.0RepeatNote=HEAT 3
TgenePPP2R1Achr6:149924404chr19:52719782ENST000003220887158_46331.0590.0RepeatNote=HEAT 1


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KATNA1
PPP2R1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKATNA1chr6:149924403chr19:52719781ENST00000335643-181_750312.0dynein and NDEL1
HgeneKATNA1chr6:149924404chr19:52719782ENST00000335643-181_750312.0dynein and NDEL1
HgeneKATNA1chr6:149924403chr19:52719781ENST00000335643-181_290312.0KATNB1
HgeneKATNA1chr6:149924404chr19:52719782ENST00000335643-181_290312.0KATNB1
HgeneKATNA1chr6:149924403chr19:52719781ENST00000335643-181_1850312.0microtubules
HgeneKATNA1chr6:149924404chr19:52719782ENST00000335643-181_1850312.0microtubules


Top

Related Drugs to KATNA1-PPP2R1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to KATNA1-PPP2R1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource