UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KDM5B-RASAL2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KDM5B-RASAL2
	FusionPDB ID: 41869
	FusionGDB2.0 ID: 41869
		Hgene	Tgene
	Gene symbol	KDM5B	RASAL2
	Gene ID	10765	9462
	Gene name	lysine demethylase 5B	RAS protein activator like 2
	Synonyms	CT31\|JARID1B\|MRT65\|PLU-1\|PLU1\|PPP1R98\|PUT1\|RBBP2H1A\|RBP2-H1	NGAP
	Cytomap	1q32.1	1q25.2
	Type of gene	protein-coding	protein-coding
	Description	lysine-specific demethylase 5Bcancer/testis antigen 31histone demethylase JARID1Bjumonji, AT rich interactive domain 1Bjumonji/ARID domain-containing protein 1Blysine (K)-specific demethylase 5Bprotein phosphatase 1, regulatory subunit 98putative D	ras GTPase-activating protein nGAPRASAL2/ACVR1 fusionRas protein activator like 1
	Modification date	20200320	20200313
	UniProtAcc	Q9UGL1	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367264, ENST00000367265, ENST00000456180,	ENST00000462775, ENST00000465723, ENST00000367649, ENST00000448150,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 9=1638	15 X 14 X 7=1470
	# samples	17	19
	** MAII score	log2(17/1638*10)=-3.26832870550331 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1470*10)=-2.95174483139278 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KDM5B [Title/Abstract] AND RASAL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KDM5B(202777230)-RASAL2(178389646), # samples:2
Anticipated loss of major functional domain due to fusion event.	KDM5B-RASAL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-RASAL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-RASAL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM5B-RASAL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KDM5B	GO:0034720	histone H3-K4 demethylation	20228790

Fusion gene breakpoints across KDM5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RASAL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-EE-A3J5-06A	KDM5B	chr1	202777230	-	RASAL2	chr1	178389646	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367265	KDM5B	chr1	202777230	-	ENST00000448150	RASAL2	chr1	178389646	+	10939	1369	934	4668	1244
ENST00000367265	KDM5B	chr1	202777230	-	ENST00000367649	RASAL2	chr1	178389646	+	4831	1369	934	4647	1237
ENST00000367264	KDM5B	chr1	202777230	-	ENST00000448150	RASAL2	chr1	178389646	+	9887	317	113	3616	1167
ENST00000367264	KDM5B	chr1	202777230	-	ENST00000367649	RASAL2	chr1	178389646	+	3779	317	113	3595	1160

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367265	ENST00000448150	KDM5B	chr1	202777230	-	RASAL2	chr1	178389646	+	0.000643022	0.9993569
ENST00000367265	ENST00000367649	KDM5B	chr1	202777230	-	RASAL2	chr1	178389646	+	0.003027692	0.9969723
ENST00000367264	ENST00000448150	KDM5B	chr1	202777230	-	RASAL2	chr1	178389646	+	0.000224248	0.9997757
ENST00000367264	ENST00000367649	KDM5B	chr1	202777230	-	RASAL2	chr1	178389646	+	0.001999508	0.99800044

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41869_41869_1_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000367649_length(amino acids)=1160AA_BP=68
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDR
NTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKD
KNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELID
HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVL
ADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERES
SLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLN
NPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLG
ARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQY
EEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMA

--------------------------------------------------------------

>41869_41869_2_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367264_RASAL2_chr1_178389646_ENST00000448150_length(amino acids)=1167AA_BP=68
MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDR
NTSFRLPSLRSTDDRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMEN
LRRTVQPNKDNCRRAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKD
KNNYVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELA
CALVHILQSTGRAKDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELID
HQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAK
VIQNLANFAKFGNKEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKL
GPLPRVLADITKSLTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYS
EKDERESSLPNGRSVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQ
NPVYHLNNPIPAMPKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRK
VDQGGLGARAKAPPSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAW
VLNNGQYEEDVEETEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKS

--------------------------------------------------------------

>41869_41869_3_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000367649_length(amino acids)=1237AA_BP=145
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTD
DRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCR
RAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTA
SVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRA
KDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAF
CKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN
KEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKATVAKLGPLPRVLADITKSLTNPTPI
QQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGRSVSLMDL
QDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAMPKASIDS
SLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAPPSLPHSA
SLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEETEQNLDE
AKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELKKDHAEMQ

--------------------------------------------------------------

>41869_41869_4_KDM5B-RASAL2_KDM5B_chr1_202777230_ENST00000367265_RASAL2_chr1_178389646_ENST00000448150_length(amino acids)=1244AA_BP=145
MGVGWDSFSSPWRRRRTAWACGETSSSEAEKAQGAAVARTTRTCCCSSRVCTGLGPSGARSLGPGAHLRLALAQPAVMEAATTLHPGPRP
ALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTGICKVRPPPGFFSKRLKGSIKRTKSQSKLDRNTSFRLPSLRSTD
DRSRGLPKLKESRSHESLLSPCSTVECLDLGRGEPVSVKPLHSSILGQDFCFEVTYLSGSKCFSCNSASERDKWMENLRRTVQPNKDNCR
RAENVLRLWIIEAKDLAPKKKYFCELCLDDTLFARTTSKTKADNIFWGEHFEFFSLPPLHSITVHIYKDVEKKKKKDKNNYVGLVNIPTA
SVTGRQFVEKWYPVSTPTPNKGKTGGPSIRIKSRFQTITILPMEQYKEFAEFVTSNYTMLCSVLEPVISVRNKEELACALVHILQSTGRA
KDFLTDLVMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDPSKCSSSELIDHQSNLKMCCELAF
CKIINSYCVFPRELKEVFASWKQQCLNRGKQDISERLISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN
KEEYMAFMNDFLEHEWGGMKRFLLEISNPDTISNTPGFDGYIDLGRELSVLHSLLWEVVSQLDKGENSFLQATVAKLGPLPRVLADITKS
LTNPTPIQQQLRRFTEHNSSPNVSGSLSSGLQKIFEDPTDSDLHKLKSPSQDNTDSYFRGKTLLLVQQASSQSMTYSEKDERESSLPNGR
SVSLMDLQDTHAAQVEHASVMLDVPIRLTGSQLSITQVASIKQLRETQSTPQSAPQVRRPLHPALNQPGGLQPLSFQNPVYHLNNPIPAM
PKASIDSSLENLSTASSRSQSNSEDFKLSGPSNSSMEDFTKRSTQSEDFSRRHTVPDRHIPLALPRQNSTGQAQIRKVDQGGLGARAKAP
PSLPHSASLRSTGSMSVVSAALVAEPVQNGSRSRQQSSSSRESPVPKVRAIQRQQTQQVQSPVDSATMSPVERTAAWVLNNGQYEEDVEE
TEQNLDEAKHAEKYEQEITKLKERLRVSSRRLEEYERRLLVQEQQMQKLLLEYKARLEDSEERLRRQQEEKDSQMKSIISRLMAVEEELK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202777230/chr1:178389646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KDM5B Q9UGL1	.
FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). {ECO:0000250\|UniProtKB:Q80Y84, ECO:0000269\|PubMed:12657635, ECO:0000269\|PubMed:16645588, ECO:0000269\|PubMed:17320161, ECO:0000269\|PubMed:17363312, ECO:0000269\|PubMed:24952722, ECO:0000269\|PubMed:26645689, ECO:0000269\|PubMed:26741168, ECO:0000269\|PubMed:27214403, ECO:0000269\|PubMed:28262558}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000367649

237_243

188.0

1281.0

Compositional bias

Note=Poly-Lys

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000367649

922_925

188.0

1281.0

Compositional bias

Note=Poly-Ser

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000462775

237_243

40.0

1140.0

Compositional bias

Note=Poly-Lys

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000462775

922_925

40.0

1140.0

Compositional bias

Note=Poly-Ser

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000367649

327_519

188.0

1281.0

Domain

Ras-GAP

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000462775

149_267

40.0

1140.0

Domain

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000462775

327_519

40.0

1140.0

Domain

Ras-GAP

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000462775

41_158

40.0

1140.0

Domain

Note=PH

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

1434_1439

68.0

1581.0

Compositional bias

Note=Poly-Lys

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

1434_1439

68.0

1545.0

Compositional bias

Note=Poly-Lys

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

32_73

68.0

1581.0

Domain

JmjN

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

453_619

68.0

1581.0

Domain

JmjC

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

97_187

68.0

1581.0

Domain

ARID

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

32_73

68.0

1545.0

Domain

JmjN

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

453_619

68.0

1545.0

Domain

JmjC

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

97_187

68.0

1545.0

Domain

ARID

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

1176_1224

68.0

1581.0

Zinc finger

PHD-type 2

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

1484_1538

68.0

1581.0

Zinc finger

PHD-type 3

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

309_359

68.0

1581.0

Zinc finger

PHD-type 1

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367264

692_744

68.0

1581.0

Zinc finger

C5HC2

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

1176_1224

68.0

1545.0

Zinc finger

PHD-type 2

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

1484_1538

68.0

1545.0

Zinc finger

PHD-type 3

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

309_359

68.0

1545.0

Zinc finger

PHD-type 1

Hgene

KDM5B

chr1:202777230

chr1:178389646

ENST00000367265

692_744

68.0

1545.0

Zinc finger

C5HC2

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000367649

149_267

188.0

1281.0

Domain

Tgene

RASAL2

chr1:202777230

chr1:178389646

ENST00000367649

41_158

188.0

1281.0

Domain

Note=PH

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KDM5B
RASAL2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to KDM5B-RASAL2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to KDM5B-RASAL2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source