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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIAA0391-FAM177A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIAA0391-FAM177A1
FusionPDB ID: 42125
FusionGDB2.0 ID: 42125
HgeneTgene
Gene symbol

KIAA0391

FAM177A1

Gene ID

9692

283635

Gene nameprotein only RNase P catalytic subunitfamily with sequence similarity 177 member A1
SynonymsKIAA0391|MRPP3C14orf24
Cytomap

14q13.2

14q13.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial ribonuclease P catalytic subunitmitochondrial RNase P protein 3mitochondrial RNase P subunit 3mitochondrial ribonuclease P protein 3proteinaceous RNase Pprotein FAM177A1
Modification date2020031320200313
UniProtAcc.

Q8N128

Ensembl transtripts involved in fusion geneENST idsENST00000250377, ENST00000321130, 
ENST00000534898, ENST00000557565, 
ENST00000603544, ENST00000604948, 
ENST00000605870, ENST00000603588, 
ENST00000554052, ENST00000280987, 
ENST00000382406, ENST00000396472, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 1 X 2=410 X 10 X 4=400
# samples 212
** MAII scorelog2(2/4*10)=2.32192809488736log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIAA0391 [Title/Abstract] AND FAM177A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FAM177A1(35522657)-KIAA0391(35649876), # samples:2
KIAA0391(35649983)-FAM177A1(35546356), # samples:5
Anticipated loss of major functional domain due to fusion event.FAM177A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM177A1-KIAA0391 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0391-FAM177A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIAA0391-FAM177A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIAA0391

GO:0097745

mitochondrial tRNA 5'-end processing

25953853


check buttonFusion gene breakpoints across KIAA0391 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM177A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A45U-01AKIAA0391chr14

35649983

-FAM177A1chr14

35546356

+
ChimerDB4HNSCTCGA-CV-A45UKIAA0391chr14

35649983

+FAM177A1chr14

35546355

+
ChimerDB4HNSCTCGA-CV-A45UKIAA0391chr14

35649983

+FAM177A1chr14

35546356

+
ChimerDB4KIRCTCGA-B0-4849-01AKIAA0391chr14

35649983

-FAM177A1chr14

35546356

+
ChimerDB4KIRCTCGA-B0-4849-01AKIAA0391chr14

35649983

+FAM177A1chr14

35546356

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000604948KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+36301105761476466
ENST00000604948KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+16361105761476466
ENST00000604948KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+36321105761476466
ENST00000557565KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+418116563812027548
ENST00000557565KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+218716563812027548
ENST00000557565KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+418316563812027548
ENST00000250377KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+416716423672013548
ENST00000250377KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+217316423672013548
ENST00000250377KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+416916423672013548
ENST00000321130KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+411815933661964532
ENST00000321130KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+212415933661964532
ENST00000321130KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+412015933661964532
ENST00000534898KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+416016353602006548
ENST00000534898KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+216616353602006548
ENST00000534898KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+416216353602006548
ENST00000603544KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+417616514242022532
ENST00000603544KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+218216514242022532
ENST00000603544KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+417816514242022532
ENST00000605870KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546355+3003478280849189
ENST00000605870KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546355+1009478280849189
ENST00000605870KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546355+3005478280849189
ENST00000604948KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+36301105761476466
ENST00000604948KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+16361105761476466
ENST00000604948KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+36321105761476466
ENST00000557565KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+418116563812027548
ENST00000557565KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+218716563812027548
ENST00000557565KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+418316563812027548
ENST00000250377KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+416716423672013548
ENST00000250377KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+217316423672013548
ENST00000250377KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+416916423672013548
ENST00000321130KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+411815933661964532
ENST00000321130KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+212415933661964532
ENST00000321130KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+412015933661964532
ENST00000534898KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+416016353602006548
ENST00000534898KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+216616353602006548
ENST00000534898KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+416216353602006548
ENST00000603544KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+417616514242022532
ENST00000603544KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+218216514242022532
ENST00000603544KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+417816514242022532
ENST00000605870KIAA0391chr1435649983+ENST00000396472FAM177A1chr1435546356+3003478280849189
ENST00000605870KIAA0391chr1435649983+ENST00000382406FAM177A1chr1435546356+1009478280849189
ENST00000605870KIAA0391chr1435649983+ENST00000280987FAM177A1chr1435546356+3005478280849189

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000604948ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0001218230.99987817
ENST00000604948ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0003098390.9996902
ENST00000604948ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.000121610.9998784
ENST00000557565ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002243360.9997757
ENST00000557565ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0004805330.99951947
ENST00000557565ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002244880.99977547
ENST00000250377ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002228380.99977714
ENST00000250377ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0004772250.9995228
ENST00000250377ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002229890.999777
ENST00000321130ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0001825720.99981743
ENST00000321130ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0004518530.99954814
ENST00000321130ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.0001827560.9998173
ENST00000534898ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002242120.9997758
ENST00000534898ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0004918380.99950814
ENST00000534898ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002243660.9997756
ENST00000603544ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002103350.99978966
ENST00000603544ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0006032520.9993968
ENST00000603544ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.0002106550.9997894
ENST00000605870ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546355+0.0017528530.99824715
ENST00000605870ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546355+0.0018774570.9981225
ENST00000605870ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546355+0.001434510.9985655
ENST00000604948ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0001218230.99987817
ENST00000604948ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0003098390.9996902
ENST00000604948ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.000121610.9998784
ENST00000557565ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002243360.9997757
ENST00000557565ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0004805330.99951947
ENST00000557565ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002244880.99977547
ENST00000250377ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002228380.99977714
ENST00000250377ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0004772250.9995228
ENST00000250377ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002229890.999777
ENST00000321130ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0001825720.99981743
ENST00000321130ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0004518530.99954814
ENST00000321130ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.0001827560.9998173
ENST00000534898ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002242120.9997758
ENST00000534898ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0004918380.99950814
ENST00000534898ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002243660.9997756
ENST00000603544ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002103350.99978966
ENST00000603544ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0006032520.9993968
ENST00000603544ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.0002106550.9997894
ENST00000605870ENST00000396472KIAA0391chr1435649983+FAM177A1chr1435546356+0.0017528530.99824715
ENST00000605870ENST00000382406KIAA0391chr1435649983+FAM177A1chr1435546356+0.0018774570.9981225
ENST00000605870ENST00000280987KIAA0391chr1435649983+FAM177A1chr1435546356+0.001434510.9985655

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42125_42125_1_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_2_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_3_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_4_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_5_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_6_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000250377_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_7_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_8_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_9_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_10_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_11_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_12_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000321130_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_13_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_14_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_15_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_16_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_17_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_18_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000534898_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_19_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_20_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_21_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_22_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_23_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_24_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000557565_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=548AA_BP=425
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK

--------------------------------------------------------------

>42125_42125_25_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_26_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_27_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_28_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_29_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_30_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000603544_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=532AA_BP=409
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESGQCSGCGKTIESIQLSPEEYECLKGKIMRDV
IDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPK

--------------------------------------------------------------

>42125_42125_31_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_32_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_33_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_34_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_35_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_36_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000604948_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=466AA_BP=343
MSAFAGAAKERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGI
VSYDLLVKYLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNT
AWNLYQELLGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCG
KTIESIQLSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAA
TSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGD

--------------------------------------------------------------

>42125_42125_37_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546355_ENST00000280987_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

>42125_42125_38_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546355_ENST00000382406_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

>42125_42125_39_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546355_ENST00000396472_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

>42125_42125_40_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546356_ENST00000280987_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

>42125_42125_41_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546356_ENST00000382406_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

>42125_42125_42_KIAA0391-FAM177A1_KIAA0391_chr14_35649983_ENST00000605870_FAM177A1_chr14_35546356_ENST00000396472_length(amino acids)=189AA_BP=66
MSPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVC
DFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMES

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:35522657/chr14:35649876)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM177A1

Q8N128

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM177A1chr14:35649983chr14:35546355ENST0000028098715136_173113.0237.0Coiled coilOntology_term=ECO:0000255
TgeneFAM177A1chr14:35649983chr14:35546355ENST0000038240626136_17390.0214.0Coiled coilOntology_term=ECO:0000255
TgeneFAM177A1chr14:35649983chr14:35546355ENST0000039647237136_17390.0214.0Coiled coilOntology_term=ECO:0000255
TgeneFAM177A1chr14:35649983chr14:35546356ENST0000028098715136_173113.0237.0Coiled coilOntology_term=ECO:0000255
TgeneFAM177A1chr14:35649983chr14:35546356ENST0000038240626136_17390.0214.0Coiled coilOntology_term=ECO:0000255
TgeneFAM177A1chr14:35649983chr14:35546356ENST0000039647237136_17390.0214.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000250377+58342_578330.0489.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000321130+47342_578409.0568.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000534898+58342_578425.0584.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000603544+47342_578409.0568.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000604948+58342_578330.0489.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546355ENST00000605870+47342_57853.0212.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000250377+58342_578330.0489.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000321130+47342_578409.0568.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000534898+58342_578425.0584.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000603544+47342_578409.0568.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000604948+58342_578330.0489.0DomainNote=PRORP
HgeneKIAA0391chr14:35649983chr14:35546356ENST00000605870+47342_57853.0212.0DomainNote=PRORP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1173_KIAA0391_35649983_FAM177A1_35546356_1173_KIAA0391_35649983_FAM177A1_35546356_ranked_0.pdbKIAA03913564998335649983ENST00000280987FAM177A1chr1435546356+
MTFYLFGIRSFPKLWKSPYLGLGPGHSYVSLFLADRCGIRNQQRLFSLKTMSPQNTKATNLIAKARYLRKDEGSNKQVYSVPHFFLAGAA
KERSQMNSQTEDHALAPVRNTIQLPTQPLNSEEWDKLKEDLKENTGKTSFESWIISQMAGCHSSIDVAKSLLAWVAAKNNGIVSYDLLVK
YLYLCVFHMQTSEVIDVFEIMKARYKTLEPRGYSLLIRGLIHSDRWREALLLLEDIKKVITPSKKNYNDCIQGALLHQDVNTAWNLYQEL
LGHDIVPMLETLKAFFDFGKDIKDDNYSNKLLDILSYLRNNQLYPGESFAHSIKTWFESVPGKQWKGQFTTVRKSGQCSGCGKTIESIQL
SPEEYECLKGKIMRDVIDGGDQYRKTTPQELKRFENFIKSRPPFDVVIDGLNVAKMFPKVRESQLTKLTWGPYLWFYMLRAATSTLSVCD
FLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESK
548


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
FAM177A1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIAA0391
FAM177A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIAA0391-FAM177A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KIAA0391-FAM177A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource