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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KIF5B-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KIF5B-RET
FusionPDB ID: 42734
FusionGDB2.0 ID: 42734
HgeneTgene
Gene symbol

KIF5B

RET

Gene ID

3799

5979

Gene namekinesin family member 5Bret proto-oncogene
SynonymsHEL-S-61|KINH|KNS|KNS1|UKHCCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

10p11.22

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionkinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chainproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020031320200322
UniProtAcc

P33176

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000493889, ENST00000302418, 
ENST00000340058, ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 17 X 10=204032 X 31 X 11=10912
# samples 2248
** MAII scorelog2(22/2040*10)=-3.2129937233342
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KIF5B [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIF5B(32317355)-RET(43612030), # samples:5
Anticipated loss of major functional domain due to fusion event.KIF5B-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF5B-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF5B-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF5B-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF5B-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KIF5B-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KIF5B-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KIF5B-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKIF5B

GO:0042391

regulation of membrane potential

19675065

HgeneKIF5B

GO:0043268

positive regulation of potassium ion transport

19675065

HgeneKIF5B

GO:0047496

vesicle transport along microtubule

28426968

HgeneKIF5B

GO:1903078

positive regulation of protein localization to plasma membrane

19675065

TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across KIF5B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..KIF5Bchr10

32311775

-RETchr10

43612031

+
ChimerKB3..KIF5Bchr10

32345110

-RETchr10

43609927

+
ChimerKB3..KIF5Bchr10

32345110

-RETchr10

43612030

+
ChimerKB3..KIF5Bchr10

32345110

-RETchr10

43612032

+
ChimerKB3..KIF5Bchr10

32345371

-RETchr10

43607546

+
ChimerKB3..KIF5Bchr10

32345371

-RETchr10

43612030

+
ChimerKB3..KIF5Bchr10

32345371

-RETchr10

43612032

+
ChimerKB4..KIF5Bchr10

32311775

-RETchr10

43612031

+
ChimerKB4..KIF5Bchr10

32317499

-RETchr10

32317499

+
ChiTaRS5.0N/AAB795249KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795250KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795251KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS5.0N/AAB795252KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS5.0N/AAB795253KIF5Bchr10

32307243

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795254KIF5Bchr10

32307243

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795255KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795256KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS5.0N/AAB795257KIF5Bchr10

32306071

-RETchr10

43609927

+
ChiTaRS5.0N/AHW088349KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS5.0N/AHW088350KIF5Bchr10

32311775

-RETchr10

43612032

+
ChiTaRS5.0N/AHW088351KIF5Bchr10

32306979

-RETchr10

43612030

+
ChiTaRS5.0N/AHW088352KIF5Bchr10

32306071

-RETchr10

43607546

+
ChiTaRS5.0N/AJB417295KIF5Bchr10

32317355

-RETchr10

43612030

+
ChiTaRS5.0N/AJB417297KIF5Bchr10

32317355

-RETchr10

43612030

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000302418KIF5Bchr1032311775-ENST00000355710RETchr1043612031+5663237245835801040
ENST00000302418KIF5Bchr1032311775-ENST00000340058RETchr1043612031+420523724583454998
ENST00000302418KIF5Bchr1032317355-ENST00000355710RETchr1043612030+547421834583391977
ENST00000302418KIF5Bchr1032317355-ENST00000340058RETchr1043612030+401621834583265935
ENST00000302418KIF5Bchr1032311775-ENST00000355710RETchr1043612032+5663237245835801040
ENST00000302418KIF5Bchr1032311775-ENST00000340058RETchr1043612032+420523724583454998
ENST00000302418KIF5Bchr1032307243-ENST00000355710RETchr1043612030+6188289745841051215
ENST00000302418KIF5Bchr1032307243-ENST00000340058RETchr1043612030+4730289745839791173
ENST00000302418KIF5Bchr1032306979-ENST00000355710RETchr1043612030+6293300245842101250
ENST00000302418KIF5Bchr1032306979-ENST00000340058RETchr1043612030+4835300245840841208

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000302418ENST00000355710KIF5Bchr1032317355-RETchr1043612030+0.0006691350.9993309
ENST00000302418ENST00000340058KIF5Bchr1032317355-RETchr1043612030+0.0018744570.9981255
ENST00000302418ENST00000355710KIF5Bchr1032311775-RETchr1043612032+0.0008882590.9991117
ENST00000302418ENST00000340058KIF5Bchr1032311775-RETchr1043612032+0.0025218490.9974782
ENST00000302418ENST00000355710KIF5Bchr1032307243-RETchr1043612030+0.0006394850.9993605
ENST00000302418ENST00000340058KIF5Bchr1032307243-RETchr1043612030+0.0020556030.9979444
ENST00000302418ENST00000355710KIF5Bchr1032306979-RETchr1043612030+0.0008586990.99914134
ENST00000302418ENST00000340058KIF5Bchr1032306979-RETchr1043612030+0.0033660140.99663395

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>42734_42734_1_KIF5B-RET_KIF5B_chr10_32306979_ENST00000302418_RET_chr10_43612030_ENST00000340058_length(amino acids)=1208AA_BP=848
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATR
VKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA
SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISF
AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI
VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLS

--------------------------------------------------------------

>42734_42734_2_KIF5B-RET_KIF5B_chr10_32306979_ENST00000302418_RET_chr10_43612030_ENST00000355710_length(amino acids)=1250AA_BP=848
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATR
VKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENA
SPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISF
AWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEI
VTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLS

--------------------------------------------------------------

>42734_42734_3_KIF5B-RET_KIF5B_chr10_32307243_ENST00000302418_RET_chr10_43612030_ENST00000340058_length(amino acids)=1173AA_BP=813
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATR
VKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGP
LLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK
ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEE
MYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAF

--------------------------------------------------------------

>42734_42734_4_KIF5B-RET_KIF5B_chr10_32307243_ENST00000302418_RET_chr10_43612030_ENST00000355710_length(amino acids)=1215AA_BP=813
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLR
DEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATR
VKKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGP
LLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMK
ISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEE
MYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNW

--------------------------------------------------------------

>42734_42734_5_KIF5B-RET_KIF5B_chr10_32311775_ENST00000302418_RET_chr10_43612031_ENST00000340058_length(amino acids)=998AA_BP=638
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC
SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE
GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGR

--------------------------------------------------------------

>42734_42734_6_KIF5B-RET_KIF5B_chr10_32311775_ENST00000302418_RET_chr10_43612031_ENST00000355710_length(amino acids)=1040AA_BP=638
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC
SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE
GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGM

--------------------------------------------------------------

>42734_42734_7_KIF5B-RET_KIF5B_chr10_32311775_ENST00000302418_RET_chr10_43612032_ENST00000340058_length(amino acids)=998AA_BP=638
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC
SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE
GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGR

--------------------------------------------------------------

>42734_42734_8_KIF5B-RET_KIF5B_chr10_32311775_ENST00000302418_RET_chr10_43612032_ENST00000355710_length(amino acids)=1040AA_BP=638
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELA
ACQLRISQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGAC
SQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAE
GRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGM

--------------------------------------------------------------

>42734_42734_9_KIF5B-RET_KIF5B_chr10_32317355_ENST00000302418_RET_chr10_43612030_ENST00000340058_length(amino acids)=935AA_BP=575
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPS
ELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ
ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTL
GGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEE

--------------------------------------------------------------

>42734_42734_10_KIF5B-RET_KIF5B_chr10_32317355_ENST00000302418_RET_chr10_43612030_ENST00000355710_length(amino acids)=977AA_BP=575
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDRVFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSG
KTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVM
DTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAE
GSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQW
LENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKL
KEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPS
ELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ
ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTL
GGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:32317355/chr10:43612030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KIF5B

P33176

RET

RTL1

FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-23268_325848.01626.0DomainKinesin motor
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-22268_325813.01626.0DomainKinesin motor
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-16268_325638.01626.0DomainKinesin motor
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-15268_325575.01626.0DomainKinesin motor
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-232685_92848.01626.0Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-222685_92813.01626.0Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-162685_92638.01626.0Nucleotide bindingNote=ATP
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-152685_92575.01626.0Nucleotide bindingNote=ATP
TgeneRETchr10:32306979chr10:43612030ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:32306979chr10:43612030ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:32307243chr10:43612030ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:32307243chr10:43612030ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:32311775chr10:43612032ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:32311775chr10:43612032ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:32317355chr10:43612030ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr10:32317355chr10:43612030ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr10:32306979chr10:43612030ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:32306979chr10:43612030ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:32307243chr10:43612030ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:32307243chr10:43612030ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:32311775chr10:43612032ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:32311775chr10:43612032ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:32317355chr10:43612030ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr10:32317355chr10:43612030ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr10:32306979chr10:43612030ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:32306979chr10:43612030ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr10:32307243chr10:43612030ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:32307243chr10:43612030ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr10:32311775chr10:43612032ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:32311775chr10:43612032ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding
TgeneRETchr10:32317355chr10:43612030ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr10:32317355chr10:43612030ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-2326329_914848.01626.0Coiled coil.
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-2226329_914813.01626.0Coiled coil.
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-1626329_914638.01626.0Coiled coil.
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-1526329_914575.01626.0Coiled coil.
HgeneKIF5Bchr10:32306979chr10:43612030ENST00000302418-2326915_963848.01626.0RegionNote=Globular
HgeneKIF5Bchr10:32307243chr10:43612030ENST00000302418-2226915_963813.01626.0RegionNote=Globular
HgeneKIF5Bchr10:32311775chr10:43612032ENST00000302418-1626915_963638.01626.0RegionNote=Globular
HgeneKIF5Bchr10:32317355chr10:43612030ENST00000302418-1526915_963575.01626.0RegionNote=Globular
TgeneRETchr10:32306979chr10:43612030ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:32306979chr10:43612030ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:32307243chr10:43612030ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:32307243chr10:43612030ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:32311775chr10:43612032ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:32311775chr10:43612032ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:32317355chr10:43612030ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr10:32317355chr10:43612030ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr10:32306979chr10:43612030ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:32306979chr10:43612030ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:32306979chr10:43612030ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:32306979chr10:43612030ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:32307243chr10:43612030ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:32307243chr10:43612030ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:32307243chr10:43612030ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:32307243chr10:43612030ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:32311775chr10:43612032ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:32311775chr10:43612032ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:32311775chr10:43612032ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:32311775chr10:43612032ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:32317355chr10:43612030ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr10:32317355chr10:43612030ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr10:32317355chr10:43612030ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr10:32317355chr10:43612030ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr10:32306979chr10:43612030ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:32306979chr10:43612030ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr10:32307243chr10:43612030ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:32307243chr10:43612030ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr10:32311775chr10:43612032ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:32311775chr10:43612032ENST000003557101020636_657712.01115.0TransmembraneHelical
TgeneRETchr10:32317355chr10:43612030ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr10:32317355chr10:43612030ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (751) >>>751.pdbFusion protein BP residue: 638
CIF file (751) >>>751.cif		KIF5Bchr1032311775-RETchr1043612031+
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDR
VFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLH
DPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSK
TNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEH
SSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDE
AKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEK
NKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTN
DKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAV
NYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKR
AAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
998
3D view using mol* of 751 (AA BP:638)
PDB file (768) >>>768.pdbFusion protein BP residue: 638
CIF file (768) >>>768.cif		KIF5Bchr1032311775-RETchr1043612031+
MADLAECNIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVIASKPYAFDR
VFQSSTSQEQVYNDCAKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLH
DPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSK
TNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEH
SSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDE
AKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVI
CCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEK
NKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTN
DKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLK
TQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAV
NYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKR
AAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSE
VKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQEDPKWEFPRKNL
VLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLS
EFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGP
GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRD
LAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLF
DHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPD
NCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPS
DSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESP
1040
3D view using mol* of 768 (AA BP:638)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KIF5B_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KIF5B_RET_751_pLDDT.png (AA BP:638)
all structure
KIF5B_RET_751_pLDDT_and_active_sites.png (AA BP:638)
all structure
KIF5B_RET_751_violinplot.png (AA BP:638)
all structure
KIF5B_RET_768_pLDDT.png (AA BP:638)
all structure
KIF5B_RET_768_pLDDT_and_active_sites.png (AA BP:638)
all structure
KIF5B_RET_768_violinplot.png (AA BP:638)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
KIF5B_RET_751.png
all structure
KIF5B_RET_768.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
7511.1061211.147296.3520.460.7940.9911.590.8251.9271.079Chain A: 656,657,658,659,660,661,662,664,682,684,7
01,705,714,728,730,731,732,733,736,737,804,805,807
,817,818
7681.01654031.03721390.8650.59330.71670.89970.57521.02070.56350.8358Chain A: 147,149,150,169,170,171,172,173,174,175,1
78,181,182,630,633,634,637,659,660,661,662,664,684
,686,687,689,690,691,693,694,696,697,698,699,700,7
01,703,704,707,796,798,799,800,804,805,818,819,820
,821,822,823,824,827,832,833,834,835,836,837,838,8
39,840,841,842,843,852,854,883,884

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
751ZINC000004098633DB11263Polydatin-8.443-8.443
751ZINC000000897089DB00358Mefloquine-8.3872-8.3897
751ZINC000003830945DB01362Iohexol-8.01741-8.01741
751ZINC000085540215DB09135Ioxilan-7.92627-7.92627
751ZINC000003830339DB01210Levobunolol-7.89282-7.89392
751ZINC000003827556DB11943Delafloxacin-6.3113-7.8771
751ZINC000003874185DB00358Mefloquine-7.84238-7.84488
751ZINC000002169830DB00194Vidarabine-7.83727-7.83727
751ZINC000022059926DB01155Gemifloxacin-7.78678-7.82768
751ZINC000019632917DB00475Chlordiazepoxide-7.7702-7.8181
751ZINC000253632968DB06290Simeprevir-7.70212-7.70872
751ZINC000000897085DB00358Mefloquine-7.68853-7.69103
751ZINC000004213946DB04861Nebivolol-7.56391-7.58371
751ZINC000001999441DB04861Nebivolol-7.51569-7.53549
751ZINC000029571072DB06636Isavuconazonium-7.09013-7.52213
751ZINC000005844792DB04861Nebivolol-7.4953-7.5151
751ZINC000011681534DB04861Nebivolol-7.48587-7.50567
751ZINC000000020220DB00537Ciprofloxacin-6.383-7.4874
751ZINC000000057533DB00809Tropicamide-7.448-7.456
751ZINC000052509463DB08820Ivacaftor-7.44165-7.44165

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000004098633DB11263PolydatinSmall moleculeOC[C@H]1O[C@@H](OC2=CC(C=CC3=CC=C(O)C=C3)=CC(O)=C2)[C@H](O)[C@@H](O)[C@@H]1OApproved
ZINC000003830339DB01210LevobunololSmall moleculeCC(C)(C)NC[C@H](O)COC1=CC=CC2=C1CCCC2=OApproved
ZINC000003827556DB11943DelafloxacinSmall moleculeNC1=NC(N2C=C(C(O)=O)C(=O)C3=CC(F)=C(N4CC(O)C4)C(Cl)=C23)=C(F)C=C1FApproved|Investigational
ZINC000002169830DB00194VidarabineSmall moleculeNC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1OApproved|Investigational
ZINC000019632917DB00475ChlordiazepoxideSmall moleculeCNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1Approved|Illicit|Investigational
ZINC000253632968DB06290SimeprevirSmall molecule[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1Approved
ZINC000011681534DB04861NebivololSmall moleculeOC(CNCC(O)C1CCC2=C(O1)C=CC(F)=C2)C1CCC2=C(O1)C=CC(F)=C2Approved|Investigational
ZINC000000020220DB00537CiprofloxacinSmall moleculeOC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=OApproved|Investigational
ZINC000052509463DB08820IvacaftorSmall moleculeCC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)CApproved

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000004098633390.3897.667669.829130.628272.364266.83701181.188610.758.482240.08510
ZINC000000897089378.3177.024589.936192.76554.441122.198220.5321034.58724.29.632310000
ZINC000003830945821.1436.563790.789299.687371.4768.079111.5461486.416818.29.451031
ZINC000085540215791.11610.896769.61332.376308.4229.811119.0021424.341716.59.57913.14231
ZINC000003830339291.3894.063611.955402.6193.154116.19101057.8625.459.203386.07900
ZINC000003827556440.7657.343641.991114.171269.717120.689137.4141132.35936.78.856257.44801
ZINC000003827556440.7659.028639.547117.652265.215120.459136.2211128.10136.79.031258.22101
ZINC000003874185378.3177.567591.505189.63358.939124.18218.7531037.43524.29.501310000
ZINC000002169830267.2443.396469.3695.245259.374114.7410784.03510.88.527244.32700
ZINC000022059926389.3855.386675.076333.398232.63867.9641.081199.52228.79.053236.53501
ZINC000022059926389.3854.357656.741321.575225.55768.44141.1671178.17628.79.183237.34601
ZINC000019632917299.7594.645553.04137.02264.707279.78871.524941.819138.565310000
ZINC000019632917299.7595.502549.003118.96574.766283.8271.453935.577138.408310000
ZINC000253632968749.9396.9571148.652820.732134.162154.91538.8422228.6291.2513.758.419162.52532
ZINC000253632968749.93911.1351103.653772.655146.278144.58240.1382184.3831.2513.758.499157.80432
ZINC000253632968749.9399.2981114.226794.485125.878154.69239.172200.51.2513.758.41163.80632
ZINC000253632968749.9398.171081.392774.076143.601146.31117.4042179.1541.2513.758.604161.00632
ZINC000000897085378.3177.557589.939192.62654.6122.313220.4011034.64724.29.439310000
ZINC000004213946405.4415.213712.775270.54687.695260.77393.7611260.0136.49.251394.55500
ZINC000004213946405.4413.313660.255261.06875.583229.84493.761216.09336.49.124395.53300
ZINC000001999441405.4414.722712.226273.48884.211260.77493.7531256.14736.49.229395.14300
ZINC000001999441405.4410.513723.645269.65591.189269.03293.7681265.84436.49.27394.03900
ZINC000005844792405.4412.88705.095278.73976.814255.78193.7611255.09936.49.355396.66500
ZINC000005844792405.4412.543700.215280.74373.672252.03693.7641255.10136.49.361310000
ZINC000011681534405.4412.335727.789280.70885.7267.62193.761272.95136.49.228395.43300
ZINC000011681534405.4416.385707.131273.32277.744262.30193.7651256.16536.49.073396.54300
ZINC000000020220331.3468.67578.412299.833178.53968.48731.5531017.371168.925248.3301
ZINC000000020220331.3468.111575.511298.04176.66769.24631.5581012.813168.79248.64801
ZINC000000057533284.3574.662541.909149.63285.754306.5220968.90905.29.752394.32200
ZINC000000057533284.3575.923559.643148.06797.146314.4310982.31205.29.501392.0400
ZINC000052509463392.49711.677688.813338.313133.173217.32701269.29613.758.435192.3211


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000004098633OC[C@H]1O[C@@H](Oc2cc(O)cc(/C=C/c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O0.0678823180.512213372
ZINC000000897089O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000003830945CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I0.0423322430.211666342
ZINC000085540215CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000003830339CC(C)(C)NC[C@H](O)COc1cccc2c1CCCC2=O0.1733436360.14827061
ZINC000003827556Nc1nc(-n2cc(C(=O)O)c(=O)c3cc(F)c(N4CC(O)C4)c(Cl)c32)c(F)cc1F0.1372155140.181774775
ZINC000003874185O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN10.0827248270.290697747
ZINC000002169830Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O0.0795547680.347763769
ZINC000022059926CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN0.0776115140.258972331
ZINC000019632917CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C10.1473206730.447326601
ZINC000253632968COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C0.0148452150.273382605
ZINC000000897085O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN10.0827248270.290697747
ZINC000004213946O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000001999441O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000029571072CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000005844792O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000011681534O[C@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O10.0555500820.198725964
ZINC000000020220O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O0.2310316290.323908212
ZINC000000057533CCN(Cc1ccncc1)C(=O)[C@H](CO)c1ccccc10.2170161260.207496747
ZINC000052509463CC(C)(C)c1cc(C(C)(C)C)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O0.2290457390.21202938


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KIF5BYWHAG, YWHAB, YWHAQ, YWHAZ, VDAC1, NME2, SFN, DTNB, SNAP23, SNAP25, KLC1, KLC2, KIF5C, YWHAH, USPL1, MARK2, MEPCE, FYCO1, RAPGEF2, APC, SPG20, CDC5L, GSK3B, NDRG1, SIRT7, RANBP2, KIAA0368, KLC4, ZBTB8B, KDM1A, MCCC1, EXOC7, DHX9, TWF1, SRP68, RNF168, YWHAE, CFTR, ACACA, CAST, COPE, COPS5, AKAP2, DIAPH1, ELP2, EPB41L1, NUP50, RNF20, PSMA2, PSMA4, PSMA5, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSME1, PTPN23, RABGAP1, SMEK2, TRIM25, STAU1, AURKB, HUWE1, PRKAR2B, VPS52, TAX1BP1, ZBTB8A, CUL7, EZH2, ABCE1, TRAK2, CCDC101, SYNE4, DTNBP1, NUP43, KPTN, AZIN1, TRIP6, CHRNA9, RPS6KB2, KIF1A, LSM2, NTRK1, MED4, L1TD1, KLC3, NHS, POU1F1, TUBA1A, OGT, SQSTM1, XPR1, NCOR1, TRAK1, KIDINS220, SLC38A10, Klc2, Klc4, Klc3, FOXQ1, Ostm1, CDH1, MYCL, COG6, EXOC1, MAP7D2, HOMER1, DLST, SOD1, BRCA1, ZNF598, EGLN3, CTNNB1, HSPA8, HDAC4, EFTUD2, ESR2, HEXIM1, PIK3R1, KDM6B, MYC, CDK9, KIAA1429, Bach1, GBF1, RFFL, HOOK1, HOOK3, BMH1, BMH2, BIRC3, LMBR1L, TRIM28, MEOX2, POU6F2, FHL2, CCDC136, LBX1, CDR2, BAG4, HSF2BP, POLR2G, GCC1, PRKAR1B, PLEKHA4, PPIB, MYO5A, KIF14, IFI16, PYHIN1, SUMO2, Rnf183, BRD4, Apc2, ORF6, SCGN, TP53, WDR5, NAA40, TPM3, SYCE1, NPEPPS, BRK1, PRPS2, HVCN1, C15orf59, HSPA2, NUP62, S100A2, CLSTN1, EP300, FGD5,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KIF5Ball structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KIF5B-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
KIF5BRETAlectinibPubMed28629549

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Related Diseases to KIF5B-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
KIF5BRETDesmoplastic StromaPubMed28629549
KIF5BRETLung AdenocarcinomaMyCancerGenome
KIF5BRETBreast Invasive Ductal CarcinomaMyCancerGenome
KIF5BRETNon-Small Cell Lung CarcinomaMyCancerGenome
KIF5BRETPoorly Differentiated Non-Small Cell Lung CancerMyCancerGenome
KIF5BRETThyroid Gland Papillary CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKIF5BC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneKIF5BC0011849Diabetes Mellitus1CTD_human
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human