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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LAMA3-OSBPL1A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LAMA3-OSBPL1A
FusionPDB ID: 43877
FusionGDB2.0 ID: 43877
HgeneTgene
Gene symbol

LAMA3

OSBPL1A

Gene ID

3910

114876

Gene namelaminin subunit alpha 4oxysterol binding protein like 1A
SynonymsCMD1JJ|LAMA3|LAMA4*-1ORP-1|ORP1|OSBPL1B
Cytomap

6q21

18q11.2

Type of geneprotein-codingprotein-coding
Descriptionlaminin subunit alpha-4laminin alpha 4 chainlaminin, alpha 4oxysterol-binding protein-related protein 1OSBP-related protein 1oxysterol binding protein-like 1Boxysterol-binding protein-related protein 1 variant 1oxysterol-binding protein-related protein 1 variant 2
Modification date2020031320200313
UniProtAcc

Q16787

.
Ensembl transtripts involved in fusion geneENST idsENST00000588770, ENST00000269217, 
ENST00000313654, ENST00000399516, 
ENST00000587184, 		ENST00000319481, 
ENST00000357041, ENST00000399441, 
ENST00000399443, ENST00000582618, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 24 X 10=672018 X 15 X 10=2700
# samples 3319
** MAII scorelog2(33/6720*10)=-4.34792330342031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2700*10)=-3.82888808360725
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LAMA3 [Title/Abstract] AND OSBPL1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LAMA3(21513899)-OSBPL1A(21892070), # samples:4
Anticipated loss of major functional domain due to fusion event.LAMA3-OSBPL1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA3-OSBPL1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA3-OSBPL1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LAMA3-OSBPL1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LAMA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OSBPL1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-IN-A7NU-01ALAMA3chr18

21513899

-OSBPL1Achr18

21892070

-
ChimerDB4STADTCGA-IN-A7NU-01ALAMA3chr18

21513899

+OSBPL1Achr18

21892070

-
ChimerDB4STADTCGA-IN-A7NULAMA3chr18

21513899

+OSBPL1Achr18

21892070

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000313654LAMA3chr1821513899+ENST00000319481OSBPL1Achr1821892070-121229103241109863581
ENST00000399516LAMA3chr1821513899+ENST00000319481OSBPL1Achr1821892070-1171386940105773525
ENST00000269217LAMA3chr1821513899+ENST00000319481OSBPL1Achr1821892070-7259424020561231972
ENST00000587184LAMA3chr1821513899+ENST00000319481OSBPL1Achr1821892070-68863867057501916

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000313654ENST00000319481LAMA3chr1821513899+OSBPL1Achr1821892070-0.0004734040.9995266
ENST00000399516ENST00000319481LAMA3chr1821513899+OSBPL1Achr1821892070-0.000334320.99966574
ENST00000269217ENST00000319481LAMA3chr1821513899+OSBPL1Achr1821892070-0.0006362190.99936384
ENST00000587184ENST00000319481LAMA3chr1821513899+OSBPL1Achr1821892070-0.0004927820.9995072

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43877_43877_1_LAMA3-OSBPL1A_LAMA3_chr18_21513899_ENST00000269217_OSBPL1A_chr18_21892070_ENST00000319481_length(amino acids)=1972AA_BP=1344
MPPAVRRSACSMGWLWIFGAALGQCLGYSSQQQRVPFLQPPGQSQLQASYVEFRPSQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDG
SGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSC
NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRS
AISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSRE
WAEAQRMMRELRNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQEN
ERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSL
QELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQ
EVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFK
KALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLF
LQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATS
SKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESD
KNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIKIGKL
QKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLS
FTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGSPIFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLL
RNSKRLKHISSSRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQDWLEA
IEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDC
LNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLG
SRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSD
PVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEP
KGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTEC
LYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIP

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>43877_43877_2_LAMA3-OSBPL1A_LAMA3_chr18_21513899_ENST00000313654_OSBPL1A_chr18_21892070_ENST00000319481_length(amino acids)=3581AA_BP=2953
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSA
LGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSE
CKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENN
YYFPDLHHMKYEIEDGSTPNGRDLRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHITIYPSWG
AAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVLLDYLVLLPRDYYEASVLQLPVTEPCAYAGPPQENCLLYQHLPVT
RFPCTLACEARHFLLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVDVNVKSSGSVLAGQVNIY
SCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQVCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALI
LDVLSGRPFPHLPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFYQAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRD
QVIAEGQIEFDISEPEVAATVKVPEGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARSLVAFYH
KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPM
AGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCRE
GSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVDIPVSFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVS
SYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQG
LYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNT
AGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHP
LTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEG
LERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHILLKQISGTDGEGNNVPSGDFSREWAEAQRMMREL
RNRNFGKHLREAEADKRESQLLLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQV
KEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIK
RNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQ
TLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVN
KLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGG
TENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDM
DGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYAR
VPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPKERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQ
NTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDH
LQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGSPIFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISS
SRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLMLLKGSTRFNKTKTFRINQDWLEAIEEHSAYSTHY
CSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVR
NFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKD
CGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAF
AVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEH
NEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDA
YKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIR

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>43877_43877_3_LAMA3-OSBPL1A_LAMA3_chr18_21513899_ENST00000399516_OSBPL1A_chr18_21892070_ENST00000319481_length(amino acids)=3525AA_BP=2897
MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARIWATATCGERGPGEGRPQPELYCKLVGGPTA
PGSGHTIQGQFCDYCNSEDPRKAHPVTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSVDFGST
YSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENGEVVVSLINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLG
HLISKAQRDPTVTRRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHG
HASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSCDPEHADGCEQGSGRCHCKPNFH
GDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPICQACWCSA
LGSYQMPCSSVTGQCECRPGVTGQRCDRCLSGAYDFPHCQGSSSACDPAGTINSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSE
CKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENN
YYFPDLHHMKYEIEDGSTPNGRDLRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHITIYPSWG
AAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVLLDYLVLLPRDYYEASVLQLPVTEPCAYAGPPQENCLLYQHLPVT
RFPCTLACEARHFLLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVDVNVKSSGSVLAGQVNIY
SCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQVCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALI
LDVLSGRPFPHLPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFYQAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRD
QVIAEGQIEFDISEPEVAATVKVPEGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARSLVAFYH
KGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPM
AGCEGCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCDPGTGACLCKENVEGTECNVCRE
GSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADRVDIPVSFNPGSNSMVADLQELPATIHSASWVAPTSYLGDKVS
SYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLADVRIQG
LYFTETQRLTLSEVGLEEASDTGSGRIALAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNT
AGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGSCHP
LTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNHGSKIEG
LERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHMLNRIRTWQKTHQGENNGLANSIRDSLNEYEAKLS
DLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELSDKV
RELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQTVIKEDLPRKA
KTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDITDEVLDGL
NPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAASKVAVPMRFNGK
SGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAV
MDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYN
FKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLMVRYKLNSELPK
ERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTSGVVRLNDTVGV
TKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGSPIFKSPQTYMDG
LLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLM
LLKGSTRFNKTKTFRINQDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLP
SFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSES
ERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLS
FLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNN
DFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHK
VEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQ
MYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYS

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>43877_43877_4_LAMA3-OSBPL1A_LAMA3_chr18_21513899_ENST00000587184_OSBPL1A_chr18_21892070_ENST00000319481_length(amino acids)=1916AA_BP=1288
MPPAVRRSACSMGWLWIFGAALGQCLGYSSQQQRVPFLQPPGQSQLQASYVEFRPSQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDG
SGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSC
NSNGQLGSCHPLTGDCINQEPKDSSPAEECDDCDSCVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRS
AISNHGSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNVHMLNRIRTWQKTHQGENNGLANSIR
DSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERALGAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASL
NEARQELSDKVRELSRSAGKTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYENILNAIKAAEDAANRAASASESALQ
TVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLKQEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKA
NDITDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQQLLPLGNISDNMDRIRELIQQARDAAS
KVAVPMRFNGKSGVEVRLPNDLEDLKGYTSLSLFLQRPNSRENGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQ
ILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELD
DLNENVLSLYNFKKTFNLNTTEVEPCRRRKEESDKNYFEGTGYARVPTQPHAPIPTFGQTIQTTVDRGLLFFAENGDRFISLNIEDGKLM
VRYKLNSELPKERGVGDAINNGRDHSIQIKIGKLQKRMWINVDVQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNLKKTS
GVVRLNDTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPPTDHLQASFGFQTFQPSGILLDHQTWTRNLQVTLEDGYIELSTSDSGSP
IFKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKRLKHISSSRQSLRLGGSNFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLG
GCSLNKPPFLMLLKGSTRFNKTKTFRINQDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMI
KECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSED
EFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKI
TMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPP
ISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFK
PCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLW
RIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPN

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:21513899/chr18:21892070)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LAMA3

Q16787

.
FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.; FUNCTION: Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751852_19412954.03334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751987_21692954.03334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752322_23882954.03334.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741852_19412898.03278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741987_21692898.03278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742322_23882898.03278.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751266_13112954.03334.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751312_13552954.03334.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751356_14042954.03334.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751405_14552954.03334.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751476_16532954.03334.0DomainLaminin IV type A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751687_17332954.03334.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751734_17862954.03334.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751787_18212954.03334.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752390_25912954.03334.0DomainLaminin G-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752598_27602954.03334.0DomainLaminin G-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752767_29272954.03334.0DomainLaminin G-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775299_3552954.03334.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775356_4252954.03334.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775426_4692954.03334.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+677543_2982954.03334.0DomainLaminin N-terminal
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775491_5352954.03334.0DomainLaminin EGF-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775536_5882954.03334.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775590_6302954.03334.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775631_6832954.03334.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775684_7282954.03334.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741266_13112898.03278.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741312_13552898.03278.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741356_14042898.03278.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741405_14552898.03278.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741476_16532898.03278.0DomainLaminin IV type A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741687_17332898.03278.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741734_17862898.03278.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741787_18212898.03278.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742390_25912898.03278.0DomainLaminin G-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742598_27602898.03278.0DomainLaminin G-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674299_3552898.03278.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674356_4252898.03278.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674426_4692898.03278.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+667443_2982898.03278.0DomainLaminin N-terminal
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674491_5352898.03278.0DomainLaminin EGF-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674536_5882898.03278.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674590_6302898.03278.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674631_6832898.03278.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674684_7282898.03278.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937299_3551289.01669.0DomainLaminin EGF-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937356_4251289.01669.0DomainLaminin EGF-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937426_4691289.01669.0DomainLaminin EGF-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+293743_2981289.01669.0DomainLaminin N-terminal
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937491_5351289.01669.0DomainLaminin EGF-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937536_5881289.01669.0DomainLaminin EGF-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937590_6301289.01669.0DomainLaminin EGF-like 6
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937631_6831289.01669.0DomainLaminin EGF-like 7
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937684_7281289.01669.0DomainLaminin EGF-like 8
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752278_22802954.03334.0MotifCell attachment site
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742278_22802898.03278.0MotifCell attachment site
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751266_14652954.03334.0RegionNote=Domain III B
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751654_18212954.03334.0RegionNote=Domain III A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67751822_23892954.03334.0RegionNote=Domain II and I
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775298_7282954.03334.0RegionNote=Domain V
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+6775796_12652954.03334.0RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741266_14652898.03278.0RegionNote=Domain III B
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741654_18212898.03278.0RegionNote=Domain III A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66741822_23892898.03278.0RegionNote=Domain II and I
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674298_7282898.03278.0RegionNote=Domain V
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+6674796_12652898.03278.0RegionNote=Domain IV 1 (domain IV B)
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937298_7281289.01669.0RegionNote=Domain V
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+2937796_12651289.01669.0RegionNote=Domain IV 1 (domain IV B)
TgeneOSBPL1Achr18:21513899chr18:21892070ENST000003194811128430_463323.0951.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST000003194811128877_913323.0951.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000357041016430_4630569.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000357041016877_9130569.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000399443014430_4630438.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000399443014877_9130438.0Coiled coilOntology_term=ECO:0000255
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000357041016235_3340569.0DomainPH
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000399443014235_3340438.0DomainPH
TgeneOSBPL1Achr18:21513899chr18:21892070ENST000003194811128469_483323.0951.0MotifFFAT
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000357041016469_4830569.0MotifFFAT
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000399443014469_4830438.0MotifFFAT
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000357041016175_2040569.0RepeatNote=ANK 3
TgeneOSBPL1Achr18:21513899chr18:21892070ENST0000035704101647_760569.0RepeatNote=ANK 1
TgeneOSBPL1Achr18:21513899chr18:21892070ENST0000035704101680_1090569.0RepeatNote=ANK 2
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000399443014175_2040438.0RepeatNote=ANK 3
TgeneOSBPL1Achr18:21513899chr18:21892070ENST0000039944301447_760438.0RepeatNote=ANK 1
TgeneOSBPL1Achr18:21513899chr18:21892070ENST0000039944301480_1090438.0RepeatNote=ANK 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371852_19411289.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371987_21691289.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372322_23881289.01669.0Coiled coilOntology_term=ECO:0000255
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67752986_31502954.03334.0DomainLaminin G-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000313654+67753157_33302954.03334.0DomainLaminin G-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742767_29272898.03278.0DomainLaminin G-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66742986_31502898.03278.0DomainLaminin G-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000399516+66743157_33302898.03278.0DomainLaminin G-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371266_13111289.01669.0DomainLaminin EGF-like 9
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371312_13551289.01669.0DomainLaminin EGF-like 10
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371356_14041289.01669.0DomainLaminin EGF-like 11
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371405_14551289.01669.0DomainLaminin EGF-like 12
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371476_16531289.01669.0DomainLaminin IV type A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371687_17331289.01669.0DomainLaminin EGF-like 13
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371734_17861289.01669.0DomainLaminin EGF-like 14
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371787_18211289.01669.0DomainLaminin EGF-like 15%3B truncated
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372390_25911289.01669.0DomainLaminin G-like 1
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372598_27601289.01669.0DomainLaminin G-like 2
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372767_29271289.01669.0DomainLaminin G-like 3
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372986_31501289.01669.0DomainLaminin G-like 4
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29373157_33301289.01669.0DomainLaminin G-like 5
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29372278_22801289.01669.0MotifCell attachment site
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371266_14651289.01669.0RegionNote=Domain III B
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371654_18211289.01669.0RegionNote=Domain III A
HgeneLAMA3chr18:21513899chr18:21892070ENST00000587184+29371822_23891289.01669.0RegionNote=Domain II and I
TgeneOSBPL1Achr18:21513899chr18:21892070ENST000003194811128235_334323.0951.0DomainPH
TgeneOSBPL1Achr18:21513899chr18:21892070ENST000003194811128175_204323.0951.0RepeatNote=ANK 3
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000319481112847_76323.0951.0RepeatNote=ANK 1
TgeneOSBPL1Achr18:21513899chr18:21892070ENST00000319481112880_109323.0951.0RepeatNote=ANK 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LAMA3_pLDDT.png
all structure
all structure
OSBPL1A_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LAMA3
OSBPL1A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneOSBPL1Achr18:21513899chr18:21892070ENST0000031948111281_237323.0951.0RAB7A


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Related Drugs to LAMA3-OSBPL1A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LAMA3-OSBPL1A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLAMA3C1328355Laryngoonychocutaneous syndrome5CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneLAMA3C0079683Herlitz Disease4CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0079301Junctional Epidermolysis Bullosa3CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0268374Adult junctional epidermolysis bullosa (disorder)3CTD_human;GENOMICS_ENGLAND
HgeneLAMA3C0027339Nail Diseases1CTD_human
HgeneLAMA3C0037299Skin Ulcer1CTD_human
HgeneLAMA3C0079297Epidermolysis Bullosa Progressiva1CTD_human
HgeneLAMA3C0399367Amelogenesis imperfecta local hypoplastic form1GENOMICS_ENGLAND