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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LETM2-ERCC2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LETM2-ERCC2
FusionPDB ID: 44492
FusionGDB2.0 ID: 44492
HgeneTgene
Gene symbol

LETM2

ERCC2

Gene ID

137994

2068

Gene nameleucine zipper and EF-hand containing transmembrane protein 2ERCC excision repair 2, TFIIH core complex helicase subunit
SynonymsSLC55A2COFS2|EM9|TFIIH|TTD|TTD1|XPD
Cytomap

8p11.23

19q13.32

Type of geneprotein-codingprotein-coding
DescriptionLETM1 domain-containing protein LETM2, mitochondrialLETM1 and EF-hand domain-containing protein 2leucine zipper-EF-hand containing transmembrane protein 1-like proteinleucine zipper-EF-hand containing transmembrane protein 2general transcription and DNA repair factor IIH helicase subunit XPDBTF2 p80CXPDDNA excision repair protein ERCC-2DNA repair protein complementing XP-D cellsTFIIH 80 kDa subunitTFIIH basal transcription factor complex 80 kDa subunitTFIIH basal tran
Modification date2020031320200315
UniProtAcc

Q2VYF4

P18074

Ensembl transtripts involved in fusion geneENST idsENST00000528827, ENST00000297720, 
ENST00000379957, ENST00000523983, 
ENST00000524874, ENST00000527710, 
ENST00000519476, 		ENST00000221481, 
ENST00000391940, ENST00000391944, 
ENST00000391945, ENST00000485403, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=13 X 4 X 3=36
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LETM2 [Title/Abstract] AND ERCC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LETM2(38262024)-ERCC2(45872405), # samples:2
Anticipated loss of major functional domain due to fusion event.LETM2-ERCC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LETM2-ERCC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LETM2-ERCC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LETM2-ERCC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC2

GO:0006283

transcription-coupled nucleotide-excision repair

8663148

TgeneERCC2

GO:0006366

transcription by RNA polymerase II

9852112

TgeneERCC2

GO:0045893

positive regulation of transcription, DNA-templated

8692842

TgeneERCC2

GO:0045944

positive regulation of transcription by RNA polymerase II

8692841


check buttonFusion gene breakpoints across LETM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERCC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-A53L-01ALETM2chr8

38262024

-ERCC2chr19

45872405

-
ChimerDB4LUSCTCGA-85-A53L-01ALETM2chr8

38262024

+ERCC2chr19

45872405

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000297720LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5135116519633421048
ENST00000297720LETM2chr838262024+ENST00000391944ERCC2chr1945872405-313511651963108970
ENST00000297720LETM2chr838262024+ENST00000485403ERCC2chr1945872405-245111651962349717
ENST00000297720LETM2chr838262024+ENST00000391940ERCC2chr1945872405-235011651962349718
ENST00000297720LETM2chr838262024+ENST00000221481ERCC2chr1945872405-178811651961443415
ENST00000524874LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5171120112733781083
ENST00000524874LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3171120112731441005
ENST00000524874LETM2chr838262024+ENST00000485403ERCC2chr1945872405-248712011272385752
ENST00000524874LETM2chr838262024+ENST00000391940ERCC2chr1945872405-238612011272385753
ENST00000524874LETM2chr838262024+ENST00000221481ERCC2chr1945872405-182412011271479450
ENST00000379957LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5315134512735221131
ENST00000379957LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3315134512732881053
ENST00000379957LETM2chr838262024+ENST00000485403ERCC2chr1945872405-263113451272529800
ENST00000379957LETM2chr838262024+ENST00000391940ERCC2chr1945872405-253013451272529801
ENST00000379957LETM2chr838262024+ENST00000221481ERCC2chr1945872405-196813451271623498
ENST00000523983LETM2chr838262024+ENST00000391945ERCC2chr1945872405-5219124913634261096
ENST00000523983LETM2chr838262024+ENST00000391944ERCC2chr1945872405-3219124913631921018
ENST00000523983LETM2chr838262024+ENST00000485403ERCC2chr1945872405-253512491362433765
ENST00000523983LETM2chr838262024+ENST00000391940ERCC2chr1945872405-243412491362433766
ENST00000523983LETM2chr838262024+ENST00000221481ERCC2chr1945872405-187212491361527463
ENST00000527710LETM2chr838262024+ENST00000391945ERCC2chr1945872405-47037331572910917
ENST00000527710LETM2chr838262024+ENST00000391944ERCC2chr1945872405-27037331572676839
ENST00000527710LETM2chr838262024+ENST00000485403ERCC2chr1945872405-20197331571917586
ENST00000527710LETM2chr838262024+ENST00000391940ERCC2chr1945872405-19187331571917587
ENST00000527710LETM2chr838262024+ENST00000221481ERCC2chr1945872405-13567331571011284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000297720ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0025119130.997488
ENST00000297720ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0051057230.99489427
ENST00000297720ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0137276380.98627234
ENST00000297720ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0147546960.9852453
ENST00000297720ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0071438340.99285614
ENST00000524874ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0022299770.9977701
ENST00000524874ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0043748530.9956252
ENST00000524874ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.016646280.98335373
ENST00000524874ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0175173260.9824827
ENST00000524874ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0167010630.98329896
ENST00000379957ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0023999930.9976
ENST00000379957ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0041258020.9958742
ENST00000379957ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0120496180.98795044
ENST00000379957ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0129832430.98701674
ENST00000379957ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0150649130.98493505
ENST00000523983ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0025638310.9974362
ENST00000523983ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0045738810.9954261
ENST00000523983ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0120653910.9879346
ENST00000523983ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0135049510.986495
ENST00000523983ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0089796310.9910204
ENST00000527710ENST00000391945LETM2chr838262024+ERCC2chr1945872405-0.0026170210.99738294
ENST00000527710ENST00000391944LETM2chr838262024+ERCC2chr1945872405-0.0106554470.98934454
ENST00000527710ENST00000485403LETM2chr838262024+ERCC2chr1945872405-0.0135248310.98647517
ENST00000527710ENST00000391940LETM2chr838262024+ERCC2chr1945872405-0.0147649720.985235
ENST00000527710ENST00000221481LETM2chr838262024+ERCC2chr1945872405-0.0065480310.99345195

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44492_44492_1_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=415AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY

--------------------------------------------------------------

>44492_44492_2_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=718AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW

--------------------------------------------------------------

>44492_44492_3_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=970AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNID
NVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFL
GFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEP
FDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFET
REDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVA
RGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKR

--------------------------------------------------------------

>44492_44492_4_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1048AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW
RLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPI
LHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGN
LLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVH
HYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLT

--------------------------------------------------------------

>44492_44492_5_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000297720_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=717AA_BP=323
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQ
TGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMR
SLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIY
CSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFD
AHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLT
RRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKW

--------------------------------------------------------------

>44492_44492_6_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=498AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE

--------------------------------------------------------------

>44492_44492_7_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=801AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV

--------------------------------------------------------------

>44492_44492_8_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1053AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSM
SVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLL
EYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPT
IANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVI
RNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEG
IDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWI

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>44492_44492_9_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1131AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV
VQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMD
ASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSA
VVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVI
MFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLT

--------------------------------------------------------------

>44492_44492_10_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000379957_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=800AA_BP=406
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVP
FMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKKEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPST
KEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEE
QLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPE
IEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVP
LPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRC
QGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHV

--------------------------------------------------------------

>44492_44492_11_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=463AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN

--------------------------------------------------------------

>44492_44492_12_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=766AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH

--------------------------------------------------------------

>44492_44492_13_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1018AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLR
DEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPL
RFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLS
PLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASW
YEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRD
QFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRED

--------------------------------------------------------------

>44492_44492_14_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1096AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH
TLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFH
PVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRN
KLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTF
DAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQL

--------------------------------------------------------------

>44492_44492_15_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000523983_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=765AA_BP=371
MLEQDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGKPQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQK
IMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRRLLRTCVDFFRLVPFMVFLIVPFMEFLLPVFLKLFPEMLPSTFESESKK
EEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQT
FGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVK
PKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKN
LCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANV
VVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLRE
ASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLH

--------------------------------------------------------------

>44492_44492_16_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=450AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPETTSASTP

--------------------------------------------------------------

>44492_44492_17_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=753AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL

--------------------------------------------------------------

>44492_44492_18_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=1005AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHANVV
VYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREA
SAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHT
LEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHP
VTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNK
LLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFD
AMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLE

--------------------------------------------------------------

>44492_44492_19_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=1083AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL
TLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLAR
VCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAET
SVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRA
IRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIA

--------------------------------------------------------------

>44492_44492_20_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000524874_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=752AA_BP=358
MAFYSYNSVLAIARTRFPSHFVHPTCSSYSPSCAFLHLPDSHLNKTCMKNYESKKYSDPSQPGNTVLHPGTRLIQKLHTSTCWLQEVPGK
PQLEQATKHPQVTSPQATKETGMEIKEGKQSYRQKIMDELKYYYNGFYLLWIDAKVAARMVWRLLHGQVLTRRERRREEKQKKKMAVKLE
LAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQTFGTNNLLRFQLLM
KLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDVKPKPIEIPLSGEGH
GVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFG
KDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKI
ADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLAN
PVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPL

--------------------------------------------------------------

>44492_44492_21_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000221481_length(amino acids)=284AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK

--------------------------------------------------------------

>44492_44492_22_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391940_length(amino acids)=587AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL

--------------------------------------------------------------

>44492_44492_23_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391944_length(amino acids)=839AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRL
RDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKP
LRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTL
SPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVAS
WYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLR
DQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE

--------------------------------------------------------------

>44492_44492_24_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000391945_length(amino acids)=917AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL
HTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDF
HPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQR
NKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLT
FDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQ

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>44492_44492_25_LETM2-ERCC2_LETM2_chr8_38262024_ENST00000527710_ERCC2_chr19_45872405_ENST00000485403_length(amino acids)=586AA_BP=192
MEEKQKKKMAVKLELAKFLQETMTEMARRNRAKMGDASTQLSSYVKQVQTGHKPSTKEIVRFSKLFEDQLALEHLDRPQLVALCKLLELQ
TFGTNNLLRFQLLMKLKSIKADDEIIAKEGVTALSVSELQAACRARGMRSLGLTEEQLRQQLTEWQDLHLKENVPPSLLLLSRTFYLIDV
KPKPIEIPLSGEGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRK
NLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHAN
VVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLR
EASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38262024/chr19:45872405)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LETM2

Q2VYF4

ERCC2

P18074

FUNCTION: ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:15494306, ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:8413672}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710208_235311.0397.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811208_235406.0492.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811208_235359.0445.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811382_385406.0492.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+71026_177311.0397.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+81126_177406.0492.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+81126_177359.0445.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+5826_177192.0278.0Topological domainMitochondrial intermembrane
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710178_198311.0397.0TransmembraneHelical
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811178_198406.0492.0TransmembraneHelical
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811178_198359.0445.0TransmembraneHelical
TgeneERCC2chr8:38262024chr19:45872405ENST00000391940113234_23711.0406.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000391940113682_69511.0406.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST00000391945123234_23735.0761.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000391945123682_69535.0761.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST00000485403012234_23711.0406.0MotifNote=DEAH box
TgeneERCC2chr8:38262024chr19:45872405ENST00000485403012682_69511.0406.0MotifNuclear localization signal
TgeneERCC2chr8:38262024chr19:45872405ENST0000039194011342_4911.0406.0Nucleotide bindingATP
TgeneERCC2chr8:38262024chr19:45872405ENST0000039194512342_4935.0761.0Nucleotide bindingATP
TgeneERCC2chr8:38262024chr19:45872405ENST0000048540301242_4911.0406.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58208_235192.0278.0Coiled coilOntology_term=ECO:0000255
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710382_385311.0397.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811382_385359.0445.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58382_385192.0278.0Compositional biasNote=Poly-Leu
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710221_438311.0397.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811221_438406.0492.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811221_438359.0445.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58221_438192.0278.0DomainLetm1 RBD
HgeneLETM2chr8:38262024chr19:45872405ENST00000297720+710199_491311.0397.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000379957+811199_491406.0492.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000523983+811199_491359.0445.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58199_491192.0278.0Topological domainMitochondrial matrix
HgeneLETM2chr8:38262024chr19:45872405ENST00000527710+58178_198192.0278.0TransmembraneHelical
TgeneERCC2chr8:38262024chr19:45872405ENST000003919401137_28311.0406.0DomainHelicase ATP-binding
TgeneERCC2chr8:38262024chr19:45872405ENST000003919451237_28335.0761.0DomainHelicase ATP-binding
TgeneERCC2chr8:38262024chr19:45872405ENST000004854030127_28311.0406.0DomainHelicase ATP-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LETM2
ERCC2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LETM2-ERCC2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LETM2-ERCC2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource