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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LGR5-CNOT2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LGR5-CNOT2
FusionPDB ID: 44591
FusionGDB2.0 ID: 44591
HgeneTgene
Gene symbol

LGR5

CNOT2

Gene ID

8549

4848

Gene nameleucine rich repeat containing G protein-coupled receptor 5CCR4-NOT transcription complex subunit 2
SynonymsFEX|GPR49|GPR67|GRP49|HG38CDC36|HSPC131|IDNADFS|NOT2|NOT2H
Cytomap

12q21.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing G-protein coupled receptor 5G-protein coupled receptor 49G-protein coupled receptor 67G-protein coupled receptor HG38orphan G protein-coupled receptor HG38CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2
Modification date2020032920200313
UniProtAcc

O75473

Q9NZN8

Ensembl transtripts involved in fusion geneENST idsENST00000266674, ENST00000536515, 
ENST00000540815, 		ENST00000548230, 
ENST00000551483, ENST00000229195, 
ENST00000418359, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 3 X 2=3027 X 20 X 10=5400
# samples 529
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/5400*10)=-4.21883460192326
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LGR5 [Title/Abstract] AND CNOT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LGR5(71928966)-CNOT2(70747609), # samples:2
Anticipated loss of major functional domain due to fusion event.LGR5-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR5-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR5-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR5-CNOT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGR5

GO:0090263

positive regulation of canonical Wnt signaling pathway

21693646|22815884

TgeneCNOT2

GO:0000122

negative regulation of transcription by RNA polymerase II

14707134|16712523


check buttonFusion gene breakpoints across LGR5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNOT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4U-01ALGR5chr12

71928966

-CNOT2chr12

70747609

+
ChimerDB4BLCATCGA-ZF-AA4U-01ALGR5chr12

71928966

+CNOT2chr12

70747609

+
ChimerDB4BLCATCGA-ZF-AA4ULGR5chr12

71928966

+CNOT2chr12

70747608

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000266674LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+190473973660195
ENST00000266674LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+190473973660195
ENST00000536515LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+164147648503151
ENST00000536515LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+164147648503151
ENST00000540815LGR5chr1271928966+ENST00000229195CNOT2chr1270747608+163947446501151
ENST00000540815LGR5chr1271928966+ENST00000418359CNOT2chr1270747608+163947446501151
ENST00000266674LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+190473973660195
ENST00000266674LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+190473973660195
ENST00000536515LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+164147648503151
ENST00000536515LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+164147648503151
ENST00000540815LGR5chr1271928966+ENST00000229195CNOT2chr1270747609+163947446501151
ENST00000540815LGR5chr1271928966+ENST00000418359CNOT2chr1270747609+163947446501151

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000266674ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.035109420.96489054
ENST00000266674ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.035109420.96489054
ENST00000536515ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.0231155120.97688454
ENST00000536515ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.0231155120.97688454
ENST00000540815ENST00000229195LGR5chr1271928966+CNOT2chr1270747608+0.0198026820.9801973
ENST00000540815ENST00000418359LGR5chr1271928966+CNOT2chr1270747608+0.0198026820.9801973
ENST00000266674ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.035109420.96489054
ENST00000266674ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.035109420.96489054
ENST00000536515ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.0231155120.97688454
ENST00000536515ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.0231155120.97688454
ENST00000540815ENST00000229195LGR5chr1271928966+CNOT2chr1270747609+0.0198026820.9801973
ENST00000540815ENST00000418359LGR5chr1271928966+CNOT2chr1270747609+0.0198026820.9801973

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44591_44591_1_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------

>44591_44591_2_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------

>44591_44591_3_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------

>44591_44591_4_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000266674_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=195AA_BP=
MSPLQPGLLRRPAWRQPAPLSPPRFSSPPTPWGQERGVWRCRRPLSCRSPRSGARRATARSSPVLLSARVRLVAPYFGHHGHLPARCAPV
LACAAAAGDRGQLSQVWCVAEGLPHTLSLRARRQDVAQGGLLRPGALGAAFQPQRLHLLPRPQYEQHQSAAPESPAQSPLPGGVTSCGKR

--------------------------------------------------------------

>44591_44591_5_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_6_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_7_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_8_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000536515_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_9_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_10_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747608_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_11_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000229195_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

>44591_44591_12_LGR5-CNOT2_LGR5_chr12_71928966_ENST00000540815_CNOT2_chr12_70747609_ENST00000418359_length(amino acids)=151AA_BP=
MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:71928966/chr12:70747609)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LGR5

O75473

CNOT2

Q9NZN8

FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22815884, ECO:0000269|PubMed:23809763}.FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. {ECO:0000269|PubMed:14707134, ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754, ECO:0000269|PubMed:22367759}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41825_66142.66666666666666908.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41725_66142.66666666666666884.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41825_66142.66666666666666908.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41725_66142.66666666666666884.0DomainNote=LRRNT
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418115_136142.66666666666666908.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41867_90142.66666666666666908.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41891_112142.66666666666666908.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417115_136142.66666666666666884.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41767_90142.66666666666666884.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41791_112142.66666666666666884.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418115_136142.66666666666666908.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41867_90142.66666666666666908.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41891_112142.66666666666666908.0RepeatNote=LRR 2
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417115_136142.66666666666666884.0RepeatNote=LRR 3
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41767_90142.66666666666666884.0RepeatNote=LRR 1
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41791_112142.66666666666666884.0RepeatNote=LRR 2
TgeneCNOT2chr12:71928966chr12:70747608ENST0000055148357437_540163.0192.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST0000055148357437_540163.0192.0RegionNote=Repressor domain

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418139_160142.66666666666666908.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418163_184142.66666666666666908.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418187_208142.66666666666666908.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418211_232142.66666666666666908.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418235_256142.66666666666666908.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418258_279142.66666666666666908.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418282_303142.66666666666666908.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418306_328142.66666666666666908.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418329_350142.66666666666666908.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418353_374142.66666666666666908.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418375_396142.66666666666666908.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418399_420142.66666666666666908.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418423_446142.66666666666666908.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417139_160142.66666666666666884.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417163_184142.66666666666666884.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417187_208142.66666666666666884.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417211_232142.66666666666666884.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417235_256142.66666666666666884.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417258_279142.66666666666666884.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417282_303142.66666666666666884.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417306_328142.66666666666666884.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417329_350142.66666666666666884.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417353_374142.66666666666666884.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417375_396142.66666666666666884.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417399_420142.66666666666666884.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417423_446142.66666666666666884.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418139_160142.66666666666666908.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418163_184142.66666666666666908.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418187_208142.66666666666666908.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418211_232142.66666666666666908.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418235_256142.66666666666666908.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418258_279142.66666666666666908.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418282_303142.66666666666666908.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418306_328142.66666666666666908.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418329_350142.66666666666666908.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418353_374142.66666666666666908.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418375_396142.66666666666666908.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418399_420142.66666666666666908.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418423_446142.66666666666666908.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417139_160142.66666666666666884.0RepeatNote=LRR 4
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417163_184142.66666666666666884.0RepeatNote=LRR 5
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417187_208142.66666666666666884.0RepeatNote=LRR 6
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417211_232142.66666666666666884.0RepeatNote=LRR 7
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417235_256142.66666666666666884.0RepeatNote=LRR 8
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417258_279142.66666666666666884.0RepeatNote=LRR 9
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417282_303142.66666666666666884.0RepeatNote=LRR 10
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417306_328142.66666666666666884.0RepeatNote=LRR 11
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417329_350142.66666666666666884.0RepeatNote=LRR 12
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417353_374142.66666666666666884.0RepeatNote=LRR 13
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417375_396142.66666666666666884.0RepeatNote=LRR 14
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417399_420142.66666666666666884.0RepeatNote=LRR 15
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417423_446142.66666666666666884.0RepeatNote=LRR 16
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+41822_561142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418583_593142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418615_638142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418660_682142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418704_722142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418744_767142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418789_802142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418824_907142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+41722_561142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417583_593142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417615_638142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417660_682142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417704_722142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417744_767142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417789_802142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417824_907142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+41822_561142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418583_593142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418615_638142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418660_682142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418704_722142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418744_767142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418789_802142.66666666666666908.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418824_907142.66666666666666908.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+41722_561142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417583_593142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417615_638142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417660_682142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417704_722142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417744_767142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417789_802142.66666666666666884.0Topological domainExtracellular
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417824_907142.66666666666666884.0Topological domainCytoplasmic
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418562_582142.66666666666666908.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418594_614142.66666666666666908.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418639_659142.66666666666666908.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418683_703142.66666666666666908.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418723_743142.66666666666666908.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418768_788142.66666666666666908.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747608ENST00000266674+418803_823142.66666666666666908.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417562_582142.66666666666666884.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417594_614142.66666666666666884.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417639_659142.66666666666666884.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417683_703142.66666666666666884.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417723_743142.66666666666666884.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417768_788142.66666666666666884.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747608ENST00000540815+417803_823142.66666666666666884.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418562_582142.66666666666666908.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418594_614142.66666666666666908.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418639_659142.66666666666666908.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418683_703142.66666666666666908.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418723_743142.66666666666666908.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418768_788142.66666666666666908.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747609ENST00000266674+418803_823142.66666666666666908.0TransmembraneHelical%3B Name%3D7
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417562_582142.66666666666666884.0TransmembraneHelical%3B Name%3D1
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417594_614142.66666666666666884.0TransmembraneHelical%3B Name%3D2
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417639_659142.66666666666666884.0TransmembraneHelical%3B Name%3D3
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417683_703142.66666666666666884.0TransmembraneHelical%3B Name%3D4
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417723_743142.66666666666666884.0TransmembraneHelical%3B Name%3D5
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417768_788142.66666666666666884.0TransmembraneHelical%3B Name%3D6
HgeneLGR5chr12:71928966chr12:70747609ENST00000540815+417803_823142.66666666666666884.0TransmembraneHelical%3B Name%3D7
TgeneCNOT2chr12:71928966chr12:70747608ENST000002291951416437_540512.0541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747608ENST000004183591517437_540512.0541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST000002291951416437_540512.0541.0RegionNote=Repressor domain
TgeneCNOT2chr12:71928966chr12:70747609ENST000004183591517437_540512.0541.0RegionNote=Repressor domain


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LGR5all structure
CNOT2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LGR5-CNOT2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LGR5-CNOT2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLGR5C0007102Malignant tumor of colon1CTD_human
HgeneLGR5C0009375Colonic Neoplasms1CTD_human
HgeneLGR5C0009402Colorectal Carcinoma1CTD_human
HgeneLGR5C0009404Colorectal Neoplasms1CTD_human