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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LIN9-EZR

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LIN9-EZR
	FusionPDB ID: 44787
	FusionGDB2.0 ID: 44787
		Hgene	Tgene
	Gene symbol	LIN9	EZR
	Gene ID	286826	7430
	Gene name	lin-9 DREAM MuvB core complex component	ezrin
	Synonyms	BARA\|BARPsv\|Lin-9\|TGS\|TGS1\|TGS2	CVIL\|CVL\|HEL-S-105\|VIL2
	Cytomap	1q42.12	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	protein lin-9 homologTUDOR gene similar proteinbeta subunit-associated regulator of apoptosislin-9 homologpRB-associated proteinrb related pathway actortype I interferon receptor beta chain-associated protein	ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)
	Modification date	20200313	20200322
	UniProtAcc	Q5TKA1	P15311
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000328205, ENST00000366801, ENST00000481685,	ENST00000476189, ENST00000337147, ENST00000367075, ENST00000392177,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	25 X 24 X 6=3600
	# samples	6	27
	** MAII score	log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/3600*10)=-3.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LIN9 [Title/Abstract] AND EZR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LIN9(226485419)-EZR(159210403), # samples:1
Anticipated loss of major functional domain due to fusion event.	LIN9-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIN9-EZR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIN9-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIN9-EZR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	EZR	GO:0048015	phosphatidylinositol-mediated signaling	25591774
Tgene	EZR	GO:0051017	actin filament bundle assembly	10793131

Fusion gene breakpoints across LIN9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EZR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-D7-A4YV	LIN9	chr1	226485419	-	EZR	chr6	159210403	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000328205	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3675	753	144	2501	785
ENST00000328205	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3668	753	144	2501	785
ENST00000328205	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	2424	753	144	2405	753
ENST00000366801	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3439	517	310	2265	651
ENST00000366801	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3432	517	310	2265	651
ENST00000366801	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	2188	517	310	2169	619
ENST00000481685	LIN9	chr1	226485419	-	ENST00000337147	EZR	chr6	159210403	-	3196	274	67	2022	651
ENST00000481685	LIN9	chr1	226485419	-	ENST00000367075	EZR	chr6	159210403	-	3189	274	67	2022	651
ENST00000481685	LIN9	chr1	226485419	-	ENST00000392177	EZR	chr6	159210403	-	1945	274	67	1926	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000328205	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.004448726	0.99555135
ENST00000328205	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.004319898	0.9956801
ENST00000328205	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.021508306	0.97849166
ENST00000366801	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.003154988	0.996845
ENST00000366801	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.003070478	0.9969296
ENST00000366801	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.012785963	0.98721397
ENST00000481685	ENST00000337147	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.002680471	0.9973195
ENST00000481685	ENST00000367075	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.002589349	0.9974107
ENST00000481685	ENST00000392177	LIN9	chr1	226485419	-	EZR	chr6	159210403	-	0.014614806	0.98538524

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44787_44787_1_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000337147_length(amino acids)=785AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVR
KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQH
KLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN
DKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMM
REKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL
EEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEA

--------------------------------------------------------------

>44787_44787_2_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000367075_length(amino acids)=785AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVR
KENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQH
KLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFN
DKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMM
REKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL
EEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEA

--------------------------------------------------------------

>44787_44787_3_LIN9-EZR_LIN9_chr1_226485419_ENST00000328205_EZR_chr6_159210403_ENST00000392177_length(amino acids)=753AA_BP=203
MRPRTEGFFPPAGASLPFSTRNKQPAVPAAAARAAEHAPGAGPGRDSGAGTAPPALRRRASPCGLLPPFLPPGSAGGGGGGARRGPPSAA
PPPRAGAGGAGPASASRGGSSAARRRGQRAPHSNLPRKDSLRPTMHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWN
EKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTTGKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFF
LQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLK
IAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQL
CMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRAL
QLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEEL
HLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDII

--------------------------------------------------------------

>44787_44787_4_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000337147_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------

>44787_44787_5_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000367075_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------

>44787_44787_6_LIN9-EZR_LIN9_chr1_226485419_ENST00000366801_EZR_chr6_159210403_ENST00000392177_length(amino acids)=619AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYL
SSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPK
IGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEK
KRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL
AAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEG

--------------------------------------------------------------

>44787_44787_7_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000337147_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------

>44787_44787_8_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000367075_length(amino acids)=651AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEI
YCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINY
FEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRR
KPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEE
AERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP
PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKY

--------------------------------------------------------------

>44787_44787_9_LIN9-EZR_LIN9_chr1_226485419_ENST00000481685_EZR_chr6_159210403_ENST00000392177_length(amino acids)=619AA_BP=69
MHRGGQPLKKRRGSFKMAELDQLPDESSSAKALVSLKEGSLSNTWNEKYSSLQKTPVWKGRNTSSAVEMINVRVTTMDAELEFAIQPNTT
GKQLFDQVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYL
SSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPK
IGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEK
KRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL
AAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:226485419/chr6:159210403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIN9 Q5TKA1	EZR P15311
FUNCTION: Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition. {ECO:0000269\|PubMed:15538385, ECO:0000269\|PubMed:16730350}.	FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269\|PubMed:17881735, ECO:0000269\|PubMed:18270268, ECO:0000269\|PubMed:19111582}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000337147

2_295

4.0

587.0

Domain

FERM

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000367075

2_295

4.0

587.0

Domain

FERM

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000337147

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

EZR

chr1:226485419

chr6:159210403

ENST00000367075

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIN9

chr1:226485419

chr6:159210403

ENST00000328205

354_413

69.0

559.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIN9

chr1:226485419

chr6:159210403

ENST00000366801

354_413

53.0

508.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

EZR

PRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, Tsc1, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, Cdk1, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, Msn, EGFR, MCM2, Mdm2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, SLC9A1, LASP1, DNM1L, FOXA1, TRIM25, HEY1, PRPF8, AAR2, PIH1D1, EFTUD2, SOCS2, ESR2, RUNX1, AGR2, MME, ZFP36L2, EEF2K, LSM1, MAP3K7, MGEA5, SRGAP2, COBL, IKBKAP, SVIL, MAPT, BCR, CAST, SHC1, NMT1, UTRN, ANK2, ANK3, ABR, GAB1, MTMR1, SNTB1, SEPT6, TAB1, PKN2, COBLL1, C6orf132, MPRIP, KIAA1211, CYFIP1, GPRIN1, R3HCC1L, PARG, SIRT2, PALM2, PHACTR4, ARFGAP1, ENAH, ZC3H15, SEPT8, USP47, DOCK7, ERBB2IP, PPP1R9B, EFHD1, SORBS1, EIF2A, TNKS1BP1, C1orf198, EPB41L1, SH2D4A, LZTFL1, CYLD, SH3GLB2, ARHGAP35, FARSB, PRMT7, ACTR10, DIP2B, ABCF2, SRP68, TRMT112, ASAP1, LIMCH1, AKAP2, WDR45, WASF2, RPA3, RPL32, POLDIP3, MACROD2, CASK, HGS, SEC16A, TIMM44, MYO1B, KIF5C, CTNND1, SRP72, AP2A1, ECD, PAK4, SLC25A5, HSPA1A, DDX6, EPHA2, TIE1, TRAPPC10, NUMB, NUP107, RPS13, OCRL, AKAP12, DST, NOTCH2, TCHH, FCHO2, KIAA0196, HDAC1, SCRIB, GOLGB1, KARS, RABEP1, PCBP2, TBR1, SEL1L2, FAM21A, FTSJ3, ABI1, EHBP1, NDRG1, SYAP1, FERMT2, CCDC124, CYFIP2, AHCYL2, PGAM5, TRAPPC9, FAM129B, TRIOBP, PEAK1, ELP3, PALMD, FAM207A, KLC4, LIN7C, DDX18, LYAR, ABI2, ITSN2, RAI14, FAM135A, ADD3, SWAP70, BAIAP2L1, TNIK, MYH13, MYO6, ICAM5, PACSIN2, SNX6, NCKAP1, TRAPPC1, NUMBL, DSG2, SKA2, EGLN1, PDLIM1, EIF4G3, EPB41, LRBA, AFD1, SNTB2, ITSN1, WDR44, HAUS6, FAM101B, DVL3, BCL11A, PLEKHA1, KIAA1429, ATG16L1, ACTC1, PHB, NEDD4, PODXL, GBF1, KRAS, HADHB, VDAC1, VDAC2, ABCC6, BIRC3, PARK2, PINK1, FANCD2, ORF3a, DUSP6, PTPN12, RAC1, SH2D3C, ERBB3, LRRC6, ZSWIM2, WDR37, S, USP1, CIT, ANLN, AURKB, CHMP4B, KIF14, PRNP, Arhgap28, ARHGEF15, HNRNPH1, SUMO2, NDN, NUPR1, RBM39, LGALS9, PMAIP1, CD274, DDRGK1, TP53, ACTB, SEPT9, ABLIM1, ACTN4, ATP2B1, BASP1, BSG, CCDC18, CDCA3, CORO1C, CTNNAL1, DEPDC1B, DLG5, DTNA, EFNB2, EPB41L5, FLOT2, FRS2, HNRNPA1L2, ITGB1, KIAA1549, KIAA1671, KIDINS220, LIMA1, LMO7, LSR, MARK2, MARK3, MB21D2, MYO5C, NEBL, OCLN, PALM2-AKAP2, PPFIBP1, PPP1R18, PPP1R9A, PPP6R1, PROSER2, PTPN14, RAP1GDS1, RASAL2, SH3D19, SLC12A2, SLC1A5, SLC29A1, SLC38A2, SLC39A14, SLC39A6, SLC3A2, SLC4A7, SLC6A8, SLC7A5, SNAP23, SPTAN1, STK10, VANGL1, VANGL2, YES1, YKT6, ZDHHC5, ANKRD26, ANKRD28, APBB1, APC, ARHGAP21, ARHGEF12, ATP1A1, CALD1, CDC42BPA, CTNNA1, DBN1, DIAPH3, DYNC1I2, DYNC1LI1, EFNB1, GOLGA3, H3F3A, HLA-A, IFT74, INA, IRS2, JMY, KANK2, KIF15, LPP, LUZP1, MACF1, MINK1, NBEA, PI4KA, PLEKHA5, RAPH1, REPS1, RTN1, SDCCAG3, SLAIN2, SLC6A15, STAU2, SYNJ1, TANC1, TDRD3, TJP1, nsp3, E, nsp3ab, SLC26A4-AS1, GOT1, ZNF622, TREML1, nsp11, nsp12, nsp13, nsp14, nsp16, nsp8, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LIN9
EZR

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LIN9-EZR

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LIN9-EZR

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	EZR	C0033578	Prostatic Neoplasms	3	CTD_human
Tgene	EZR	C0376358	Malignant neoplasm of prostate	3	CTD_human
Tgene	EZR	C0007097	Carcinoma	1	CTD_human
Tgene	EZR	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	EZR	C0024667	Animal Mammary Neoplasms	1	CTD_human
Tgene	EZR	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Tgene	EZR	C0027627	Neoplasm Metastasis	1	CTD_human
Tgene	EZR	C0029408	Degenerative polyarthritis	1	CTD_human
Tgene	EZR	C0086743	Osteoarthrosis Deformans	1	CTD_human
Tgene	EZR	C0205696	Anaplastic carcinoma	1	CTD_human
Tgene	EZR	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene	EZR	C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene	EZR	C0205699	Carcinomatosis	1	CTD_human
Tgene	EZR	C1257925	Mammary Carcinoma, Animal	1	CTD_human