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Fusion Protein:LONP1-MAP2K7 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: LONP1-MAP2K7 | FusionPDB ID: 49422 | FusionGDB2.0 ID: 49422 | Hgene | Tgene | Gene symbol | LONP1 | MAP2K7 | Gene ID | 9361 | 5609 |
| Gene name | lon peptidase 1, mitochondrial | mitogen-activated protein kinase kinase 7 | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | JNKK2|MAPKK7|MEK|MEK 7|MKK7|PRKMK7|SAPKK-4|SAPKK4 | |
| Cytomap | 19p13.3 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | dual specificity mitogen-activated protein kinase kinase 7JNK-activating kinase 2MAP kinase kinase 7MAPK/ERK kinase 7SAPK kinase 4c-Jun N-terminal kinase kinase 2stress-activated protein kinase kinase 4 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P36776 | O14733 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000590511, ENST00000360614, ENST00000590729, ENST00000593119, ENST00000585374, ENST00000540670, | ENST00000397979, ENST00000397981, ENST00000397983, ENST00000545011, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 18 X 14 X 12=3024 | 2 X 4 X 2=16 |
| # samples | 23 | 4 | |
| ** MAII score | log2(23/3024*10)=-3.7167523732767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: LONP1 [Title/Abstract] AND MAP2K7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LONP1(5719715)-MAP2K7(7974640), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. LONP1-MAP2K7 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Tgene | MAP2K7 | GO:0006970 | response to osmotic stress | 9535930 |
| Tgene | MAP2K7 | GO:0009408 | response to heat | 9535930 |
| Tgene | MAP2K7 | GO:0009411 | response to UV | 9535930 |
| Tgene | MAP2K7 | GO:0034612 | response to tumor necrosis factor | 9535930 |
| Tgene | MAP2K7 | GO:0051403 | stress-activated MAPK cascade | 9535930 |
| Fusion gene breakpoints across LONP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MAP2K7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-C8-A12L-01A | LONP1 | chr19 | 5719715 | - | MAP2K7 | chr19 | 7974640 | + |
| ChimerDB4 | BRCA | TCGA-C8-A12L | LONP1 | chr19 | 5719714 | - | MAP2K7 | chr19 | 7974639 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000585374 | LONP1 | chr19 | 5719715 | - | ENST00000397981 | MAP2K7 | chr19 | 7974640 | + | 3438 | 234 | 14 | 1390 | 458 |
| ENST00000585374 | LONP1 | chr19 | 5719715 | - | ENST00000545011 | MAP2K7 | chr19 | 7974640 | + | 3542 | 234 | 14 | 1495 | 493 |
| ENST00000585374 | LONP1 | chr19 | 5719715 | - | ENST00000397983 | MAP2K7 | chr19 | 7974640 | + | 3398 | 234 | 14 | 1369 | 451 |
| ENST00000585374 | LONP1 | chr19 | 5719715 | - | ENST00000397979 | MAP2K7 | chr19 | 7974640 | + | 3417 | 234 | 14 | 1369 | 451 |
| ENST00000585374 | LONP1 | chr19 | 5719714 | - | ENST00000397981 | MAP2K7 | chr19 | 7974639 | + | 3438 | 234 | 14 | 1390 | 458 |
| ENST00000585374 | LONP1 | chr19 | 5719714 | - | ENST00000545011 | MAP2K7 | chr19 | 7974639 | + | 3542 | 234 | 14 | 1495 | 493 |
| ENST00000585374 | LONP1 | chr19 | 5719714 | - | ENST00000397983 | MAP2K7 | chr19 | 7974639 | + | 3398 | 234 | 14 | 1369 | 451 |
| ENST00000585374 | LONP1 | chr19 | 5719714 | - | ENST00000397979 | MAP2K7 | chr19 | 7974639 | + | 3417 | 234 | 14 | 1369 | 451 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000585374 | ENST00000397981 | LONP1 | chr19 | 5719715 | - | MAP2K7 | chr19 | 7974640 | + | 0.010810332 | 0.9891896 |
| ENST00000585374 | ENST00000545011 | LONP1 | chr19 | 5719715 | - | MAP2K7 | chr19 | 7974640 | + | 0.024254145 | 0.97574586 |
| ENST00000585374 | ENST00000397983 | LONP1 | chr19 | 5719715 | - | MAP2K7 | chr19 | 7974640 | + | 0.00811897 | 0.9918811 |
| ENST00000585374 | ENST00000397979 | LONP1 | chr19 | 5719715 | - | MAP2K7 | chr19 | 7974640 | + | 0.007978765 | 0.99202126 |
| ENST00000585374 | ENST00000397981 | LONP1 | chr19 | 5719714 | - | MAP2K7 | chr19 | 7974639 | + | 0.010810332 | 0.9891896 |
| ENST00000585374 | ENST00000545011 | LONP1 | chr19 | 5719714 | - | MAP2K7 | chr19 | 7974639 | + | 0.024254145 | 0.97574586 |
| ENST00000585374 | ENST00000397983 | LONP1 | chr19 | 5719714 | - | MAP2K7 | chr19 | 7974639 | + | 0.00811897 | 0.9918811 |
| ENST00000585374 | ENST00000397979 | LONP1 | chr19 | 5719714 | - | MAP2K7 | chr19 | 7974639 | + | 0.007978765 | 0.99202126 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >49422_49422_1_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397979_length(amino acids)=451AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF -------------------------------------------------------------- >49422_49422_2_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397981_length(amino acids)=458AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS -------------------------------------------------------------- >49422_49422_3_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000397983_length(amino acids)=451AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF -------------------------------------------------------------- >49422_49422_4_LONP1-MAP2K7_LONP1_chr19_5719714_ENST00000585374_MAP2K7_chr19_7974639_ENST00000545011_length(amino acids)=493AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQVPPSLWRGEGGGPARLDPSWERQWGAGGGGRPGTLQP SLSSQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAM ELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAP ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE -------------------------------------------------------------- >49422_49422_5_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397979_length(amino acids)=451AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF -------------------------------------------------------------- >49422_49422_6_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397981_length(amino acids)=458AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFP YKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLS -------------------------------------------------------------- >49422_49422_7_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000397983_length(amino acids)=451AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAV KQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHG VIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTD FEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFF -------------------------------------------------------------- >49422_49422_8_LONP1-MAP2K7_LONP1_chr19_5719715_ENST00000585374_MAP2K7_chr19_7974640_ENST00000545011_length(amino acids)=493AA_BP=73 MAASTGYVRLWGAARCWVLRRPMLAAAGGRRGRRGRPGHNGAHAHDDPRCVSAPAAHRHHPQPGVPALYQDYRALQLPLANDGGSRSPSS ESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQVPPSLWRGEGGGPARLDPSWERQWGAGGGGRPGTLQP SLSSQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAM ELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAP ERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5719715/chr19:7974640) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | MAP2K7 |
| FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}. | FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397979 | 0 | 11 | 120_380 | 41.333333333333336 | 420.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397981 | 0 | 11 | 120_380 | 41.333333333333336 | 427.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397983 | 1 | 12 | 120_380 | 57.333333333333336 | 436.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397979 | 0 | 11 | 120_380 | 41.333333333333336 | 420.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397981 | 0 | 11 | 120_380 | 41.333333333333336 | 427.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397983 | 1 | 12 | 120_380 | 57.333333333333336 | 436.0 | Domain | Protein kinase | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397979 | 0 | 11 | 126_134 | 41.333333333333336 | 420.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397981 | 0 | 11 | 126_134 | 41.333333333333336 | 427.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397983 | 1 | 12 | 126_134 | 57.333333333333336 | 436.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397979 | 0 | 11 | 126_134 | 41.333333333333336 | 420.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397981 | 0 | 11 | 126_134 | 41.333333333333336 | 427.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397983 | 1 | 12 | 126_134 | 57.333333333333336 | 436.0 | Nucleotide binding | ATP | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397979 | 0 | 11 | 377_400 | 41.333333333333336 | 420.0 | Region | Note=DVD domain | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397981 | 0 | 11 | 377_400 | 41.333333333333336 | 427.0 | Region | Note=DVD domain | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397983 | 1 | 12 | 377_400 | 57.333333333333336 | 436.0 | Region | Note=DVD domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397979 | 0 | 11 | 377_400 | 41.333333333333336 | 420.0 | Region | Note=DVD domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397981 | 0 | 11 | 377_400 | 41.333333333333336 | 427.0 | Region | Note=DVD domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397983 | 1 | 12 | 377_400 | 57.333333333333336 | 436.0 | Region | Note=DVD domain |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LONP1 | chr19:5719714 | chr19:7974639 | ENST00000360614 | - | 1 | 18 | 124_368 | 143.0 | 960.0 | Domain | Lon N-terminal |
| Hgene | LONP1 | chr19:5719714 | chr19:7974639 | ENST00000360614 | - | 1 | 18 | 759_949 | 143.0 | 960.0 | Domain | Lon proteolytic |
| Hgene | LONP1 | chr19:5719715 | chr19:7974640 | ENST00000360614 | - | 1 | 18 | 124_368 | 143.0 | 960.0 | Domain | Lon N-terminal |
| Hgene | LONP1 | chr19:5719715 | chr19:7974640 | ENST00000360614 | - | 1 | 18 | 759_949 | 143.0 | 960.0 | Domain | Lon proteolytic |
| Hgene | LONP1 | chr19:5719714 | chr19:7974639 | ENST00000360614 | - | 1 | 18 | 523_530 | 143.0 | 960.0 | Nucleotide binding | ATP |
| Hgene | LONP1 | chr19:5719715 | chr19:7974640 | ENST00000360614 | - | 1 | 18 | 523_530 | 143.0 | 960.0 | Nucleotide binding | ATP |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397979 | 0 | 11 | 2_30 | 41.333333333333336 | 420.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397981 | 0 | 11 | 2_30 | 41.333333333333336 | 427.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397983 | 1 | 12 | 2_30 | 57.333333333333336 | 436.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397979 | 0 | 11 | 2_30 | 41.333333333333336 | 420.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397981 | 0 | 11 | 2_30 | 41.333333333333336 | 427.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397983 | 1 | 12 | 2_30 | 57.333333333333336 | 436.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397979 | 0 | 11 | 37_57 | 41.333333333333336 | 420.0 | Region | D domain | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397981 | 0 | 11 | 37_57 | 41.333333333333336 | 427.0 | Region | D domain | |
| Tgene | MAP2K7 | chr19:5719714 | chr19:7974639 | ENST00000397983 | 1 | 12 | 37_57 | 57.333333333333336 | 436.0 | Region | D domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397979 | 0 | 11 | 37_57 | 41.333333333333336 | 420.0 | Region | D domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397981 | 0 | 11 | 37_57 | 41.333333333333336 | 427.0 | Region | D domain | |
| Tgene | MAP2K7 | chr19:5719715 | chr19:7974640 | ENST00000397983 | 1 | 12 | 37_57 | 57.333333333333336 | 436.0 | Region | D domain |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| LONP1 | |
| MAP2K7 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to LONP1-MAP2K7 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LONP1-MAP2K7 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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