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Fusion Protein:LONP1-SAFB2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: LONP1-SAFB2 | FusionPDB ID: 49426 | FusionGDB2.0 ID: 49426 | Hgene | Tgene | Gene symbol | LONP1 | SAFB2 | Gene ID | 9361 | 9667 |
| Gene name | lon peptidase 1, mitochondrial | scaffold attachment factor B2 | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | - | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | scaffold attachment factor B2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | P36776 | . | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000360614, ENST00000540670, ENST00000585374, ENST00000590729, ENST00000593119, ENST00000590511, | ENST00000591310, ENST00000252542, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 18 X 14 X 12=3024 | 8 X 8 X 5=320 |
| # samples | 23 | 9 | |
| ** MAII score | log2(23/3024*10)=-3.7167523732767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/320*10)=-1.83007499855769 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: LONP1 [Title/Abstract] AND SAFB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SAFB2(5598804)-LONP1(5708414), # samples:3 LONP1(5705783)-SAFB2(5600271), # samples:1 LONP1(5705782)-SAFB2(5604947), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. SAFB2-LONP1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. SAFB2-LONP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. LONP1-SAFB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. LONP1-SAFB2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Fusion gene breakpoints across LONP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SAFB2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-AR-A251-01A | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - |
| ChimerDB4 | BRCA | TCGA-AR-A251 | LONP1 | chr19 | 5705782 | - | SAFB2 | chr19 | 5604947 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000360614 | LONP1 | chr19 | 5705783 | - | ENST00000252542 | SAFB2 | chr19 | 5600271 | - | 3072 | 1525 | 38 | 2827 | 929 |
| ENST00000593119 | LONP1 | chr19 | 5705783 | - | ENST00000252542 | SAFB2 | chr19 | 5600271 | - | 2755 | 1208 | 33 | 2510 | 825 |
| ENST00000540670 | LONP1 | chr19 | 5705783 | - | ENST00000252542 | SAFB2 | chr19 | 5600271 | - | 2839 | 1292 | 369 | 2594 | 741 |
| ENST00000590729 | LONP1 | chr19 | 5705783 | - | ENST00000252542 | SAFB2 | chr19 | 5600271 | - | 2583 | 1036 | 59 | 2338 | 759 |
| ENST00000585374 | LONP1 | chr19 | 5705782 | - | ENST00000252542 | SAFB2 | chr19 | 5604947 | - | 2982 | 1172 | 1238 | 2737 | 499 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000360614 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - | 0.005275876 | 0.9947241 |
| ENST00000593119 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - | 0.009283451 | 0.9907165 |
| ENST00000540670 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - | 0.016348477 | 0.9836516 |
| ENST00000590729 | ENST00000252542 | LONP1 | chr19 | 5705783 | - | SAFB2 | chr19 | 5600271 | - | 0.00664826 | 0.99335176 |
| ENST00000585374 | ENST00000252542 | LONP1 | chr19 | 5705782 | - | SAFB2 | chr19 | 5604947 | - | 0.033374153 | 0.9666258 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >49426_49426_1_LONP1-SAFB2_LONP1_chr19_5705782_ENST00000585374_SAFB2_chr19_5604947_ENST00000252542_length(amino acids)=499AA_BP=163 MSTSDEATKCISHLHRTELHGRMISVEKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDIKKEE KDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIR ETERRREREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQE RRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERH GRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRG -------------------------------------------------------------- >49426_49426_2_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000360614_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=929AA_BP=1 MKRLFRATRPSGTEARAGRHVRFAASGNDASCVSRQYGRAMAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASP PWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIK IIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAE NKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQA GQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLE KDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSG SRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAF HERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPE GKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEG RGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEG -------------------------------------------------------------- >49426_49426_3_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000540670_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=741AA_BP=1 MVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRK SKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNP IYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIE EKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTV VMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKAR LQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMED RYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPR GGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDR -------------------------------------------------------------- >49426_49426_4_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000590729_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=759AA_BP=0 MTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKL RMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEALTAEIVKTIRDIIALNPLY RESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQL KIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGP TNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQ REREQRLEAFHERKEKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDL DRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGG YGSDKRLSEGRGLPPPPRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQG -------------------------------------------------------------- >49426_49426_5_LONP1-SAFB2_LONP1_chr19_5705783_ENST00000593119_SAFB2_chr19_5600271_ENST00000252542_length(amino acids)=825AA_BP=0 MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLR RKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKK EAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDM GAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRER LKELVVPKHVMDVVDEELSKLGLLDNHSSEFKTVIKKEEKIEKKEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSK GEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEKARLQRERL QLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADF PRPDHRFHDFDHRDRGQYQDHAIDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPPPRGGRDWG EHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGVAGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPH -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5598804/chr19:5708414) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | . |
| FUNCTION: ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters (PubMed:12198491, PubMed:15870080, PubMed:17420247, PubMed:8248235). Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein, helicase Twinkle (TWNK) and the large ribosomal subunit protein bL32m. bL32m is protected from degradation by LONP1 when it is bound to a nucleic acid (RNA), but TWNK is not (PubMed:17579211, PubMed:28377575). {ECO:0000255|HAMAP-Rule:MF_03120, ECO:0000269|PubMed:12198491, ECO:0000269|PubMed:15870080, ECO:0000269|PubMed:17420247, ECO:0000269|PubMed:17579211, ECO:0000269|PubMed:28377575, ECO:0000269|PubMed:8248235}. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LONP1 | chr19:5705782 | chr19:5604947 | ENST00000360614 | - | 8 | 18 | 124_368 | 455.6666666666667 | 960.0 | Domain | Lon N-terminal |
| Hgene | LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 124_368 | 455.6666666666667 | 960.0 | Domain | Lon N-terminal |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 482_545 | 432.0 | 954.0 | Compositional bias | Note=Lys-rich | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 619_724 | 432.0 | 954.0 | Compositional bias | Note=Glu-rich | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 621_788 | 432.0 | 954.0 | Compositional bias | Note=Arg-rich | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 792_926 | 432.0 | 954.0 | Compositional bias | Note=Gly-rich | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 619_724 | 519.6666666666666 | 954.0 | Compositional bias | Note=Glu-rich | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 621_788 | 519.6666666666666 | 954.0 | Compositional bias | Note=Arg-rich | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 792_926 | 519.6666666666666 | 954.0 | Compositional bias | Note=Gly-rich | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 713_730 | 432.0 | 954.0 | Motif | Nuclear localization signal | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 713_730 | 519.6666666666666 | 954.0 | Motif | Nuclear localization signal |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LONP1 | chr19:5705782 | chr19:5604947 | ENST00000360614 | - | 8 | 18 | 759_949 | 455.6666666666667 | 960.0 | Domain | Lon proteolytic |
| Hgene | LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 759_949 | 455.6666666666667 | 960.0 | Domain | Lon proteolytic |
| Hgene | LONP1 | chr19:5705782 | chr19:5604947 | ENST00000360614 | - | 8 | 18 | 523_530 | 455.6666666666667 | 960.0 | Nucleotide binding | ATP |
| Hgene | LONP1 | chr19:5705783 | chr19:5600271 | ENST00000360614 | - | 8 | 18 | 523_530 | 455.6666666666667 | 960.0 | Nucleotide binding | ATP |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 482_545 | 519.6666666666666 | 954.0 | Compositional bias | Note=Lys-rich | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 30_64 | 432.0 | 954.0 | Domain | SAP | |
| Tgene | SAFB2 | chr19:5705782 | chr19:5604947 | ENST00000252542 | 8 | 21 | 407_485 | 432.0 | 954.0 | Domain | RRM | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 30_64 | 519.6666666666666 | 954.0 | Domain | SAP | |
| Tgene | SAFB2 | chr19:5705783 | chr19:5600271 | ENST00000252542 | 10 | 21 | 407_485 | 519.6666666666666 | 954.0 | Domain | RRM |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| LONP1 | |
| SAFB2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to LONP1-SAFB2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LONP1-SAFB2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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