UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MAP2K2-INSR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP2K2-INSR
FusionPDB ID: 51187
FusionGDB2.0 ID: 51187
HgeneTgene
Gene symbol

MAP2K2

INSR

Gene ID

5605

3643

Gene namemitogen-activated protein kinase kinase 2insulin receptor
SynonymsCFC4|MAPKK2|MEK2|MKK2|PRKMK2CD220|HHF5
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
Descriptiondual specificity mitogen-activated protein kinase kinase 2ERK activator kinase 2MAP kinase kinase 2MAPK/ERK kinase 2mitogen-activated protein kinase kinase 2, p45insulin receptorIR
Modification date2020032720200313
UniProtAcc

P36507

P06213

Ensembl transtripts involved in fusion geneENST idsENST00000599345, ENST00000394867, 
ENST00000262948, 		ENST00000302850, 
ENST00000341500, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 6 X 6=36020 X 13 X 8=2080
# samples 1020
** MAII scorelog2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2080*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAP2K2 [Title/Abstract] AND INSR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP2K2(4110507)-INSR(7132328), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP2K2-INSR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP2K2

GO:0036289

peptidyl-serine autophosphorylation

8388392

HgeneMAP2K2

GO:0071902

positive regulation of protein serine/threonine kinase activity

8388392

TgeneINSR

GO:0001934

positive regulation of protein phosphorylation

7556070

TgeneINSR

GO:0002092

positive regulation of receptor internalization

25401701

TgeneINSR

GO:0007186

G protein-coupled receptor signaling pathway

9092559

TgeneINSR

GO:0008284

positive regulation of cell proliferation

17925406

TgeneINSR

GO:0008286

insulin receptor signaling pathway

6849137|8440175|20455999

TgeneINSR

GO:0018108

peptidyl-tyrosine phosphorylation

8496180

TgeneINSR

GO:0032148

activation of protein kinase B activity

7556070

TgeneINSR

GO:0032869

cellular response to insulin stimulus

8440175

TgeneINSR

GO:0043410

positive regulation of MAPK cascade

20455999

TgeneINSR

GO:0045725

positive regulation of glycogen biosynthetic process

17925406

TgeneINSR

GO:0046326

positive regulation of glucose import

3518947

TgeneINSR

GO:0046777

protein autophosphorylation

6849137|8496180

TgeneINSR

GO:0060267

positive regulation of respiratory burst

9092559


check buttonFusion gene breakpoints across MAP2K2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INSR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1410-01AMAP2K2chr19

4110507

-INSRchr19

7132328

-
ChimerDB4OVTCGA-13-1410MAP2K2chr19

4110506

-INSRchr19

7132328

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262948MAP2K2chr194110507-ENST00000341500INSRchr197132328-69727042542170638
ENST00000262948MAP2K2chr194110507-ENST00000302850INSRchr197132328-26007042542170638
ENST00000262948MAP2K2chr194110506-ENST00000341500INSRchr197132328-69727042542170638
ENST00000262948MAP2K2chr194110506-ENST00000302850INSRchr197132328-26007042542170638

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262948ENST00000341500MAP2K2chr194110507-INSRchr197132328-0.0008052650.9991948
ENST00000262948ENST00000302850MAP2K2chr194110507-INSRchr197132328-0.0076571130.9923429
ENST00000262948ENST00000341500MAP2K2chr194110506-INSRchr197132328-0.0008052650.9991948
ENST00000262948ENST00000302850MAP2K2chr194110506-INSRchr197132328-0.0076571130.9923429

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51187_51187_1_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------

>51187_51187_2_MAP2K2-INSR_MAP2K2_chr19_4110506_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------

>51187_51187_3_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000302850_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------

>51187_51187_4_MAP2K2-INSR_MAP2K2_chr19_4110507_ENST00000262948_INSR_chr19_7132328_ENST00000341500_length(amino acids)=638AA_BP=150
MLARRKPVLPALTINPTIAEGPSPTSEGASEANLVDLQKKLEELELDEQQKKRLEAFLTQKAKVGELKDDDFERISELGAGNGGVVTKVQ
HRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMELHLCVSRKHFALERGCRLRGLSPGNYSVR
IRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPD
EWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME
LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGG
KGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFL
EIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRIL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:4110507/chr19:7132328)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP2K2

P36507

INSR

P06213

FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126). {ECO:0000250|UniProtKB:Q63932, ECO:0000269|PubMed:29433126}.FUNCTION: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-31178_86150.0401.0Nucleotide bindingATP
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-31178_86150.0401.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221023_1298894.01383.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211023_1298882.01371.0DomainProtein kinase
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221023_1298894.01383.0DomainProtein kinase
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211023_1298882.01371.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221104_1110894.01383.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221163_1164894.01383.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211104_1110882.01371.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211163_1164882.01371.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221104_1110894.01383.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221163_1164894.01383.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211104_1110882.01371.0Nucleotide bindingATP
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211163_1164882.01371.0Nucleotide bindingATP
TgeneINSRchr19:4110506chr19:7132328ENST0000030285012221361_1364894.01383.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110506chr19:7132328ENST0000034150011211361_1364882.01371.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110507chr19:7132328ENST0000030285012221361_1364894.01383.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110507chr19:7132328ENST0000034150011211361_1364882.01371.0RegionNote=PIK3R1-binding
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222980_1382894.01383.0Topological domainCytoplasmic
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121980_1382882.01371.0Topological domainCytoplasmic
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222980_1382894.01383.0Topological domainCytoplasmic
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121980_1382882.01371.0Topological domainCytoplasmic
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222957_979894.01383.0TransmembraneHelical
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121957_979882.01371.0TransmembraneHelical
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222957_979894.01383.0TransmembraneHelical
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121957_979882.01371.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-311266_315150.0401.0Compositional biasNote=Pro-rich
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-311266_315150.0401.0Compositional biasNote=Pro-rich
HgeneMAP2K2chr19:4110506chr19:7132328ENST00000262948-31172_369150.0401.0DomainProtein kinase
HgeneMAP2K2chr19:4110507chr19:7132328ENST00000262948-31172_369150.0401.0DomainProtein kinase
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222182_339894.01383.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110506chr19:7132328ENST00000302850122228_174894.01383.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121182_339882.01371.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110506chr19:7132328ENST00000341500112128_174882.01371.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222182_339894.01383.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110507chr19:7132328ENST00000302850122228_174894.01383.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121182_339882.01371.0Compositional biasNote=Cys-rich
TgeneINSRchr19:4110507chr19:7132328ENST00000341500112128_174882.01371.0Compositional biasNote=Leu-rich
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222624_726894.01383.0DomainFibronectin type-III 1
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222757_842894.01383.0DomainFibronectin type-III 2
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222853_947894.01383.0DomainFibronectin type-III 3
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121624_726882.01371.0DomainFibronectin type-III 1
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121757_842882.01371.0DomainFibronectin type-III 2
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121853_947882.01371.0DomainFibronectin type-III 3
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222624_726894.01383.0DomainFibronectin type-III 1
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222757_842894.01383.0DomainFibronectin type-III 2
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222853_947894.01383.0DomainFibronectin type-III 3
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121624_726882.01371.0DomainFibronectin type-III 1
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121757_842882.01371.0DomainFibronectin type-III 2
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121853_947882.01371.0DomainFibronectin type-III 3
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222733_741894.01383.0RegionNote=Insulin-binding
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121733_741882.01371.0RegionNote=Insulin-binding
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222733_741894.01383.0RegionNote=Insulin-binding
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121733_741882.01371.0RegionNote=Insulin-binding
TgeneINSRchr19:4110506chr19:7132328ENST00000302850122228_758894.01383.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST000003028501222763_956894.01383.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST00000341500112128_758882.01371.0Topological domainExtracellular
TgeneINSRchr19:4110506chr19:7132328ENST000003415001121763_956882.01371.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST00000302850122228_758894.01383.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST000003028501222763_956894.01383.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST00000341500112128_758882.01371.0Topological domainExtracellular
TgeneINSRchr19:4110507chr19:7132328ENST000003415001121763_956882.01371.0Topological domainExtracellular


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAP2K2
INSR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to MAP2K2-INSR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MAP2K2-INSR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource