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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAPK1-YDJC

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAPK1-YDJC
	FusionPDB ID: 51551
	FusionGDB2.0 ID: 51551
		Hgene	Tgene
	Gene symbol	MAPK1	YDJC
	Gene ID	5594	150223
	Gene name	mitogen-activated protein kinase 1	YdjC chitooligosaccharide deacetylase homolog
	Synonyms	ERK\|ERK-2\|ERK2\|ERT1\|MAPK2\|P42MAPK\|PRKM1\|PRKM2\|p38\|p40\|p41\|p41mapk\|p42-MAPK	-
	Cytomap	22q11.22	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2	carbohydrate deacetylaseUPF0249 protein ydjC homologYdjC homolog
	Modification date	20200327	20200320
	UniProtAcc	Q8NDC0	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000215832, ENST00000398822, ENST00000544786, ENST00000491588,	ENST00000292778, ENST00000398873,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 16 X 10=3200	1 X 1 X 1=1
	# samples	24	1
	** MAII score	log2(24/3200*10)=-3.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAPK1 [Title/Abstract] AND YDJC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAPK1(22221612)-YDJC(21983696), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAPK1-YDJC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPK1-YDJC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPK1-YDJC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAPK1-YDJC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPK1	GO:0006468	protein phosphorylation	23184662
Hgene	MAPK1	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	16314496
Hgene	MAPK1	GO:0018105	peptidyl-serine phosphorylation	15850461
Hgene	MAPK1	GO:0034198	cellular response to amino acid starvation	11096076
Hgene	MAPK1	GO:0038127	ERBB signaling pathway	15133037
Hgene	MAPK1	GO:0051403	stress-activated MAPK cascade	11096076
Hgene	MAPK1	GO:0070371	ERK1 and ERK2 cascade	16314496
Hgene	MAPK1	GO:0070849	response to epidermal growth factor	18794356

Fusion gene breakpoints across MAPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across YDJC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A8OQ-01A	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000215832	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1285	308	104	955	283
ENST00000215832	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	1104	308	19	777	252
ENST00000398822	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1336	359	38	1006	322
ENST00000398822	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	1155	359	70	828	252
ENST00000544786	MAPK1	chr22	22221612	-	ENST00000292778	YDJC	chr22	21983696	-	1096	119	161	766	201
ENST00000544786	MAPK1	chr22	22221612	-	ENST00000398873	YDJC	chr22	21983696	-	915	119	148	588	146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000215832	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.40291193	0.59708804
ENST00000215832	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.28885064	0.71114933
ENST00000398822	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.46154806	0.5384519
ENST00000398822	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.2906936	0.7093064
ENST00000544786	ENST00000292778	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.46834335	0.5316566
ENST00000544786	ENST00000398873	MAPK1	chr22	22221612	-	YDJC	chr22	21983696	-	0.37773857	0.6222614

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51551_51551_1_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=283AA_BP=1
MREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGAALHQPLVHRRGRLRHGVVREELEAQLSCFRELLGRAPTH
ADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFACAVERDARAAVGPFSRHGLRWTDAFVGLSTCGRHMSAHR
VSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERLHELRVLTAPTLRAQLAQDGVQLCALDDLDSKRPGEEVPC

--------------------------------------------------------------

>51551_51551_2_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000215832_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=252AA_BP=1
MSALQLSRSASSFLLPVSVGGCTGGGAVPAGGATRAERRPPSVELSAAEAAAARQPTWRRRRRRARARRWSAGRCSTWGRATPTSRTSAR
APTAWCGAGGARGPTKLLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSV

--------------------------------------------------------------

>51551_51551_3_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=322AA_BP=1
MAGRQAIGPSGCRLFSSPARRLPSSSRSASAAAPAAAQSLREGRQELSGGRRASSSARRRRRRPGSQHGGGGGGGRGPGDGPRAGVRRGA
ALHQPLVHRRGRLRHGVVREELEAQLSCFRELLGRAPTHADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFA
CAVERDARAAVGPFSRHGLRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERL

--------------------------------------------------------------

>51551_51551_4_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000398822_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=252AA_BP=1
MSALQLSRSASSFLLPVSVGGCTGGGAVPAGGATRAERRPPSVELSAAEAAAARQPTWRRRRRRARARRWSAGRCSTWGRATPTSRTSAR
APTAWCGAGGARGPTKLLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSV

--------------------------------------------------------------

>51551_51551_5_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000292778_length(amino acids)=201AA_BP=
MLGRAPTHADGHQHVHVLPGVCQVFAEALQAYGVRFTRLPLERGVGGCTWLEAPARAFACAVERDARAAVGPFSRHGLRWTDAFVGLSTC
GRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCSWERLHELRVLTAPTLRAQLAQDGVQLCALDDLDSK

--------------------------------------------------------------

>51551_51551_6_MAPK1-YDJC_MAPK1_chr22_22221612_ENST00000544786_YDJC_chr22_21983696_ENST00000398873_length(amino acids)=146AA_BP=
MLPGAAGQGPHARGRAPARARAPRWTDAFVGLSTCGRHMSAHRVSGALARVLEGTLAGHTLTAELMAHPGYPSVPPTGGCGEGPDAFSCS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:22221612/chr22:21983696)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPK1 Q8NDC0	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

2_9

39.666666666666664

3486.3333333333335

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

2_9

39.666666666666664

361.0

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

2_9

39.666666666666664

317.0

Compositional bias

Note=Poly-Ala

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

31_39

39.666666666666664

3486.3333333333335

Nucleotide binding

ATP

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

31_39

39.666666666666664

361.0

Nucleotide binding

ATP

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

31_39

39.666666666666664

317.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

259_277

39.666666666666664

3486.3333333333335

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

259_277

39.666666666666664

361.0

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

259_277

39.666666666666664

317.0

DNA binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

25_313

39.666666666666664

3486.3333333333335

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

25_313

39.666666666666664

361.0

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

25_313

39.666666666666664

317.0

Domain

Protein kinase

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

185_187

39.666666666666664

3486.3333333333335

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

318_322

39.666666666666664

3486.3333333333335

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

327_333

39.666666666666664

3486.3333333333335

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

185_187

39.666666666666664

361.0

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

318_322

39.666666666666664

361.0

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

327_333

39.666666666666664

361.0

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

185_187

39.666666666666664

317.0

Motif

TXY

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

318_322

39.666666666666664

317.0

Motif

Cytoplasmic retention motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

327_333

39.666666666666664

317.0

Motif

Nuclear translocation motif

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

105_108

39.666666666666664

3486.3333333333335

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000215832

153_154

39.666666666666664

3486.3333333333335

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

105_108

39.666666666666664

361.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000398822

153_154

39.666666666666664

361.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

105_108

39.666666666666664

317.0

Region

Note=Inhibitor-binding

Hgene

MAPK1

chr22:22221612

chr22:21983696

ENST00000544786

153_154

39.666666666666664

317.0

Region

Note=Inhibitor-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAPK1
YDJC

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAPK1-YDJC

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAPK1-YDJC

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source