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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AP2A2-DRD4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AP2A2-DRD4
FusionPDB ID: 5225
FusionGDB2.0 ID: 5225
HgeneTgene
Gene symbol

AP2A2

DRD4

Gene ID

161

1815

Gene nameadaptor related protein complex 2 subunit alpha 2dopamine receptor D4
SynonymsADTAB|CLAPA2|HIP-9|HIP9|HYPJD4DR
Cytomap

11p15.5

11p15.5

Type of geneprotein-codingprotein-coding
DescriptionAP-2 complex subunit alpha-2100 kDa coated vesicle protein Cadapter-related protein complex 2 subunit alpha-2adaptin, alpha Badaptor related protein complex 2 alpha 2 subunitalpha-adaptin C; Huntingtin interacting protein Jalpha2-adaptinclathrin asD(4) dopamine receptorD(2C) dopamine receptordopamine D4 receptorseven transmembrane helix receptor
Modification date2020031320200329
UniProtAcc

O94973

.
Ensembl transtripts involved in fusion geneENST idsENST00000332231, ENST00000448903, 
ENST00000534328, ENST00000525891, 
ENST00000528733, ENST00000176183, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 12=15604 X 5 X 3=60
# samples 227
** MAII scorelog2(22/1560*10)=-2.82597060022495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AP2A2 [Title/Abstract] AND DRD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AP2A2(977224)-DRD4(639432), # samples:1
AP2A2(977224)-DRD4(640401), # samples:1
AP2A2(977224)-DRD4(639433), # samples:1
AP2A2(970311)-DRD4(640401), # samples:1
AP2A2(977223)-DRD4(639432), # samples:1
AP2A2(977223)-DRD4(640400), # samples:1
Anticipated loss of major functional domain due to fusion event.AP2A2-DRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-DRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AP2A2-DRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AP2A2-DRD4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAP2A2

GO:0072583

clathrin-dependent endocytosis

23676497

TgeneDRD4

GO:0000187

activation of MAPK activity

9843378|15755724

TgeneDRD4

GO:0007195

adenylate cyclase-inhibiting dopamine receptor signaling pathway

7512953|9003072|9843378

TgeneDRD4

GO:0007212

dopamine receptor signaling pathway

1840645

TgeneDRD4

GO:0032417

positive regulation of sodium:proton antiporter activity

7512953

TgeneDRD4

GO:0033674

positive regulation of kinase activity

15755724

TgeneDRD4

GO:0034776

response to histamine

16839358

TgeneDRD4

GO:0050482

arachidonic acid secretion

7512953

TgeneDRD4

GO:0050709

negative regulation of protein secretion

16839358

TgeneDRD4

GO:1901386

negative regulation of voltage-gated calcium channel activity

7921596


check buttonFusion gene breakpoints across AP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DRD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OR-A5J7-01AAP2A2chr11

977223

+DRD4chr11

639432

+
ChimerDB4ACCTCGA-OR-A5J7-01AAP2A2chr11

977223

+DRD4chr11

640400

+
ChimerDB4ACCTCGA-OR-A5J7-01AAP2A2chr11

977224

+DRD4chr11

639433

+
ChimerDB4ACCTCGA-OR-A5J7-01AAP2A2chr11

977224

+DRD4chr11

640401

+
ChimerDB4ACCTCGA-OR-A5J7AP2A2chr11

977224

+DRD4chr11

639432

+
ChimerDB4UCECTCGA-EO-A3KW-01AAP2A2chr11

970311

+DRD4chr11

640401

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534328AP2A2chr11977224+ENST00000176183DRD4chr11639432+18237451421719525
ENST00000332231AP2A2chr11977224+ENST00000176183DRD4chr11639432+18227441411718525
ENST00000448903AP2A2chr11977224+ENST00000176183DRD4chr11639432+18227441411718525
ENST00000534328AP2A2chr11977224+ENST00000176183DRD4chr11639433+18237451421719525
ENST00000332231AP2A2chr11977224+ENST00000176183DRD4chr11639433+18227441411718525
ENST00000448903AP2A2chr11977224+ENST00000176183DRD4chr11639433+18227441411718525
ENST00000534328AP2A2chr11977223+ENST00000176183DRD4chr11639432+18237451421719525
ENST00000332231AP2A2chr11977223+ENST00000176183DRD4chr11639432+18227441411718525
ENST00000448903AP2A2chr11977223+ENST00000176183DRD4chr11639432+18227441411718525

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534328ENST00000176183AP2A2chr11977224+DRD4chr11639432+0.0416984370.9583016
ENST00000332231ENST00000176183AP2A2chr11977224+DRD4chr11639432+0.0413940250.95860595
ENST00000448903ENST00000176183AP2A2chr11977224+DRD4chr11639432+0.0413940250.95860595
ENST00000534328ENST00000176183AP2A2chr11977224+DRD4chr11639433+0.0416984370.9583016
ENST00000332231ENST00000176183AP2A2chr11977224+DRD4chr11639433+0.0413940250.95860595
ENST00000448903ENST00000176183AP2A2chr11977224+DRD4chr11639433+0.0413940250.95860595
ENST00000534328ENST00000176183AP2A2chr11977223+DRD4chr11639432+0.0416984370.9583016
ENST00000332231ENST00000176183AP2A2chr11977223+DRD4chr11639432+0.0413940250.95860595
ENST00000448903ENST00000176183AP2A2chr11977223+DRD4chr11639432+0.0413940250.95860595

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5225_5225_1_AP2A2-DRD4_AP2A2_chr11_977223_ENST00000332231_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_2_AP2A2-DRD4_AP2A2_chr11_977223_ENST00000448903_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_3_AP2A2-DRD4_AP2A2_chr11_977223_ENST00000534328_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_4_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000332231_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_5_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000332231_DRD4_chr11_639433_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_6_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000448903_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_7_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000448903_DRD4_chr11_639433_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_8_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000534328_DRD4_chr11_639432_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

>5225_5225_9_AP2A2-DRD4_AP2A2_chr11_977224_ENST00000534328_DRD4_chr11_639433_ENST00000176183_length(amino acids)=525AA_BP=368
MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTE
KQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSP
DLVPMGDWTSRVVHLLNDQHLVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSA
AVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLP
QDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:977224/chr11:639432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AP2A2

O94973

.
FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 (PubMed:23676497). The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). {ECO:0000250, ECO:0000269|PubMed:12960147, ECO:0000269|PubMed:14745134, ECO:0000269|PubMed:15473838, ECO:0000269|PubMed:19033387, ECO:0000269|PubMed:23676497}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAP2A2chr11:977223chr11:639432ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977223chr11:639432ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977223chr11:639432ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977223chr11:639432ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977223chr11:639432ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977223chr11:639432ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:639432ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639432ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639432ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:639432ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639432ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639432ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:639433ENST00000332231+52211_12201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639433ENST00000332231+52257_61201.0941.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639433ENST00000332231+5225_80201.0941.0RegionNote=Lipid-binding
HgeneAP2A2chr11:977224chr11:639433ENST00000448903+52211_12201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639433ENST00000448903+52257_61201.0940.0RegionPhosphatidylinositol 3%2C4%2C5-trisphosphate binding
HgeneAP2A2chr11:977224chr11:639433ENST00000448903+5225_80201.0940.0RegionNote=Lipid-binding
TgeneDRD4chr11:977223chr11:639432ENST0000017618304249_31295.0420.0RegionNote=4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P
TgeneDRD4chr11:977224chr11:639432ENST0000017618304249_31295.0420.0RegionNote=4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P
TgeneDRD4chr11:977224chr11:639433ENST0000017618304249_31295.0420.0RegionNote=4 X 16 AA approximate tandem repeats of [PA]-A-P-G-L-P-[PQR]-[DG]-P-C-G-P-D-C-A-P
TgeneDRD4chr11:977223chr11:639432ENST0000017618304249_26495.0420.0RepeatNote=1%3B approximate
TgeneDRD4chr11:977223chr11:639432ENST0000017618304265_28095.0420.0RepeatNote=2
TgeneDRD4chr11:977223chr11:639432ENST0000017618304281_29695.0420.0RepeatNote=3
TgeneDRD4chr11:977223chr11:639432ENST0000017618304297_31295.0420.0RepeatNote=4%3B approximate
TgeneDRD4chr11:977224chr11:639432ENST0000017618304249_26495.0420.0RepeatNote=1%3B approximate
TgeneDRD4chr11:977224chr11:639432ENST0000017618304265_28095.0420.0RepeatNote=2
TgeneDRD4chr11:977224chr11:639432ENST0000017618304281_29695.0420.0RepeatNote=3
TgeneDRD4chr11:977224chr11:639432ENST0000017618304297_31295.0420.0RepeatNote=4%3B approximate
TgeneDRD4chr11:977224chr11:639433ENST0000017618304249_26495.0420.0RepeatNote=1%3B approximate
TgeneDRD4chr11:977224chr11:639433ENST0000017618304265_28095.0420.0RepeatNote=2
TgeneDRD4chr11:977224chr11:639433ENST0000017618304281_29695.0420.0RepeatNote=3
TgeneDRD4chr11:977224chr11:639433ENST0000017618304297_31295.0420.0RepeatNote=4%3B approximate
TgeneDRD4chr11:977223chr11:639432ENST0000017618304132_15295.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977223chr11:639432ENST0000017618304174_19295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977223chr11:639432ENST0000017618304214_34695.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977223chr11:639432ENST0000017618304368_38295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977223chr11:639432ENST0000017618304404_41995.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977223chr11:639432ENST000001761830493_11095.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639432ENST0000017618304132_15295.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639432ENST0000017618304174_19295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639432ENST0000017618304214_34695.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639432ENST0000017618304368_38295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639432ENST0000017618304404_41995.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639432ENST000001761830493_11095.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639433ENST0000017618304132_15295.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639433ENST0000017618304174_19295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639433ENST0000017618304214_34695.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639433ENST0000017618304368_38295.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639433ENST0000017618304404_41995.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639433ENST000001761830493_11095.0420.0Topological domainExtracellular
TgeneDRD4chr11:977223chr11:639432ENST0000017618304111_13195.0420.0TransmembraneHelical%3B Name%3D3
TgeneDRD4chr11:977223chr11:639432ENST0000017618304153_17395.0420.0TransmembraneHelical%3B Name%3D4
TgeneDRD4chr11:977223chr11:639432ENST0000017618304193_21395.0420.0TransmembraneHelical%3B Name%3D5
TgeneDRD4chr11:977223chr11:639432ENST0000017618304347_36795.0420.0TransmembraneHelical%3B Name%3D6
TgeneDRD4chr11:977223chr11:639432ENST0000017618304383_40395.0420.0TransmembraneHelical%3B Name%3D7
TgeneDRD4chr11:977224chr11:639432ENST0000017618304111_13195.0420.0TransmembraneHelical%3B Name%3D3
TgeneDRD4chr11:977224chr11:639432ENST0000017618304153_17395.0420.0TransmembraneHelical%3B Name%3D4
TgeneDRD4chr11:977224chr11:639432ENST0000017618304193_21395.0420.0TransmembraneHelical%3B Name%3D5
TgeneDRD4chr11:977224chr11:639432ENST0000017618304347_36795.0420.0TransmembraneHelical%3B Name%3D6
TgeneDRD4chr11:977224chr11:639432ENST0000017618304383_40395.0420.0TransmembraneHelical%3B Name%3D7
TgeneDRD4chr11:977224chr11:639433ENST0000017618304111_13195.0420.0TransmembraneHelical%3B Name%3D3
TgeneDRD4chr11:977224chr11:639433ENST0000017618304153_17395.0420.0TransmembraneHelical%3B Name%3D4
TgeneDRD4chr11:977224chr11:639433ENST0000017618304193_21395.0420.0TransmembraneHelical%3B Name%3D5
TgeneDRD4chr11:977224chr11:639433ENST0000017618304347_36795.0420.0TransmembraneHelical%3B Name%3D6
TgeneDRD4chr11:977224chr11:639433ENST0000017618304383_40395.0420.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDRD4chr11:977223chr11:639432ENST00000176183041_2995.0420.0Topological domainExtracellular
TgeneDRD4chr11:977223chr11:639432ENST000001761830451_7195.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639432ENST00000176183041_2995.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639432ENST000001761830451_7195.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977224chr11:639433ENST00000176183041_2995.0420.0Topological domainExtracellular
TgeneDRD4chr11:977224chr11:639433ENST000001761830451_7195.0420.0Topological domainCytoplasmic
TgeneDRD4chr11:977223chr11:639432ENST000001761830430_5095.0420.0TransmembraneHelical%3B Name%3D1
TgeneDRD4chr11:977223chr11:639432ENST000001761830472_9295.0420.0TransmembraneHelical%3B Name%3D2
TgeneDRD4chr11:977224chr11:639432ENST000001761830430_5095.0420.0TransmembraneHelical%3B Name%3D1
TgeneDRD4chr11:977224chr11:639432ENST000001761830472_9295.0420.0TransmembraneHelical%3B Name%3D2
TgeneDRD4chr11:977224chr11:639433ENST000001761830430_5095.0420.0TransmembraneHelical%3B Name%3D1
TgeneDRD4chr11:977224chr11:639433ENST000001761830472_9295.0420.0TransmembraneHelical%3B Name%3D2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AP2A2
DRD4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AP2A2-DRD4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AP2A2-DRD4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource