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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MEGF11-RPL4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MEGF11-RPL4
FusionPDB ID: 52857
FusionGDB2.0 ID: 52857
HgeneTgene
Gene symbol

MEGF11

RPL4

Gene ID

84465

6124

Gene namemultiple EGF like domains 11ribosomal protein L4
Synonyms-L4
Cytomap

15q22.31

15q22.31

Type of geneprotein-codingprotein-coding
Descriptionmultiple epidermal growth factor-like domains protein 11multiple EGF-like domains protein 1160S ribosomal protein L460S ribosomal protein L1large ribosomal subunit protein uL4
Modification date2020031320200327
UniProtAcc

A6BM72

.
Ensembl transtripts involved in fusion geneENST idsENST00000288745, ENST00000360698, 
ENST00000395625, ENST00000409699, 
ENST00000422354, ENST00000395614, 
ENST00000478721, 		ENST00000568588, 
ENST00000564517, ENST00000307961, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 9 X 2=16216 X 14 X 5=1120
# samples 917
** MAII scorelog2(9/162*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1120*10)=-2.71989208080726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MEGF11 [Title/Abstract] AND RPL4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MEGF11(66273116)-RPL4(66795867), # samples:2
Anticipated loss of major functional domain due to fusion event.MEGF11-RPL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MEGF11-RPL4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MEGF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPL4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-7298-01AMEGF11chr15

66273116

-RPL4chr15

66795867

-
ChimerDB4LGGTCGA-DU-7298MEGF11chr15

66273116

-RPL4chr15

66795867

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000422354MEGF11chr1566273116-ENST00000307961RPL4chr1566795867-3574903272183718
ENST00000395625MEGF11chr1566273116-ENST00000307961RPL4chr1566795867-34738022502082610

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000422354ENST00000307961MEGF11chr1566273116-RPL4chr1566795867-0.002193880.99780613
ENST00000395625ENST00000307961MEGF11chr1566273116-RPL4chr1566795867-0.0062939320.99370605

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52857_52857_1_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000395625_RPL4_chr15_66795867_ENST00000307961_length(amino acids)=610AA_BP=184
MSRNRMHTPSIRSITHDAQTSSTGSSAPGTALCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGA
CVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACP
PGWTACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRS
GQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVLLLKKLKAW
NDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTW
RKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVDKAAAA

--------------------------------------------------------------

>52857_52857_2_MEGF11-RPL4_MEGF11_chr15_66273116_ENST00000422354_RPL4_chr15_66795867_ENST00000307961_length(amino acids)=718AA_BP=292
MLAAPCSCLALWPGSGSGGQDRATGRPIPGPAAGAGPGMVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYT
RCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHC
SNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRC
PCQNGGTCHHITGECACPPGWTACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGT
GRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVE
GYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRF
CIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:66273116/chr15:66795867)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MEGF11

A6BM72

.
FUNCTION: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521143_173179.0970.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52124_101179.0970.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52195_130179.0970.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723143_173254.01840.6666666666667DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723181_216254.01840.6666666666667DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72324_101254.01840.6666666666667DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72395_130254.01840.6666666666667DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622143_173179.0970.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62224_101179.0970.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62295_130179.0970.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723143_173254.01045.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723181_216254.01045.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72324_101254.01045.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72395_130254.01045.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723143_173254.01045.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723181_216254.01045.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72324_101254.01045.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72395_130254.01045.0DomainEGF-like 1
TgeneRPL4chr15:66273116chr15:66795867ENST00000307961010364_4271.0428.0Compositional biasNote=Lys-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521181_216179.0970.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521224_259179.0970.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521267_302179.0970.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521310_345179.0970.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521399_434179.0970.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521442_477179.0970.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521490_520179.0970.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521571_606179.0970.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521659_694179.0970.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521707_737179.0970.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521750_780179.0970.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521788_823179.0970.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723224_259254.01840.6666666666667DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723267_302254.01840.6666666666667DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723310_345254.01840.6666666666667DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723399_434254.01840.6666666666667DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723442_477254.01840.6666666666667DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723490_520254.01840.6666666666667DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723571_606254.01840.6666666666667DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723659_694254.01840.6666666666667DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723707_737254.01840.6666666666667DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723750_780254.01840.6666666666667DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723788_823254.01840.6666666666667DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723143_1730138.0DomainEGF-like 2
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723181_2160138.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723224_2590138.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72324_1010138.0DomainEMI
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723267_3020138.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723310_3450138.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723399_4340138.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723442_4770138.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723490_5200138.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723571_6060138.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723659_6940138.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723707_7370138.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723750_7800138.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723788_8230138.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72395_1300138.0DomainEGF-like 1
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622181_216179.0970.0DomainEGF-like 3
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622224_259179.0970.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622267_302179.0970.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622310_345179.0970.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622399_434179.0970.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622442_477179.0970.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622490_520179.0970.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622571_606179.0970.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622659_694179.0970.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622707_737179.0970.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622750_780179.0970.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622788_823179.0970.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723224_259254.01045.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723267_302254.01045.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723310_345254.01045.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723399_434254.01045.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723442_477254.01045.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723490_520254.01045.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723571_606254.01045.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723659_694254.01045.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723707_737254.01045.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723750_780254.01045.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723788_823254.01045.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723224_259254.01045.0DomainEGF-like 4
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723267_302254.01045.0DomainEGF-like 5
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723310_345254.01045.0DomainEGF-like 6
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723399_434254.01045.0DomainEGF-like 7
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723442_477254.01045.0DomainEGF-like 8
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723490_520254.01045.0DomainEGF-like 9
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723571_606254.01045.0DomainEGF-like 10
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723659_694254.01045.0DomainEGF-like 11
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723707_737254.01045.0DomainEGF-like 12
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723750_780254.01045.0DomainEGF-like 13
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723788_823254.01045.0DomainEGF-like 14
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-52120_848179.0970.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521870_1044179.0970.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-72320_848254.01840.6666666666667Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723870_1044254.01840.6666666666667Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-72320_8480138.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723870_10440138.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-62220_848179.0970.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622870_1044179.0970.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-72320_848254.01045.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723870_1044254.01045.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-72320_848254.01045.0Topological domainExtracellular
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723870_1044254.01045.0Topological domainCytoplasmic
HgeneMEGF11chr15:66273116chr15:66795867ENST00000288745-521849_869179.0970.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000360698-723849_869254.01840.6666666666667TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395614-723849_8690138.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000395625-622849_869179.0970.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000409699-723849_869254.01045.0TransmembraneHelical
HgeneMEGF11chr15:66273116chr15:66795867ENST00000422354-723849_869254.01045.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1460_MEGF11_66273116_RPL4_66795867_ranked_0.pdbMEGF116627311666273116ENST00000307961RPL4chr1566795867-
MLAAPCSCLALWPGSGSGGQDRATGRPIPGPAAGAGPGMVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYT
RCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHC
SNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRC
PCQNGGTCHHITGECACPPGWTACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGT
GRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVE
GYKKTKEAVLLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRF
CIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMINTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNT
718


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MEGF11_pLDDT.png
all structure
all structure
RPL4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MEGF11
RPL4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MEGF11-RPL4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MEGF11-RPL4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource