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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MFSD8-HIPK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MFSD8-HIPK2
FusionPDB ID: 53289
FusionGDB2.0 ID: 53289
HgeneTgene
Gene symbol

MFSD8

HIPK2

Gene ID

256471

28996

Gene namemajor facilitator superfamily domain containing 8homeodomain interacting protein kinase 2
SynonymsCCMD|CLN7PRO0593
Cytomap

4q28.2

7q34

Type of geneprotein-codingprotein-coding
Descriptionmajor facilitator superfamily domain-containing protein 8ceroid-lipofuscinosis, neuronal 7, late infantilehomeodomain-interacting protein kinase 2hHIPk2
Modification date2020032920200313
UniProtAcc

Q8NHS3

Q9H2X6

Ensembl transtripts involved in fusion geneENST idsENST00000515130, ENST00000513559, 
ENST00000541133, ENST00000296468, 
ENST00000342645, ENST00000406875, 
ENST00000428878, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 2 X 1=28 X 8 X 3=192
# samples 29
** MAII scorelog2(2/2*10)=3.32192809488736log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MFSD8 [Title/Abstract] AND HIPK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MFSD8(128870959)-HIPK2(139305309), # samples:2
Anticipated loss of major functional domain due to fusion event.MFSD8-HIPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
MFSD8-HIPK2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHIPK2

GO:0006468

protein phosphorylation

19448668

TgeneHIPK2

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

TgeneHIPK2

GO:0045766

positive regulation of angiogenesis

19046997

TgeneHIPK2

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across MFSD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HIPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7704-01AMFSD8chr4

128870959

-HIPK2chr7

139305309

-
ChimerDB4STADTCGA-BR-7704MFSD8chr4

128870958

-HIPK2chr7

139305309

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296468MFSD8chr4128870959-ENST00000406875HIPK2chr7139305309-136613263482303651
ENST00000296468MFSD8chr4128870959-ENST00000428878HIPK2chr7139305309-25213263482222624
ENST00000296468MFSD8chr4128870959-ENST00000342645HIPK2chr7139305309-14643263481463371
ENST00000296468MFSD8chr4128870958-ENST00000406875HIPK2chr7139305309-136613263482303651
ENST00000296468MFSD8chr4128870958-ENST00000428878HIPK2chr7139305309-25213263482222624
ENST00000296468MFSD8chr4128870958-ENST00000342645HIPK2chr7139305309-14643263481463371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296468ENST00000406875MFSD8chr4128870959-HIPK2chr7139305309-0.0044469480.9955531
ENST00000296468ENST00000428878MFSD8chr4128870959-HIPK2chr7139305309-0.03832510.96167487
ENST00000296468ENST00000342645MFSD8chr4128870959-HIPK2chr7139305309-0.0067798550.9932201
ENST00000296468ENST00000406875MFSD8chr4128870958-HIPK2chr7139305309-0.0044469480.9955531
ENST00000296468ENST00000428878MFSD8chr4128870958-HIPK2chr7139305309-0.03832510.96167487
ENST00000296468ENST00000342645MFSD8chr4128870958-HIPK2chr7139305309-0.0067798550.9932201

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>53289_53289_1_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(amino acids)=371AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSQRKNVIS
CVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPGNLGPGQGRNLSLESGFPA

--------------------------------------------------------------

>53289_53289_2_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(amino acids)=651AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTC
EVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTST
VSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSS
YKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL
AAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASP

--------------------------------------------------------------

>53289_53289_3_MFSD8-HIPK2_MFSD8_chr4_128870958_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(amino acids)=624AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQG
LQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNT
HAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAM
VHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTS
PYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYR
QQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGST

--------------------------------------------------------------

>53289_53289_4_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000342645_length(amino acids)=371AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSQRKNVIS
CVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPGNLGPGQGRNLSLESGFPA

--------------------------------------------------------------

>53289_53289_5_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000406875_length(amino acids)=651AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAVAQRSMPL
QTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVA
THTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTC
EVSSSQAISSPQRSKRVKENTPPRCAMVHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTST
VSKQRKNVISCVTVHDSPYSDSSSNTSPYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSS
YKSKSSSNVTSTSGHSSGSSSGAITYRQQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHL
AAAAAAAHLPTQPHLYTYTAPAALGSTGTVAHLVASQGSARHTVQHTAYPASIVHQVPVSMGPRVLPSPTIHPSQYPAQFAHQTYISASP

--------------------------------------------------------------

>53289_53289_6_MFSD8-HIPK2_MFSD8_chr4_128870959_ENST00000296468_HIPK2_chr7_139305309_ENST00000428878_length(amino acids)=624AA_BP=
MEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIVCPPGFQG
LQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQLADWRNT
HAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSSVRNVSTCEVSSSQAISSPQRSKRVKENTPPRCAM
VHSSPACSTSVTCGWGDVASSTTRERQRQTIVIPDTPSPTVSVITISSDTDEEEEQKHAPTSTVSKQRKNVISCVTVHDSPYSDSSSNTS
PYSVQQRAGHNNANAFDTKGSLENHCTGNPRTIIVPPLKTQASEVLVECDSLVPVNTSHHSSSYKSKSSSNVTSTSGHSSGSSSGAITYR
QQRPGPHFQQQQPLNLSQAQQHITTDRTGSHRRQQAYITPTMAQAPYSFPHNSPSHGTVHPHLAAAAAAAHLPTQPHLYTYTAPAALGST

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:128870959/chr7:139305309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MFSD8

Q8NHS3

HIPK2

Q9H2X6

FUNCTION: May be a carrier that transport small solutes by using chemiosmotic ion gradients. {ECO:0000305}.FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41313_1466.0519.0MotifNote=Dileucine internalization motif
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41313_1466.0519.0MotifNote=Dileucine internalization motif
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-4131_4066.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-4131_4066.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41341_6166.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41341_6166.0519.0TransmembraneHelical
TgeneHIPK2chr4:128870958chr7:139305309ENST000004068755151088_1094539.66666666666661199.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870958chr7:139305309ENST000004288785151088_1094539.66666666666661172.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870959chr7:139305309ENST000004068755151088_1094539.66666666666661199.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870959chr7:139305309ENST000004288785151088_1094539.66666666666661172.0Compositional biasNote=Poly-Ala
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515802_805539.66666666666661199.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515832_835539.66666666666661199.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515802_805539.66666666666661172.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515832_835539.66666666666661172.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515802_805539.66666666666661199.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515832_835539.66666666666661199.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515802_805539.66666666666661172.0MotifNote=Nuclear localization signal 1 (NLS1)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515832_835539.66666666666661172.0MotifNote=Nuclear localization signal 2 (NLS2)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515873_980539.66666666666661199.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515984_1198539.66666666666661199.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515873_980539.66666666666661172.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515984_1198539.66666666666661172.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515873_980539.66666666666661199.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515984_1198539.66666666666661199.0RegionNote=Autoinhibitory domain (AID)
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515873_980539.66666666666661172.0RegionRequired for localization to nuclear speckles
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515984_1198539.66666666666661172.0RegionNote=Autoinhibitory domain (AID)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413127_13166.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413153_17366.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413195_21166.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413233_26666.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413288_30466.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413326_33766.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413359_41266.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413434_45166.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413473_48266.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413504_51866.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41362_7466.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41396_10566.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413127_13166.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413153_17366.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413195_21166.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413233_26666.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413288_30466.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413326_33766.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413359_41266.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413434_45166.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413473_48266.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413504_51866.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41362_7466.0519.0Topological domainExtracellular
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41396_10566.0519.0Topological domainCytoplasmic
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413106_12666.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413132_15266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413174_19466.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413212_23266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413267_28766.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413305_32566.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413338_35866.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413413_43366.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413452_47266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-413483_50366.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870958chr7:139305309ENST00000296468-41375_9566.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413106_12666.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413132_15266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413174_19466.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413212_23266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413267_28766.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413305_32566.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413338_35866.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413413_43366.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413452_47266.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-413483_50366.0519.0TransmembraneHelical
HgeneMFSD8chr4:128870959chr7:139305309ENST00000296468-41375_9566.0519.0TransmembraneHelical
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515199_527539.66666666666661199.0DomainProtein kinase
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515199_527539.66666666666661172.0DomainProtein kinase
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515199_527539.66666666666661199.0DomainProtein kinase
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515199_527539.66666666666661172.0DomainProtein kinase
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515205_213539.66666666666661199.0Nucleotide bindingATP
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515205_213539.66666666666661172.0Nucleotide bindingATP
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515205_213539.66666666666661199.0Nucleotide bindingATP
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515205_213539.66666666666661172.0Nucleotide bindingATP
TgeneHIPK2chr4:128870958chr7:139305309ENST0000040687551597_230539.66666666666661199.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870958chr7:139305309ENST0000042887851597_230539.66666666666661172.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870959chr7:139305309ENST0000040687551597_230539.66666666666661199.0RegionTranscriptional corepression
TgeneHIPK2chr4:128870959chr7:139305309ENST0000042887851597_230539.66666666666661172.0RegionTranscriptional corepression


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MFSD8
HIPK2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneHIPK2chr4:128870958chr7:139305309ENST00000406875515189_520539.66666666666661199.0DAXX
TgeneHIPK2chr4:128870958chr7:139305309ENST00000428878515189_520539.66666666666661172.0DAXX
TgeneHIPK2chr4:128870959chr7:139305309ENST00000406875515189_520539.66666666666661199.0DAXX
TgeneHIPK2chr4:128870959chr7:139305309ENST00000428878515189_520539.66666666666661172.0DAXX


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Related Drugs to MFSD8-HIPK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MFSD8-HIPK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource