| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:MIDN-ABCA7 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: MIDN-ABCA7 | FusionPDB ID: 53600 | FusionGDB2.0 ID: 53600 | Hgene | Tgene | Gene symbol | MIDN | ABCA7 | Gene ID | 90007 | 10347 |
| Gene name | midnolin | ATP binding cassette subfamily A member 7 | |
| Synonyms | - | ABCA-SSN|ABCX|AD9 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | midnolinmidbrain nucleolar protein | phospholipid-transporting ATPase ABCA7ATP-binding cassette sub-family A member 7ATP-binding cassette, sub-family A (ABC1), member 7autoantigen SS-Nmacrophage ABC transporter | |
| Modification date | 20200313 | 20200320 | |
| UniProtAcc | Q504T8 | Q8IZY2 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000300952, ENST00000591446, | ENST00000533574, ENST00000263094, ENST00000433129, ENST00000435683, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 7 X 6=378 | 5 X 4 X 4=80 |
| # samples | 13 | 5 | |
| ** MAII score | log2(13/378*10)=-1.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: MIDN [Title/Abstract] AND ABCA7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MIDN(1251900)-ABCA7(1061781), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | MIDN-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MIDN-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MIDN-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MIDN-ABCA7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ABCA7 | GO:0033344 | cholesterol efflux | 14570867 |
| Tgene | ABCA7 | GO:0033700 | phospholipid efflux | 14570867 |
| Tgene | ABCA7 | GO:0034380 | high-density lipoprotein particle assembly | 14570867 |
| Tgene | ABCA7 | GO:0038027 | apolipoprotein A-I-mediated signaling pathway | 14570867 |
| Tgene | ABCA7 | GO:0045332 | phospholipid translocation | 24097981 |
| Fusion gene breakpoints across MIDN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across ABCA7 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-05-4418-01A | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000300952 | MIDN | chr19 | 1251900 | + | ENST00000263094 | ABCA7 | chr19 | 1061781 | + | 2021 | 899 | 341 | 1876 | 511 |
| ENST00000300952 | MIDN | chr19 | 1251900 | + | ENST00000433129 | ABCA7 | chr19 | 1061781 | + | 2021 | 899 | 341 | 1876 | 511 |
| ENST00000300952 | MIDN | chr19 | 1251900 | + | ENST00000435683 | ABCA7 | chr19 | 1061781 | + | 1877 | 899 | 341 | 1876 | 512 |
| ENST00000591446 | MIDN | chr19 | 1251900 | + | ENST00000263094 | ABCA7 | chr19 | 1061781 | + | 1915 | 793 | 235 | 1770 | 511 |
| ENST00000591446 | MIDN | chr19 | 1251900 | + | ENST00000433129 | ABCA7 | chr19 | 1061781 | + | 1915 | 793 | 235 | 1770 | 511 |
| ENST00000591446 | MIDN | chr19 | 1251900 | + | ENST00000435683 | ABCA7 | chr19 | 1061781 | + | 1771 | 793 | 235 | 1770 | 512 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000300952 | ENST00000263094 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.069852434 | 0.9301475 |
| ENST00000300952 | ENST00000433129 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.069852434 | 0.9301475 |
| ENST00000300952 | ENST00000435683 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.060296644 | 0.9397034 |
| ENST00000591446 | ENST00000263094 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.07410727 | 0.92589265 |
| ENST00000591446 | ENST00000433129 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.07410727 | 0.92589265 |
| ENST00000591446 | ENST00000435683 | MIDN | chr19 | 1251900 | + | ABCA7 | chr19 | 1061781 | + | 0.06453184 | 0.9354682 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >53600_53600_1_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000263094_length(amino acids)=511AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- >53600_53600_2_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000433129_length(amino acids)=511AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- >53600_53600_3_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000300952_ABCA7_chr19_1061781_ENST00000435683_length(amino acids)=512AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- >53600_53600_4_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000263094_length(amino acids)=511AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- >53600_53600_5_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000433129_length(amino acids)=511AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- >53600_53600_6_MIDN-ABCA7_MIDN_chr19_1251900_ENST00000591446_ABCA7_chr19_1061781_ENST00000435683_length(amino acids)=512AA_BP=24 MDFGLAFRGRDFLEEDARCSAPPSARRTRHPGSLSPLSRRRGEDWRRPPPPAPQRAPGMEPQPGGARSCRRGAPGGACELGPAAEAAPMS LAIHSTTGTRYDLAVPPDETVEGLRKRLSQRLKVPKERLALLHKDTRLSSGKLQEFGVGDGSKLTLVPTVEAGLMSQASRPEQSVMQALE SLTETQCFGLLGVNGAGKTSTFRMVTGDTLASRGEAVLAGHSVAREPSAAHLSMGYCPQSDAIFELLTGREHLELLARLRGVPEAQVAQT AGSGLARLGLSWYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNSLLAVVREGRSVMLTSHSMEECEALCSRL AIMVNGRFRCLGSPQHLKGRFAAGHTLTLRVPAARSQPAAAFVAAEFPGAELREAHGGRLRFQLPPGGRCALARVFGELAVHGAEHGVED -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1251900/chr19:1061781) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MIDN | ABCA7 |
| FUNCTION: Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion. {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7}. | FUNCTION: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP (PubMed:24097981). Transports preferentially phosphatidylserine over phosphatidylcholine (PubMed:24097981). Plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:14592415, PubMed:12917409, PubMed:12925201, PubMed:14570867). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409, PubMed:14570867, PubMed:14592415). May also mediate cholesterol efflux (PubMed:14570867). May regulate cellular ceramide homeostasis during keratinocyte differentiation (PubMed:12925201). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791). Amyloid-beta is the main component of amyloid plaques found in the brains of Alzheimer patients (PubMed:26260791). {ECO:0000250|UniProtKB:Q91V24, ECO:0000269|PubMed:12917409, ECO:0000269|PubMed:12925201, ECO:0000269|PubMed:14570867, ECO:0000269|PubMed:14592415, ECO:0000269|PubMed:24097981, ECO:0000269|PubMed:26260791}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | MIDN | chr19:1251900 | chr19:1061781 | ENST00000300952 | + | 4 | 8 | 31_105 | 128.0 | 469.0 | Domain | Ubiquitin-like |
| Hgene | MIDN | chr19:1251900 | chr19:1061781 | ENST00000591446 | + | 3 | 7 | 31_105 | 128.0 | 469.0 | Domain | Ubiquitin-like |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1793_2025 | 1683.0 | 2009.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1827_1834 | 1821.0 | 2147.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1827_1834 | 1821.0 | 2147.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1827_1834 | 1683.0 | 2009.0 | Nucleotide binding | ATP 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1683_1703 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1729_1749 | 1683.0 | 2009.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1793_2025 | 1821.0 | 2147.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 807_1038 | 1821.0 | 2147.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1793_2025 | 1821.0 | 2147.0 | Domain | ABC transporter 2 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 807_1038 | 1821.0 | 2147.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 807_1038 | 1683.0 | 2009.0 | Domain | ABC transporter 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 841_848 | 1821.0 | 2147.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 841_848 | 1821.0 | 2147.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 841_848 | 1683.0 | 2009.0 | Nucleotide binding | ATP 1 | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1264_1537 | 1821.0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 43_549 | 1821.0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1264_1537 | 1821.0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 43_549 | 1821.0 | 2147.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1264_1537 | 1683.0 | 2009.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 43_549 | 1683.0 | 2009.0 | Topological domain | Extracellular | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1243_1263 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1538_1558 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1584_1604 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1621_1641 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1649_1669 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1683_1703 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 1729_1749 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 22_42 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 550_570 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 593_613 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 626_646 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 655_675 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 687_707 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 727_747 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000263094 | 39 | 47 | 849_869 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1243_1263 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1538_1558 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1584_1604 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1621_1641 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1649_1669 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1683_1703 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 1729_1749 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 22_42 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 550_570 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 593_613 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 626_646 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 655_675 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 687_707 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 727_747 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000433129 | 38 | 46 | 849_869 | 1821.0 | 2147.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1243_1263 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1538_1558 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1584_1604 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1621_1641 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 1649_1669 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 22_42 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 550_570 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 593_613 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 626_646 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 655_675 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 687_707 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 727_747 | 1683.0 | 2009.0 | Transmembrane | Helical | |
| Tgene | ABCA7 | chr19:1251900 | chr19:1061781 | ENST00000435683 | 33 | 41 | 849_869 | 1683.0 | 2009.0 | Transmembrane | Helical |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| MIDN | |
| ABCA7 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to MIDN-ABCA7 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to MIDN-ABCA7 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies