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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MTHFD1L-AKAP12

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MTHFD1L-AKAP12
FusionPDB ID: 55675
FusionGDB2.0 ID: 55675
HgeneTgene
Gene symbol

MTHFD1L

AKAP12

Gene ID

25902

9590

Gene namemethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeA-kinase anchoring protein 12
SynonymsFTHFSDC1|MTC1THFS|dJ292B18.2AKAP250|SSeCKS
Cytomap

6q25.1

6q25.1

Type of geneprotein-codingprotein-coding
Descriptionmonofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1A-kinase anchor protein 12A kinase (PRKA) anchor protein 12A-kinase anchor protein, 250kDaAKAP 250Src-Suppressed C Kinase Substratekinase scaffold protein gravinmyasthenia gravis autoantigen gravin
Modification date2020031320200327
UniProtAcc

Q6UB35

Q02952

Ensembl transtripts involved in fusion geneENST idsENST00000367321, ENST00000367307, 
ENST00000478643, 		ENST00000354675, 
ENST00000359755, ENST00000490177, 
ENST00000253332, ENST00000402676, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 14 X 5=7709 X 9 X 6=486
# samples 1311
** MAII scorelog2(13/770*10)=-2.56634682255381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/486*10)=-2.14345279008112
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MTHFD1L [Title/Abstract] AND AKAP12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MTHFD1L(151336829)-AKAP12(151626882), # samples:1
Anticipated loss of major functional domain due to fusion event.MTHFD1L-AKAP12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTHFD1L-AKAP12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MTHFD1L-AKAP12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MTHFD1L-AKAP12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMTHFD1L

GO:0006760

folic acid-containing compound metabolic process

12937168

HgeneMTHFD1L

GO:0009257

10-formyltetrahydrofolate biosynthetic process

12937168

HgeneMTHFD1L

GO:0015942

formate metabolic process

16171773


check buttonFusion gene breakpoints across MTHFD1L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AKAP12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NA-A4R1MTHFD1Lchr6

151336829

+AKAP12chr6

151626882

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367321MTHFD1Lchr6151336829+ENST00000402676AKAP12chr6151626882+1089028602580462673
ENST00000367321MTHFD1Lchr6151336829+ENST00000253332AKAP12chr6151626882+910628602580462673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367321ENST00000402676MTHFD1Lchr6151336829+AKAP12chr6151626882+0.0009694380.9990306
ENST00000367321ENST00000253332MTHFD1Lchr6151336829+AKAP12chr6151626882+0.0019606670.9980393

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>55675_55675_1_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000253332_length(amino acids)=2673AA_BP=1
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEE
EEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDK
TEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSK
SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR
LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEP
AKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ
VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK
SATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL
AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP
DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER
SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEET
TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE
TDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD
FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQ
YADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLE
HETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA
HLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGI
LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD
ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA

--------------------------------------------------------------

>55675_55675_2_MTHFD1L-AKAP12_MTHFD1L_chr6_151336829_ENST00000367321_AKAP12_chr6_151626882_ENST00000402676_length(amino acids)=2673AA_BP=1
MSGTAYQTKVPKAVTSRPAARRPPPSARHGRRVQCPLGAPGTRRKRQVLPAAAAAAAACSPGTRPAALGSRSSVSPENQPSRAMGTRLPL
VLRQLRRPPQPPGPPRRLRVPCRASSGGGGGGGGGREGLLGQRRPQDGQARSSCSPGGRTPAARDSIVREVIQNSKEVLSLLQEKNPAFK
PVLAIIQAGDDNLMQEINQNLAEEAGLNITHICLPPDSSEAEIIDEILKINEDTRVHGLALQISENLFSNKVLNALKPEKDVDGVTDINL
GKLVRGDAHECFVSPVAKAVIELLEKSGVNLDGKKILVVGAHGSLEAALQCLFQRKGSMTMSIQWKTRQLQSKLHEADIVVLGSPKPEEI
PLTWIQPGTTVLNCSHDFLSGKVGCGSPRIHFGGLIEEDDVILLAAALRIQNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISR
GQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKYVLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQ
GPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAIDTRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINK
TDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNTEKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASD
KSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIK
CRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLVADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELA
KRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEE
EEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDK
TEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSK
SAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPR
LSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEP
AKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQ
VPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVK
SATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGIL
AGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRP
DGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEER
SPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEET
TEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKE
TDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVAD
FDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQ
YADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLE
HETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGA
HLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGI
LELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSD
ISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:151336829/chr6:151626882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MTHFD1L

Q6UB35

AKAP12

Q02952

FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269|PubMed:16171773}.FUNCTION: Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+242834_42862.0932.6666666666666Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+2428423_430862.0932.6666666666666Nucleotide bindingATP
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+242831_348862.0932.6666666666666RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
TgeneAKAP12chr6:151336829chr6:151626882ENST000002533320498_10154.02015.0Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000003546750398_10101968.0Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000003597550398_10101993.3333333333333Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST000004026761598_10154.02706.3333333333335Compositional biasNote=Poly-Glu
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204607_62754.02015.0MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204756_77654.02015.0MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204801_82154.02015.0MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503607_62701968.0MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503756_77601968.0MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503801_82101968.0MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503607_62701993.3333333333333MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503756_77601993.3333333333333MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503801_82101993.3333333333333MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615607_62754.02706.3333333333335MotifAKAP CaM-binding 1
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615756_77654.02706.3333333333335MotifAKAP CaM-binding 2
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615801_82154.02706.3333333333335MotifAKAP CaM-binding 3
TgeneAKAP12chr6:151336829chr6:151626882ENST00000253332041541_155454.02015.0RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000025333204266_55754.02015.0RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000354675031541_155401968.0RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035467503266_55701968.0RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000359755031541_155401993.3333333333333RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000035975503266_55701993.3333333333333RegionInvolved in PKC-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST00000402676151541_155454.02706.3333333333335RegionRII-binding
TgeneAKAP12chr6:151336829chr6:151626882ENST0000040267615266_55754.02706.3333333333335RegionInvolved in PKC-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+1834_420276.0Compositional biasNote=Poly-Gly
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+18423_4300276.0Nucleotide bindingATP
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+1831_3480276.0RegionNote=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367307+18349_9780276.0RegionNote=Formyltetrahydrofolate synthetase
HgeneMTHFD1Lchr6:151336829chr6:151626882ENST00000367321+2428349_978862.0932.6666666666666RegionNote=Formyltetrahydrofolate synthetase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MTHFD1L
AKAP12


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MTHFD1L-AKAP12


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MTHFD1L-AKAP12


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource