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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MYH11-MYLK

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MYH11-MYLK
FusionPDB ID: 56300
FusionGDB2.0 ID: 56300
HgeneTgene
Gene symbol

MYH11

MYLK

Gene ID

4629

4638

Gene namemyosin heavy chain 11myosin light chain kinase
SynonymsAAT4|FAA4|SMHC|SMMHCAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK
Cytomap

16p13.11

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionmyosin-11epididymis secretory sperm binding proteinmyosin heavy chain, smooth muscle isoformmyosin, heavy chain 11, smooth musclemyosin, heavy polypeptide 11, smooth musclemyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2020032220200320
UniProtAcc

P35749

Q86YV6

Ensembl transtripts involved in fusion geneENST idsENST00000300036, ENST00000396324, 
ENST00000452625, ENST00000576790, 
ENST00000573908, 		ENST00000346322, 
ENST00000354792, ENST00000418370, 
ENST00000475616, ENST00000510775, 
ENST00000578202, ENST00000583087, 
ENST00000359169, ENST00000360304, 
ENST00000360772, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 31 X 8=768814 X 15 X 4=840
# samples 3215
** MAII scorelog2(32/7688*10)=-4.58646452588639
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MYH11 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MYH11(15809021)-MYLK(123383105), # samples:1
MYLK(123333009)-MYH11(15797744), # samples:1
Anticipated loss of major functional domain due to fusion event.MYH11-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-MYLK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-MYLK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MYH11-MYLK seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MYH11-MYLK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MYH11-MYLK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080


check buttonFusion gene breakpoints across MYH11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYLK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HR-01AMYH11chr16

15809021

-MYLKchr3

123383105

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000452625MYH11chr1615809021-ENST00000360772MYLKchr3123383105-1153957226174822473
ENST00000452625MYH11chr1615809021-ENST00000359169MYLKchr3123383105-929057226174822473
ENST00000452625MYH11chr1615809021-ENST00000360304MYLKchr3123383105-944357226176352524
ENST00000576790MYH11chr1615809021-ENST00000360772MYLKchr3123383105-1154057238374832466
ENST00000576790MYH11chr1615809021-ENST00000359169MYLKchr3123383105-929157238374832466
ENST00000576790MYH11chr1615809021-ENST00000360304MYLKchr3123383105-944457238376362517

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000452625ENST00000360772MYH11chr1615809021-MYLKchr3123383105-0.004466480.99553347
ENST00000452625ENST00000359169MYH11chr1615809021-MYLKchr3123383105-0.0099582940.99004173
ENST00000452625ENST00000360304MYH11chr1615809021-MYLKchr3123383105-0.0080109320.9919891
ENST00000576790ENST00000360772MYH11chr1615809021-MYLKchr3123383105-0.0045799560.9954201
ENST00000576790ENST00000359169MYH11chr1615809021-MYLKchr3123383105-0.0102048970.98979515
ENST00000576790ENST00000360304MYH11chr1615809021-MYLKchr3123383105-0.0082100280.99178994

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>56300_56300_1_MYH11-MYLK_MYH11_chr16_15809021_ENST00000452625_MYLK_chr3_123383105_ENST00000359169_length(amino acids)=2473AA_BP=1887
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPL
NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD

--------------------------------------------------------------

>56300_56300_2_MYH11-MYLK_MYH11_chr16_15809021_ENST00000452625_MYLK_chr3_123383105_ENST00000360304_length(amino acids)=2524AA_BP=1887
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKK
LSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEV
VEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGE

--------------------------------------------------------------

>56300_56300_3_MYH11-MYLK_MYH11_chr16_15809021_ENST00000452625_MYLK_chr3_123383105_ENST00000360772_length(amino acids)=2473AA_BP=1887
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITQGPSFAYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTG
YIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL
SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFR
WILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIER
PNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKF
VADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGV
LEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQ
AMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQ
LTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKV
TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA
SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTE
LEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG
QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV
STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR
LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME
DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETE
LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQE
DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNE
SARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQE
SEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEI
WDSANKTWKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV
SDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERI
IDEDFELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGY
ATDMWSIGVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPL
NAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISD

--------------------------------------------------------------

>56300_56300_4_MYH11-MYLK_MYH11_chr16_15809021_ENST00000576790_MYLK_chr3_123383105_ENST00000359169_length(amino acids)=2466AA_BP=1880
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI
ETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVS
SVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVN
KALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGV
LALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKD
VDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRIC
RQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL
ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL
LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK
KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI
ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS
TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE
HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL
EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD
LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD
DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ
RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER
ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE
RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQESEHMKVE
NSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKT
WKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIE
ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFEL
TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSI
GVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLES
EEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDA

--------------------------------------------------------------

>56300_56300_5_MYH11-MYLK_MYH11_chr16_15809021_ENST00000576790_MYLK_chr3_123383105_ENST00000360304_length(amino acids)=2517AA_BP=1880
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI
ETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVS
SVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVN
KALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGV
LALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKD
VDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRIC
RQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL
ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL
LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK
KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI
ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS
TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE
HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL
EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD
LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD
DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ
RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER
ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE
RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQESEHMKVE
NSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKT
WKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIE
ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFEL
TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSI
GVICYILVSGLSPFMGDNDNETLANVTSATWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMK
KYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAAR

--------------------------------------------------------------

>56300_56300_6_MYH11-MYLK_MYH11_chr16_15809021_ENST00000576790_MYLK_chr3_123383105_ENST00000360772_length(amino acids)=2466AA_BP=1880
MEIWDQQGTMAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNP
PKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDRED
QSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANI
ETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVS
SVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVN
KALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGV
LALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKD
VDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRIC
RQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYL
ARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNL
LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK
KLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI
ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDS
TATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE
HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL
EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD
LVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD
DVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ
RALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAER
ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE
RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQIQESEHMKVE
NSENGSKLTILAARQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKT
WKELATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKVSDFYDIE
ERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFEL
TERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVLFGTPEFVAPEVINYEPIGYATDMWSI
GVICYILNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLES
EEDVSQAFLEAVAEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDA

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:15809021/chr3:123383105)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MYH11

P35749

MYLK

Q86YV6

FUNCTION: Muscle contraction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-394131_811871.01973.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-3941786_8151871.01973.0DomainIQ
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-394185_7831871.01973.0DomainMyosin motor
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-404231_811878.01980.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-4042786_8151878.01980.0DomainIQ
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-404285_7831878.01980.0DomainMyosin motor
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-404331_811878.02132.0DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-4043786_8151878.02132.0DomainIQ
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-404385_7831878.02132.0DomainMyosin motor
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-394231_811871.01912.6666666666667DomainMyosin N-terminal SH3-like
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-3942786_8151871.01912.6666666666667DomainIQ
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-394285_7831871.01912.6666666666667DomainMyosin motor
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-3941178_1851871.01973.0Nucleotide bindingATP
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-4042178_1851878.01980.0Nucleotide bindingATP
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-4043178_1851878.02132.0Nucleotide bindingATP
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-3942178_1851871.01912.6666666666667Nucleotide bindingATP
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-3941661_6831871.01973.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-3941762_7761871.01973.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-4042661_6831878.01980.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-4042762_7761878.01980.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-4043661_6831878.02132.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-4043762_7761878.02132.0RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-3942661_6831871.01912.6666666666667RegionActin-binding
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-3942762_7761871.01912.6666666666667RegionActin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331906_19141208.01846.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331906_19141277.01864.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341906_19141277.01915.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341906_19141277.01864.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031906_19140155.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311906_19141277.01915.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041906_19140155.0Compositional biasNote=Poly-Glu
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331238_13261208.01846.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331334_14261208.01846.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331464_17191208.01846.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331809_18981208.01846.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331334_14261277.01864.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331464_17191277.01864.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331809_18981277.01864.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341334_14261277.01915.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341464_17191277.01915.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341809_18981277.01915.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341334_14261277.01864.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341464_17191277.01864.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341809_18981277.01864.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031098_11860155.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031238_13260155.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031334_14260155.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031464_17190155.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003161_2490155.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031809_18980155.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST000004183700333_1220155.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003414_5030155.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003514_5990155.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003620_7110155.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003721_8210155.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311334_14261277.01915.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311464_17191277.01915.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311809_18981277.01915.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041098_11860155.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041238_13260155.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041334_14260155.0DomainFibronectin type-III
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041464_17190155.0DomainProtein kinase
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704161_2490155.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041809_18980155.0DomainNote=Ig-like C2-type 9
TgeneMYLKchr16:15809021chr3:123383105ENST000005830870433_1220155.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704414_5030155.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704514_5990155.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704620_7110155.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704721_8210155.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331470_14781208.01846.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331470_14781277.01864.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341470_14781277.01915.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341470_14781277.01864.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031470_14780155.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311470_14781277.01915.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041470_14780155.0Nucleotide bindingATP
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331711_17741208.01846.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331711_17741277.01864.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341711_17741277.01915.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341711_17741277.01864.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031711_17740155.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003948_9630155.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311711_17741277.01915.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041061_14600155.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041711_17740155.0RegionNote=Calmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704868_9980155.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704923_9630155.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704948_9630155.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704999_10630155.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031004_10150155.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031016_10270155.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031028_10390155.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031040_10510155.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST00000418370031052_10630155.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003868_8950155.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003896_9230155.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003924_9510155.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003952_9790155.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003980_9980155.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000041837003999_10030155.0RepeatNote=2-1%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041004_10150155.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041016_10270155.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041028_10390155.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041040_10510155.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST00000583087041052_10630155.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704868_8950155.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704896_9230155.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704924_9510155.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704952_9790155.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704980_9980155.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000058308704999_10030155.0RepeatNote=2-1%3B truncated

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-3941844_19341871.01973.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-4042844_19341878.01980.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-4043844_19341878.02132.0Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-3942844_19341871.01912.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneMYH11chr16:15809021chr3:123383105ENST00000300036-39411935_19721871.01973.0RegionNote=C-terminal
HgeneMYH11chr16:15809021chr3:123383105ENST00000396324-40421935_19721878.01980.0RegionNote=C-terminal
HgeneMYH11chr16:15809021chr3:123383105ENST00000452625-40431935_19721878.02132.0RegionNote=C-terminal
HgeneMYH11chr16:15809021chr3:123383105ENST00000576790-39421935_19721871.01912.6666666666667RegionNote=C-terminal
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331098_11861208.01846.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033161_2491208.01846.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000346322203333_1221208.01846.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033414_5031208.01846.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033514_5991208.01846.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033620_7111208.01846.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033721_8211208.01846.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331098_11861277.01864.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331238_13261277.01864.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133161_2491277.01864.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000359169213333_1221277.01864.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133414_5031277.01864.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133514_5991277.01864.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133620_7111277.01864.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133721_8211277.01864.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341098_11861277.01915.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341238_13261277.01915.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134161_2491277.01915.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000360304213433_1221277.01915.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134414_5031277.01915.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134514_5991277.01915.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134620_7111277.01915.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134721_8211277.01915.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341098_11861277.01864.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341238_13261277.01864.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234161_2491277.01864.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000360772223433_1221277.01864.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234414_5031277.01864.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234514_5991277.01864.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234620_7111277.01864.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234721_8211277.01864.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311098_11861277.01915.0DomainNote=Ig-like C2-type 7
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311238_13261277.01915.0DomainNote=Ig-like C2-type 8
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831161_2491277.01915.0DomainNote=Ig-like C2-type 2
TgeneMYLKchr16:15809021chr3:123383105ENST00000475616183133_1221277.01915.0DomainNote=Ig-like C2-type 1
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831414_5031277.01915.0DomainNote=Ig-like C2-type 3
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831514_5991277.01915.0DomainNote=Ig-like C2-type 4
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831620_7111277.01915.0DomainNote=Ig-like C2-type 5
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831721_8211277.01915.0DomainNote=Ig-like C2-type 6
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331061_14601208.01846.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033868_9981208.01846.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033923_9631208.01846.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033948_9631208.01846.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033999_10631208.01846.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331061_14601277.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133868_9981277.01864.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133923_9631277.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133948_9631277.01864.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133999_10631277.01864.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341061_14601277.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134868_9981277.01915.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134923_9631277.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134948_9631277.01915.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134999_10631277.01915.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341061_14601277.01864.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234868_9981277.01864.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234923_9631277.01864.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234948_9631277.01864.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234999_10631277.01864.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311061_14601277.01915.0RegionActin-binding (calcium/calmodulin-insensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831868_9981277.01915.0RegionNote=5 X 28 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831923_9631277.01915.0RegionActin-binding (calcium/calmodulin-sensitive)
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831948_9631277.01915.0RegionCalmodulin-binding
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831999_10631277.01915.0RegionNote=6 X 12 AA approximate tandem repeats
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331004_10151208.01846.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331016_10271208.01846.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331028_10391208.01846.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331040_10511208.01846.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST0000034632220331052_10631208.01846.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033868_8951208.01846.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033896_9231208.01846.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033924_9511208.01846.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033952_9791208.01846.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033980_9981208.01846.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST000003463222033999_10031208.01846.0RepeatNote=2-1%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331004_10151277.01864.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331016_10271277.01864.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331028_10391277.01864.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331040_10511277.01864.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST0000035916921331052_10631277.01864.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133868_8951277.01864.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133896_9231277.01864.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133924_9511277.01864.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133952_9791277.01864.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133980_9981277.01864.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST000003591692133999_10031277.01864.0RepeatNote=2-1%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341004_10151277.01915.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341016_10271277.01915.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341028_10391277.01915.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341040_10511277.01915.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST0000036030421341052_10631277.01915.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134868_8951277.01915.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134896_9231277.01915.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134924_9511277.01915.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134952_9791277.01915.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134980_9981277.01915.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST000003603042134999_10031277.01915.0RepeatNote=2-1%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341004_10151277.01864.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341016_10271277.01864.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341028_10391277.01864.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341040_10511277.01864.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST0000036077222341052_10631277.01864.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234868_8951277.01864.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234896_9231277.01864.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234924_9511277.01864.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234952_9791277.01864.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234980_9981277.01864.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST000003607722234999_10031277.01864.0RepeatNote=2-1%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311004_10151277.01915.0RepeatNote=2-2
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311016_10271277.01915.0RepeatNote=2-3
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311028_10391277.01915.0RepeatNote=2-4
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311040_10511277.01915.0RepeatNote=2-5
TgeneMYLKchr16:15809021chr3:123383105ENST0000047561618311052_10631277.01915.0RepeatNote=2-6
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831868_8951277.01915.0RepeatNote=1-1
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831896_9231277.01915.0RepeatNote=1-2
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831924_9511277.01915.0RepeatNote=1-3
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831952_9791277.01915.0RepeatNote=1-4
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831980_9981277.01915.0RepeatNote=1-5%3B truncated
TgeneMYLKchr16:15809021chr3:123383105ENST000004756161831999_10031277.01915.0RepeatNote=2-1%3B truncated


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MYH11all structure
MYLK


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MYH11-MYLK


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MYH11-MYLK


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneMYH11C4707243Familial thoracic aortic aneurysm and aortic dissection10CLINGEN;GENOMICS_ENGLAND
HgeneMYH11C0023467Leukemia, Myelocytic, Acute2CTD_human
HgeneMYH11C0023479Acute myelomonocytic leukemia2CTD_human;ORPHANET
HgeneMYH11C0026998Acute Myeloid Leukemia, M12CTD_human
HgeneMYH11C1851504Aortic aneurysm, familial thoracic 42CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneMYH11C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
HgeneMYH11C1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET