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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:APP-PRKAA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: APP-PRKAA1
FusionPDB ID: 5701
FusionGDB2.0 ID: 5701
HgeneTgene
Gene symbol

APP

PRKAA1

Gene ID

351

5562

Gene nameamyloid beta precursor proteinprotein kinase AMP-activated catalytic subunit alpha 1
SynonymsAAA|ABETA|ABPP|AD1|APPI|CTFgamma|CVAP|PN-II|PN2|preA4AMPK|AMPKa1
Cytomap

21q21.3

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionamyloid-beta precursor proteinalzheimer disease amyloid proteinamyloid beta (A4) precursor proteinamyloid beta A4 proteinamyloid precursor proteinbeta-amyloid peptidebeta-amyloid peptide(1-40)beta-amyloid peptide(1-42)beta-amyloid precursor protei5'-AMP-activated protein kinase catalytic subunit alpha-15'-AMP-activated protein kinase, catalytic alpha-1 chainACACA kinaseAMP -activate kinase alpha 1 subunitAMP-activated protein kinase, catalytic, alpha-1AMPK alpha 1AMPK subunit alpha-1HMGCR k
Modification date2020032920200327
UniProtAcc

Q8NEU8

.
Ensembl transtripts involved in fusion geneENST idsENST00000474136, ENST00000346798, 
ENST00000348990, ENST00000354192, 
ENST00000357903, ENST00000358918, 
ENST00000359726, ENST00000439274, 
ENST00000440126, ENST00000448388, 
ENST00000296800, ENST00000354209, 
ENST00000397128, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 25 X 12=93009 X 8 X 4=288
# samples 3310
** MAII scorelog2(33/9300*10)=-4.81669278663694
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/288*10)=-1.52606881166759
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: APP [Title/Abstract] AND PRKAA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)APP(27423315)-PRKAA1(40775605), # samples:1
Anticipated loss of major functional domain due to fusion event.APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APP-PRKAA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAPP

GO:0001934

positive regulation of protein phosphorylation

11404397

HgeneAPP

GO:0008285

negative regulation of cell proliferation

22944668

HgeneAPP

GO:1905606

regulation of presynapse assembly

19726636

TgenePRKAA1

GO:0006468

protein phosphorylation

17028174

TgenePRKAA1

GO:0010508

positive regulation of autophagy

22012985

TgenePRKAA1

GO:0010628

positive regulation of gene expression

17028174


check buttonFusion gene breakpoints across APP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKAA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5718APPchr21

27423315

-PRKAA1chr5

40775605

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000346798APPchr2127423315-ENST00000397128PRKAA1chr540775605-5506696342106690
ENST00000346798APPchr2127423315-ENST00000354209PRKAA1chr540775605-2160696342151705
ENST00000346798APPchr2127423315-ENST00000296800PRKAA1chr540775605-1576696341077347
ENST00000354192APPchr2127423315-ENST00000397128PRKAA1chr540775605-54316211272031634
ENST00000354192APPchr2127423315-ENST00000354209PRKAA1chr540775605-20856211272076649
ENST00000354192APPchr2127423315-ENST00000296800PRKAA1chr540775605-15016211271002291
ENST00000348990APPchr2127423315-ENST00000397128PRKAA1chr540775605-56198091472219690
ENST00000348990APPchr2127423315-ENST00000354209PRKAA1chr540775605-22738091472264705
ENST00000348990APPchr2127423315-ENST00000296800PRKAA1chr540775605-16898091471190347
ENST00000357903APPchr2127423315-ENST00000397128PRKAA1chr540775605-56398291672239690
ENST00000357903APPchr2127423315-ENST00000354209PRKAA1chr540775605-22938291672284705
ENST00000357903APPchr2127423315-ENST00000296800PRKAA1chr540775605-17098291671210347
ENST00000358918APPchr2127423315-ENST00000397128PRKAA1chr540775605-56728622002272690
ENST00000358918APPchr2127423315-ENST00000354209PRKAA1chr540775605-23268622002317705
ENST00000358918APPchr2127423315-ENST00000296800PRKAA1chr540775605-17428622001243347
ENST00000359726APPchr2127423315-ENST00000397128PRKAA1chr540775605-56728622002272690
ENST00000359726APPchr2127423315-ENST00000354209PRKAA1chr540775605-23268622002317705
ENST00000359726APPchr2127423315-ENST00000296800PRKAA1chr540775605-17428622001243347
ENST00000448388APPchr2127423315-ENST00000397128PRKAA1chr540775605-55597491682159663
ENST00000448388APPchr2127423315-ENST00000354209PRKAA1chr540775605-22137491682204678
ENST00000448388APPchr2127423315-ENST00000296800PRKAA1chr540775605-16297491681130320
ENST00000440126APPchr2127423315-ENST00000397128PRKAA1chr540775605-57239132392323694
ENST00000440126APPchr2127423315-ENST00000354209PRKAA1chr540775605-23779132392368709
ENST00000440126APPchr2127423315-ENST00000296800PRKAA1chr540775605-17939132391294351
ENST00000439274APPchr2127423315-ENST00000397128PRKAA1chr540775605-5338528341938634
ENST00000439274APPchr2127423315-ENST00000354209PRKAA1chr540775605-1992528341983649
ENST00000439274APPchr2127423315-ENST00000296800PRKAA1chr540775605-140852834909291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000346798ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001890690.999811
ENST00000346798ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0022005270.99779946
ENST00000346798ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003023910.9996977
ENST00000354192ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001787480.99982125
ENST00000354192ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0015893060.9984107
ENST00000354192ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003892580.9996107
ENST00000348990ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001986360.99980134
ENST00000348990ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.002896420.9971035
ENST00000348990ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0004154560.9995845
ENST00000357903ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001998770.99980015
ENST00000357903ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0031124320.9968876
ENST00000357903ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0004375780.99956244
ENST00000358918ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002074470.9997925
ENST00000358918ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0034168880.99658316
ENST00000358918ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0005270110.99947304
ENST00000359726ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002074470.9997925
ENST00000359726ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0034168880.99658316
ENST00000359726ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0005270110.99947304
ENST00000448388ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002124530.9997875
ENST00000448388ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0025368250.9974631
ENST00000448388ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.000253570.9997464
ENST00000440126ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0002208240.99977916
ENST00000440126ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0011477070.99885225
ENST00000440126ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0002342750.9997657
ENST00000439274ENST00000397128APPchr2127423315-PRKAA1chr540775605-0.0001738410.99982613
ENST00000439274ENST00000354209APPchr2127423315-PRKAA1chr540775605-0.0013153670.9986846
ENST00000439274ENST00000296800APPchr2127423315-PRKAA1chr540775605-0.0003212780.99967873

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>5701_5701_1_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD

--------------------------------------------------------------

>5701_5701_2_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA

--------------------------------------------------------------

>5701_5701_3_APP-PRKAA1_APP_chr21_27423315_ENST00000346798_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN

--------------------------------------------------------------

>5701_5701_4_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD

--------------------------------------------------------------

>5701_5701_5_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA

--------------------------------------------------------------

>5701_5701_6_APP-PRKAA1_APP_chr21_27423315_ENST00000348990_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN

--------------------------------------------------------------

>5701_5701_7_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV

--------------------------------------------------------------

>5701_5701_8_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI
KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP
VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG

--------------------------------------------------------------

>5701_5701_9_APP-PRKAA1_APP_chr21_27423315_ENST00000354192_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV
PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK

--------------------------------------------------------------

>5701_5701_10_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD

--------------------------------------------------------------

>5701_5701_11_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA

--------------------------------------------------------------

>5701_5701_12_APP-PRKAA1_APP_chr21_27423315_ENST00000357903_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN

--------------------------------------------------------------

>5701_5701_13_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD

--------------------------------------------------------------

>5701_5701_14_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA

--------------------------------------------------------------

>5701_5701_15_APP-PRKAA1_APP_chr21_27423315_ENST00000358918_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN

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>5701_5701_16_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=347AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD

--------------------------------------------------------------

>5701_5701_17_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=705AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDE
KESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVI
LYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEAL
KEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNP
QKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEA

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>5701_5701_18_APP-PRKAA1_APP_chr21_27423315_ENST00000359726_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=690AA_BP=220
MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQ
PVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDH
VPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVL
SCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHL
GIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSN

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>5701_5701_19_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=291AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV

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>5701_5701_20_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=649AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF
LRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATI
KDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDS
FLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNP
VTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPG

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>5701_5701_21_APP-PRKAA1_APP_chr21_27423315_ENST00000439274_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=634AA_BP=164
MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCET
HLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVME
YVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEV
ISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERV
PFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPVDLTPRPGSHTIEFFEMCANLIK

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>5701_5701_22_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=351AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL

--------------------------------------------------------------

>5701_5701_23_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=709AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTK
ELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWS
SGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMID
DEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLD
ELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDE

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>5701_5701_24_APP-PRKAA1_APP_chr21_27423315_ENST00000440126_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=694AA_BP=224
MEPALPQIQMDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVV
EANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGI
DKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQIL
SGVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSE
EEVLSCLYNRNHQDPLAVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSG

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>5701_5701_25_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000296800_length(amino acids)=320AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI

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>5701_5701_26_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000354209_length(amino acids)=678AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVVHRDL
KPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGI
FYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPL
AVAYHLIIDNRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIM
AEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAE

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>5701_5701_27_APP-PRKAA1_APP_chr21_27423315_ENST00000448388_PRKAA1_chr5_40775605_ENST00000397128_length(amino acids)=663AA_BP=193
MLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRC
LVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSD
VWWGGADTDYADGRYQVISTPSDIFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAKI
ADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLL
KHMLQVDPMKRATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIMN
EAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWK
VVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:27423315/chr5:40775605)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APP

Q8NEU8

.
FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (PubMed:26583432, PubMed:15016378, PubMed:24879834). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (PubMed:15016378). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (PubMed:26583432). Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (PubMed:24879834) (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (PubMed:24879834). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (PubMed:19433865) (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (PubMed:19433865). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:24879834, ECO:0000269|PubMed:26583432}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51828_189220.66666666666666771.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51628_189220.66666666666666696.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51728_189220.66666666666666752.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51728_189220.66666666666666753.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51728_189220.66666666666666715.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51728_189215.66666666666666747.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518131_189220.66666666666666771.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518181_188220.66666666666666771.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51828_123220.66666666666666771.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51896_110220.66666666666666771.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516131_189220.66666666666666696.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516181_188220.66666666666666696.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51628_123220.66666666666666696.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51696_110220.66666666666666696.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41528_123164.66666666666666640.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41596_110164.66666666666666640.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517131_189220.66666666666666752.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517181_188220.66666666666666752.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51728_123220.66666666666666752.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51796_110220.66666666666666752.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517131_189220.66666666666666753.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517181_188220.66666666666666753.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51728_123220.66666666666666753.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51796_110220.66666666666666753.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517131_189220.66666666666666715.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517181_188220.66666666666666715.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51728_123220.66666666666666715.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51796_110220.66666666666666715.0RegionHeparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517131_189215.66666666666666747.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517181_188215.66666666666666747.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51728_123215.66666666666666747.0RegionGFLD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51796_110215.66666666666666747.0RegionHeparin-binding
TgenePRKAA1chr21:27423315chr5:40775605ENST00000354209110302_38189.66666666666667575.0RegionNote=AIS
TgenePRKAA1chr21:27423315chr5:40775605ENST0000039712819302_38189.66666666666667560.0RegionNote=AIS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518230_260220.66666666666666771.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518274_280220.66666666666666771.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516230_260220.66666666666666696.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516274_280220.66666666666666696.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415230_260164.66666666666666640.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415274_280164.66666666666666640.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517230_260220.66666666666666752.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517274_280220.66666666666666752.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517230_260220.66666666666666753.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517274_280220.66666666666666753.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517230_260220.66666666666666715.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517274_280220.66666666666666715.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517230_260215.66666666666666747.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517274_280215.66666666666666747.0Compositional biasNote=Poly-Thr
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518374_565220.66666666666666771.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516374_565220.66666666666666696.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41528_189164.66666666666666640.0DomainE1
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415374_565164.66666666666666640.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517374_565220.66666666666666752.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517374_565220.66666666666666753.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517374_565220.66666666666666715.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517374_565215.66666666666666747.0DomainE2
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518344_365220.66666666666666771.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518724_734220.66666666666666771.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516344_365220.66666666666666696.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516724_734220.66666666666666696.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415344_365164.66666666666666640.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415724_734164.66666666666666640.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517344_365220.66666666666666752.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517724_734220.66666666666666752.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517344_365220.66666666666666753.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517724_734220.66666666666666753.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517344_365220.66666666666666715.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517724_734220.66666666666666715.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517344_365215.66666666666666747.0MotifOX-2
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517724_734215.66666666666666747.0MotifNote=Basolateral sorting signal
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518391_423220.66666666666666771.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518491_522220.66666666666666771.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518523_540220.66666666666666771.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516391_423220.66666666666666696.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516491_522220.66666666666666696.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516523_540220.66666666666666696.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415131_189164.66666666666666640.0RegionCuBD subdomain
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415181_188164.66666666666666640.0RegionNote=Zinc-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415391_423164.66666666666666640.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415491_522164.66666666666666640.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415523_540164.66666666666666640.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517391_423220.66666666666666752.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517491_522220.66666666666666752.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517523_540220.66666666666666752.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517391_423220.66666666666666753.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517491_522220.66666666666666753.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517523_540220.66666666666666753.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517391_423220.66666666666666715.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517491_522220.66666666666666715.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517523_540220.66666666666666715.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517391_423215.66666666666666747.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517491_522215.66666666666666747.0RegionNote=Heparin-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517523_540215.66666666666666747.0RegionCollagen-binding
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-51818_701220.66666666666666771.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518723_770220.66666666666666771.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-51618_701220.66666666666666696.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516723_770220.66666666666666696.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-41518_701164.66666666666666640.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415723_770164.66666666666666640.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-51718_701220.66666666666666752.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517723_770220.66666666666666752.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-51718_701220.66666666666666753.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517723_770220.66666666666666753.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-51718_701220.66666666666666715.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517723_770220.66666666666666715.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-51718_701215.66666666666666747.0Topological domainExtracellular
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517723_770215.66666666666666747.0Topological domainCytoplasmic
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518702_722220.66666666666666771.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516702_722220.66666666666666696.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415702_722164.66666666666666640.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517702_722220.66666666666666752.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517702_722220.66666666666666753.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517702_722220.66666666666666715.0TransmembraneHelical
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517702_722215.66666666666666747.0TransmembraneHelical
TgenePRKAA1chr21:27423315chr5:40775605ENST0000035420911027_27989.66666666666667575.0DomainProtein kinase
TgenePRKAA1chr21:27423315chr5:40775605ENST000003971281927_27989.66666666666667560.0DomainProtein kinase
TgenePRKAA1chr21:27423315chr5:40775605ENST0000035420911033_4189.66666666666667575.0Nucleotide bindingATP
TgenePRKAA1chr21:27423315chr5:40775605ENST000003971281933_4189.66666666666667560.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
APP
PRKAA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518732_751220.66666666666666771.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516732_751220.66666666666666696.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415732_751164.66666666666666640.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517732_751220.66666666666666752.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517732_751220.66666666666666753.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517732_751220.66666666666666715.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517732_751215.66666666666666747.0G(o)-alpha
HgeneAPPchr21:27423315chr5:40775605ENST00000346798-518695_722220.66666666666666771.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000348990-516695_722220.66666666666666696.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000354192-415695_722164.66666666666666640.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000357903-517695_722220.66666666666666752.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000358918-517695_722220.66666666666666753.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000359726-517695_722220.66666666666666715.0PSEN1
HgeneAPPchr21:27423315chr5:40775605ENST00000440126-517695_722215.66666666666666747.0PSEN1


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Related Drugs to APP-PRKAA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to APP-PRKAA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource