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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NACC2-NTRK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NACC2-NTRK2
FusionPDB ID: 57095
FusionGDB2.0 ID: 57095
HgeneTgene
Gene symbol

NACC2

NTRK2

Gene ID

138151

4915

Gene nameNACC family member 2neurotrophic receptor tyrosine kinase 2
SynonymsBEND9|BTBD14|BTBD14A|BTBD31|NAC-2|RBBEIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

9q34.3

9q21.33

Type of geneprotein-codingprotein-coding
Descriptionnucleus accumbens-associated protein 2BEN domain containing 9BTB (POZ) domain containing 14ABTB/POZ domain-containing protein 14ANACC family member 2, BEN and BTB (POZ) domain containingrepressor with BTB domain and BEN domaintranscription repressorBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020031320200313
UniProtAcc

Q96BF6

Q16620

Ensembl transtripts involved in fusion geneENST idsENST00000371753, ENST00000277554, 
ENST00000467669, 		ENST00000277120, 
ENST00000304053, ENST00000323115, 
ENST00000359847, ENST00000376208, 
ENST00000376213, ENST00000376214, 
ENST00000395866, ENST00000395882, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 4=6410 X 9 X 7=630
# samples 510
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NACC2 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.NACC2-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NACC2-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
NACC2-NTRK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
NACC2-NTRK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNACC2

GO:0008285

negative regulation of cell proliferation

22926524

HgeneNACC2

GO:0034629

cellular protein-containing complex localization

22926524

HgeneNACC2

GO:0045892

negative regulation of transcription, DNA-templated

22926524

HgeneNACC2

GO:0051260

protein homooligomerization

22926524

HgeneNACC2

GO:1900477

negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter

22926524

HgeneNACC2

GO:1902231

positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage

22926524


check buttonFusion gene breakpoints across NACC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB3..NACC2chr9

138905709

-NTRK2chr9

87359887

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277554NACC2chr9138905709-ENST00000376214NTRK2chr987359887+4788131313062634442
ENST00000277554NACC2chr9138905709-ENST00000376213NTRK2chr987359887+4740131313062586426
ENST00000277554NACC2chr9138905709-ENST00000395882NTRK2chr987359887+667913131231334403
ENST00000277554NACC2chr9138905709-ENST00000304053NTRK2chr987359887+786113131231334403
ENST00000277554NACC2chr9138905709-ENST00000376208NTRK2chr987359887+781313131231334403
ENST00000277554NACC2chr9138905709-ENST00000277120NTRK2chr987359887+3692131313062634442
ENST00000277554NACC2chr9138905709-ENST00000323115NTRK2chr987359887+3473131313062586426
ENST00000277554NACC2chr9138905709-ENST00000359847NTRK2chr987359887+667513131231334403
ENST00000277554NACC2chr9138905709-ENST00000395866NTRK2chr987359887+203613131231334403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57095_57095_1_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000277120_length(amino acids)=442AA_BP=2
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV
ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL
CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ
SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG

--------------------------------------------------------------

>57095_57095_2_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000304053_length(amino acids)=403AA_BP=
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV

--------------------------------------------------------------

>57095_57095_3_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000323115_length(amino acids)=426AA_BP=2
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN
GSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD
ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY
LASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ

--------------------------------------------------------------

>57095_57095_4_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000359847_length(amino acids)=403AA_BP=
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV

--------------------------------------------------------------

>57095_57095_5_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000376208_length(amino acids)=403AA_BP=
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV

--------------------------------------------------------------

>57095_57095_6_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000376213_length(amino acids)=426AA_BP=2
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISN
GSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD
ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVY
LASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ

--------------------------------------------------------------

>57095_57095_7_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000376214_length(amino acids)=442AA_BP=2
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASV
ISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNL
CPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQ
SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLG

--------------------------------------------------------------

>57095_57095_8_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000395866_length(amino acids)=403AA_BP=
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV

--------------------------------------------------------------

>57095_57095_9_NACC2-NTRK2_NACC2_chr9_138905709_ENST00000277554_NTRK2_chr9_87359887_ENST00000395882_length(amino acids)=403AA_BP=
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQ
QILSFCYTGRLTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAGSEPQSPCNQLQPAAAAAAPYVVSPSVPIPL
LTRVKHEAMELPPAGPGLAPKRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDS
PTSYHNEEDEEDDEAYDTMVEEQYGQMYIKASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSEGDPGEKLELV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NACC2

Q96BF6

NTRK2

Q16620

FUNCTION: Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. {ECO:0000269|PubMed:22926524}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (163) >>>163.pdbFusion protein BP residue:
CIF file (163) >>>163.cif		NACC2chr9138905709-NTRK2chr987359887+
MRAQPRRCPPAMSQMLHIEIPNFGNTVLGCLNEQRLLGLYCDVSIVVKGQ
AFKAHRAVLAASSLYFRDLFSGNSKSAFELPGSVPPACFQQILSFCYTGR
LTMTASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQTAVIEDAG
SEPQSPCNQLQPAAAAAAPYVVSPSVPIPLLTRVKHEAMELPPAGPGLAP
KRPLETGPRDGVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQM
PYPQGERTSPGASSLPTTDSPTSYHNEEDEEDDEAYDTMVEEQYGQMYIK
ASGSYAVQEKPEPVPLESRSCVLIRRDLVALPASLISQIGYRCHPKLYSE
GDPGEKLELVAGSGVYITRGQLMNCHLCAGVKHKVLLRRLLATFFDRLWN
403
3D view using mol* of 163 (AA BP:)
PDB file (186) >>>186.pdbFusion protein BP residue: 2
CIF file (186) >>>186.cif		NACC2chr9138905709-NTRK2chr987359887+
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFC
LLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEG
GPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGE
GAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQ
HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT
ELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFG
MSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEI
FTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHM
426
3D view using mol* of 186 (AA BP:2)
PDB file (204) >>>204.pdbFusion protein BP residue: 2
CIF file (204) >>>204.cif		NACC2chr9138905709-NTRK2chr987359887+
MTDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFC
LLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFV
QHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDN
ARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLR
AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATR
NCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKF
TTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
442
3D view using mol* of 204 (AA BP:2)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NACC2_pLDDT.png
all structure
all structure
NTRK2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NACC2_NTRK2_163_PAE.png (AA BP:)
all structure
NACC2_NTRK2_163_pLDDT.png (AA BP:)
all structure
NACC2_NTRK2_163_pLDDT_and_active_sites.png (AA BP:)
all structure
NACC2_NTRK2_163_violinplot.png (AA BP:)
all structure
NACC2_NTRK2_186_pLDDT.png (AA BP:2)
all structure
NACC2_NTRK2_186_pLDDT_and_active_sites.png (AA BP:2)
all structure
NACC2_NTRK2_186_violinplot.png (AA BP:2)
all structure
NACC2_NTRK2_204_PAE.png (AA BP:2)
all structure
NACC2_NTRK2_204_pLDDT.png (AA BP:2)
all structure
NACC2_NTRK2_204_pLDDT_and_active_sites.png (AA BP:2)
all structure
NACC2_NTRK2_204_violinplot.png (AA BP:2)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
NACC2_NTRK2_163.png
all structure
NACC2_NTRK2_186.png
all structure
NACC2_NTRK2_204.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
1631.0762321.125606.7670.4130.7421.0051.4380.7991.81.069Chain A: 64,65,83,84,109,112,113,114,116,117,119,1
21,124,125,128,129,131,132,369,372,373,376,377,379
,380,381,384,385,388,389,391,392,394,395,396
1861.0471400.995530.2780.5680.7680.9950.3471.2460.2780.888Chain A: 73,74,75,79,80,81,83,84,85,86,88,89,151,1
52,153,176,178,179,180,182,184,185,188,189,192,219
,298,299,300,303,304,307,310,312,318
2041.0533721.11044.0920.5360.7150.9360.9920.8231.2061.035Chain A: 115,116,117,118,119,120,121,122,127,130,1
32,133,134,135,136,137,139,140,143,144,145,167,168
,169,192,193,194,196,201,204,205,207,208,211,212,2
14,215,235,286,289,290,291,292,293,294,295,296,301
,314,315,316,317,318,320,323,326,329,330,332,333,3
34,335,336,340,348,350,358

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NACC2EPS8, NACC2, HDAC1, HDAC2, MTA1, MTA2, RBBP7, RBBP4, CHD4, MTA3, FOXP3, TRIM25, HNRNPL, TP63, NACC1, BCAN, ZBTB34, OSBPL1A, FHL2, GOPC, FEM1A, TRAPPC9, B4GALT2, DNAJB6, TWIST2, RPP21, SENP3, DHDH, SOHLH1, KLHDC10, HSPB8, C11orf71, PPARD, RFXANK, CPNE4, TPGS1, NPAS1, DCTN3, ZYG11B, KLHL22, TFPT, DNAJB8, CIB3, C6orf141, MEF2BNB, NCAPH2, INF2, AANAT,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NACC2all structure
NTRK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to NACC2-NTRK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NACC2-NTRK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
NACC2NTRK2Squamous Cell CarcinomaMyCancerGenome
NACC2NTRK2Cancer Of Unknown PrimaryMyCancerGenome
NACC2NTRK2NosMyCancerGenome
NACC2NTRK2High-Grade Neuroepithelial TumorMyCancerGenome
NACC2NTRK2Invasive Breast CarcinomaMyCancerGenome
NACC2NTRK2Lung AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET