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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NAPEPLD-RELN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NAPEPLD-RELN
	FusionPDB ID: 57231
	FusionGDB2.0 ID: 57231
		Hgene	Tgene
	Gene symbol	NAPEPLD	RELN
	Gene ID	222236	5649
	Gene name	N-acyl phosphatidylethanolamine phospholipase D	reelin
	Synonyms	C7orf18\|FMP30\|NAPE-PLD	ETL7\|LIS2\|PRO1598\|RL
	Cytomap	7q22.1	7q22.1
	Type of gene	protein-coding	protein-coding
	Description	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase DNAPE-hydrolyzing phospholipase D	reelin
	Modification date	20200313	20200322
	UniProtAcc	Q6IQ20	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000341533, ENST00000417955, ENST00000427257, ENST00000455523, ENST00000465647,	ENST00000473945, ENST00000343529, ENST00000424685, ENST00000428762,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 3=90	11 X 11 X 6=726
	# samples	6	11
	** MAII score	log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/726*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NAPEPLD [Title/Abstract] AND RELN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NAPEPLD(102768930)-RELN(103143677), # samples:3
Anticipated loss of major functional domain due to fusion event.	NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NAPEPLD-RELN seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NAPEPLD-RELN seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NAPEPLD	GO:0070292	N-acylphosphatidylethanolamine metabolic process	25684574

Fusion gene breakpoints across NAPEPLD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RELN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-AJ-A2QM-01A	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000343529	RELN	chr7	103143677	-	3863	732	438	2834	798
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000428762	RELN	chr7	103143677	-	3869	732	438	2840	800
ENST00000341533	NAPEPLD	chr7	102768930	-	ENST00000424685	RELN	chr7	103143677	-	3869	732	438	2840	800
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000343529	RELN	chr7	103143677	-	3723	592	79	2694	871
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000428762	RELN	chr7	103143677	-	3729	592	79	2700	873
ENST00000455523	NAPEPLD	chr7	102768930	-	ENST00000424685	RELN	chr7	103143677	-	3729	592	79	2700	873

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341533	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000528951	0.999471
ENST00000341533	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000515142	0.9994848
ENST00000341533	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000528266	0.9994717
ENST00000455523	ENST00000343529	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187951	0.99981207
ENST00000455523	ENST00000428762	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187056	0.999813
ENST00000455523	ENST00000424685	NAPEPLD	chr7	102768930	-	RELN	chr7	103143677	-	0.000187601	0.9998124

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57231_57231_1_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000343529_length(amino acids)=798AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------

>57231_57231_2_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000424685_length(amino acids)=800AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------

>57231_57231_3_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000341533_RELN_chr7_103143677_ENST00000428762_length(amino acids)=800AA_BP=98
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDH
SSVPSSKEISVGCKVSEKIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKY
SDMQWAIDNFYLGPGCLDNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFG
GSTVRQAVTQDLDLRGAKFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLR
WWQPFVISNGIVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSR
ELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVS
SSATQFRWIQKGEETEKQSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGV
IGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPK

--------------------------------------------------------------

>57231_57231_4_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000343529_length(amino acids)=871AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------

>57231_57231_5_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000424685_length(amino acids)=873AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------

>57231_57231_6_NAPEPLD-RELN_NAPEPLD_chr7_102768930_ENST00000455523_RELN_chr7_103143677_ENST00000428762_length(amino acids)=873AA_BP=171
MARRRELKRCLQLLASSAEPARRARVRKNPSACRGRPSRYAAALCAGTLWPEAAELRRRALPATPSASSSPKDMDENESNQSLMTSSQYP
KEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEISVGCKVSE
KIAQNQIHVQYSTDFGVSWNYLVPQCLPADPKCSGSVSQPSVFFPTKGWKRITYPLPESLVGNPVRFRFYQKYSDMQWAIDNFYLGPGCL
DNCRGHGDCLREQCICDPGYSGPNCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAEDTALYFGGSTVRQAVTQDLDLRGA
KFLQYWGRIGSENNMTSCHRPICRKEGVLLDYSTDGGITWTLLHEMDYQKYISVRHDYILLPEDALTNTTRLRWWQPFVISNGIVVSGVE
RAQWALDNILIGGAEINPSQLVDTFDDEGTSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVG
CEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNSVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEK
QSWAIDHVYIGEACPKLCSGHGYCTTGAICICDESFQGDDCSVFSHDLPSYIKDNFESARVTEANWETIQGGVIGSGCGQLAPYAHGDSL
YFNGCQIRQAATKPLDLTRASKIMFVLQIGSMSQTDSCNSDLSGPHAVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEAR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:102768930/chr7:103143677)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NAPEPLD Q6IQ20	.
FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). {ECO:0000250\|UniProtKB:Q8BH82, ECO:0000269\|PubMed:14634025, ECO:0000269\|PubMed:16527816, ECO:0000269\|PubMed:25684574, ECO:0000269\|PubMed:27571266}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3431_3460

2758.0

3459.0

Compositional bias

Note=Arg-rich (basic)

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3431_3460

2758.0

3461.0

Compositional bias

Note=Arg-rich (basic)

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2852_2883

2758.0

3459.0

Domain

EGF-like 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3227_3259

2758.0

3459.0

Domain

EGF-like 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2852_2883

2758.0

3461.0

Domain

EGF-like 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3227_3259

2758.0

3461.0

Domain

EGF-like 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2777_2788

2758.0

3459.0

Repeat

Note=BNR 13

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2978_2989

2758.0

3459.0

Repeat

Note=BNR 14

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3142_3154

2758.0

3459.0

Repeat

Note=BNR 15

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

3362_3373

2758.0

3459.0

Repeat

Note=BNR 16

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2777_2788

2758.0

3461.0

Repeat

Note=BNR 13

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2978_2989

2758.0

3461.0

Repeat

Note=BNR 14

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3142_3154

2758.0

3461.0

Repeat

Note=BNR 15

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

3362_3373

2758.0

3461.0

Repeat

Note=BNR 16

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1029_1060

2758.0

3459.0

Domain

EGF-like 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1408_1441

2758.0

3459.0

Domain

EGF-like 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1764_1795

2758.0

3459.0

Domain

EGF-like 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2128_2160

2758.0

3459.0

Domain

EGF-like 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2477_2508

2758.0

3459.0

Domain

EGF-like 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

26_190

2758.0

3459.0

Domain

Reelin

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

670_701

2758.0

3459.0

Domain

EGF-like 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1029_1060

2758.0

3461.0

Domain

EGF-like 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1408_1441

2758.0

3461.0

Domain

EGF-like 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1764_1795

2758.0

3461.0

Domain

EGF-like 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2128_2160

2758.0

3461.0

Domain

EGF-like 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2477_2508

2758.0

3461.0

Domain

EGF-like 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

26_190

2758.0

3461.0

Domain

Reelin

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

670_701

2758.0

3461.0

Domain

EGF-like 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1156_1167

2758.0

3459.0

Repeat

Note=BNR 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1322_1333

2758.0

3459.0

Repeat

Note=BNR 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1534_1545

2758.0

3459.0

Repeat

Note=BNR 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1685_1696

2758.0

3459.0

Repeat

Note=BNR 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

1883_1894

2758.0

3459.0

Repeat

Note=BNR 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2042_2053

2758.0

3459.0

Repeat

Note=BNR 9

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2249_2260

2758.0

3459.0

Repeat

Note=BNR 10

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2398_2409

2758.0

3459.0

Repeat

Note=BNR 11

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

2597_2608

2758.0

3459.0

Repeat

Note=BNR 12

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

592_603

2758.0

3459.0

Repeat

Note=BNR 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

798_809

2758.0

3459.0

Repeat

Note=BNR 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000343529

951_962

2758.0

3459.0

Repeat

Note=BNR 3

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1156_1167

2758.0

3461.0

Repeat

Note=BNR 4

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1322_1333

2758.0

3461.0

Repeat

Note=BNR 5

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1534_1545

2758.0

3461.0

Repeat

Note=BNR 6

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1685_1696

2758.0

3461.0

Repeat

Note=BNR 7

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

1883_1894

2758.0

3461.0

Repeat

Note=BNR 8

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2042_2053

2758.0

3461.0

Repeat

Note=BNR 9

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2249_2260

2758.0

3461.0

Repeat

Note=BNR 10

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2398_2409

2758.0

3461.0

Repeat

Note=BNR 11

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

2597_2608

2758.0

3461.0

Repeat

Note=BNR 12

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

592_603

2758.0

3461.0

Repeat

Note=BNR 1

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

798_809

2758.0

3461.0

Repeat

Note=BNR 2

Tgene

RELN

chr7:102768930

chr7:103143677

ENST00000428762

951_962

2758.0

3461.0

Repeat

Note=BNR 3

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NAPEPLD
RELN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to NAPEPLD-RELN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to NAPEPLD-RELN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source