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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:NFX1-DNAJA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: NFX1-DNAJA1
FusionPDB ID: 59009
FusionGDB2.0 ID: 59009
HgeneTgene
Gene symbol

NFX1

DNAJA1

Gene ID

4799

3301

Gene namenuclear transcription factor, X-box binding 1DnaJ heat shock protein family (Hsp40) member A1
SynonymsNFX2|TEG-42|Tex42DJ-2|DjA1|HDJ2|HSDJ|HSJ-2|HSJ2|HSPF4|NEDD7|hDJ-2
Cytomap

9p13.3

9p21.1

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional repressor NF-X1nuclear transcription factor, X box-binding protein 1dnaJ homolog subfamily A member 1DnaJ (Hsp40) homolog, subfamily A, member 1dnaJ protein homolog 2heat shock 40 kDa protein 4heat shock protein J2heat shock protein, DNAJ-like 2human DnaJ protein 2neural precursor cell expressed, developmentally do
Modification date2020031320200313
UniProtAcc

ZNFX1

P31689

Ensembl transtripts involved in fusion geneENST idsENST00000318524, ENST00000379521, 
ENST00000379540, ENST00000463421, 
ENST00000495015, ENST00000544625, 
ENST00000330899, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 12 X 11=21122 X 5 X 4=40
# samples 225
** MAII scorelog2(22/2112*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: NFX1 [Title/Abstract] AND DNAJA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)NFX1(33290595)-DNAJA1(33029883), # samples:3
Anticipated loss of major functional domain due to fusion event.NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NFX1-DNAJA1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFX1

GO:0000122

negative regulation of transcription by RNA polymerase II

7964459

HgeneNFX1

GO:0051865

protein autoubiquitination

10500182

TgeneDNAJA1

GO:0031397

negative regulation of protein ubiquitination

12150907

TgeneDNAJA1

GO:0051223

regulation of protein transport

14752510

TgeneDNAJA1

GO:1903748

negative regulation of establishment of protein localization to mitochondrion

14752510

TgeneDNAJA1

GO:1905259

negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway

14752510


check buttonFusion gene breakpoints across NFX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAJA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A0CG-01ANFX1chr9

33319125

+DNAJA1chr9

33038683

+
ChimerDB4OVTCGA-61-1743NFX1chr9

33328676

+DNAJA1chr9

33034213

+
ChimerDB4UCSTCGA-N8-A56S-01ANFX1chr9

33290595

-DNAJA1chr9

33029883

+
ChimerDB4UCSTCGA-N8-A56S-01ANFX1chr9

33290595

+DNAJA1chr9

33029883

+
ChimerDB4UCSTCGA-N8-A56SNFX1chr9

33290595

+DNAJA1chr9

33029882

+
ChimerDB4UCSTCGA-N8-A56SNFX1chr9

33290595

+DNAJA1chr9

33029883

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379540NFX1chr933319125+ENST00000330899DNAJA1chr933038683+31911968501981643
ENST00000379521NFX1chr933319125+ENST00000330899DNAJA1chr933038683+31901967491980643
ENST00000318524NFX1chr933319125+ENST00000330899DNAJA1chr933038683+31571934161947643
ENST00000379540NFX1chr933290595+ENST00000330899DNAJA1chr933029883+19758750970306
ENST00000379521NFX1chr933290595+ENST00000330899DNAJA1chr933029883+19748649969306
ENST00000318524NFX1chr933290595+ENST00000330899DNAJA1chr933029883+19415316936306
ENST00000379540NFX1chr933290595+ENST00000330899DNAJA1chr933029882+19758750970306
ENST00000379521NFX1chr933290595+ENST00000330899DNAJA1chr933029882+19748649969306
ENST00000318524NFX1chr933290595+ENST00000330899DNAJA1chr933029882+19415316936306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379540ENST00000330899NFX1chr933319125+DNAJA1chr933038683+0.0015547540.9984452
ENST00000379521ENST00000330899NFX1chr933319125+DNAJA1chr933038683+0.0015515950.9984484
ENST00000318524ENST00000330899NFX1chr933319125+DNAJA1chr933038683+0.0016085080.99839145
ENST00000379540ENST00000330899NFX1chr933290595+DNAJA1chr933029883+0.0002674840.99973255
ENST00000379521ENST00000330899NFX1chr933290595+DNAJA1chr933029883+0.0002622910.9997377
ENST00000318524ENST00000330899NFX1chr933290595+DNAJA1chr933029883+0.0002866350.99971336
ENST00000379540ENST00000330899NFX1chr933290595+DNAJA1chr933029882+0.0002674840.99973255
ENST00000379521ENST00000330899NFX1chr933290595+DNAJA1chr933029882+0.0002622910.9997377
ENST00000318524ENST00000330899NFX1chr933290595+DNAJA1chr933029882+0.0002866350.99971336

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>59009_59009_1_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000318524_DNAJA1_chr9_33029882_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_2_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000318524_DNAJA1_chr9_33029883_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_3_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000379521_DNAJA1_chr9_33029882_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_4_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000379521_DNAJA1_chr9_33029883_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_5_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000379540_DNAJA1_chr9_33029882_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_6_NFX1-DNAJA1_NFX1_chr9_33290595_ENST00000379540_DNAJA1_chr9_33029883_ENST00000330899_length(amino acids)=306AA_BP=10
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV

--------------------------------------------------------------

>59009_59009_7_NFX1-DNAJA1_NFX1_chr9_33319125_ENST00000318524_DNAJA1_chr9_33038683_ENST00000330899_length(amino acids)=643AA_BP=
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------

>59009_59009_8_NFX1-DNAJA1_NFX1_chr9_33319125_ENST00000379521_DNAJA1_chr9_33038683_ENST00000330899_length(amino acids)=643AA_BP=
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------

>59009_59009_9_NFX1-DNAJA1_NFX1_chr9_33319125_ENST00000379540_DNAJA1_chr9_33038683_ENST00000330899_length(amino acids)=643AA_BP=
MRHGMAEAPPVSGTFKFNTDAAEFIPQEKKNSGLNCGTQRRLDSNRIGRRNYSSPPPCHLSRQVPYDEISAVHQHSYHPSGSKPKSQQTS
FQSSPCNKSPKSHGLQNQPWQKLRNEKHHIRVKKAQSLAEQTSDTAGLESSTRSESGTDLREHSPSESEKEVVGADPRGAKPKKATQFVY
SYGRGPKVKGKLKCEWSNRTTPKPEDAGPESTKPVGVFHPDSSEASSRKGVLDGYGARRNEQRRYPQKRPPWEVEGARPRPGRNPPKQEG
HRHTNAGHRNNMGPIPKDDLNERPAKSTCDSENLAVINKSSRRVDQEKCTVRRQDPQVVSPFSRGKQNHVLKNVETHTGSLIEQLTTEKY
ECMVCCELVRVTAPVWSCQSCYHVFHLNCIKKWARSPASQADGQSGWRCPACQNVSAHVPNTYTCFCGKVKNPEWSRNEIPHSCGEVCRK
KQPGQDCPHSCNLLCHPGPCPPCPAFMTKTCECGRTRHTVRCGQAVSVHCSNPCENILNCGQHQCAELCHGGQCQPCQIILNQVCYCGST
SRDVLCGTDVGKSDGFGDFSCLKICGKDLKCGNHTCSQVCHPQPCQQCPRLPQLVRCCPCGQTPLSQLLELGSSSRKTCMDPVPSCGKVC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:33290595/chr9:33029883)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFX1

ZNFX1

DNAJA1

P31689

1918FUNCTION: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202). {ECO:0000269|PubMed:10816573, ECO:0000269|PubMed:14752510, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24512202, ECO:0000269|PubMed:9192730}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916358_409635.3333333333334834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916453_471635.3333333333334834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916506_525635.3333333333334834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916567_586635.3333333333334834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921358_409635.33333333333341025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921453_471635.33333333333341025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921506_525635.33333333333341025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921567_586635.33333333333341025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924358_409635.33333333333341121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924453_471635.33333333333341121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924506_525635.33333333333341121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924567_586635.33333333333341121.0Zinc fingerNote=NF-X1-type 3
TgeneDNAJA1chr9:33290595chr9:33029882ENST0000033089929134_141103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029882ENST0000033089929150_157103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029882ENST0000033089929177_184103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029882ENST0000033089929193_200103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029883ENST0000033089929134_141103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029883ENST0000033089929150_157103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029883ENST0000033089929177_184103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029883ENST0000033089929193_200103.33333333333333398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33290595chr9:33029882ENST0000033089929121_205103.33333333333333398.0Zinc fingerNote=CR-type
TgeneDNAJA1chr9:33290595chr9:33029883ENST0000033089929121_205103.33333333333333398.0Zinc fingerNote=CR-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+1161084_10898.333333333333334834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+1211084_10898.3333333333333341025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+1241084_10898.3333333333333341121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+1161084_10898.333333333333334834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+1211084_10898.3333333333333341025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+1241084_10898.3333333333333341121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+9161084_1089635.3333333333334834.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+9211084_1089635.33333333333341025.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+9241084_1089635.33333333333341121.0Compositional biasNote=Poly-Pro
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116994_10628.333333333333334834.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121994_10628.3333333333333341025.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124994_10628.3333333333333341121.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116994_10628.333333333333334834.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121994_10628.3333333333333341025.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124994_10628.3333333333333341121.0DomainR3H
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916994_1062635.3333333333334834.0DomainR3H
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921994_1062635.33333333333341025.0DomainR3H
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924994_1062635.33333333333341121.0DomainR3H
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116358_4098.333333333333334834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116453_4718.333333333333334834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116506_5258.333333333333334834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116567_5868.333333333333334834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116632_6558.333333333333334834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116694_7138.333333333333334834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116721_7408.333333333333334834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116832_8548.333333333333334834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+116863_8848.333333333333334834.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121358_4098.3333333333333341025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121453_4718.3333333333333341025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121506_5258.3333333333333341025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121567_5868.3333333333333341025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121632_6558.3333333333333341025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121694_7138.3333333333333341025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121721_7408.3333333333333341025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121832_8548.3333333333333341025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+121863_8848.3333333333333341025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124358_4098.3333333333333341121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124453_4718.3333333333333341121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124506_5258.3333333333333341121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124567_5868.3333333333333341121.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124632_6558.3333333333333341121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124694_7138.3333333333333341121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124721_7408.3333333333333341121.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124832_8548.3333333333333341121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+124863_8848.3333333333333341121.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116358_4098.333333333333334834.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116453_4718.333333333333334834.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116506_5258.333333333333334834.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116567_5868.333333333333334834.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116632_6558.333333333333334834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116694_7138.333333333333334834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116721_7408.333333333333334834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116832_8548.333333333333334834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+116863_8848.333333333333334834.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121358_4098.3333333333333341025.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121453_4718.3333333333333341025.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121506_5258.3333333333333341025.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121567_5868.3333333333333341025.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121632_6558.3333333333333341025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121694_7138.3333333333333341025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121721_7408.3333333333333341025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121832_8548.3333333333333341025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+121863_8848.3333333333333341025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124358_4098.3333333333333341121.0Zinc fingerRING-type%3B atypical
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124453_4718.3333333333333341121.0Zinc fingerNote=NF-X1-type 1
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124506_5258.3333333333333341121.0Zinc fingerNote=NF-X1-type 2
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124567_5868.3333333333333341121.0Zinc fingerNote=NF-X1-type 3
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124632_6558.3333333333333341121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124694_7138.3333333333333341121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124721_7408.3333333333333341121.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124832_8548.3333333333333341121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+124863_8848.3333333333333341121.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916632_655635.3333333333334834.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916694_713635.3333333333334834.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916721_740635.3333333333334834.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916832_854635.3333333333334834.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33038683ENST00000318524+916863_884635.3333333333334834.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921632_655635.33333333333341025.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921694_713635.33333333333341025.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921721_740635.33333333333341025.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921832_854635.33333333333341025.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33038683ENST00000379521+921863_884635.33333333333341025.0Zinc fingerNote=NF-X1-type 8
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924632_655635.33333333333341121.0Zinc fingerNote=NF-X1-type 4
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924694_713635.33333333333341121.0Zinc fingerNote=NF-X1-type 5
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924721_740635.33333333333341121.0Zinc fingerNote=NF-X1-type 6
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924832_854635.33333333333341121.0Zinc fingerNote=NF-X1-type 7
HgeneNFX1chr9:33319125chr9:33038683ENST00000379540+924863_884635.33333333333341121.0Zinc fingerNote=NF-X1-type 8
TgeneDNAJA1chr9:33290595chr9:33029882ENST000003308992975_96103.33333333333333398.0Compositional biasNote=Gly-rich
TgeneDNAJA1chr9:33290595chr9:33029883ENST000003308992975_96103.33333333333333398.0Compositional biasNote=Gly-rich
TgeneDNAJA1chr9:33319125chr9:33038683ENST000003308997975_96325.0398.0Compositional biasNote=Gly-rich
TgeneDNAJA1chr9:33290595chr9:33029882ENST00000330899296_68103.33333333333333398.0DomainNote=J
TgeneDNAJA1chr9:33290595chr9:33029883ENST00000330899296_68103.33333333333333398.0DomainNote=J
TgeneDNAJA1chr9:33319125chr9:33038683ENST00000330899796_68325.0398.0DomainNote=J
TgeneDNAJA1chr9:33319125chr9:33038683ENST0000033089979134_141325.0398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33319125chr9:33038683ENST0000033089979150_157325.0398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33319125chr9:33038683ENST0000033089979177_184325.0398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33319125chr9:33038683ENST0000033089979193_200325.0398.0RepeatNote=CXXCXGXG motif
TgeneDNAJA1chr9:33319125chr9:33038683ENST0000033089979121_205325.0398.0Zinc fingerNote=CR-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>555_NFX1_33290595_DNAJA1_33029883_ranked_0.pdbNFX13329059533290595ENST00000330899DNAJA1chr933029883+
MRHGMAEAPPVSGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQ
GHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALC
GFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQV
306


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
NFX1_pLDDT.png
all structure
all structure
DNAJA1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
NFX1
DNAJA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNFX1chr9:33290595chr9:33029882ENST00000318524+1169_268.333333333333334834.0PABPC1 and PABC4
HgeneNFX1chr9:33290595chr9:33029882ENST00000379521+1219_268.3333333333333341025.0PABPC1 and PABC4
HgeneNFX1chr9:33290595chr9:33029882ENST00000379540+1249_268.3333333333333341121.0PABPC1 and PABC4
HgeneNFX1chr9:33290595chr9:33029883ENST00000318524+1169_268.333333333333334834.0PABPC1 and PABC4
HgeneNFX1chr9:33290595chr9:33029883ENST00000379521+1219_268.3333333333333341025.0PABPC1 and PABC4
HgeneNFX1chr9:33290595chr9:33029883ENST00000379540+1249_268.3333333333333341121.0PABPC1 and PABC4


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Related Drugs to NFX1-DNAJA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to NFX1-DNAJA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource