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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:OGT-POLA1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OGT-POLA1
	FusionPDB ID: 61437
	FusionGDB2.0 ID: 61437
		Hgene	Tgene
	Gene symbol	OGT	POLA1
	Gene ID	8473	5422
	Gene name	O-linked N-acetylglucosamine (GlcNAc) transferase	DNA polymerase alpha 1, catalytic subunit
	Synonyms	HINCUT-1\|HRNT1\|MRX106\|O-GLCNAC\|OGT1	NSX\|POLA\|VEODS\|p180
	Cytomap	Xq13.1	Xp22.11-p21.3
	Type of gene	protein-coding	protein-coding
	Description	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunitO-GlcNAc transferase p110 subunitO-GlcNAc transferase subunit p110O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminy	DNA polymerase alpha catalytic subunitDNA polymerase alpha catalytic subunit p180polymerase (DNA directed), alpha 1, catalytic subunitpolymerase (DNA) alpha 1, catalytic subunitpolymerase (DNA-directed), alpha (70kD)
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000498566, ENST00000373701, ENST00000373719,	ENST00000379059, ENST00000379068, ENST00000493342,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 9 X 4=324	10 X 10 X 7=700
	# samples	10	12
	** MAII score	log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/700*10)=-2.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: OGT [Title/Abstract] AND POLA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OGT(70757922)-POLA1(24828015), # samples:3
Anticipated loss of major functional domain due to fusion event.	OGT-POLA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OGT-POLA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OGT-POLA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OGT-POLA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	OGT	GO:0006110	regulation of glycolytic process	22923583
Hgene	OGT	GO:0006493	protein O-linked glycosylation	21240259\|21285374\|22923583\|23222540\|23352454\|24474760
Hgene	OGT	GO:0006915	apoptotic process	20824293
Hgene	OGT	GO:0032868	response to insulin	18288188
Hgene	OGT	GO:0035020	regulation of Rac protein signal transduction	18288188
Hgene	OGT	GO:0043981	histone H4-K5 acetylation	20018852
Hgene	OGT	GO:0043982	histone H4-K8 acetylation	20018852
Hgene	OGT	GO:0043984	histone H4-K16 acetylation	20018852
Hgene	OGT	GO:0045862	positive regulation of proteolysis	21285374
Hgene	OGT	GO:0045944	positive regulation of transcription by RNA polymerase II	23222540\|23353889
Hgene	OGT	GO:0046626	regulation of insulin receptor signaling pathway	18288188
Hgene	OGT	GO:0048015	phosphatidylinositol-mediated signaling	18288188
Tgene	POLA1	GO:0006269	DNA replication, synthesis of RNA primer	2175912
Tgene	POLA1	GO:0006270	DNA replication initiation	2175912
Tgene	POLA1	GO:0006272	leading strand elongation	2175912\|7910375
Tgene	POLA1	GO:0006273	lagging strand elongation	2175912\|7910375
Tgene	POLA1	GO:0006281	DNA repair	3335506

Fusion gene breakpoints across OGT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POLA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A8IC-01A	OGT	chrX	70757922	-	POLA1	chrX	24828015	+
ChimerDB4	PRAD	TCGA-KK-A8IC-01A	OGT	chrX	70757922	+	POLA1	chrX	24828015	+
ChimerDB4	PRAD	TCGA-KK-A8IC	OGT	chrX	70757922	+	POLA1	chrX	24828015	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000373719

OGT

chrX

70757922

ENST00000379068

POLA1

chrX

24828015

3158

679

2121

684

ENST00000373719

OGT

chrX

70757922

ENST00000379059

POLA1

chrX

24828015

3158

679

2121

684

ENST00000373701

OGT

chrX

70757922

ENST00000379068

POLA1

chrX

24828015

3088

609

2051

674

ENST00000373701

OGT

chrX

70757922

ENST00000379059

POLA1

chrX

24828015

3088

609

2051

674

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000373719	ENST00000379068	OGT	chrX	70757922	+	POLA1	chrX	24828015	+	0.001064185	0.99893576
ENST00000373719	ENST00000379059	OGT	chrX	70757922	+	POLA1	chrX	24828015	+	0.001064185	0.99893576
ENST00000373701	ENST00000379068	OGT	chrX	70757922	+	POLA1	chrX	24828015	+	0.001924151	0.99807584
ENST00000373701	ENST00000379059	OGT	chrX	70757922	+	POLA1	chrX	24828015	+	0.001924151	0.99807584

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61437_61437_1_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379059_length(amino acids)=674AA_BP=194
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQ
EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAAL
VVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPD
KKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATW
LGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSN
KLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLK

--------------------------------------------------------------

>61437_61437_2_OGT-POLA1_OGT_chrX_70757922_ENST00000373701_POLA1_chrX_24828015_ENST00000379068_length(amino acids)=674AA_BP=194
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTGLAELAHREYQAGDFEAAERHCMQLWRQ
EPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDME
GAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAAL
VVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPD
KKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATW
LGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSN
KLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLK

--------------------------------------------------------------

>61437_61437_3_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379059_length(amino acids)=684AA_BP=204
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA
ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
AALVAAGDMEGAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLL
LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKA
LTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID
GIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKAS
PLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKL

--------------------------------------------------------------

>61437_61437_4_OGT-POLA1_OGT_chrX_70757922_ENST00000373719_POLA1_chrX_24828015_ENST00000379068_length(amino acids)=684AA_BP=204
MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA
ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA
AALVAAGDMEGAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLL
LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKA
LTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID
GIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKAS
PLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:70757922/chrX:24828015)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

21_54

144.0

1037.0

Repeat

Note=TPR 1

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

89_122

144.0

1037.0

Repeat

Note=TPR 2

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

123_156

154.0

1047.0

Repeat

Note=TPR 3

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

21_54

154.0

1047.0

Repeat

Note=TPR 1

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

89_122

154.0

1047.0

Repeat

Note=TPR 2

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

1047_1050

982.0

1463.0

Compositional bias

Note=Poly-Leu

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

1051_1054

982.0

1463.0

Compositional bias

Note=Poly-Lys

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

1348_1374

982.0

1463.0

Motif

CysB motif

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

1245_1376

982.0

1463.0

Region

DNA-binding

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

1283_1318

982.0

1463.0

Zinc finger

CysA-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

487_503

144.0

1037.0

Motif

Nuclear localization signal

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

487_503

154.0

1047.0

Motif

Nuclear localization signal

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

906_908

144.0

1037.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

911_914

144.0

1037.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

930_932

144.0

1037.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

906_908

154.0

1047.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

911_914

154.0

1047.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

930_932

154.0

1047.0

Nucleotide binding

UDP

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

991_1010

144.0

1037.0

Region

Note=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

991_1010

154.0

1047.0

Region

Note=Required for phosphatidylinositol 3%2C4%2C5-triphosphate binding

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

123_156

144.0

1037.0

Repeat

Note=TPR 3

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

157_190

144.0

1037.0

Repeat

Note=TPR 4

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

191_224

144.0

1037.0

Repeat

Note=TPR 5

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

225_258

144.0

1037.0

Repeat

Note=TPR 6

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

259_292

144.0

1037.0

Repeat

Note=TPR 7

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

293_326

144.0

1037.0

Repeat

Note=TPR 8

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

327_360

144.0

1037.0

Repeat

Note=TPR 9

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

361_394

144.0

1037.0

Repeat

Note=TPR 10

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

395_428

144.0

1037.0

Repeat

Note=TPR 11

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

429_462

144.0

1037.0

Repeat

Note=TPR 12

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373701

463_473

144.0

1037.0

Repeat

Note=TPR 13%3B truncated

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

157_190

154.0

1047.0

Repeat

Note=TPR 4

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

191_224

154.0

1047.0

Repeat

Note=TPR 5

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

225_258

154.0

1047.0

Repeat

Note=TPR 6

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

259_292

154.0

1047.0

Repeat

Note=TPR 7

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

293_326

154.0

1047.0

Repeat

Note=TPR 8

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

327_360

154.0

1047.0

Repeat

Note=TPR 9

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

361_394

154.0

1047.0

Repeat

Note=TPR 10

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

395_428

154.0

1047.0

Repeat

Note=TPR 11

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

429_462

154.0

1047.0

Repeat

Note=TPR 12

Hgene

OGT

chrX:70757922

chrX:24828015

ENST00000373719

463_473

154.0

1047.0

Repeat

Note=TPR 13%3B truncated

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

75_112

982.0

1463.0

Compositional bias

Note=Asp-rich

Tgene

POLA1

chrX:70757922

chrX:24828015

ENST00000379059

650_715

982.0

1463.0

Region

DNA-binding

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1407_OGT_70757922_POLA1_24828015_ranked_0.pdb	OGT	70757922	70757922	ENST00000379059	POLA1	chrX	24828015	+	MKPVTAAAAQALQSIATAAALVLLPPNTFLLVVAAAGPITSFLLSLEKLQMASSVGNVADSTEPTKRMLSFQGLAELAHREYQAGDFEAA ERHCMQLWRQEPDNTGVLLLLSSIHFQCRRLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLA AALVAAGDMEGAVQAYVSALQYNPILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLL LLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKA LTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPID GIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKAS PLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKL	684

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

OGT_pLDDT.png

POLA1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
OGT
POLA1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to OGT-POLA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to OGT-POLA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source