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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PAIP1-DAB2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PAIP1-DAB2
FusionPDB ID: 62379
FusionGDB2.0 ID: 62379
HgeneTgene
Gene symbol

PAIP1

DAB2

Gene ID

10605

1601

Gene namepoly(A) binding protein interacting protein 1DAB adaptor protein 2
Synonyms-DOC-2|DOC2
Cytomap

5p12

5p13.1

Type of geneprotein-codingprotein-coding
Descriptionpolyadenylate-binding protein-interacting protein 1PABC1-interacting protein 1PABP-interacting protein 1PAIP-1disabled homolog 2DAB2, clathrin adaptor proteinDab, mitogen-responsive phosphoprotein, homolog 2adaptor molecule disabled-2differentially expressed in ovarian carcinoma 2differentially-expressed protein 2disabled homolog 2, mitogen-responsive phosp
Modification date2020031320200313
UniProtAcc.

Q5VWQ8

Ensembl transtripts involved in fusion geneENST idsENST00000306846, ENST00000338972, 
ENST00000436644, ENST00000514514, 
ENST00000512525, ENST00000320816, 
ENST00000339788, ENST00000545653, 
ENST00000509337, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=808 X 9 X 2=144
# samples 610
** MAII scorelog2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/144*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PAIP1 [Title/Abstract] AND DAB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PAIP1(43555932)-DAB2(39375186), # samples:3
Anticipated loss of major functional domain due to fusion event.PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PAIP1-DAB2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDAB2

GO:0010718

positive regulation of epithelial to mesenchymal transition

15734730

TgeneDAB2

GO:0010862

positive regulation of pathway-restricted SMAD protein phosphorylation

11387212

TgeneDAB2

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

11387212

TgeneDAB2

GO:0043066

negative regulation of apoptotic process

15734730

TgeneDAB2

GO:0060391

positive regulation of SMAD protein signal transduction

11387212


check buttonFusion gene breakpoints across PAIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DAB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1506-01APAIP1chr5

43555932

-DAB2chr5

39375186

-
ChimerDB4OVTCGA-13-1506PAIP1chr5

43555931

-DAB2chr5

39375186

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000306846PAIP1chr543555932-ENST00000509337DAB2chr539375186-1144668233733166
ENST00000436644PAIP1chr543555932-ENST00000509337DAB2chr539375186-9214453305100
ENST00000338972PAIP1chr543555932-ENST00000339788DAB2chr539375186-234552611735679
ENST00000338972PAIP1chr543555932-ENST00000320816DAB2chr539375186-234552611735679
ENST00000338972PAIP1chr543555932-ENST00000545653DAB2chr539375186-234552611735679
ENST00000514514PAIP1chr543555932-ENST00000509337DAB2chr539375186-90542923149487
ENST00000306846PAIP1chr543555931-ENST00000509337DAB2chr539375186-1144668233733166
ENST00000436644PAIP1chr543555931-ENST00000509337DAB2chr539375186-9214453305100
ENST00000338972PAIP1chr543555931-ENST00000339788DAB2chr539375186-234552611735679
ENST00000338972PAIP1chr543555931-ENST00000320816DAB2chr539375186-234552611735679
ENST00000338972PAIP1chr543555931-ENST00000545653DAB2chr539375186-234552611735679
ENST00000514514PAIP1chr543555931-ENST00000509337DAB2chr539375186-90542923149487

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000306846ENST00000509337PAIP1chr543555932-DAB2chr539375186-0.09886490.9011351
ENST00000436644ENST00000509337PAIP1chr543555932-DAB2chr539375186-0.076541760.9234583
ENST00000338972ENST00000339788PAIP1chr543555932-DAB2chr539375186-0.83539140.1646086
ENST00000338972ENST00000320816PAIP1chr543555932-DAB2chr539375186-0.83539140.1646086
ENST00000338972ENST00000545653PAIP1chr543555932-DAB2chr539375186-0.83539140.1646086
ENST00000514514ENST00000509337PAIP1chr543555932-DAB2chr539375186-0.040216870.9597831
ENST00000306846ENST00000509337PAIP1chr543555931-DAB2chr539375186-0.09886490.9011351
ENST00000436644ENST00000509337PAIP1chr543555931-DAB2chr539375186-0.076541760.9234583
ENST00000338972ENST00000339788PAIP1chr543555931-DAB2chr539375186-0.83539140.1646086
ENST00000338972ENST00000320816PAIP1chr543555931-DAB2chr539375186-0.83539140.1646086
ENST00000338972ENST00000545653PAIP1chr543555931-DAB2chr539375186-0.83539140.1646086
ENST00000514514ENST00000509337PAIP1chr543555931-DAB2chr539375186-0.040216870.9597831

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>62379_62379_1_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000306846_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=166AA_BP=145
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQ

--------------------------------------------------------------

>62379_62379_2_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000338972_DAB2_chr5_39375186_ENST00000320816_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_3_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000338972_DAB2_chr5_39375186_ENST00000339788_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_4_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000338972_DAB2_chr5_39375186_ENST00000545653_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_5_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000436644_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=100AA_BP=
MGENWKAEGSRAGRALWSGGCSGCRPLRQKHRAAEPGPAALLLHEARVRRGGYSRPAAPSPRVLSRAQRQRPLEEEAEEEEHVGRFRSGP

--------------------------------------------------------------

>62379_62379_6_PAIP1-DAB2_PAIP1_chr5_43555931_ENST00000514514_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=87AA_BP=66

--------------------------------------------------------------

>62379_62379_7_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000306846_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=166AA_BP=145
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQ

--------------------------------------------------------------

>62379_62379_8_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000338972_DAB2_chr5_39375186_ENST00000320816_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_9_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000338972_DAB2_chr5_39375186_ENST00000339788_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_10_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000338972_DAB2_chr5_39375186_ENST00000545653_length(amino acids)=79AA_BP=

--------------------------------------------------------------

>62379_62379_11_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000436644_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=100AA_BP=
MGENWKAEGSRAGRALWSGGCSGCRPLRQKHRAAEPGPAALLLHEARVRRGGYSRPAAPSPRVLSRAQRQRPLEEEAEEEEHVGRFRSGP

--------------------------------------------------------------

>62379_62379_12_PAIP1-DAB2_PAIP1_chr5_43555932_ENST00000514514_DAB2_chr5_39375186_ENST00000509337_length(amino acids)=87AA_BP=66

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:43555932/chr5:39375186)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DAB2

Q5VWQ8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon (IFN) or lipopolysaccharide (LPS). Modulates the balance between phosphatidylinositol 3-kinase (PI3K)-AKT-mediated cell survival and apoptosis stimulated kinase (MAP3K5)-JNK signaling pathways; sequesters both AKT1 and MAP3K5 and counterbalances the activity of each kinase by modulating their phosphorylation status in response to proinflammatory stimuli. Acts as a regulator of the endoplasmic reticulum (ER) unfolded protein response (UPR) pathway; specifically involved in transduction of the ER stress-response to the JNK cascade through ERN1. Mediates TNF-alpha-induced apoptosis activation by facilitating dissociation of inhibitor 14-3-3 from MAP3K5; recruits the PP2A phosphatase complex which dephosphorylates MAP3K5 on 'Ser-966', leading to the dissociation of 13-3-3 proteins and activation of the MAP3K5-JNK signaling pathway in endothelial cells. Mediates also TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. Acts a negative regulator in the IFN-gamma-mediated JAK-STAT signaling cascade by inhibiting smooth muscle cell (VSMCs) proliferation and intimal expansion, and thus, prevents graft arteriosclerosis (GA). Acts as a GTPase-activating protein (GAP) for the ADP ribosylation factor 6 (ARF6) and Ras. Promotes hydrolysis of the ARF6-bound GTP and thus, negatively regulates phosphatidylinositol 4,5-bisphosphate (PIP2)-dependent TLR4-TIRAP-MyD88 and NF-kappa-B signaling pathways in endothelial cells in response to lipopolysaccharides (LPS). Binds specifically to phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 3-phosphate (PtdIns3P). In response to vascular endothelial growth factor (VEGFA), acts as a negative regulator of the VEGFR2-PI3K-mediated angiogenic signaling pathway by inhibiting endothelial cell migration and tube formation. In the developing brain, promotes both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex in a glial-dependent locomotion process. Probable downstream effector of the Reelin signaling pathway; promotes Purkinje cell (PC) dendrites development and formation of cerebellar synapses. Functions also as a tumor suppressor protein in prostate cancer progression; prevents cell proliferation and epithelial-to-mesenchymal transition (EMT) through activation of the glycogen synthase kinase-3 beta (GSK3B)-induced beta-catenin and inhibition of PI3K-AKT and Ras-MAPK survival downstream signaling cascades, respectively. {ECO:0000269|PubMed:12813029, ECO:0000269|PubMed:17389591, ECO:0000269|PubMed:18292600, ECO:0000269|PubMed:19033661, ECO:0000269|PubMed:19903888, ECO:0000269|PubMed:19948740, ECO:0000269|PubMed:20080667, ECO:0000269|PubMed:20154697, ECO:0000269|PubMed:21700930, ECO:0000269|PubMed:22696229}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAIP1chr5:43555931chr5:39375186ENST00000306846-21110_36145.0480.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000306846-21145_98145.0480.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000338972-21110_3633.0368.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000436644-21110_3666.0401.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000306846-21110_36145.0480.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000306846-21145_98145.0480.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000338972-21110_3633.0368.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000436644-21110_3666.0401.0Compositional biasNote=Gly-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000306846-211116_143145.0480.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgenePAIP1chr5:43555932chr5:39375186ENST00000306846-211116_143145.0480.0RegionNote=PABPC1-interacting motif-2 (PAM2)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePAIP1chr5:43555931chr5:39375186ENST00000338972-21145_9833.0368.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000436644-21145_9866.0401.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000338972-21145_9833.0368.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555932chr5:39375186ENST00000436644-21145_9866.0401.0Compositional biasNote=Pro-rich
HgenePAIP1chr5:43555931chr5:39375186ENST00000306846-211159_376145.0480.0DomainNote=MIF4G
HgenePAIP1chr5:43555931chr5:39375186ENST00000338972-211159_37633.0368.0DomainNote=MIF4G
HgenePAIP1chr5:43555931chr5:39375186ENST00000436644-211159_37666.0401.0DomainNote=MIF4G
HgenePAIP1chr5:43555932chr5:39375186ENST00000306846-211159_376145.0480.0DomainNote=MIF4G
HgenePAIP1chr5:43555932chr5:39375186ENST00000338972-211159_37633.0368.0DomainNote=MIF4G
HgenePAIP1chr5:43555932chr5:39375186ENST00000436644-211159_37666.0401.0DomainNote=MIF4G
HgenePAIP1chr5:43555931chr5:39375186ENST00000306846-211440_479145.0480.0RegionNote=PABPC1-interacting motif-1 (PAM1)
HgenePAIP1chr5:43555931chr5:39375186ENST00000338972-211116_14333.0368.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgenePAIP1chr5:43555931chr5:39375186ENST00000338972-211440_47933.0368.0RegionNote=PABPC1-interacting motif-1 (PAM1)
HgenePAIP1chr5:43555931chr5:39375186ENST00000436644-211116_14366.0401.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgenePAIP1chr5:43555931chr5:39375186ENST00000436644-211440_47966.0401.0RegionNote=PABPC1-interacting motif-1 (PAM1)
HgenePAIP1chr5:43555932chr5:39375186ENST00000306846-211440_479145.0480.0RegionNote=PABPC1-interacting motif-1 (PAM1)
HgenePAIP1chr5:43555932chr5:39375186ENST00000338972-211116_14333.0368.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgenePAIP1chr5:43555932chr5:39375186ENST00000338972-211440_47933.0368.0RegionNote=PABPC1-interacting motif-1 (PAM1)
HgenePAIP1chr5:43555932chr5:39375186ENST00000436644-211116_14366.0401.0RegionNote=PABPC1-interacting motif-2 (PAM2)
HgenePAIP1chr5:43555932chr5:39375186ENST00000436644-211440_47966.0401.0RegionNote=PABPC1-interacting motif-1 (PAM1)
TgeneDAB2chr5:43555931chr5:39375186ENST00000320816121545_196749.01191.0DomainPID
TgeneDAB2chr5:43555931chr5:39375186ENST00000339788111445_196531.01036.3333333333333DomainPID
TgeneDAB2chr5:43555931chr5:39375186ENST00000509337101345_196728.0805.0DomainPID
TgeneDAB2chr5:43555931chr5:39375186ENST00000545653111445_196728.01149.0DomainPID
TgeneDAB2chr5:43555932chr5:39375186ENST00000320816121545_196749.01191.0DomainPID
TgeneDAB2chr5:43555932chr5:39375186ENST00000339788111445_196531.01036.3333333333333DomainPID
TgeneDAB2chr5:43555932chr5:39375186ENST00000509337101345_196728.0805.0DomainPID
TgeneDAB2chr5:43555932chr5:39375186ENST00000545653111445_196728.01149.0DomainPID
TgeneDAB2chr5:43555931chr5:39375186ENST000003208161215293_295749.01191.0MotifNote=DPF 1
TgeneDAB2chr5:43555931chr5:39375186ENST000003208161215298_300749.01191.0MotifNote=DPF 2
TgeneDAB2chr5:43555931chr5:39375186ENST000003397881114293_295531.01036.3333333333333MotifNote=DPF 1
TgeneDAB2chr5:43555931chr5:39375186ENST000003397881114298_300531.01036.3333333333333MotifNote=DPF 2
TgeneDAB2chr5:43555931chr5:39375186ENST000005093371013293_295728.0805.0MotifNote=DPF 1
TgeneDAB2chr5:43555931chr5:39375186ENST000005093371013298_300728.0805.0MotifNote=DPF 2
TgeneDAB2chr5:43555931chr5:39375186ENST000005456531114293_295728.01149.0MotifNote=DPF 1
TgeneDAB2chr5:43555931chr5:39375186ENST000005456531114298_300728.01149.0MotifNote=DPF 2
TgeneDAB2chr5:43555932chr5:39375186ENST000003208161215293_295749.01191.0MotifNote=DPF 1
TgeneDAB2chr5:43555932chr5:39375186ENST000003208161215298_300749.01191.0MotifNote=DPF 2
TgeneDAB2chr5:43555932chr5:39375186ENST000003397881114293_295531.01036.3333333333333MotifNote=DPF 1
TgeneDAB2chr5:43555932chr5:39375186ENST000003397881114298_300531.01036.3333333333333MotifNote=DPF 2
TgeneDAB2chr5:43555932chr5:39375186ENST000005093371013293_295728.0805.0MotifNote=DPF 1
TgeneDAB2chr5:43555932chr5:39375186ENST000005093371013298_300728.0805.0MotifNote=DPF 2
TgeneDAB2chr5:43555932chr5:39375186ENST000005456531114293_295728.01149.0MotifNote=DPF 1
TgeneDAB2chr5:43555932chr5:39375186ENST000005456531114298_300728.01149.0MotifNote=DPF 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PAIP1
DAB2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PAIP1-DAB2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PAIP1-DAB2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource