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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PCSK5-RAB3IP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PCSK5-RAB3IP
FusionPDB ID: 63522
FusionGDB2.0 ID: 63522
HgeneTgene
Gene symbol

PCSK5

RAB3IP

Gene ID

5125

117177

Gene nameproprotein convertase subtilisin/kexin type 5RAB3A interacting protein
SynonymsPC5|PC6|PC6A|SPC6RABIN3|RABIN8
Cytomap

9q21.13

12q15

Type of geneprotein-codingprotein-coding
Descriptionproprotein convertase subtilisin/kexin type 5prohormone convertase 5proprotein convertase 6protease PC6subtilasesubtilisin/kexin-like protease PC5rab-3A-interacting proteinSSX2 interacting proteinrab3A-interacting proteinrabin-3
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000376752, ENST00000376767, 
ENST00000545128, 		ENST00000325555, 
ENST00000362025, ENST00000483530, 
ENST00000550536, ENST00000551641, 
ENST00000553099, ENST00000550847, 
ENST00000247833, ENST00000378815, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 8=64020 X 17 X 10=3400
# samples 1229
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/3400*10)=-3.55140994101013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PCSK5 [Title/Abstract] AND RAB3IP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PCSK5(78506289)-RAB3IP(70178500), # samples:2
Anticipated loss of major functional domain due to fusion event.PCSK5-RAB3IP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCSK5-RAB3IP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePCSK5

GO:0006465

signal peptide processing

16912035

HgenePCSK5

GO:0016485

protein processing

8901832|15606899

HgenePCSK5

GO:0016486

peptide hormone processing

8901832

HgenePCSK5

GO:0043043

peptide biosynthetic process

8901832

TgeneRAB3IP

GO:0006612

protein targeting to membrane

23382462


check buttonFusion gene breakpoints across PCSK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RAB3IP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BE-01APCSK5chr9

78506289

+RAB3IPchr12

70178500

+
ChimerDB4SARCTCGA-WK-A8Y0-01APCSK5chr9

78506289

+RAB3IPchr12

70178500

+
ChimerDB4SARCTCGA-WK-A8Y0-01APCSK5chr9

78506289

+RAB3IPchr12

70188217

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545128PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+35347304751602375
ENST00000545128PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+24117304751167230
ENST00000376767PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+35087044491576375
ENST00000376767PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+23857044491141230
ENST00000376752PCSK5chr978506289+ENST00000247833RAB3IPchr1270178500+34736694141541375
ENST00000376752PCSK5chr978506289+ENST00000378815RAB3IPchr1270178500+23506694141106230
ENST00000545128PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+34387304751506343
ENST00000545128PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+23157304751071198
ENST00000376767PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+34127044491480343
ENST00000376767PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+22897044491045198
ENST00000376752PCSK5chr978506289+ENST00000247833RAB3IPchr1270188217+33776694141445343
ENST00000376752PCSK5chr978506289+ENST00000378815RAB3IPchr1270188217+22546694141010198

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545128ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001653330.99983466
ENST00000545128ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.0176859520.982314
ENST00000376767ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001522170.99984777
ENST00000376767ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.014206810.9857932
ENST00000376752ENST00000247833PCSK5chr978506289+RAB3IPchr1270178500+0.0001427790.9998572
ENST00000376752ENST00000378815PCSK5chr978506289+RAB3IPchr1270178500+0.0126071410.98739284
ENST00000545128ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.000388430.99961156
ENST00000545128ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.096191950.9038081
ENST00000376767ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.000355860.99964416
ENST00000376767ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.077280780.9227192
ENST00000376752ENST00000247833PCSK5chr978506289+RAB3IPchr1270188217+0.0003331730.9996668
ENST00000376752ENST00000378815PCSK5chr978506289+RAB3IPchr1270188217+0.091782320.90821767

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63522_63522_1_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------

>63522_63522_2_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------

>63522_63522_3_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------

>63522_63522_4_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376752_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------

>63522_63522_5_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------

>63522_63522_6_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------

>63522_63522_7_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------

>63522_63522_8_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000376767_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------

>63522_63522_9_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000247833_length(amino acids)=375AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR

--------------------------------------------------------------

>63522_63522_10_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70178500_ENST00000378815_length(amino acids)=230AA_BP=80
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK

--------------------------------------------------------------

>63522_63522_11_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000247833_length(amino acids)=343AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEA
DLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSIEPVGLQPIRFVKASAVECGGPKKCALTGQSKS

--------------------------------------------------------------

>63522_63522_12_PCSK5-RAB3IP_PCSK5_chr9_78506289_ENST00000545128_RAB3IP_chr12_70188217_ENST00000378815_length(amino acids)=198AA_BP=84
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQEAHKM
VREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKKGHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:78506289/chr12:70178500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211812_185364.0914.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371812_185364.01861.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211812_185364.0914.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371812_185364.01861.0Compositional biasNote=Asp-rich
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121134_45364.0914.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121461_60164.0914.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121869_91364.0914.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137134_45364.01861.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137461_60164.01861.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137869_91364.01861.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121134_45364.0914.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121461_60164.0914.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121869_91364.0914.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137134_45364.01861.0DomainPeptidase S8
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137461_60164.01861.0DomainP/Homo B
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137869_91364.01861.0DomainNote=PLAC
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121519_52164.0914.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137519_52164.01861.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121519_52164.0914.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137519_52164.01861.0MotifCell attachment site
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211807_182664.0914.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211838_186064.0914.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121636_172764.0914.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371807_182664.01861.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371838_186064.01861.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137636_172764.01861.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211807_182664.0914.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211838_186064.0914.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121636_172764.0914.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371807_182664.01861.0RegionAC 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371838_186064.01861.0RegionAC 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137636_172764.01861.0RegionNote=CRM (Cys-rich motif)
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211032_107764.0914.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211079_112164.0914.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211125_116864.0914.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211177_122164.0914.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211225_127264.0914.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211274_131864.0914.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211320_136364.0914.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211365_141164.0914.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211415_146164.0914.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211465_151064.0914.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211514_155964.0914.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211563_161064.0914.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211614_165964.0914.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211665_171264.0914.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121630_68064.0914.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121683_73064.0914.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121734_77764.0914.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121779_82464.0914.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121832_87964.0914.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121882_92764.0914.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121929_97964.0914.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121982_102864.0914.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371032_107764.01861.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371079_112164.01861.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371125_116864.01861.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371177_122164.01861.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371225_127264.01861.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371274_131864.01861.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371320_136364.01861.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371365_141164.01861.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371415_146164.01861.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371465_151064.01861.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371514_155964.01861.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371563_161064.01861.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371614_165964.01861.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371665_171264.01861.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137630_68064.01861.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137683_73064.01861.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137734_77764.01861.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137779_82464.01861.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137832_87964.01861.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137882_92764.01861.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137929_97964.01861.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137982_102864.01861.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211032_107764.0914.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211079_112164.0914.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211125_116864.0914.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211177_122164.0914.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211225_127264.0914.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211274_131864.0914.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211320_136364.0914.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211365_141164.0914.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211415_146164.0914.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211465_151064.0914.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211514_155964.0914.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211563_161064.0914.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211614_165964.0914.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211665_171264.0914.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121630_68064.0914.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121683_73064.0914.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121734_77764.0914.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121779_82464.0914.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121832_87964.0914.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121882_92764.0914.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121929_97964.0914.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121982_102864.0914.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371032_107764.01861.0RepeatNote=FU 9
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371079_112164.01861.0RepeatNote=FU 10
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371125_116864.01861.0RepeatNote=FU 11
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371177_122164.01861.0RepeatNote=FU 12
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371225_127264.01861.0RepeatNote=FU 13
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371274_131864.01861.0RepeatNote=FU 14
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371320_136364.01861.0RepeatNote=FU 15
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371365_141164.01861.0RepeatNote=FU 16
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371415_146164.01861.0RepeatNote=FU 17
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371465_151064.01861.0RepeatNote=FU 18
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371514_155964.01861.0RepeatNote=FU 19
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371563_161064.01861.0RepeatNote=FU 20
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371614_165964.01861.0RepeatNote=FU 21
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371665_171264.01861.0RepeatNote=FU 22
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137630_68064.01861.0RepeatNote=FU 1
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137683_73064.01861.0RepeatNote=FU 2
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137734_77764.01861.0RepeatNote=FU 3
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137779_82464.01861.0RepeatNote=FU 4
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137832_87964.01861.0RepeatNote=FU 5
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137882_92764.01861.0RepeatNote=FU 6
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137929_97964.01861.0RepeatNote=FU 7
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137982_102864.01861.0RepeatNote=FU 8
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+121115_174364.0914.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211765_186064.0914.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+137115_174364.01861.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371765_186064.01861.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+121115_174364.0914.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211765_186064.0914.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+137115_174364.01861.0Topological domainExtracellular
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371765_186064.01861.0Topological domainCytoplasmic
HgenePCSK5chr9:78506289chr12:70178500ENST00000376752+1211744_176464.0914.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70178500ENST00000545128+1371744_176464.01861.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70188217ENST00000376752+1211744_176464.0914.0TransmembraneHelical
HgenePCSK5chr9:78506289chr12:70188217ENST00000545128+1371744_176464.01861.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>740_PCSK5_78506289_RAB3IP_70178500_ranked_0.pdbPCSK57850628978506289ENST00000378815RAB3IPchr1270178500+
MCAPLVRGTSQRAREQRGAGTMGWGSRCCCPGRLDLLCVLALLGGCLLPVCRTRVYTNHWAVKIAGGFPEANRIASKYGFINIGQELKLK
DEECERLSKVRDQLGQELEELTASLFEEAHKMVREANIKQATAEKQLKEAQGKIDVLQAEVAALKTLVLSSSPTSPTQEPLPGGKTPFKK
GHTRNKSTSSAMSGSHQDLSVIQPIVKDCKEADLSLYNEFRLWKDEPTMDRTCPFLDKIYQEDIFPCLTFSKSELASAVLEAVENNTLSI
EPVGLQPIRFVKASAVECGGPKKCALTGQSKSCKHRIKLGDSSNYYYISPFCRYRITSVCNFFTYIRYIQQGLVKQQDVDQMFWEVMQLR
375


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PCSK5_pLDDT.png
all structure
all structure
RAB3IP_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PCSK5
RAB3IP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PCSK5-RAB3IP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PCSK5-RAB3IP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource