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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PDGFB-DGCR2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PDGFB-DGCR2
	FusionPDB ID: 63834
	FusionGDB2.0 ID: 63834
		Hgene	Tgene
	Gene symbol	PDGFB	DGCR2
	Gene ID	5155	9993
	Gene name	platelet derived growth factor subunit B	DiGeorge syndrome critical region gene 2
	Synonyms	IBGC5\|PDGF-2\|PDGF2\|SIS\|SSV\|c-sis	DGS-C\|IDD\|LAN\|SEZ-12
	Cytomap	22q13.1	22q11.21
	Type of gene	protein-coding	protein-coding
	Description	platelet-derived growth factor subunit BPDGF subunit BPDGF, B chainbecaplerminepididymis secretory sperm binding proteinplatelet-derived growth factor 2platelet-derived growth factor B chainplatelet-derived growth factor beta polypeptide (simian sa	integral membrane protein DGCR2/IDDDiGeorge syndrome critical region protein 2integral membrane protein deleted in DiGeorge syndrome
	Modification date	20200313	20200313
	UniProtAcc	P01127	P98153
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000331163, ENST00000381551,	ENST00000263196, ENST00000473832, ENST00000537045, ENST00000545799,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 5 X 3=60	10 X 10 X 5=500
	# samples	5	11
	** MAII score	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PDGFB [Title/Abstract] AND DGCR2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PDGFB(39626089)-DGCR2(19077003), # samples:3
Anticipated loss of major functional domain due to fusion event.	PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PDGFB-DGCR2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. PDGFB-DGCR2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PDGFB	GO:0001938	positive regulation of endothelial cell proliferation	9685360
Hgene	PDGFB	GO:0002548	monocyte chemotaxis	17991872
Hgene	PDGFB	GO:0006468	protein phosphorylation	17942966
Hgene	PDGFB	GO:0008284	positive regulation of cell proliferation	2439522\|2836953\|7073684
Hgene	PDGFB	GO:0009611	response to wounding	2538439
Hgene	PDGFB	GO:0010512	negative regulation of phosphatidylinositol biosynthetic process	2538439
Hgene	PDGFB	GO:0010544	negative regulation of platelet activation	2538439
Hgene	PDGFB	GO:0010628	positive regulation of gene expression	23554459\|24008408
Hgene	PDGFB	GO:0010629	negative regulation of gene expression	23554459\|25089138
Hgene	PDGFB	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	10734101\|11788434\|17942966
Hgene	PDGFB	GO:0014911	positive regulation of smooth muscle cell migration	9409235
Hgene	PDGFB	GO:0018105	peptidyl-serine phosphorylation	16530387
Hgene	PDGFB	GO:0018108	peptidyl-tyrosine phosphorylation	10734101\|16530387
Hgene	PDGFB	GO:0030335	positive regulation of cell migration	11788434\|21245381
Hgene	PDGFB	GO:0031954	positive regulation of protein autophosphorylation	12070119\|16530387
Hgene	PDGFB	GO:0032091	negative regulation of protein binding	22619279
Hgene	PDGFB	GO:0032147	activation of protein kinase activity	16530387
Hgene	PDGFB	GO:0032148	activation of protein kinase B activity	16530387
Hgene	PDGFB	GO:0035655	interleukin-18-mediated signaling pathway	21321938
Hgene	PDGFB	GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	19019919
Hgene	PDGFB	GO:0043406	positive regulation of MAP kinase activity	9685360\|11788434\|16530387\|17942966
Hgene	PDGFB	GO:0043536	positive regulation of blood vessel endothelial cell migration	9685360
Hgene	PDGFB	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	16530387
Hgene	PDGFB	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	16530387
Hgene	PDGFB	GO:0045840	positive regulation of mitotic nuclear division	10644978\|10734101\|17942966
Hgene	PDGFB	GO:0045892	negative regulation of transcription, DNA-templated	16530387\|25089138
Hgene	PDGFB	GO:0045893	positive regulation of transcription, DNA-templated	16530387\|17324121
Hgene	PDGFB	GO:0048008	platelet-derived growth factor receptor signaling pathway	2439522\|2536956\|2836953\|19088079\|21245381\|23554459
Hgene	PDGFB	GO:0048146	positive regulation of fibroblast proliferation	2439522\|10644978\|17324121
Hgene	PDGFB	GO:0048661	positive regulation of smooth muscle cell proliferation	21321938
Hgene	PDGFB	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	21245381
Hgene	PDGFB	GO:0050921	positive regulation of chemotaxis	9409235\|19019919
Hgene	PDGFB	GO:0060326	cell chemotaxis	16014047\|17991872\|21245381
Hgene	PDGFB	GO:0061098	positive regulation of protein tyrosine kinase activity	16530387
Hgene	PDGFB	GO:0070374	positive regulation of ERK1 and ERK2 cascade	11788434\|16530387\|17942966
Hgene	PDGFB	GO:0071363	cellular response to growth factor stimulus	21245381
Hgene	PDGFB	GO:0072126	positive regulation of glomerular mesangial cell proliferation	11788434\|16014047
Hgene	PDGFB	GO:0090280	positive regulation of calcium ion import	19019919
Hgene	PDGFB	GO:1900127	positive regulation of hyaluronan biosynthetic process	17324121
Hgene	PDGFB	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	26493107
Hgene	PDGFB	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	19088079
Hgene	PDGFB	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	12070119\|19088079\|23554459
Hgene	PDGFB	GO:1904754	positive regulation of vascular associated smooth muscle cell migration	12070119\|19088079\|23554459
Hgene	PDGFB	GO:1905064	negative regulation of vascular smooth muscle cell differentiation	19088079
Hgene	PDGFB	GO:1905176	positive regulation of vascular smooth muscle cell dedifferentiation	19088079
Hgene	PDGFB	GO:2000379	positive regulation of reactive oxygen species metabolic process	19019919
Hgene	PDGFB	GO:2000573	positive regulation of DNA biosynthetic process	10644978\|10734101\|11788434\|12070119\|16530387\|17942966\|19019919
Hgene	PDGFB	GO:2000591	positive regulation of metanephric mesenchymal cell migration	10734101

Fusion gene breakpoints across PDGFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DGCR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-TM-A84J-01A	PDGFB	chr22	39626088	-	DGCR2	chr22	19055737	-
ChimerDB4	LGG	TCGA-TM-A84J-01A	PDGFB	chr22	39626088	-	DGCR2	chr22	19077002	-
ChimerDB4	LGG	TCGA-TM-A84J-01A	PDGFB	chr22	39626089	-	DGCR2	chr22	19077003	-
ChimerDB4	LGG	TCGA-TM-A84J	PDGFB	chr22	39626088	-	DGCR2	chr22	19055738	-
ChimerDB4	LGG	TCGA-TM-A84J	PDGFB	chr22	39626088	-	DGCR2	chr22	19077003	-
ChimerDB4	LGG	TCGA-TM-A84J	PDGFB	chr22	39626089	-	DGCR2	chr22	19077003	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000331163	PDGFB	chr22	39626088	-	ENST00000545799	DGCR2	chr22	19055738	-	5798	1389	1831	473	452
ENST00000381551	PDGFB	chr22	39626088	-	ENST00000545799	DGCR2	chr22	19055738	-	5002	593	19	1200	393
ENST00000331163	PDGFB	chr22	39626088	-	ENST00000545799	DGCR2	chr22	19055737	-	5798	1389	1831	473	452
ENST00000381551	PDGFB	chr22	39626088	-	ENST00000545799	DGCR2	chr22	19055737	-	5002	593	19	1200	393

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000331163	ENST00000545799	PDGFB	chr22	39626088	-	DGCR2	chr22	19055738	-	0.14309576	0.8569042
ENST00000381551	ENST00000545799	PDGFB	chr22	39626088	-	DGCR2	chr22	19055738	-	0.14971963	0.8502804
ENST00000331163	ENST00000545799	PDGFB	chr22	39626088	-	DGCR2	chr22	19055737	-	0.14309576	0.8569042
ENST00000381551	ENST00000545799	PDGFB	chr22	39626088	-	DGCR2	chr22	19055737	-	0.14971963	0.8502804

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63834_63834_1_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055737_ENST00000545799_length(amino acids)=452AA_BP=0
MYHGITHTPIFECHLPATFQGAVPASDNILIANPQLALVLPTKAPLGLVPFLGQDKAQLLVSGEGGERAIQALAGLRGIPVVLPAQVDPV
AAGRAFVVVPPCRALPAEANGLRHVHRVEVRRVASSGPPLPRIHSLLPMMRTHLPGHFSLLLGTPRASGHRPCSCHCLTLACQVVFQRHR
GLLKDWLLPHNLDLSHLDRSQLHLGGAALHVAVVAAAGAALHLHTGRPHQEVGVGAVYEAPGDLEHLGARLALGDHGRLSNGQGTQAPSS
TSQALQLASRVGAGHVQVQLGPIFLSGVSVQQALEIIKGADRVVTQHLIKLLGNGVPLGADQTQVAAERQEERPAAIHADSGPGPAGPRT
RRSSAPPPRPGWGAGEGGGLGSGPRRSGAQASAAAAHPHGPRAPPPPAPAPSLGGRGGPGRRTWVRGRYLGGSRARVSIHGRGAASRTSR

--------------------------------------------------------------

>63834_63834_2_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000331163_DGCR2_chr22_19055738_ENST00000545799_length(amino acids)=452AA_BP=0
MYHGITHTPIFECHLPATFQGAVPASDNILIANPQLALVLPTKAPLGLVPFLGQDKAQLLVSGEGGERAIQALAGLRGIPVVLPAQVDPV
AAGRAFVVVPPCRALPAEANGLRHVHRVEVRRVASSGPPLPRIHSLLPMMRTHLPGHFSLLLGTPRASGHRPCSCHCLTLACQVVFQRHR
GLLKDWLLPHNLDLSHLDRSQLHLGGAALHVAVVAAAGAALHLHTGRPHQEVGVGAVYEAPGDLEHLGARLALGDHGRLSNGQGTQAPSS
TSQALQLASRVGAGHVQVQLGPIFLSGVSVQQALEIIKGADRVVTQHLIKLLGNGVPLGADQTQVAAERQEERPAAIHADSGPGPAGPRT
RRSSAPPPRPGWGAGEGGGLGSGPRRSGAQASAAAAHPHGPRAPPPPAPAPSLGGRGGPGRRTWVRGRYLGGSRARVSIHGRGAASRTSR

--------------------------------------------------------------

>63834_63834_3_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055737_ENST00000545799_length(amino acids)=393AA_BP=191
MSRNGEMFIMGLGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKT
RTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPV
TRSPGGSQEQREVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLN
GSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKDWGVSDTMVHRRLLCPCVGTLHTHLKLGARF

--------------------------------------------------------------

>63834_63834_4_PDGFB-DGCR2_PDGFB_chr22_39626088_ENST00000381551_DGCR2_chr22_19055738_ENST00000545799_length(amino acids)=393AA_BP=191
MSRNGEMFIMGLGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKT
RTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPV
TRSPGGSQEQREVTGEVRPHHGKEAVDPRQGRARGGDPSHFHAVNVAQPVRFSRKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLN
GSLATFSTDQELRFVLAQEWDQPERSFGWKDQRKLWVGYQYVITGRNRSLEGRWEVAFKDWGVSDTMVHRRLLCPCVGTLHTHLKLGARF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:39626089/chr22:19077003)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
PDGFB P01127	DGCR2 P98153
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250\|UniProtKB:P31240, ECO:0000269\|PubMed:26599395}.	FUNCTION: Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

115_241

67.33333333333333

551.0

Domain

C-type lectin

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

270_333

67.33333333333333

551.0

Domain

Note=VWFC

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

115_241

26.333333333333332

510.0

Domain

C-type lectin

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

270_333

26.333333333333332

510.0

Domain

Note=VWFC

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

28_68

26.333333333333332

510.0

Domain

LDL-receptor class A

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

115_241

67.33333333333333

551.0

Domain

C-type lectin

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

270_333

67.33333333333333

551.0

Domain

Note=VWFC

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

115_241

26.333333333333332

510.0

Domain

C-type lectin

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

270_333

26.333333333333332

510.0

Domain

Note=VWFC

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

28_68

26.333333333333332

510.0

Domain

LDL-receptor class A

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

369_550

67.33333333333333

551.0

Topological domain

Cytoplasmic

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

369_550

26.333333333333332

510.0

Topological domain

Cytoplasmic

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

369_550

67.33333333333333

551.0

Topological domain

Cytoplasmic

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

369_550

26.333333333333332

510.0

Topological domain

Cytoplasmic

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

350_368

67.33333333333333

551.0

Transmembrane

Helical

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

350_368

26.333333333333332

510.0

Transmembrane

Helical

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

350_368

67.33333333333333

551.0

Transmembrane

Helical

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

350_368

26.333333333333332

510.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

28_68

67.33333333333333

551.0

Domain

LDL-receptor class A

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

28_68

67.33333333333333

551.0

Domain

LDL-receptor class A

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000263196

21_349

67.33333333333333

551.0

Topological domain

Extracellular

Tgene

DGCR2

chr22:39626088

chr22:19055737

ENST00000537045

21_349

26.333333333333332

510.0

Topological domain

Extracellular

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000263196

21_349

67.33333333333333

551.0

Topological domain

Extracellular

Tgene

DGCR2

chr22:39626088

chr22:19055738

ENST00000537045

21_349

26.333333333333332

510.0

Topological domain

Extracellular

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PDGFB
DGCR2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to PDGFB-DGCR2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to PDGFB-DGCR2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	PDGFB	C3809645	BASAL GANGLIA CALCIFICATION, IDIOPATHIC, 5	5	CTD_human;GENOMICS_ENGLAND;UNIPROT
Hgene	PDGFB	C0393590	Fahr's syndrome (disorder)	3	GENOMICS_ENGLAND;ORPHANET
Hgene	PDGFB	C0004782	Basal Ganglia Diseases	1	CTD_human
Hgene	PDGFB	C0006663	Calcinosis	1	CTD_human
Hgene	PDGFB	C0015371	Extrapyramidal Disorders	1	CTD_human
Hgene	PDGFB	C0016059	Fibrosis	1	CTD_human
Hgene	PDGFB	C0017566	Gingival Hyperplasia	1	CTD_human
Hgene	PDGFB	C0025286	Meningioma	1	ORPHANET
Hgene	PDGFB	C0034069	Pulmonary Fibrosis	1	CTD_human
Hgene	PDGFB	C0035309	Retinal Diseases	1	CTD_human
Hgene	PDGFB	C0040028	Thrombocythemia, Essential	1	CTD_human
Hgene	PDGFB	C0263628	Tumoral calcinosis	1	CTD_human
Hgene	PDGFB	C0521174	Microcalcification	1	CTD_human
Hgene	PDGFB	C0750951	Lenticulostriate Disorders	1	CTD_human
Hgene	PDGFB	C1623038	Cirrhosis	1	CTD_human
Hgene	PDGFB	C2239176	Liver carcinoma	1	CTD_human
Hgene	PDGFB	C3489628	Thrombocytosis, Autosomal Dominant	1	CTD_human
Hgene	PDGFB	C4551624	Idiopathic basal ganglia calcification 1	1	CTD_human
Hgene	PDGFB	C4721507	Alveolitis, Fibrosing	1	CTD_human