UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ARID3A-MORC2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ARID3A-MORC2
	FusionPDB ID: 6448
	FusionGDB2.0 ID: 6448
		Hgene	Tgene
	Gene symbol	ARID3A	MORC2
	Gene ID	1820	22880
	Gene name	AT-rich interaction domain 3A	MORC family CW-type zinc finger 2
	Synonyms	BRIGHT\|DRIL1\|DRIL3\|E2FBP1	CMT2Z\|ZCW3\|ZCWCC1
	Cytomap	19p13.3	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	AT-rich interactive domain-containing protein 3AARID domain-containing 3AARID domain-containing protein 3AAT rich interactive domain 3A (BRIGHT- like) proteinAT rich interactive domain 3A (BRIGHT-like)B-cell regulator of IgH transcriptionE2F-binding	ATPase MORC2zinc finger CW-type coiled-coil domain protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q99856	Q9Y6X9
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263620, ENST00000592216,	ENST00000469915, ENST00000215862, ENST00000397641,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 6 X 6=252	5 X 5 X 5=125
	# samples	8	5
	** MAII score	log2(8/252*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ARID3A [Title/Abstract] AND MORC2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ARID3A(929896)-MORC2(31328756), # samples:4
Anticipated loss of major functional domain due to fusion event.	ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARID3A-MORC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MORC2	GO:0006338	chromatin remodeling	23260667
Tgene	MORC2	GO:0006974	cellular response to DNA damage stimulus	23260667
Tgene	MORC2	GO:0045814	negative regulation of gene expression, epigenetic	28581500\|29211708
Tgene	MORC2	GO:0090309	positive regulation of methylation-dependent chromatin silencing	28581500\|29211708

Fusion gene breakpoints across ARID3A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MORC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-EY-A2ON-01A	ARID3A	chr19	929895	+	MORC2	chr22	31328755	-
ChimerDB4	UCEC	TCGA-EY-A2ON-01A	ARID3A	chr19	929896	-	MORC2	chr22	31328756	-
ChimerDB4	UCEC	TCGA-EY-A2ON-01A	ARID3A	chr19	929896	+	MORC2	chr22	31328756	-
ChimerDB4	UCEC	TCGA-EY-A2ON	ARID3A	chr19	929896	+	MORC2	chr22	31328756	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263620	ARID3A	chr19	929896	+	ENST00000397641	MORC2	chr22	31328756	-	2945	695	186	1271	361
ENST00000263620	ARID3A	chr19	929896	+	ENST00000215862	MORC2	chr22	31328756	-	1464	695	186	1271	361
ENST00000263620	ARID3A	chr19	929895	+	ENST00000397641	MORC2	chr22	31328755	-	2945	695	186	1271	361
ENST00000263620	ARID3A	chr19	929895	+	ENST00000215862	MORC2	chr22	31328755	-	1464	695	186	1271	361

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263620	ENST00000397641	ARID3A	chr19	929896	+	MORC2	chr22	31328756	-	0.001437452	0.9985625
ENST00000263620	ENST00000215862	ARID3A	chr19	929896	+	MORC2	chr22	31328756	-	0.003753719	0.9962463
ENST00000263620	ENST00000397641	ARID3A	chr19	929895	+	MORC2	chr22	31328755	-	0.001437452	0.9985625
ENST00000263620	ENST00000215862	ARID3A	chr19	929895	+	MORC2	chr22	31328755	-	0.003753719	0.9962463

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6448_6448_1_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000215862_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG

--------------------------------------------------------------

>6448_6448_2_ARID3A-MORC2_ARID3A_chr19_929895_ENST00000263620_MORC2_chr22_31328755_ENST00000397641_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG

--------------------------------------------------------------

>6448_6448_3_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000215862_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG

--------------------------------------------------------------

>6448_6448_4_ARID3A-MORC2_ARID3A_chr19_929896_ENST00000263620_MORC2_chr22_31328756_ENST00000397641_length(amino acids)=361AA_BP=170
MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP
DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL
MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE
LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:929896/chr22:31328756)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARID3A Q99856	MORC2 Q9Y6X9
FUNCTION: Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation. {ECO:0000269\|PubMed:11812999, ECO:0000269\|PubMed:12692263}.	FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269\|PubMed:20110259, ECO:0000269\|PubMed:20225202, ECO:0000269\|PubMed:23260667, ECO:0000269\|PubMed:24286864, ECO:0000269\|PubMed:28581500, ECO:0000269\|PubMed:29211708, ECO:0000269\|PubMed:29440755}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

67_70

122.66666666666667

594.0

Compositional bias

Note=Poly-Ala

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

67_70

122.66666666666667

594.0

Compositional bias

Note=Poly-Ala

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

966_1016

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

966_1016

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

966_1016

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

966_1016

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

424_445

122.66666666666667

594.0

Compositional bias

Note=Ala-rich

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

550_579

122.66666666666667

594.0

Compositional bias

Note=Gly-rich

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

89_157

122.66666666666667

594.0

Compositional bias

Note=Glu-rich

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

424_445

122.66666666666667

594.0

Compositional bias

Note=Ala-rich

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

550_579

122.66666666666667

594.0

Compositional bias

Note=Gly-rich

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

89_157

122.66666666666667

594.0

Compositional bias

Note=Glu-rich

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

238_330

122.66666666666667

594.0

Domain

ARID

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

444_541

122.66666666666667

594.0

Domain

REKLES

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

238_330

122.66666666666667

594.0

Domain

ARID

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

444_541

122.66666666666667

594.0

Domain

REKLES

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

119_156

122.66666666666667

594.0

Region

Note=Acidic

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

445_488

122.66666666666667

594.0

Region

Important for nuclear localization

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

490_513

122.66666666666667

594.0

Region

Note=Homodimerization

Hgene

ARID3A

chr19:929895

chr22:31328755

ENST00000263620

537_557

122.66666666666667

594.0

Region

Important for cytoplasmic localization

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

119_156

122.66666666666667

594.0

Region

Note=Acidic

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

445_488

122.66666666666667

594.0

Region

Important for nuclear localization

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

490_513

122.66666666666667

594.0

Region

Note=Homodimerization

Hgene

ARID3A

chr19:929896

chr22:31328756

ENST00000263620

537_557

122.66666666666667

594.0

Region

Important for cytoplasmic localization

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

282_362

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

547_584

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

741_761

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

282_362

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

547_584

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

741_761

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

282_362

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

547_584

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

741_761

778.6666666666666

971.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

282_362

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

547_584

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

741_761

840.6666666666666

1033.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

87_89

778.6666666666666

971.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

99_105

778.6666666666666

971.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

87_89

840.6666666666666

1033.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

99_105

840.6666666666666

1033.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

87_89

778.6666666666666

971.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

99_105

778.6666666666666

971.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

87_89

840.6666666666666

1033.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

99_105

840.6666666666666

1033.0

Nucleotide binding

ATP

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000215862

490_544

778.6666666666666

971.0

Zinc finger

CW-type

Tgene

MORC2

chr19:929895

chr22:31328755

ENST00000397641

490_544

840.6666666666666

1033.0

Zinc finger

CW-type

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000215862

490_544

778.6666666666666

971.0

Zinc finger

CW-type

Tgene

MORC2

chr19:929896

chr22:31328756

ENST00000397641

490_544

840.6666666666666

1033.0

Zinc finger

CW-type

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>710_ARID3A_929896_MORC2_31328756_ranked_0.pdb	ARID3A	929895	929896	ENST00000215862	MORC2	chr22	31328756	-	MHCPGSPAAPTLQCGRAPSPQGPPPPPTPSARGGGGGGGGGGPGRRAMKLQAVMETLLQRQQRARQELEARQQLPPDPPAAPPGRARAAP DEDREPESARMQRAQMAALAAMRAAAAGLGHPASPGGSEDGPPGSEEEDAAREGTPGSPGRGREGPGEEHFEDMASDEDMVEKGSEDVRL MKPPSPEHQSLDTQQEGGEEEVGPVAQQAIAVAEPSTSECLRIEPDTTALSTNHETIDLLVQILRNCLRYFLPPSFPISKKQLSAMNSDE LISFPLKEYFKQYEVGLQNLCNSYQSRADSRAKASEESLRTSERKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKG	361

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ARID3A_pLDDT.png

MORC2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ARID3A
MORC2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ARID3A-MORC2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ARID3A-MORC2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source