UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:PLEKHM2-IGF2BP2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: PLEKHM2-IGF2BP2
	FusionPDB ID: 66318
	FusionGDB2.0 ID: 66318
		Hgene	Tgene
	Gene symbol	PLEKHM2	IGF2BP2
	Gene ID	23207	10644
	Gene name	pleckstrin homology and RUN domain containing M2	insulin like growth factor 2 mRNA binding protein 2
	Synonyms	SKIP	IMP-2\|IMP2\|VICKZ2
	Cytomap	1p36.21	3q27.2
	Type of gene	protein-coding	protein-coding
	Description	pleckstrin homology domain-containing family M member 2PH domain-containing family M member 2SifA (Salmonella-induced filaments A) and kinesin-interacting proteinnovel RUN and PH domain-containing proteinpleckstrin homology domain containing, family M	insulin-like growth factor 2 mRNA-binding protein 2IGF-II mRNA-binding protein 2IGF2 mRNA-binding protein 2VICKZ family member 2
	Modification date	20200313	20200313
	UniProtAcc	.	Q9Y6M1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000375793, ENST00000375799, ENST00000477849,	ENST00000494906, ENST00000346192, ENST00000382199, ENST00000421047, ENST00000457616,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 6=378	7 X 7 X 4=196
	# samples	9	7
	** MAII score	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: PLEKHM2 [Title/Abstract] AND IGF2BP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	PLEKHM2(16046415)-IGF2BP2(185410550), # samples:5
Anticipated loss of major functional domain due to fusion event.	PLEKHM2-IGF2BP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHM2-IGF2BP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHM2-IGF2BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. PLEKHM2-IGF2BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	PLEKHM2	GO:1903527	positive regulation of membrane tubulation	18996344

Fusion gene breakpoints across PLEKHM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IGF2BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-R6-A6Y2-01B	PLEKHM2	chr1	16046415	-	IGF2BP2	chr3	185410550	-
ChimerDB4	ESCA	TCGA-R6-A6Y2-01B	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-
ChimerDB4	ESCA	TCGA-R6-A6Y2	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375799	PLEKHM2	chr1	16046415	+	ENST00000382199	IGF2BP2	chr3	185410550	-	4131	879	137	2338	733
ENST00000375799	PLEKHM2	chr1	16046415	+	ENST00000421047	IGF2BP2	chr3	185410550	-	4068	879	137	1081	314
ENST00000375799	PLEKHM2	chr1	16046415	+	ENST00000457616	IGF2BP2	chr3	185410550	-	3895	879	137	1081	314
ENST00000375799	PLEKHM2	chr1	16046415	+	ENST00000346192	IGF2BP2	chr3	185410550	-	3766	879	137	2209	690
ENST00000375793	PLEKHM2	chr1	16046415	+	ENST00000382199	IGF2BP2	chr3	185410550	-	4073	821	79	2280	733
ENST00000375793	PLEKHM2	chr1	16046415	+	ENST00000421047	IGF2BP2	chr3	185410550	-	4010	821	79	1023	314
ENST00000375793	PLEKHM2	chr1	16046415	+	ENST00000457616	IGF2BP2	chr3	185410550	-	3837	821	79	1023	314
ENST00000375793	PLEKHM2	chr1	16046415	+	ENST00000346192	IGF2BP2	chr3	185410550	-	3708	821	79	2151	690

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375799	ENST00000382199	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.002989434	0.9970106
ENST00000375799	ENST00000421047	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.003513132	0.9964869
ENST00000375799	ENST00000457616	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.00444739	0.9955526
ENST00000375799	ENST00000346192	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.004740981	0.995259
ENST00000375793	ENST00000382199	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.00312896	0.99687105
ENST00000375793	ENST00000421047	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.00348256	0.9965174
ENST00000375793	ENST00000457616	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.004348695	0.9956513
ENST00000375793	ENST00000346192	PLEKHM2	chr1	16046415	+	IGF2BP2	chr3	185410550	-	0.004816753	0.9951833

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>66318_66318_1_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000346192_length(amino acids)=690AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH
IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLT

--------------------------------------------------------------

>66318_66318_2_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000382199_length(amino acids)=733AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYF
SSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKL
KEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQE

--------------------------------------------------------------

>66318_66318_3_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000421047_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------

>66318_66318_4_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375793_IGF2BP2_chr3_185410550_ENST00000457616_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------

>66318_66318_5_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000346192_length(amino acids)=690AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNTHSGYFSSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAH
IKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLT

--------------------------------------------------------------

>66318_66318_6_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000382199_length(amino acids)=733AA_BP=245
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEVNTDTETAVVNVTYATREEAKIA
MEKLSGHQFENYSFKISYIPDEEVSSPSPPQRAQRGDHSSREQGHAPGGTSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSR
VDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEIPLKILAHNGLVGRLIGKEGRNLKKIEHETGTKITISSLQDL
SIYNPERTITVKGTVEACASAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLSPPAGPRGAPPAAPYHPFTTHSGYF
SSLYPHHQFGPFPHHHSYPEQEIVNLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKL
KEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQE

--------------------------------------------------------------

>66318_66318_7_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000421047_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------

>66318_66318_8_PLEKHM2-IGF2BP2_PLEKHM2_chr1_16046415_ENST00000375799_IGF2BP2_chr3_185410550_ENST00000457616_length(amino acids)=314AA_BP=
MAAAPGPRRGKRRRGGGGGGGGGGGDGGSAMEPGEVKDRILENISLSVKKLQSYFAACEDEIPAIRNHDKVLQRLCEHLDHALLYGLQDL
SSGYWVLVVHFTRREAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALVCSHDHLTLFLTLVSGLEFIR
FELDLDAPYLDLAPYMPDYYKPQYLLDFEDRLPSSVHGSDSLSLNSFNSVTSTNLEWDDSAIAPSSEDCTAQDQGNCTTGEAAGAEIPSG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16046415/chr3:185410550)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IGF2BP2 Q9Y6M1
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts. {ECO:0000250, ECO:0000269\|PubMed:23640942, ECO:0000269\|PubMed:9891060}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

36_158

217.33333333333334

1020.0

Domain

RUN

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

193_258

113.33333333333333

557.0

Domain

KH 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

274_341

113.33333333333333

557.0

Domain

KH 2

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

427_492

113.33333333333333

557.0

Domain

KH 3

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

509_575

113.33333333333333

557.0

Domain

KH 4

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

193_258

113.33333333333333

600.0

Domain

KH 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

274_341

113.33333333333333

600.0

Domain

KH 2

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

427_492

113.33333333333333

600.0

Domain

KH 3

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

509_575

113.33333333333333

600.0

Domain

KH 4

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

193_258

0.0

543.0

Domain

KH 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

274_341

0.0

543.0

Domain

KH 2

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

3_76

0.0

543.0

Domain

RRM 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

427_492

0.0

543.0

Domain

KH 3

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

509_575

0.0

543.0

Domain

KH 4

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000421047

82_157

0.0

543.0

Domain

RRM 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

317_320

217.33333333333334

1020.0

Compositional bias

Note=Poly-Lys

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

323_326

217.33333333333334

1020.0

Compositional bias

Note=Poly-Lys

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

506_511

217.33333333333334

1020.0

Compositional bias

Note=Poly-Gly

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

593_596

217.33333333333334

1020.0

Compositional bias

Note=Poly-Leu

Hgene

PLEKHM2

chr1:16046415

chr3:185410550

ENST00000375799

771_873

217.33333333333334

1020.0

Domain

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

3_76

113.33333333333333

557.0

Domain

RRM 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000346192

82_157

113.33333333333333

557.0

Domain

RRM 2

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

3_76

113.33333333333333

600.0

Domain

RRM 1

Tgene

IGF2BP2

chr1:16046415

chr3:185410550

ENST00000382199

82_157

113.33333333333333

600.0

Domain

RRM 2

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

PLEKHM2_pLDDT.png

IGF2BP2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
PLEKHM2
IGF2BP2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	PLEKHM2	chr1:16046415	chr3:185410550	ENST00000375799	+	6	20	1_310	217.33333333333334	1020.0	KIF5B
Hgene	PLEKHM2	chr1:16046415	chr3:185410550	ENST00000375799	+	6	20	762_885	217.33333333333334	1020.0	sifA

Top

Related Drugs to PLEKHM2-IGF2BP2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to PLEKHM2-IGF2BP2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source