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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PPARG-CRYBA4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PPARG-CRYBA4
FusionPDB ID: 67349
FusionGDB2.0 ID: 67349
HgeneTgene
Gene symbol

PPARG

CRYBA4

Gene ID

5468

1413

Gene nameperoxisome proliferator activated receptor gammacrystallin beta A4
SynonymsCIMT1|GLM1|NR1C3|PPARG1|PPARG2|PPARgammaCTRCT23|CYRBA4|MCOPCT4
Cytomap

3p25.2

22q12.1

Type of geneprotein-codingprotein-coding
Descriptionperoxisome proliferator-activated receptor gammaPPAR-gammanuclear receptor subfamily 1 group C member 3peroxisome proliferator-activated nuclear receptor gamma variant 1beta-crystallin A4beta crystallin A4 chain transcript PSbeta crystallin alpha 4 chainbeta-A4 crystallincrystallin, beta polypeptide A4eye lens structural protein
Modification date2020032920200328
UniProtAcc

P37231

P53673

Ensembl transtripts involved in fusion geneENST idsENST00000287820, ENST00000309576, 
ENST00000397000, ENST00000397010, 
ENST00000397012, ENST00000397015, 
ENST00000397026, ENST00000539812, 
ENST00000466315, ENST00000354760, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 9 X 5=3153 X 3 X 3=27
# samples 133
** MAII scorelog2(13/315*10)=-1.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PPARG [Title/Abstract] AND CRYBA4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PPARG(12422990)-CRYBA4(27019198), # samples:1
Anticipated loss of major functional domain due to fusion event.PPARG-CRYBA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARG-CRYBA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARG-CRYBA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PPARG-CRYBA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPARG

GO:0000122

negative regulation of transcription by RNA polymerase II

12700342

HgenePPARG

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

18293083

HgenePPARG

GO:0007165

signal transduction

9568716

HgenePPARG

GO:0010742

macrophage derived foam cell differentiation

26504087

HgenePPARG

GO:0010745

negative regulation of macrophage derived foam cell differentiation

19114110

HgenePPARG

GO:0010871

negative regulation of receptor biosynthetic process

12700342

HgenePPARG

GO:0010887

negative regulation of cholesterol storage

19114110

HgenePPARG

GO:0010891

negative regulation of sequestering of triglyceride

12700342

HgenePPARG

GO:0016525

negative regulation of angiogenesis

28566713

HgenePPARG

GO:0030224

monocyte differentiation

9568716

HgenePPARG

GO:0032526

response to retinoic acid

16239304

HgenePPARG

GO:0042953

lipoprotein transport

9568716

HgenePPARG

GO:0043537

negative regulation of blood vessel endothelial cell migration

28566713

HgenePPARG

GO:0045713

low-density lipoprotein particle receptor biosynthetic process

9568716

HgenePPARG

GO:0045944

positive regulation of transcription by RNA polymerase II

9568715|12700342|16239304|17611579

HgenePPARG

GO:0048469

cell maturation

9568716

HgenePPARG

GO:0048662

negative regulation of smooth muscle cell proliferation

20622039

HgenePPARG

GO:0051091

positive regulation of DNA-binding transcription factor activity

18293083

HgenePPARG

GO:0061614

pri-miRNA transcription by RNA polymerase II

28566713

HgenePPARG

GO:0071404

cellular response to low-density lipoprotein particle stimulus

9568716

HgenePPARG

GO:1904706

negative regulation of vascular smooth muscle cell proliferation

28522568


check buttonFusion gene breakpoints across PPARG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CRYBA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-HQ-A2OE-01APPARGchr3

12422990

+CRYBA4chr22

27019198

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397010PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+15177801358369329
ENST00000309576PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+13706331211222329
ENST00000397015PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+12555181221069315
ENST00000397012PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+15067691347358329
ENST00000397026PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+15347971375395326
ENST00000397000PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+1201464681015315
ENST00000539812PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+1201464681015315
ENST00000287820PPARGchr312422990+ENST00000354760CRYBA4chr2227019198+13386011211152343

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397010ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0109194590.98908055
ENST00000309576ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0097643640.9902356
ENST00000397015ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0097944930.99020547
ENST00000397012ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0053573750.9946426
ENST00000397026ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0033730440.996627
ENST00000397000ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0099762920.9900238
ENST00000539812ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0099762920.9900238
ENST00000287820ENST00000354760PPARGchr312422990+CRYBA4chr2227019198+0.0033496970.9966503

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>67349_67349_1_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000287820_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=343AA_BP=160
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVV
ADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAEC
PSVLELGFETVRSLKVLSGAWVGFEHAGFQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELS

--------------------------------------------------------------

>67349_67349_2_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000309576_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0
MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA
QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV
PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC

--------------------------------------------------------------

>67349_67349_3_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397000_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG
FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC

--------------------------------------------------------------

>67349_67349_4_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397010_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0
MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA
QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV
PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC

--------------------------------------------------------------

>67349_67349_5_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397012_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=329AA_BP=0
MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA
QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV
PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC

--------------------------------------------------------------

>67349_67349_6_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397015_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG
FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC

--------------------------------------------------------------

>67349_67349_7_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000397026_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=326AA_BP=0
MRSSVPHPCSLLDPADALHLEGRGMRAPLPEMFVVTGMVIAFQHILKSSVARKLGANPGPRVDVEGPYFIAFPSHGLEGRIVIAQLSFLA
QEVLLLEDCQPRVTVVSTGRRPEGGEPLGGVGRVAAPGIPAWIFASFQNVLLPLEASMLKAHPRSTQHFQRSHSLEAKLQHAGALGRELV
PPALEAVLIPHHHLASFTSMNSIVKSRSFISTDTTFNCHEGVGRLFMRLIVELSLLRIIRWRCRLHFDCTLVLLKFQVILVICNHWICSC

--------------------------------------------------------------

>67349_67349_8_PPARG-CRYBA4_PPARG_chr3_12422990_ENST00000539812_CRYBA4_chr22_27019198_ENST00000354760_length(amino acids)=315AA_BP=132
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSE
KTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKMVVWDEDGFQGRRHEFTAECPSVLELGFETVRSLKVLSGAWVGFEHAG
FQGQQYILERGEYPSWDAWGGNTAYPAERLTSFRPAACANHRDSRLTIFEQENFLGKKGELSDDYPSLQAMGWEGNEVGSFHVHSGAWVC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:12422990/chr22:27019198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPARG

P37231

CRYBA4

P53673

FUNCTION: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). {ECO:0000250|UniProtKB:P37238, ECO:0000269|PubMed:16150867, ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:9065481}.; FUNCTION: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. {ECO:0000269|PubMed:25504154}.FUNCTION: Crystallins are the dominant structural components of the vertebrate eye lens.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37139_159160.0506.0Zinc fingerNR C4-type
TgeneCRYBA4chr3:12422990chr22:27019198ENST0000035476016105_14613.0197.0DomainBeta/gamma crystallin 'Greek key' 3
TgeneCRYBA4chr3:12422990chr22:27019198ENST000003547601612_5113.0197.0DomainBeta/gamma crystallin 'Greek key' 1
TgeneCRYBA4chr3:12422990chr22:27019198ENST0000035476016147_19513.0197.0DomainBeta/gamma crystallin 'Greek key' 4
TgeneCRYBA4chr3:12422990chr22:27019198ENST000003547601652_9813.0197.0DomainBeta/gamma crystallin 'Greek key' 2
TgeneCRYBA4chr3:12422990chr22:27019198ENST000003547601699_10413.0197.0RegionNote=Connecting peptide

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37136_210160.0506.0DNA bindingNuclear receptor
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48136_210132.0478.0DNA bindingNuclear receptor
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48136_210132.0478.0DNA bindingNuclear receptor
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48136_210132.0478.0DNA bindingNuclear receptor
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37136_210132.0478.0DNA bindingNuclear receptor
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37238_503160.0506.0DomainNR LBD
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48238_503132.0478.0DomainNR LBD
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48238_503132.0478.0DomainNR LBD
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48238_503132.0478.0DomainNR LBD
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37238_503132.0478.0DomainNR LBD
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37495_503160.0506.0Motif9aaTAD
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48495_503132.0478.0Motif9aaTAD
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48495_503132.0478.0Motif9aaTAD
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48495_503132.0478.0Motif9aaTAD
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37495_503132.0478.0Motif9aaTAD
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37176_198160.0506.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48139_159132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48176_198132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48139_159132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48176_198132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48139_159132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48176_198132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37139_159132.0478.0Zinc fingerNR C4-type
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37176_198132.0478.0Zinc fingerNR C4-type
TgeneCRYBA4chr3:12422990chr22:27019198ENST00000354760162_1113.0197.0RegionNote=N-terminal arm


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PPARGNCOA4, GADD45G, Gadd45b, DNTTIP2, PPARGC1A, HDAC3, HDAC4, RB1, EP300, EDF1, FABP1, NR0B2, SVIL, NRIP1, POU1F1, CREBBP, RXRA, MED24, MSX2, PML, ZBTB5, NR2E3, MAFF, ZBTB20, ZBTB3, ZNF496, ZBTB9, ZSCAN1, PIAS1, NCOR1, NCOR2, HMGA1, SP1, TFAP2A, CEBPB, MED1, ZNHIT3, TRIP4, JMJD1C, NFKBIB, SERPINH1, NCOA1, TRIM24, NCOA2, NCOA3, GRIP1, KAT5, LRIF1, HDAC1, MECP2, EZH2, NCOA6, NR0B1, COPS5, FHOD1, KIF1A, RXRB, ROBO4, KLF4, KDM4C, TNP1, KCTD13, RAD54L2, ANP32A, APP, RELA, UBC, CDC34, JAZF1, MED14, BCAS2, NEDD4, Rxra, SMARCD3, SMARCA4, CDK5, MIF4GD, USP7, ALOX15B, NR3C1, MUC1, NSD1, PAXIP1, ASH2L, RBBP5, PRKAA1, PRKAA2, CTNNB1, SFPQ, NR4A1, NR4A2, JUN, NFE2L3, PHB2, STAT5A, VDR, RXRG, MAP2K1, CAV1, SMAD3, PDIA2, PPM1B, Foxo1, daf-12, XRCC6, XRCC5, MAPK1, RANBP3, XPO1, Ncor1, JUND, LMO4, RFX5, CIITA, TCF4, NFKB1, PPARG, PRKCA, PIN1, STAT6, IKBKB, KAT2A, KIF11, CEP350, UBE2I, KLF5, IGFBP3, EGFR, MDM2, YWHAB, YWHAG, PPARGC1B, STAT1, STUB1, Pparg, FLYWCH2, PAK4, TNIP2, MFHAS1, TP53, VIMP, SELK, SIRT1, Smurf1, HSPA8, BAG2, RPS3, HNRNPM, HNRNPH1, TUFM, CCT3, DDX17, HSPA1B, TCP1, VCP, BAG5, DHX9, PGAM1, ATP5O, PGD, RUVBL1, RUVBL2, HSPA9, HSPA5, LCP1, CCT8, PPEF2, LGALS7, MRE11A, TOP2B, NAT10, TLN1, RPA2, LIG3, VPS29, RPS8, PBRM1, ZC3HAV1, KHSRP, GIGYF2, MCM7, HSPA6, TRIM28, HEATR1, LRPPRC, RPL10A, SAFB2, SF3B3, NOP14, RPL7A, RPL9, GTF2I, DNAJC7, EFTUD2, DDX18, SH3BGRL, DDX58, HNRNPK, DNAJA3, NUP93, NBN, PSMD11, ILF3, RAD50, SMARCA5, U2SURP, RSL1D1, PSMC1, NOP2, DDX52, UTP14A, ARPC2, ILF2, RPS4X, GTPBP4, H2AFY, DSP, NOP58, POF1B, LGALS3, GNL3, MSN, S100A9, HSP90AA1, DNAJA1, ARPC5, POLR1C, RRP9, UBR5, ATMIN, PROX1, SRSF1, NR1H3, NR1H2, Ppargc1a, MAPK9, ADCY4, GATA5, RARA, TRIM37, ESRRA, TRIM63, VHL, TRIM13, C6orf106, TRIM27, TRIB3, HDAC9, KMT2D, KDM6A, HIVEP1, SMARCA2, KMT2C, KAT2B, SMARCC1, SMARCD1, ZNF536, TBL1X, TADA2A, TADA3, NDUFA8, MLLT6, GPS2, BCL7A, ARID2, ZZZ3, ARID1B, KDM2B, DPF1, DPF2, TBL1XR1, CSRP2BP, BRD9, BRD7, MBIP, GLTSCR1, TRPS1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PPARGall structure
CRYBA4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePPARGchr3:12422990chr22:27019198ENST00000287820+37205_280160.0506.0FAM120B
HgenePPARGchr3:12422990chr22:27019198ENST00000309576+48205_280132.0478.0FAM120B
HgenePPARGchr3:12422990chr22:27019198ENST00000397010+48205_280132.0478.0FAM120B
HgenePPARGchr3:12422990chr22:27019198ENST00000397012+48205_280132.0478.0FAM120B
HgenePPARGchr3:12422990chr22:27019198ENST00000397015+37205_280132.0478.0FAM120B


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Related Drugs to PPARG-CRYBA4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PPARG-CRYBA4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePPARGC0011860Diabetes Mellitus, Non-Insulin-Dependent6CTD_human;GENOMICS_ENGLAND
HgenePPARGC0238463Papillary thyroid carcinoma4ORPHANET
HgenePPARGC0002152Alloxan Diabetes3CTD_human
HgenePPARGC0002395Alzheimer's Disease3CTD_human
HgenePPARGC0011265Presenile dementia3CTD_human
HgenePPARGC0011853Diabetes Mellitus, Experimental3CTD_human
HgenePPARGC0020538Hypertensive disease3CTD_human
HgenePPARGC0021655Insulin Resistance3CTD_human
HgenePPARGC0022660Kidney Failure, Acute3CTD_human
HgenePPARGC0028754Obesity3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgenePPARGC0035126Reperfusion Injury3CTD_human
HgenePPARGC0038433Streptozotocin Diabetes3CTD_human
HgenePPARGC0276496Familial Alzheimer Disease (FAD)3CTD_human
HgenePPARGC0494463Alzheimer Disease, Late Onset3CTD_human
HgenePPARGC0546126Acute Confusional Senile Dementia3CTD_human
HgenePPARGC0750900Alzheimer's Disease, Focal Onset3CTD_human
HgenePPARGC0750901Alzheimer Disease, Early Onset3CTD_human
HgenePPARGC0920563Insulin Sensitivity3CTD_human
HgenePPARGC1565662Acute Kidney Insufficiency3CTD_human
HgenePPARGC1720861Familial Partial Lipodystrophy, Type 33CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgenePPARGC2609414Acute kidney injury3CTD_human
HgenePPARGC0021368Inflammation2CTD_human
HgenePPARGC0022116Ischemia2CTD_human
HgenePPARGC0024623Malignant neoplasm of stomach2CTD_human
HgenePPARGC0025202melanoma2CTD_human
HgenePPARGC0030297Pancreatic Neoplasm2CTD_human
HgenePPARGC0038356Stomach Neoplasms2CTD_human
HgenePPARGC0346647Malignant neoplasm of pancreas2CTD_human
HgenePPARGC1708349Hereditary Diffuse Gastric Cancer2CTD_human
HgenePPARGC0001418Adenocarcinoma1CTD_human
HgenePPARGC0004153Atherosclerosis1CTD_human
HgenePPARGC0004763Barrett Esophagus1CTD_human
HgenePPARGC0007102Malignant tumor of colon1CTD_human;UNIPROT
HgenePPARGC0009375Colonic Neoplasms1CTD_human
HgenePPARGC0009402Colorectal Carcinoma1CTD_human
HgenePPARGC0009404Colorectal Neoplasms1CTD_human
HgenePPARGC0010346Crohn Disease1CTD_human
HgenePPARGC0011849Diabetes Mellitus1CTD_human
HgenePPARGC0011859Lipoatrophic Diabetes Mellitus1ORPHANET
HgenePPARGC0011881Diabetic Nephropathy1CTD_human
HgenePPARGC0017658Glomerulonephritis1CTD_human
HgenePPARGC0017667Nodular glomerulosclerosis1CTD_human
HgenePPARGC0018801Heart failure1CTD_human
HgenePPARGC0018802Congestive heart failure1CTD_human
HgenePPARGC0023212Left-Sided Heart Failure1CTD_human
HgenePPARGC0023645Lichen planus follicularis1GENOMICS_ENGLAND
HgenePPARGC0023794Lipoidosis1CTD_human
HgenePPARGC0023903Liver neoplasms1CTD_human
HgenePPARGC0025517Metabolic Diseases1CTD_human
HgenePPARGC0027746Nerve Degeneration1CTD_human
HgenePPARGC0029408Degenerative polyarthritis1CTD_human
HgenePPARGC0030246Pustulosis of Palms and Soles1CTD_human
HgenePPARGC0030625Passive Cutaneous Anaphylaxis1GENOMICS_ENGLAND
HgenePPARGC0033860Psoriasis1CTD_human
HgenePPARGC0035078Kidney Failure1CTD_human
HgenePPARGC0038525Subarachnoid Hemorrhage1CTD_human
HgenePPARGC0040136Thyroid Neoplasm1CTD_human
HgenePPARGC0079772T-Cell Lymphoma1CTD_human
HgenePPARGC0085278Antiphospholipid Syndrome1CTD_human
HgenePPARGC0085413Polycystic Kidney, Autosomal Dominant1CTD_human
HgenePPARGC0086743Osteoarthrosis Deformans1CTD_human
HgenePPARGC0086873Pseudopelade1GENOMICS_ENGLAND
HgenePPARGC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgenePPARGC0156147Crohn's disease of large bowel1CTD_human
HgenePPARGC0205641Adenocarcinoma, Basal Cell1CTD_human
HgenePPARGC0205642Adenocarcinoma, Oxyphilic1CTD_human
HgenePPARGC0205643Carcinoma, Cribriform1CTD_human
HgenePPARGC0205644Carcinoma, Granular Cell1CTD_human
HgenePPARGC0205645Adenocarcinoma, Tubular1CTD_human
HgenePPARGC0206726gliosarcoma1ORPHANET
HgenePPARGC0221032Familial generalized lipodystrophy1ORPHANET
HgenePPARGC0221406Pituitary-dependent Cushing's disease1CTD_human
HgenePPARGC0235527Heart Failure, Right-Sided1CTD_human
HgenePPARGC0236811Chronobiology Disorders1CTD_human
HgenePPARGC0242339Dyslipidemias1CTD_human
HgenePPARGC0242488Acute Lung Injury1CTD_human
HgenePPARGC0267380Crohn's disease of the ileum1CTD_human
HgenePPARGC0270192Perinatal Subarachnoid Hemorrhage1CTD_human
HgenePPARGC0271694Familial partial lipodystrophy1CTD_human
HgenePPARGC0282548Leukostasis1CTD_human
HgenePPARGC0334588Giant Cell Glioblastoma1ORPHANET
HgenePPARGC0345904Malignant neoplasm of liver1CTD_human
HgenePPARGC0472383Subarachnoid Hemorrhage, Spontaneous1CTD_human
HgenePPARGC0525045Mood Disorders1PSYGENET
HgenePPARGC0549473Thyroid carcinoma1CTD_human
HgenePPARGC0598784Dyslipoproteinemias1CTD_human
HgenePPARGC0678202Regional enteritis1CTD_human
HgenePPARGC0751220Inappropriate ACTH Secretion Syndrome1CTD_human
HgenePPARGC0751530Subarachnoid Hemorrhage, Aneurysmal1CTD_human
HgenePPARGC0795688Subarachnoid Hemorrhage, Intracranial1CTD_human
HgenePPARGC0813142Circadian Rhythm Disorders1CTD_human
HgenePPARGC0887800Psychogenic Inversion of Circadian Rhythm1CTD_human
HgenePPARGC0887850Polycystic Kidney, Type 1 Autosomal Dominant Disease1CTD_human
HgenePPARGC0949272IIeocolitis1CTD_human
HgenePPARGC1258085Barrett Epithelium1CTD_human
HgenePPARGC1563937Atherogenesis1CTD_human
HgenePPARGC1565489Renal Insufficiency1CTD_human
HgenePPARGC1704377Bright Disease1CTD_human
HgenePPARGC1720859Familial Partial Lipodystrophy, Type 11CTD_human
HgenePPARGC1720860Familial Partial Lipodystrophy, Type 21CTD_human
HgenePPARGC1959583Myocardial Failure1CTD_human
HgenePPARGC1961112Heart Decompensation1CTD_human
HgenePPARGC2239176Liver carcinoma1CTD_human
HgenePPARGC2751306Polycystic kidney disease, type 21CTD_human
HgenePPARGC2931367Thyroid cancer, follicular1CTD_human
HgenePPARGC2936846Scarring alopecia1GENOMICS_ENGLAND