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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ARPC3-APAF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ARPC3-APAF1
FusionPDB ID: 6805
FusionGDB2.0 ID: 6805
HgeneTgene
Gene symbol

ARPC3

APAF1

Gene ID

10094

317

Gene nameactin related protein 2/3 complex subunit 3apoptotic peptidase activating factor 1
SynonymsARC21|p21-ArcAPAF-1|CED4
Cytomap

12q24.11

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionactin-related protein 2/3 complex subunit 3ARP2/3 protein complex subunit p21actin related protein 2/3 complex, subunit 3, 21kDaarp2/3 complex 21 kDa subunitapoptotic protease-activating factor 1
Modification date2020031320200315
UniProtAcc

O15145

O14727

Ensembl transtripts involved in fusion geneENST idsENST00000228825, ENST00000471641, 
ENST00000547666, ENST00000547743, 
ENST00000333991, ENST00000339433, 
ENST00000357310, ENST00000359972, 
ENST00000547045, ENST00000549007, 
ENST00000550527, ENST00000551964, 
ENST00000552268, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 3=1081 X 1 X 1=1
# samples 61
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: ARPC3 [Title/Abstract] AND APAF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ARPC3(110883257)-APAF1(99126198), # samples:2
Anticipated loss of major functional domain due to fusion event.ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ARPC3-APAF1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARPC3

GO:0034314

Arp2/3 complex-mediated actin nucleation

11741539

TgeneAPAF1

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

21827945

TgeneAPAF1

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

9267021


check buttonFusion gene breakpoints across ARPC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across APAF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1022-01AARPC3chr12

110883257

-APAF1chr12

99126198

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228825ARPC3chr12110883257-ENST00000333991APAF1chr1299126198+326025310399129

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228825ENST00000333991ARPC3chr12110883257-APAF1chr1299126198+0.93405380.065946266

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>6805_6805_1_ARPC3-APAF1_ARPC3_chr12_110883257_ENST00000228825_APAF1_chr12_99126198_ENST00000333991_length(amino acids)=129AA_BP=72
MQGRKLHVRTRPFRFASAYLAQAARPEALRCTWILLLWVETRAPPRCRLTTLLSWILIPNSSETWHCCLSEVNSKDLPPERWWNVVTGES

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110883257/chr12:99126198)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARPC3

O15145

APAF1

O14727

FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). {ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9230079}.FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168910_921318.3333333333333339.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857910_921318.3333333333333339.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681001_1040318.3333333333333339.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681042_1080318.3333333333333339.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681083_1122318.3333333333333339.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681125_1164318.3333333333333339.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681175_1212318.3333333333333339.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681213_1248318.3333333333333339.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168613_652318.3333333333333339.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168655_694318.3333333333333339.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168697_738318.3333333333333339.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168741_780318.3333333333333339.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168796_836318.3333333333333339.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168838_877318.3333333333333339.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168880_910318.3333333333333339.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168922_958318.3333333333333339.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168959_998318.3333333333333339.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261175_12121157.01206.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261213_12481157.01206.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261175_12121146.01195.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261213_12481146.01195.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251175_12121157.01206.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251213_12481157.01206.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261213_12481189.01238.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271213_12481200.01249.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571001_1040318.3333333333333339.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571042_1080318.3333333333333339.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571083_1122318.3333333333333339.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571125_1164318.3333333333333339.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571175_1212318.3333333333333339.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571213_1248318.3333333333333339.0RepeatNote=WD 2-8
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857613_652318.3333333333333339.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857655_694318.3333333333333339.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857697_738318.3333333333333339.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857741_780318.3333333333333339.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857796_836318.3333333333333339.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857838_877318.3333333333333339.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857880_910318.3333333333333339.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857922_958318.3333333333333339.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857959_998318.3333333333333339.0RepeatNote=WD 2-2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAPAF1chr12:110883257chr12:99126198ENST000003339916895_98318.3333333333333339.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000357310242695_981157.01206.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000359972242695_981146.01195.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000547045232595_981157.01206.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000550527242695_981189.01238.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST00000551964252795_981200.01249.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST000005522685795_98318.3333333333333339.0Compositional biasNote=Poly-Ser
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168104_415318.3333333333333339.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST00000333991681_90318.3333333333333339.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426104_4151157.01206.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261_901157.01206.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426104_4151146.01195.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261_901146.01195.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325104_4151157.01206.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251_901157.01206.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426104_4151189.01238.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261_901189.01238.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527104_4151200.01249.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271_901200.01249.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857104_415318.3333333333333339.0DomainNote=NB-ARC
TgeneAPAF1chr12:110883257chr12:99126198ENST00000552268571_90318.3333333333333339.0DomainCARD
TgeneAPAF1chr12:110883257chr12:99126198ENST0000033399168154_161318.3333333333333339.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426154_1611157.01206.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426154_1611146.01195.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325154_1611157.01206.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426154_1611189.01238.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527154_1611200.01249.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055226857154_161318.3333333333333339.0Nucleotide bindingATP
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426910_9211157.01206.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426910_9211146.01195.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325910_9211157.01206.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426910_9211189.01238.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527910_9211200.01249.0RegionInterpropeller linker
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261001_10401157.01206.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261042_10801157.01206.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261083_11221157.01206.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035731024261125_11641157.01206.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426613_6521157.01206.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426655_6941157.01206.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426697_7381157.01206.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426741_7801157.01206.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426796_8361157.01206.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426838_8771157.01206.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426880_9101157.01206.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426922_9581157.01206.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003573102426959_9981157.01206.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261001_10401146.01195.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261042_10801146.01195.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261083_11221146.01195.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000035997224261125_11641146.01195.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426613_6521146.01195.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426655_6941146.01195.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426697_7381146.01195.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426741_7801146.01195.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426796_8361146.01195.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426838_8771146.01195.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426880_9101146.01195.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426922_9581146.01195.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000003599722426959_9981146.01195.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251001_10401157.01206.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251042_10801157.01206.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251083_11221157.01206.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000054704523251125_11641157.01206.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325613_6521157.01206.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325655_6941157.01206.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325697_7381157.01206.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325741_7801157.01206.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325796_8361157.01206.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325838_8771157.01206.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325880_9101157.01206.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325922_9581157.01206.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005470452325959_9981157.01206.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261001_10401189.01238.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261042_10801189.01238.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261083_11221189.01238.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261125_11641189.01238.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055052724261175_12121189.01238.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426613_6521189.01238.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426655_6941189.01238.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426697_7381189.01238.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426741_7801189.01238.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426796_8361189.01238.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426838_8771189.01238.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426880_9101189.01238.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426922_9581189.01238.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005505272426959_9981189.01238.0RepeatNote=WD 2-2
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271001_10401200.01249.0RepeatNote=WD 2-3
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271042_10801200.01249.0RepeatNote=WD 2-4
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271083_11221200.01249.0RepeatNote=WD 2-5
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271125_11641200.01249.0RepeatNote=WD 2-6
TgeneAPAF1chr12:110883257chr12:99126198ENST0000055196425271175_12121200.01249.0RepeatNote=WD 2-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527613_6521200.01249.0RepeatNote=WD 1-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527655_6941200.01249.0RepeatNote=WD 1-2
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527697_7381200.01249.0RepeatNote=WD 1-3
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527741_7801200.01249.0RepeatNote=WD 1-4
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527796_8361200.01249.0RepeatNote=WD 1-5
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527838_8771200.01249.0RepeatNote=WD 1-6
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527880_9101200.01249.0RepeatNote=WD 1-7
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527922_9581200.01249.0RepeatNote=WD 2-1
TgeneAPAF1chr12:110883257chr12:99126198ENST000005519642527959_9981200.01249.0RepeatNote=WD 2-2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ARPC3
APAF1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ARPC3-APAF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ARPC3-APAF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource