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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PRMT7-WWOX

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PRMT7-WWOX
FusionPDB ID: 68942
FusionGDB2.0 ID: 68942
HgeneTgene
Gene symbol

PRMT7

WWOX

Gene ID

54496

51741

Gene nameprotein arginine methyltransferase 7WW domain containing oxidoreductase
SynonymsSBIDDSD16S432E|EIEE28|FOR|FRA16D|HHCMA56|PRO0128|SCAR12|SDR41C1|WOX1
Cytomap

16q22.1

16q23.1-q23.2

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 7[Myelin basic protein]-arginine N-methyltransferase PRMT7histone-arginine N-methyltransferase PRMT7WW domain-containing oxidoreductaseWW domain-containing protein WWOXfragile site FRA16D oxidoreductaseshort chain dehydrogenase/reductase family 41C member 1
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000339507, ENST00000348497, 
ENST00000441236, ENST00000449359, 
ENST00000564441, 		ENST00000355860, 
ENST00000402655, ENST00000406884, 
ENST00000408984, ENST00000539474, 
ENST00000565791, ENST00000569818, 
ENST00000566780, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 4=8030 X 23 X 10=6900
# samples 436
** MAII scorelog2(4/80*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/6900*10)=-4.26052755022322
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PRMT7 [Title/Abstract] AND WWOX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PRMT7(68382334)-WWOX(78420757), # samples:1
PRMT7(68380183)-WWOX(78420757), # samples:1
Anticipated loss of major functional domain due to fusion event.PRMT7-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRMT7-WWOX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PRMT7-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PRMT7-WWOX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT7

GO:0016571

histone methylation

15494416

HgenePRMT7

GO:0018216

peptidyl-arginine methylation

15044439

TgeneWWOX

GO:0030178

negative regulation of Wnt signaling pathway

19465938

TgeneWWOX

GO:0071560

cellular response to transforming growth factor beta stimulus

19366691


check buttonFusion gene breakpoints across PRMT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WWOX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4QI-01APRMT7chr16

68380183

+WWOXchr16

78420757

+
ChimerDB4STADTCGA-BR-A4QI-01APRMT7chr16

68382334

+WWOXchr16

78420757

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449359PRMT7chr1668382334+ENST00000566780WWOXchr1678420757+29901390612118685
ENST00000441236PRMT7chr1668382334+ENST00000566780WWOXchr1678420757+369520957662823685
ENST00000339507PRMT7chr1668382334+ENST00000566780WWOXchr1678420757+384322437642971735
ENST00000449359PRMT7chr1668380183+ENST00000566780WWOXchr1678420757+27681168611896611
ENST00000441236PRMT7chr1668380183+ENST00000566780WWOXchr1678420757+347318737662601611
ENST00000348497PRMT7chr1668380183+ENST00000566780WWOXchr1678420757+340118017662529587
ENST00000339507PRMT7chr1668380183+ENST00000566780WWOXchr1678420757+362120217642749661

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449359ENST00000566780PRMT7chr1668382334+WWOXchr1678420757+0.0058761440.9941239
ENST00000441236ENST00000566780PRMT7chr1668382334+WWOXchr1678420757+0.0061400510.9938599
ENST00000339507ENST00000566780PRMT7chr1668382334+WWOXchr1678420757+0.0055887490.9944113
ENST00000449359ENST00000566780PRMT7chr1668380183+WWOXchr1678420757+0.0079011630.9920988
ENST00000441236ENST00000566780PRMT7chr1668380183+WWOXchr1678420757+0.008298930.99170107
ENST00000348497ENST00000566780PRMT7chr1668380183+WWOXchr1678420757+0.0079081590.9920919
ENST00000339507ENST00000566780PRMT7chr1668380183+WWOXchr1678420757+0.0076674020.9923326

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>68942_68942_1_PRMT7-WWOX_PRMT7_chr16_68380183_ENST00000339507_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=661AA_BP=419
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALV
LDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPS
YEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMF
SIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAH
HDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTHKAKVEAMTLDLALLRSVQHFAEAFKAKNVP
LHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAY
NRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCM

--------------------------------------------------------------

>68942_68942_2_PRMT7-WWOX_PRMT7_chr16_68380183_ENST00000348497_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=587AA_BP=345
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALV
LDIGTGTGLLSMMAVTAGADFCYAIEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQ
VSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLP
QEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTHKAKVEAMTLDLALL
RSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDF
SRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPE

--------------------------------------------------------------

>68942_68942_3_PRMT7-WWOX_PRMT7_chr16_68380183_ENST00000441236_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=611AA_BP=369
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRVFKPMADAAVKIVEKNGFSDKIKV
INKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQ
VIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAP
FWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRT
DRYVQALRTHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPA
RVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFT

--------------------------------------------------------------

>68942_68942_4_PRMT7-WWOX_PRMT7_chr16_68380183_ENST00000449359_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=611AA_BP=369
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRVFKPMADAAVKIVEKNGFSDKIKV
INKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQ
VIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAP
FWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRT
DRYVQALRTHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPA
RVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFT

--------------------------------------------------------------

>68942_68942_5_PRMT7-WWOX_PRMT7_chr16_68382334_ENST00000339507_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=735AA_BP=493
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALV
LDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPS
YEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMF
SIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAH
HDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFT
VESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWS
LTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHR
RLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWA

--------------------------------------------------------------

>68942_68942_6_PRMT7-WWOX_PRMT7_chr16_68382334_ENST00000441236_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=685AA_BP=443
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRVFKPMADAAVKIVEKNGFSDKIKV
INKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQ
VIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAP
FWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRT
DRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKHKAKVEA
MTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIN
DSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATT

--------------------------------------------------------------

>68942_68942_7_PRMT7-WWOX_PRMT7_chr16_68382334_ENST00000449359_WWOX_chr16_78420757_ENST00000566780_length(amino acids)=685AA_BP=443
MSTRTQLARLLFCAKTGELVGTMKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRVFKPMADAAVKIVEKNGFSDKIKV
INKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQ
VIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAP
FWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRT
DRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKHKAKVEA
MTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDIN
DSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68382334/chr16:78420757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT7chr16:68380183chr16:78420757ENST00000339507+111914_345397.0693.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68380183chr16:78420757ENST00000441236+101814_345347.0643.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68380183chr16:78420757ENST00000449359+91714_345347.0643.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68382334chr16:78420757ENST00000339507+141914_345471.0693.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68382334chr16:78420757ENST00000441236+131814_345421.0643.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68382334chr16:78420757ENST00000449359+121714_345421.0643.0DomainSAM-dependent MTase PRMT-type 1
TgeneWWOXchr16:68380183chr16:78420757ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST000004026550516_490312.0DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST000004026550557_900312.0DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST000004068840616_490235.0DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST000004068840657_900235.0DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST000003558600616_490190.0DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST000003558600657_900190.0DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST000004026550516_490312.0DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST000004026550557_900312.0DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST000004068840616_490235.0DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST000004068840657_900235.0DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST000005698180116_49037.0DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST000005698180157_90037.0DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST000004026550550_550312.0MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST000004068840650_550235.0MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST000003558600650_550190.0MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST000004026550550_550312.0MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST000004068840650_550235.0MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST000005698180150_55037.0MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr16:68380183chr16:78420757ENST0000040265505131_1370312.0Nucleotide bindingNADP
TgeneWWOXchr16:68380183chr16:78420757ENST0000040688406131_1370235.0Nucleotide bindingNADP
TgeneWWOXchr16:68380183chr16:78420757ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST0000035586006131_1370190.0Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST0000040265505131_1370312.0Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST0000040688406131_1370235.0Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST0000056981801131_137037.0Nucleotide bindingNADP
TgeneWWOXchr16:68380183chr16:78420757ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68380183chr16:78420757ENST0000040265505209_2730312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68380183chr16:78420757ENST0000040688406209_2730235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68380183chr16:78420757ENST00000408984410209_273172.0311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68380183chr16:78420757ENST0000056678049209_273172.0415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68380183chr16:78420757ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST0000035586006209_2730190.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST0000040265505209_2730312.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST0000040688406209_2730235.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST00000408984410209_273172.0311.6666666666667RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST0000056678049209_273172.0415.0RegionMediates targeting to the mitochondria
TgeneWWOXchr16:68382334chr16:78420757ENST0000056981801209_273037.0RegionMediates targeting to the mitochondria

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRMT7chr16:68380183chr16:78420757ENST00000339507+1119358_684397.0693.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68380183chr16:78420757ENST00000348497+91414_345323.0545.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68380183chr16:78420757ENST00000348497+914358_684323.0545.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68380183chr16:78420757ENST00000441236+1018358_684347.0643.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68380183chr16:78420757ENST00000449359+917358_684347.0643.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68382334chr16:78420757ENST00000339507+1419358_684471.0693.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68382334chr16:78420757ENST00000348497+11414_3450545.0DomainSAM-dependent MTase PRMT-type 1
HgenePRMT7chr16:68382334chr16:78420757ENST00000348497+114358_6840545.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68382334chr16:78420757ENST00000441236+1318358_684421.0643.0DomainSAM-dependent MTase PRMT-type 2
HgenePRMT7chr16:68382334chr16:78420757ENST00000449359+1217358_684421.0643.0DomainSAM-dependent MTase PRMT-type 2
TgeneWWOXchr16:68380183chr16:78420757ENST0000040898441016_49172.0311.6666666666667DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST0000040898441057_90172.0311.6666666666667DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST000005667804916_49172.0415.0DomainWW 1
TgeneWWOXchr16:68380183chr16:78420757ENST000005667804957_90172.0415.0DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST0000040898441016_49172.0311.6666666666667DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST0000040898441057_90172.0311.6666666666667DomainWW 2
TgeneWWOXchr16:68382334chr16:78420757ENST000005667804916_49172.0415.0DomainWW 1
TgeneWWOXchr16:68382334chr16:78420757ENST000005667804957_90172.0415.0DomainWW 2
TgeneWWOXchr16:68380183chr16:78420757ENST0000040898441050_55172.0311.6666666666667MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST000005667804950_55172.0415.0MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST0000040898441050_55172.0311.6666666666667MotifNuclear localization signal
TgeneWWOXchr16:68382334chr16:78420757ENST000005667804950_55172.0415.0MotifNuclear localization signal
TgeneWWOXchr16:68380183chr16:78420757ENST00000408984410131_137172.0311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr16:68380183chr16:78420757ENST0000056678049131_137172.0415.0Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST00000408984410131_137172.0311.6666666666667Nucleotide bindingNADP
TgeneWWOXchr16:68382334chr16:78420757ENST0000056678049131_137172.0415.0Nucleotide bindingNADP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PRMT7
WWOX


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWWOXchr16:68380183chr16:78420757ENST00000408984410125_414172.0311.6666666666667MAPT
TgeneWWOXchr16:68380183chr16:78420757ENST0000056678049125_414172.0415.0MAPT
TgeneWWOXchr16:68382334chr16:78420757ENST00000408984410125_414172.0311.6666666666667MAPT
TgeneWWOXchr16:68382334chr16:78420757ENST0000056678049125_414172.0415.0MAPT


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Related Drugs to PRMT7-WWOX


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PRMT7-WWOX


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource