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Fusion Protein:RBM10-TFE3 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: RBM10-TFE3 | FusionPDB ID: 72752 | FusionGDB2.0 ID: 72752 | Hgene | Tgene | Gene symbol | RBM10 | TFE3 | Gene ID | 8241 | 7030 |
Gene name | RNA binding motif protein 10 | transcription factor binding to IGHM enhancer 3 | |
Synonyms | DXS8237E|GPATC9|GPATCH9|S1-1|TARPS|ZRANB5 | RCCP2|RCCX1|TFEA|bHLHe33 | |
Cytomap | Xp11.3 | Xp11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | RNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9 | transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3 | |
Modification date | 20200313 | 20200327 | |
UniProtAcc | . | P19532 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000329236, ENST00000345781, ENST00000377604, ENST00000478410, | ENST00000487451, ENST00000315869, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 17 X 8 X 9=1224 | 14 X 15 X 6=1260 |
# samples | 18 | 15 | |
** MAII score | log2(18/1224*10)=-2.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: RBM10 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | RBM10(47041725)-TFE3(48895639), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | KIRP | TCGA-DZ-6131-01A | RBM10 | chrX | 47041725 | - | TFE3 | chrX | 48895639 | - |
ChimerDB4 | KIRP | TCGA-DZ-6131-01A | RBM10 | chrX | 47041725 | + | TFE3 | chrX | 48895639 | - |
ChimerDB4 | KIRP | TCGA-DZ-6131 | RBM10 | chrX | 47041725 | + | TFE3 | chrX | 48895639 | - |
ChimerKB4 | . | . | RBM10 | chrX | 47041560 | + | TFE3 | chrX | 47041560 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000377604 | RBM10 | chrX | 47041725 | + | ENST00000315869 | TFE3 | chrX | 48895639 | - | 5067 | 2692 | 424 | 3639 | 1071 |
ENST00000329236 | RBM10 | chrX | 47041725 | + | ENST00000315869 | TFE3 | chrX | 48895639 | - | 4470 | 2095 | 61 | 3042 | 993 |
ENST00000345781 | RBM10 | chrX | 47041725 | + | ENST00000315869 | TFE3 | chrX | 48895639 | - | 4426 | 2051 | 14 | 2998 | 994 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000377604 | ENST00000315869 | RBM10 | chrX | 47041725 | + | TFE3 | chrX | 48895639 | - | 0.004157387 | 0.99584264 |
ENST00000329236 | ENST00000315869 | RBM10 | chrX | 47041725 | + | TFE3 | chrX | 48895639 | - | 0.006056023 | 0.993944 |
ENST00000345781 | ENST00000315869 | RBM10 | chrX | 47041725 | + | TFE3 | chrX | 48895639 | - | 0.005462841 | 0.9945372 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >72752_72752_1_RBM10-TFE3_RBM10_chrX_47041725_ENST00000329236_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=993AA_BP=661 MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV RVIKDKQTQLNRGFAFIQLSTIEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGE GTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSA EASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQS QQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNL LDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKAS VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGG PAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSME -------------------------------------------------------------- >72752_72752_2_RBM10-TFE3_RBM10_chrX_47041725_ENST00000345781_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=994AA_BP=662 MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV RVIKDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGG EGTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQS AEASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQ SQQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGN LLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKA SVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGG GPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSM -------------------------------------------------------------- >72752_72752_3_RBM10-TFE3_RBM10_chrX_47041725_ENST00000377604_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=1071AA_BP=215 MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASP GSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRN KSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLD QQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRG FAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVD YSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANS QSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRT YVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:47041725/chrX:48895639) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | TFE3 |
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250|UniProtKB:Q64092, ECO:0000269|PubMed:2338243, ECO:0000269|PubMed:29146937, ECO:0000269|PubMed:30733432, ECO:0000269|PubMed:31672913}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 113_125 | 572.0 | 853.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 80_87 | 572.0 | 853.0 | Compositional bias | Note=Poly-Arg |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 113_125 | 573.0 | 854.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 80_87 | 573.0 | 854.0 | Compositional bias | Note=Poly-Arg |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 113_125 | 650.0 | 931.0 | Compositional bias | Note=Poly-Glu |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 561_607 | 650.0 | 931.0 | Compositional bias | Note=Tyr-rich |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 80_87 | 650.0 | 931.0 | Compositional bias | Note=Poly-Arg |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 129_209 | 572.0 | 853.0 | Domain | RRM 1 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 300_384 | 572.0 | 853.0 | Domain | RRM 2 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 129_209 | 573.0 | 854.0 | Domain | RRM 1 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 300_384 | 573.0 | 854.0 | Domain | RRM 2 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 129_209 | 650.0 | 931.0 | Domain | RRM 1 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 300_384 | 650.0 | 931.0 | Domain | RRM 2 |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 212_242 | 572.0 | 853.0 | Zinc finger | RanBP2-type |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 212_242 | 573.0 | 854.0 | Zinc finger | RanBP2-type |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 212_242 | 650.0 | 931.0 | Zinc finger | RanBP2-type |
Tgene | TFE3 | chrX:47041725 | chrX:48895639 | ENST00000315869 | 3 | 10 | 346_399 | 260.0 | 576.0 | Domain | bHLH | |
Tgene | TFE3 | chrX:47041725 | chrX:48895639 | ENST00000315869 | 3 | 10 | 260_271 | 260.0 | 576.0 | Region | Strong transcription activation domain | |
Tgene | TFE3 | chrX:47041725 | chrX:48895639 | ENST00000315869 | 3 | 10 | 409_430 | 260.0 | 576.0 | Region | Note=Leucine-zipper |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 561_607 | 572.0 | 853.0 | Compositional bias | Note=Tyr-rich |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 561_607 | 573.0 | 854.0 | Compositional bias | Note=Tyr-rich |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 858_904 | 572.0 | 853.0 | Domain | G-patch |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 858_904 | 573.0 | 854.0 | Domain | G-patch |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 858_904 | 650.0 | 931.0 | Domain | G-patch |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000329236 | + | 16 | 23 | 759_784 | 572.0 | 853.0 | Zinc finger | C2H2-type%3B atypical |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000345781 | + | 16 | 23 | 759_784 | 573.0 | 854.0 | Zinc finger | C2H2-type%3B atypical |
Hgene | RBM10 | chrX:47041725 | chrX:48895639 | ENST00000377604 | + | 17 | 24 | 759_784 | 650.0 | 931.0 | Zinc finger | C2H2-type%3B atypical |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file >>>1844_RBM10_47041725_TFE3_48895639_ranked_0.pdb | RBM10 | 47041725 | 47041725 | ENST00000315869 | TFE3 | chrX | 48895639 | - | MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASP GSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRN KSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLD QQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRG FAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVD YSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANS QSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRT YVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA | 1071 |
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
TFE3_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
TFE3 | AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1, |
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Gene | STRING network |
RBM10 | |
TFE3 | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to RBM10-TFE3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to RBM10-TFE3 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | TFE3 | C4518356 | MiT family translocation renal cell carcinoma | 2 | ORPHANET |
Tgene | TFE3 | C0206657 | Alveolar Soft Part Sarcoma | 1 | ORPHANET |
Tgene | TFE3 | C0206732 | Epithelioid hemangioendothelioma | 1 | ORPHANET |