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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RCOR1-PPP2R5C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RCOR1-PPP2R5C
	FusionPDB ID: 73329
	FusionGDB2.0 ID: 73329
		Hgene	Tgene
	Gene symbol	RCOR1	PPP2R5C
	Gene ID	23186	5527
	Gene name	REST corepressor 1	protein phosphatase 2 regulatory subunit B'gamma
	Synonyms	COREST\|RCOR	B56G\|B56gamma\|PR61G
	Cytomap	14q32.31-q32.32	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	REST corepressor 1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262241, ENST00000570597,	ENST00000328724, ENST00000334743, ENST00000350249, ENST00000445439, ENST00000554442, ENST00000556068, ENST00000556260, ENST00000556946, ENST00000557095, ENST00000557714, ENST00000422945,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 9 X 10=900	15 X 17 X 10=2550
	# samples	20	22
	** MAII score	log2(20/900*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2550*10)=-3.53492181822156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RCOR1 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RCOR1(103148315)-PPP2R5C(102323023), # samples:3 RCOR1(103059662)-PPP2R5C(102391478), # samples:3
Anticipated loss of major functional domain due to fusion event.	RCOR1-PPP2R5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RCOR1-PPP2R5C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RCOR1-PPP2R5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RCOR1-PPP2R5C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RCOR1	GO:0045892	negative regulation of transcription, DNA-templated	10449787
Hgene	RCOR1	GO:0070933	histone H4 deacetylation	17555596
Tgene	PPP2R5C	GO:0008285	negative regulation of cell proliferation	17245430

Fusion gene breakpoints across RCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP2R5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ACC	TCGA-OR-A5J7-01A	RCOR1	chr14	103148315	-	PPP2R5C	chr14	102323023	+
ChimerDB4	ACC	TCGA-OR-A5J7-01A	RCOR1	chr14	103148315	+	PPP2R5C	chr14	102323023	+
ChimerDB4	OV	TCGA-13-1410-01A	RCOR1	chr14	103059662	-	PPP2R5C	chr14	102391478	+
ChimerDB4	OV	TCGA-13-1410-01A	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391478	+
ChimerDB4	OV	TCGA-13-1410	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391477	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262241	RCOR1	chr14	103148315	+	ENST00000422945	PPP2R5C	chr14	102323023	+	4869	671	25	2151	708
ENST00000570597	RCOR1	chr14	103148315	+	ENST00000422945	PPP2R5C	chr14	102323023	+	4634	436	0	1916	638
ENST00000262241	RCOR1	chr14	103059662	+	ENST00000422945	PPP2R5C	chr14	102391478	+	3436	587	863	177	228
ENST00000570597	RCOR1	chr14	103059662	+	ENST00000422945	PPP2R5C	chr14	102391478	+	3201	352	628	2	209
ENST00000262241	RCOR1	chr14	103059662	+	ENST00000422945	PPP2R5C	chr14	102391477	+	3436	587	863	177	228
ENST00000570597	RCOR1	chr14	103059662	+	ENST00000422945	PPP2R5C	chr14	102391477	+	3201	352	628	2	209

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262241	ENST00000422945	RCOR1	chr14	103148315	+	PPP2R5C	chr14	102323023	+	0.000838566	0.9991615
ENST00000570597	ENST00000422945	RCOR1	chr14	103148315	+	PPP2R5C	chr14	102323023	+	0.000334823	0.99966514
ENST00000262241	ENST00000422945	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391478	+	0.013100892	0.98689914
ENST00000570597	ENST00000422945	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391478	+	0.012053427	0.98794657
ENST00000262241	ENST00000422945	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391477	+	0.013100892	0.98689914
ENST00000570597	ENST00000422945	RCOR1	chr14	103059662	+	PPP2R5C	chr14	102391477	+	0.012053427	0.98794657

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73329_73329_1_RCOR1-PPP2R5C_RCOR1_chr14_103059662_ENST00000262241_PPP2R5C_chr14_102391477_ENST00000422945_length(amino acids)=228AA_BP=1
MRRTHVIAYGTGSKKALSVTDWYGTGSMYFLQNPEKNWRARPRRGAPEASGRPGRPAHRPCSELPRLSWCGGPEAARTCGVQEDGPSSDL
SVPGSKSGTTAWYWGPTLMPPPPCSSSLDEPELPSSQELLLLLPLGAAAAKLLFWPLLGAAAAEAAAAEAEEAAAPEAAVAAGEAQAAEA

--------------------------------------------------------------

>73329_73329_2_RCOR1-PPP2R5C_RCOR1_chr14_103059662_ENST00000262241_PPP2R5C_chr14_102391478_ENST00000422945_length(amino acids)=228AA_BP=1
MRRTHVIAYGTGSKKALSVTDWYGTGSMYFLQNPEKNWRARPRRGAPEASGRPGRPAHRPCSELPRLSWCGGPEAARTCGVQEDGPSSDL
SVPGSKSGTTAWYWGPTLMPPPPCSSSLDEPELPSSQELLLLLPLGAAAAKLLFWPLLGAAAAEAAAAEAEEAAAPEAAVAAGEAQAAEA

--------------------------------------------------------------

>73329_73329_3_RCOR1-PPP2R5C_RCOR1_chr14_103059662_ENST00000570597_PPP2R5C_chr14_102391477_ENST00000422945_length(amino acids)=209AA_BP=1
MRRTHVIAYGTGSKKALSVTDWYGTGSMYFLQNPEKNWRARPRRGAPEASGRPGRPAHRPCSELPRLSWCGGPEAARTCGVQEDGPSSDL
SVPGSKSGTTAWYWGPTLMPPPPCSSSLDEPELPSSQELLLLLPLGAAAAKLLFWPLLGAAAAEAAAAEAEEAAAPEAAVAAGEAQAAEA

--------------------------------------------------------------

>73329_73329_4_RCOR1-PPP2R5C_RCOR1_chr14_103059662_ENST00000570597_PPP2R5C_chr14_102391478_ENST00000422945_length(amino acids)=209AA_BP=1
MRRTHVIAYGTGSKKALSVTDWYGTGSMYFLQNPEKNWRARPRRGAPEASGRPGRPAHRPCSELPRLSWCGGPEAARTCGVQEDGPSSDL
SVPGSKSGTTAWYWGPTLMPPPPCSSSLDEPELPSSQELLLLLPLGAAAAKLLFWPLLGAAAAEAAAAEAEEAAAPEAAVAAGEAQAAEA

--------------------------------------------------------------

>73329_73329_5_RCOR1-PPP2R5C_RCOR1_chr14_103148315_ENST00000262241_PPP2R5C_chr14_102323023_ENST00000422945_length(amino acids)=708AA_BP=19
MRSARRWGLEAAPRSARLGLPRLGLAPVGSRRARPAPRRPRAPSPVSAPPPQEPRVPATFARPRPPPMPAMVEKGPEVSGKRRGRNNAAA
SASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQA
VVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKYVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWKEVKRAALSEMVEYITHNRNV
ITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLQLLELFDSEDP
RERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIFLLKVLLPLHKVKSLSVYHPQ
LAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIM
SLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKEREEAWVKIENLAKANPQYTVY

--------------------------------------------------------------

>73329_73329_6_RCOR1-PPP2R5C_RCOR1_chr14_103148315_ENST00000570597_PPP2R5C_chr14_102323023_ENST00000422945_length(amino acids)=638AA_BP=146
MVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSG
SSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKYVPPADQEKLFIQKLRQCCVLFDFVSDPLSDLKWK
EVKRAALSEMVEYITHNRNVITEPIYPEVVHMFAVNMFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAK
KYIDQKFVLQLLELFDSEDPRERDFLKTTLHRIYGKFLGLRAYIRKQINNIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKIF
LLKVLLPLHKVKSLSVYHPQLAYCVVQFLEKDSTLTEPVVMALLKYWPKTHSPKEVMFLNELEEILDVIEPSEFVKIMEPLFRQLAKCVS
SPHFQVAERALYYWNNEYIMSLISDNAAKILPIMFPSLYRNSKTHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQFKAEKLKEKLKMKER
EEAWVKIENLAKANPQYTVYSQASTMSIPVAMETDGPLFEDVQMLRKTVKDEAHQAQKDPKKDRPLARRKSELPQDPHTKKALEAHCRAD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:103148315/chr14:102323023)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

21_77

117.33333333333333

483.0

Compositional bias

Note=Ala-rich

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

21_77

117.33333333333333

483.0

Compositional bias

Note=Ala-rich

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

21_77

145.33333333333334

483.0

Compositional bias

Note=Ala-rich

Tgene

PPP2R5C

chr14:103059662

chr14:102391477

ENST00000445439

416_422

450.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391478

ENST00000445439

416_422

450.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103148315

chr14:102323023

ENST00000328724

416_422

86.33333333333333

541.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103148315

chr14:102323023

ENST00000334743

416_422

31.333333333333332

525.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103148315

chr14:102323023

ENST00000350249

416_422

31.333333333333332

486.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103148315

chr14:102323023

ENST00000422945

416_422

62.333333333333336

556.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103148315

chr14:102323023

ENST00000445439

416_422

31.333333333333332

450.0

Motif

Nuclear localization signal

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

244_273

117.33333333333333

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

334_369

117.33333333333333

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

244_273

117.33333333333333

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

334_369

117.33333333333333

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

244_273

145.33333333333334

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

334_369

145.33333333333334

483.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

103_189

117.33333333333333

483.0

Domain

ELM2

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

190_241

117.33333333333333

483.0

Domain

SANT 1

Hgene

RCOR1

chr14:103059662

chr14:102391477

ENST00000570597

381_432

117.33333333333333

483.0

Domain

SANT 2

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

103_189

117.33333333333333

483.0

Domain

ELM2

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

190_241

117.33333333333333

483.0

Domain

SANT 1

Hgene

RCOR1

chr14:103059662

chr14:102391478

ENST00000570597

381_432

117.33333333333333

483.0

Domain

SANT 2

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

103_189

145.33333333333334

483.0

Domain

ELM2

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

190_241

145.33333333333334

483.0

Domain

SANT 1

Hgene

RCOR1

chr14:103148315

chr14:102323023

ENST00000570597

381_432

145.33333333333334

483.0

Domain

SANT 2

Tgene

PPP2R5C

chr14:103059662

chr14:102391477

ENST00000328724

416_422

497.0

541.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391477

ENST00000334743

416_422

481.0

525.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391477

ENST00000350249

416_422

442.0

486.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391477

ENST00000422945

416_422

512.0

556.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391478

ENST00000328724

416_422

497.0

541.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391478

ENST00000334743

416_422

481.0

525.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391478

ENST00000350249

416_422

442.0

486.0

Motif

Nuclear localization signal

Tgene

PPP2R5C

chr14:103059662

chr14:102391478

ENST00000422945

416_422

512.0

556.0

Motif

Nuclear localization signal

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RCOR1
PPP2R5C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	RCOR1	chr14:103059662	chr14:102391477	ENST00000570597	+	2	12	78_257	117.33333333333333	483.0	HDAC1
Hgene	RCOR1	chr14:103059662	chr14:102391478	ENST00000570597	+	2	12	78_257	117.33333333333333	483.0	HDAC1
Hgene	RCOR1	chr14:103148315	chr14:102323023	ENST00000570597	+	3	12	78_257	145.33333333333334	483.0	HDAC1
Hgene	RCOR1	chr14:103059662	chr14:102391477	ENST00000570597	+	2	12	296_384	117.33333333333333	483.0	KDM1A
Hgene	RCOR1	chr14:103059662	chr14:102391478	ENST00000570597	+	2	12	296_384	117.33333333333333	483.0	KDM1A
Hgene	RCOR1	chr14:103148315	chr14:102323023	ENST00000570597	+	3	12	296_384	145.33333333333334	483.0	KDM1A

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Related Drugs to RCOR1-PPP2R5C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RCOR1-PPP2R5C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source