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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RNF170-ADAM32

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RNF170-ADAM32
FusionPDB ID: 74887
FusionGDB2.0 ID: 74887
HgeneTgene
Gene symbol

RNF170

ADAM32

Gene ID

81790

203102

Gene namering finger protein 170ADAM metallopeptidase domain 32
SynonymsADSA|SNAX1-
Cytomap

8p11.21

8p11.22

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase RNF170RING-type E3 ubiquitin transferase RNF170putative LAG1-interacting proteindisintegrin and metalloproteinase domain-containing protein 32a disintegrin and metalloprotease domain 32a disintegrin and metalloproteinase domain 32metalloproteinase 12-like proteintesticular tissue protein Li 13
Modification date2020031320200313
UniProtAcc.

Q8TC27

Ensembl transtripts involved in fusion geneENST idsENST00000319104, ENST00000527424, 
ENST00000534961, ENST00000319073, 
ENST00000526349, 		ENST00000524303, 
ENST00000379907, ENST00000437682, 
ENST00000519315, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 6=32411 X 12 X 8=1056
# samples 1013
** MAII scorelog2(10/324*10)=-1.6959938131099
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1056*10)=-3.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RNF170 [Title/Abstract] AND ADAM32 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RNF170(42742871)-ADAM32(39079129), # samples:3
Anticipated loss of major functional domain due to fusion event.RNF170-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF170-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF170-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF170-ADAM32 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNF170-ADAM32 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RNF170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAM32 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-CM-6166-01ARNF170chr8

42742871

-ADAM32chr8

39079129

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000319104RNF170chr842742871-ENST00000437682ADAM32chr839079129+14872462881376362
ENST00000319104RNF170chr842742871-ENST00000519315ADAM32chr839079129+13312462881220310
ENST00000319104RNF170chr842742871-ENST00000379907ADAM32chr839079129+14872462881376362
ENST00000527424RNF170chr842742871-ENST00000437682ADAM32chr839079129+16233824241512362
ENST00000527424RNF170chr842742871-ENST00000519315ADAM32chr839079129+14673824241356310
ENST00000527424RNF170chr842742871-ENST00000379907ADAM32chr839079129+16233824241512362

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000319104ENST00000437682RNF170chr842742871-ADAM32chr839079129+0.058722330.9412776
ENST00000319104ENST00000519315RNF170chr842742871-ADAM32chr839079129+0.259652730.7403473
ENST00000319104ENST00000379907RNF170chr842742871-ADAM32chr839079129+0.058722330.9412776
ENST00000527424ENST00000437682RNF170chr842742871-ADAM32chr839079129+0.0281128830.97188705
ENST00000527424ENST00000519315RNF170chr842742871-ADAM32chr839079129+0.122442630.8775574
ENST00000527424ENST00000379907RNF170chr842742871-ADAM32chr839079129+0.0281128830.97188705

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>74887_74887_1_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000379907_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------

>74887_74887_2_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000437682_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------

>74887_74887_3_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000319104_ADAM32_chr8_39079129_ENST00000519315_length(amino acids)=310AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI

--------------------------------------------------------------

>74887_74887_4_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000379907_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------

>74887_74887_5_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000437682_length(amino acids)=362AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI
VTTAIVLARKQLKKWFAKEEEFPSSESKSEGSTQTYASQSSSEGSTQTYASQTRSESSSQADTSKSKSEDSAEAYTSRSKSQDSTQTQSS

--------------------------------------------------------------

>74887_74887_6_RNF170-ADAM32_RNF170_chr8_42742871_ENST00000527424_ADAM32_chr8_39079129_ENST00000519315_length(amino acids)=310AA_BP=
MKDGAKCYKGLCCKDCQILQSGVECRPKAHPECDIAENCNGTSPECGPDITLINGLSCKNNKFICYDGDCHDLDARCESVFGKGSRNAPF
ACYEEIQSQSDRFGNCGRDRNNKYVFCGWRNLICGRLVCTYPTRKPFHQENGDVIYAFVRDSVCITVDYKLPRTVPDPLAVKNGSQCDIG
RVCVNRECVESRIIKASAHVCSQQCSGHGVCDSRNKCHCSPGYKPPNCQIRSKGFSIFPEEDMGSIMERASGKTENTWLLGFLIALPILI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:42742871/chr8:39079129)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADAM32

Q8TC27

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-261_2445.666666666666664201.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-271_2445.666666666666664259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-271_2445.666666666666664259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2625_4545.666666666666664201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2725_4545.666666666666664259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2725_4545.666666666666664259.0TransmembraneHelical
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125480_502411.0788.0Compositional biasNote=Cys-rich
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125622_654411.0788.0DomainEGF-like
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125704_787411.0788.0Topological domainCytoplasmic
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125683_703411.0788.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-261_240163.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26223_2230163.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26245_2580163.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2646_2010163.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26223_22345.666666666666664201.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26245_25845.666666666666664201.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2646_20145.666666666666664201.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-171_240175.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17223_2230175.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17245_2580175.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1746_2010175.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27223_22345.666666666666664259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27245_25845.666666666666664259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2746_20145.666666666666664259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27223_22345.666666666666664259.0Topological domainLumenal
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27245_25845.666666666666664259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2746_20145.666666666666664259.0Topological domainCytoplasmic
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26202_2220163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-26224_2440163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2625_450163.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26202_22245.666666666666664201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-26224_24445.666666666666664201.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17202_2220175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-17224_2440175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1725_450175.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27202_22245.666666666666664259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-27224_24445.666666666666664259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27202_22245.666666666666664259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-27224_24445.666666666666664259.0TransmembraneHelical
HgeneRNF170chr8:42742871chr8:39079129ENST00000319073-2687_1300163.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000319104-2687_13045.666666666666664201.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000526349-1787_1300175.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000527424-2787_13045.666666666666664259.0Zinc fingerRING-type
HgeneRNF170chr8:42742871chr8:39079129ENST00000534961-2787_13045.666666666666664259.0Zinc fingerRING-type
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125186_383411.0788.0DomainPeptidase M12B
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125391_479411.0788.0DomainDisintegrin
TgeneADAM32chr8:42742871chr8:39079129ENST000003799071125175_682411.0788.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RNF170
ADAM32


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RNF170-ADAM32


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RNF170-ADAM32


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource