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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ROR1-IL12RB2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ROR1-IL12RB2
FusionPDB ID: 75361
FusionGDB2.0 ID: 75361
HgeneTgene
Gene symbol

ROR1

IL12RB2

Gene ID

6095

3595

Gene nameRAR related orphan receptor Ainterleukin 12 receptor subunit beta 2
SynonymsIDDECA|NR1F1|ROR1|ROR2|ROR3|RZR-ALPHA|RZRA-
Cytomap

15q22.2

1p31.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor ROR-alphaROR-alphanuclear receptor RZR-alphanuclear receptor subfamily 1 group F member 1retinoic acid receptor-related orphan receptor alpharetinoid-related orphan receptor alphathyroid hormone nuclear receptor alpha variant 4traninterleukin-12 receptor subunit beta-2IL-12 receptor subunit beta-2IL-12R subunit beta-2interleukin 12 receptor, beta 2interleukin-12 receptor beta-2 chain
Modification date2020032220200315
UniProtAcc.

Q99665

Ensembl transtripts involved in fusion geneENST idsENST00000482426, ENST00000371079, 
ENST00000371080, ENST00000545203, 
ENST00000262345, ENST00000371000, 
ENST00000541374, ENST00000544434, 
ENST00000465396, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 10 X 7=10503 X 4 X 3=36
# samples 174
** MAII scorelog2(17/1050*10)=-2.62678267641578
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ROR1 [Title/Abstract] AND IL12RB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ROR1(64475048)-IL12RB2(67787285), # samples:1
Anticipated loss of major functional domain due to fusion event.ROR1-IL12RB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROR1-IL12RB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ROR1-IL12RB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ROR1-IL12RB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneROR1

GO:0006355

regulation of transcription, DNA-templated

9328355

HgeneROR1

GO:0030522

intracellular receptor signaling pathway

19965867

HgeneROR1

GO:0036315

cellular response to sterol

19965867

HgeneROR1

GO:0045893

positive regulation of transcription, DNA-templated

7926749

HgeneROR1

GO:0045944

positive regulation of transcription by RNA polymerase II

17545671|19955433

TgeneIL12RB2

GO:0032729

positive regulation of interferon-gamma production

11114383


check buttonFusion gene breakpoints across ROR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IL12RB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A2NG-06AROR1chr1

64475048

-IL12RB2chr1

67787285

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371080ROR1chr164475048-ENST00000371000IL12RB2chr167787285+37835593572462701
ENST00000371080ROR1chr164475048-ENST00000262345IL12RB2chr167787285+38835593573071904
ENST00000371080ROR1chr164475048-ENST00000541374IL12RB2chr167787285+27185593572462701
ENST00000371080ROR1chr164475048-ENST00000544434IL12RB2chr167787285+28725593572813818
ENST00000371079ROR1chr164475048-ENST00000371000IL12RB2chr167787285+37625383362441701
ENST00000371079ROR1chr164475048-ENST00000262345IL12RB2chr167787285+38625383363050904
ENST00000371079ROR1chr164475048-ENST00000541374IL12RB2chr167787285+26975383362441701
ENST00000371079ROR1chr164475048-ENST00000544434IL12RB2chr167787285+28515383362792818

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371080ENST00000371000ROR1chr164475048-IL12RB2chr167787285+0.0120790850.9879209
ENST00000371080ENST00000262345ROR1chr164475048-IL12RB2chr167787285+0.002901670.9970983
ENST00000371080ENST00000541374ROR1chr164475048-IL12RB2chr167787285+0.0159594440.98404056
ENST00000371080ENST00000544434ROR1chr164475048-IL12RB2chr167787285+0.0059866940.99401337
ENST00000371079ENST00000371000ROR1chr164475048-IL12RB2chr167787285+0.0124533420.9875466
ENST00000371079ENST00000262345ROR1chr164475048-IL12RB2chr167787285+0.0030061430.9969939
ENST00000371079ENST00000541374ROR1chr164475048-IL12RB2chr167787285+0.0164107590.9835893
ENST00000371079ENST00000544434ROR1chr164475048-IL12RB2chr167787285+0.0061963130.9938036

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75361_75361_1_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000262345_length(amino acids)=904AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL
QPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKY
PIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYK
VLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCD

--------------------------------------------------------------

>75361_75361_2_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000371000_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------

>75361_75361_3_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000541374_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------

>75361_75361_4_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371079_IL12RB2_chr1_67787285_ENST00000544434_length(amino acids)=818AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISEIPYRVSQNSHP
INSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTC
AKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLV
DLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLK

--------------------------------------------------------------

>75361_75361_5_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000262345_length(amino acids)=904AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL
QPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTCAKKY
PIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLVDLYK
VLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLKMRCD

--------------------------------------------------------------

>75361_75361_6_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000371000_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------

>75361_75361_7_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000541374_length(amino acids)=701AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISENIKSYICYEIR
VYALSGDQGGCSSILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYWKERDSNSQPQLCEIPYRVSQNSHPINSL

--------------------------------------------------------------

>75361_75361_8_ROR1-IL12RB2_ROR1_chr1_64475048_ENST00000371080_IL12RB2_chr1_67787285_ENST00000544434_length(amino acids)=818AA_BP=67
MGAAAAAASARGGMHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDACKRGDVTVKPSHVILLGSTVN
ITCSLKPRQGCFHYSRRNKLILYKFDRRINFHHGHSLNSQVTGLPLGTTLFVCKLACINSDEIQICGAEIFVGVAPEQPQNLSCIQKGEQ
GTVACTWERGRDTHLYTEYTLQLSGPKNLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPLPPW
DIRIKFQKASVSRCTLYWRDEGLVLLNRLRYRPSNSRLWNMVNVTKAKGRHDLLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPE
EEPTGMLDVWYMKRHIDYSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAVAVSAANSKGSSLP
TRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYVVEWRELHPGGDTQVPLNWLRSRPYNVSALISEIPYRVSQNSHP
INSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKANWMAFVAPSICIAIIMVGIFSTHYFQQKVFVLLAALRPQWCSREIPDPANSTC
AKKYPIAEEKTQLPLDRLLIDWPTPEDPEPLVISEVLHQVTPVFRHPPCSNWPQREKGIQGHQASEKDMMHSASSPPPPRALQAESRQLV
DLYKVLESRGSDPKPENPACPWTVLPAGDLPTHDGYLPSNIDDLPSHEAPLADSLEELEPQHISLSVFPSSSLHPLTFSCGDKLTLDQLK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:64475048/chr1:67787285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IL12RB2

Q99665

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116208_21125.333333333333332863.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116750_75325.333333333333332863.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115208_21125.333333333333332660.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115750_75325.333333333333332660.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216208_21125.333333333333332660.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216750_75325.333333333333332660.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114208_21125.333333333333332777.0Compositional biasNote=Poly-Ser
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114750_75325.333333333333332777.0Compositional biasNote=Poly-Pro
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116126_22125.333333333333332863.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116226_31925.333333333333332863.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116320_41925.333333333333332863.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116423_52025.333333333333332863.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116521_62025.333333333333332863.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115126_22125.333333333333332660.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115226_31925.333333333333332660.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115320_41925.333333333333332660.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115423_52025.333333333333332660.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115521_62025.333333333333332660.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216126_22125.333333333333332660.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216226_31925.333333333333332660.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216320_41925.333333333333332660.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216423_52025.333333333333332660.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216521_62025.333333333333332660.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114126_22125.333333333333332777.0DomainFibronectin type-III 1
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114226_31925.333333333333332777.0DomainFibronectin type-III 2
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114320_41925.333333333333332777.0DomainFibronectin type-III 3
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114423_52025.333333333333332777.0DomainFibronectin type-III 4
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114521_62025.333333333333332777.0DomainFibronectin type-III 5
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116305_30925.333333333333332863.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116662_67025.333333333333332863.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115305_30925.333333333333332660.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115662_67025.333333333333332660.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216305_30925.333333333333332660.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216662_67025.333333333333332660.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114305_30925.333333333333332777.0MotifNote=WSXWS motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114662_67025.333333333333332777.0MotifNote=Box 1 motif
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116796_80125.333333333333332863.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115796_80125.333333333333332660.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216796_80125.333333333333332660.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114796_80125.333333333333332777.0RegionNote=Required for STAT4 binding
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000026234511624_62225.333333333333332863.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116644_86225.333333333333332863.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000037100011524_62225.333333333333332660.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115644_86225.333333333333332660.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000054137421624_62225.333333333333332660.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216644_86225.333333333333332660.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST0000054443411424_62225.333333333333332777.0Topological domainExtracellular
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114644_86225.333333333333332777.0Topological domainCytoplasmic
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000262345116623_64325.333333333333332863.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000371000115623_64325.333333333333332660.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000541374216623_64325.333333333333332660.0TransmembraneHelical
TgeneIL12RB2chr1:64475048chr1:67787285ENST00000544434114623_64325.333333333333332777.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29753_78254.333333333333336938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29784_85154.333333333333336938.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29853_87654.333333333333336938.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27753_78254.333333333333336394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27784_85154.333333333333336394.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27853_87654.333333333333336394.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16753_7820389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16784_8510389.0Compositional biasNote=Pro-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16853_8760389.0Compositional biasNote=Ser/Thr-rich
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29165_29954.333333333333336938.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29312_39154.333333333333336938.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-2942_14754.333333333333336938.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29473_74654.333333333333336938.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27165_29954.333333333333336394.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27312_39154.333333333333336394.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-2742_14754.333333333333336394.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27473_74654.333333333333336394.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16165_2990389.0DomainFZ
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16312_3910389.0DomainKringle
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-1642_1470389.0DomainNote=Ig-like C2-type
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16473_7460389.0DomainProtein kinase
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29479_48754.333333333333336938.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27479_48754.333333333333336394.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16479_4870389.0Nucleotide bindingATP
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-2930_40654.333333333333336938.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29428_93754.333333333333336938.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-2730_40654.333333333333336394.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27428_93754.333333333333336394.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-1630_4060389.0Topological domainExtracellular
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16428_9370389.0Topological domainCytoplasmic
HgeneROR1chr1:64475048chr1:67787285ENST00000371079-29407_42754.333333333333336938.0TransmembraneHelical
HgeneROR1chr1:64475048chr1:67787285ENST00000371080-27407_42754.333333333333336394.0TransmembraneHelical
HgeneROR1chr1:64475048chr1:67787285ENST00000545203-16407_4270389.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ROR1
IL12RB2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ROR1-IL12RB2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ROR1-IL12RB2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource