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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RPL10-GNB2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RPL10-GNB2
FusionPDB ID: 75768
FusionGDB2.0 ID: 75768
HgeneTgene
Gene symbol

RPL10

GNB2

Gene ID

6138

2783

Gene nameribosomal protein L15G protein subunit beta 2
SynonymsDBA12|EC45|L15|RPL10|RPLY10|RPYL10-
Cytomap

3p24.2

7q22.1

Type of geneprotein-codingprotein-coding
Description60S ribosomal protein L15large ribosomal subunit protein eL15guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2G protein, beta-2 subunitepididymis secretory sperm binding proteing protein subunit beta-2guanine nucleotide binding protein (G protein), beta polypeptide 2guanine nucleotide-binding pr
Modification date2020031320200313
UniProtAcc.

P62879

Ensembl transtripts involved in fusion geneENST idsENST00000479366, ENST00000369817, 
ENST00000424325, ENST00000406022, 
ENST00000303210, ENST00000424361, 
ENST00000436220, ENST00000419828, 
ENST00000393924, ENST00000393926, 
ENST00000427895, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 7=9246 X 7 X 2=84
# samples 177
** MAII scorelog2(17/924*10)=-2.44235810527836
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RPL10 [Title/Abstract] AND GNB2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPL10(153626883)-GNB2(100274974), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across RPL10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GNB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8531RPL10chrX

153626883

+GNB2chr7

100274974

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000369817RPL10chrX153626883+ENST00000303210GNB2chr7100274974+17925994411418325
ENST00000369817RPL10chrX153626883+ENST00000436220GNB2chr7100274974+17665994411418325
ENST00000369817RPL10chrX153626883+ENST00000424361GNB2chr7100274974+17565994411418325
ENST00000424325RPL10chrX153626883+ENST00000303210GNB2chr7100274974+1404211531030325
ENST00000424325RPL10chrX153626883+ENST00000436220GNB2chr7100274974+1378211531030325
ENST00000424325RPL10chrX153626883+ENST00000424361GNB2chr7100274974+1368211531030325

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369817ENST00000303210RPL10chrX153626883+GNB2chr7100274974+0.0048720020.99512804
ENST00000369817ENST00000436220RPL10chrX153626883+GNB2chr7100274974+0.0047188840.99528104
ENST00000369817ENST00000424361RPL10chrX153626883+GNB2chr7100274974+0.0048546430.9951454
ENST00000424325ENST00000303210RPL10chrX153626883+GNB2chr7100274974+0.0057703490.9942297
ENST00000424325ENST00000436220RPL10chrX153626883+GNB2chr7100274974+0.0056374640.9943625
ENST00000424325ENST00000424361RPL10chrX153626883+GNB2chr7100274974+0.0059599480.99404013

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75768_75768_1_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000303210_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

>75768_75768_2_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000424361_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

>75768_75768_3_RPL10-GNB2_RPL10_chrX_153626883_ENST00000369817_GNB2_chr7_100274974_ENST00000436220_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

>75768_75768_4_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000303210_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

>75768_75768_5_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000424361_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

>75768_75768_6_RPL10-GNB2_RPL10_chrX_153626883_ENST00000424325_GNB2_chr7_100274974_ENST00000436220_length(amino acids)=325AA_BP=53
MTERPPVFDRTLWFLRAQTDRLYKPCAGGGAPLSLRCATEDPGVAMGRRPARWLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAY
APSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPD
GRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:153626883/chr7:100274974)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GNB2

P62879

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310141_17067.66666666666667341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310182_21267.66666666666667341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310224_25467.66666666666667341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310268_29867.66666666666667341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST00000303210310310_34067.66666666666667341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST0000030321031095_12567.66666666666667341.0RepeatNote=WD 2
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429141_17067.66666666666667341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429182_21267.66666666666667341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429224_25467.66666666666667341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429268_29867.66666666666667341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392429310_34067.66666666666667341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST000003939242995_12567.66666666666667341.0RepeatNote=WD 2
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310141_17067.66666666666667341.0RepeatNote=WD 3
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310182_21267.66666666666667341.0RepeatNote=WD 4
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310224_25467.66666666666667341.0RepeatNote=WD 5
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310268_29867.66666666666667341.0RepeatNote=WD 6
TgeneGNB2chrX:153626883chr7:100274974ENST00000393926310310_34067.66666666666667341.0RepeatNote=WD 7
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392631095_12567.66666666666667341.0RepeatNote=WD 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGNB2chrX:153626883chr7:100274974ENST0000030321031053_8367.66666666666667341.0RepeatNote=WD 1
TgeneGNB2chrX:153626883chr7:100274974ENST000003939242953_8367.66666666666667341.0RepeatNote=WD 1
TgeneGNB2chrX:153626883chr7:100274974ENST0000039392631053_8367.66666666666667341.0RepeatNote=WD 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RPL10
GNB2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RPL10-GNB2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RPL10-GNB2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource