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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ATP1B1-RCSD1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP1B1-RCSD1
	FusionPDB ID: 7806
	FusionGDB2.0 ID: 7806
		Hgene	Tgene
	Gene symbol	ATP1B1	RCSD1
	Gene ID	481	92241
	Gene name	ATPase Na+/K+ transporting subunit beta 1	RCSD domain containing 1
	Synonyms	ATP1B	CAPZIP\|MK2S4
	Cytomap	1q24.2	1q24.2
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium-transporting ATPase subunit beta-1ATPase, Na+/K+ transporting, beta 1 polypeptideBeta 1-subunit of Na(+),K(+)-ATPaseNa, K-ATPase beta-1 polypeptideadenosinetriphosphatasesodium pump subunit beta-1sodium-potassium ATPase subunit beta	capZ-interacting proteinRCSD domain-containing protein 1protein kinase substrate CapZIPprotein kinase substrate MK2S4
	Modification date	20200313	20200313
	UniProtAcc	P05026	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367813, ENST00000367815, ENST00000367816, ENST00000499679,	ENST00000472038, ENST00000367854, ENST00000537350,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	11 X 12 X 7=924	9 X 8 X 6=432
	# samples	16	9
	** MAII score	log2(16/924*10)=-2.5298209465287 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ATP1B1 [Title/Abstract] AND RCSD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP1B1(169099328)-RCSD1(167653137), # samples:3
Anticipated loss of major functional domain due to fusion event.	ATP1B1-RCSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1B1-RCSD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1B1-RCSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1B1-RCSD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP1B1	GO:0006883	cellular sodium ion homeostasis	10636900\|19542013
Hgene	ATP1B1	GO:0030007	cellular potassium ion homeostasis	10636900\|19542013
Hgene	ATP1B1	GO:0032781	positive regulation of ATPase activity	10636900
Hgene	ATP1B1	GO:0036376	sodium ion export across plasma membrane	10636900\|19542013
Hgene	ATP1B1	GO:0046034	ATP metabolic process	23954377
Hgene	ATP1B1	GO:0050821	protein stabilization	10636900
Hgene	ATP1B1	GO:0072659	protein localization to plasma membrane	18522992
Hgene	ATP1B1	GO:0086009	membrane repolarization	19542013
Hgene	ATP1B1	GO:1901018	positive regulation of potassium ion transmembrane transporter activity	10636900
Hgene	ATP1B1	GO:1903278	positive regulation of sodium ion export across plasma membrane	10636900
Hgene	ATP1B1	GO:1903288	positive regulation of potassium ion import	10636900
Hgene	ATP1B1	GO:1990573	potassium ion import across plasma membrane	10636900\|19542013
Tgene	RCSD1	GO:0071474	cellular hyperosmotic response	15850461

Fusion gene breakpoints across ATP1B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RCSD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-86-8281-01A	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+
ChimerDB4	LUAD	TCGA-86-8281-01A	ATP1B1	chr1	169099328	-	RCSD1	chr1	167653137	+
ChimerDB4	LUAD	TCGA-86-8281-01A	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367816	ATP1B1	chr1	169099328	+	ENST00000367854	RCSD1	chr1	167653137	+	3975	1177	529	2421	630
ENST00000367816	ATP1B1	chr1	169099328	+	ENST00000537350	RCSD1	chr1	167653137	+	2422	1177	529	2331	600
ENST00000367815	ATP1B1	chr1	169099328	+	ENST00000367854	RCSD1	chr1	167653137	+	3953	1155	507	2399	630
ENST00000367815	ATP1B1	chr1	169099328	+	ENST00000537350	RCSD1	chr1	167653137	+	2400	1155	507	2309	600
ENST00000499679	ATP1B1	chr1	169099328	+	ENST00000367854	RCSD1	chr1	167653137	+	3512	714	201	1958	585
ENST00000499679	ATP1B1	chr1	169099328	+	ENST00000537350	RCSD1	chr1	167653137	+	1959	714	201	1868	555
ENST00000367813	ATP1B1	chr1	169099328	+	ENST00000367854	RCSD1	chr1	167653137	+	3455	657	24	1901	625
ENST00000367813	ATP1B1	chr1	169099328	+	ENST00000537350	RCSD1	chr1	167653137	+	1902	657	24	1811	595
ENST00000367816	ATP1B1	chr1	169099327	+	ENST00000367854	RCSD1	chr1	167653136	+	3975	1177	529	2421	630
ENST00000367816	ATP1B1	chr1	169099327	+	ENST00000537350	RCSD1	chr1	167653136	+	2422	1177	529	2331	600
ENST00000367815	ATP1B1	chr1	169099327	+	ENST00000367854	RCSD1	chr1	167653136	+	3953	1155	507	2399	630
ENST00000367815	ATP1B1	chr1	169099327	+	ENST00000537350	RCSD1	chr1	167653136	+	2400	1155	507	2309	600
ENST00000499679	ATP1B1	chr1	169099327	+	ENST00000367854	RCSD1	chr1	167653136	+	3512	714	201	1958	585
ENST00000499679	ATP1B1	chr1	169099327	+	ENST00000537350	RCSD1	chr1	167653136	+	1959	714	201	1868	555
ENST00000367813	ATP1B1	chr1	169099327	+	ENST00000367854	RCSD1	chr1	167653136	+	3455	657	24	1901	625
ENST00000367813	ATP1B1	chr1	169099327	+	ENST00000537350	RCSD1	chr1	167653136	+	1902	657	24	1811	595

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367816	ENST00000367854	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.002002043	0.99799794
ENST00000367816	ENST00000537350	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.018239781	0.9817602
ENST00000367815	ENST00000367854	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.001717615	0.99828243
ENST00000367815	ENST00000537350	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.016269194	0.9837308
ENST00000499679	ENST00000367854	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.001044879	0.99895513
ENST00000499679	ENST00000537350	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.008267664	0.99173236
ENST00000367813	ENST00000367854	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.001076956	0.998923
ENST00000367813	ENST00000537350	ATP1B1	chr1	169099328	+	RCSD1	chr1	167653137	+	0.009557982	0.990442
ENST00000367816	ENST00000367854	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.002002043	0.99799794
ENST00000367816	ENST00000537350	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.018239781	0.9817602
ENST00000367815	ENST00000367854	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.001717615	0.99828243
ENST00000367815	ENST00000537350	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.016269194	0.9837308
ENST00000499679	ENST00000367854	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.001044879	0.99895513
ENST00000499679	ENST00000537350	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.008267664	0.99173236
ENST00000367813	ENST00000367854	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.001076956	0.998923
ENST00000367813	ENST00000537350	ATP1B1	chr1	169099327	+	RCSD1	chr1	167653136	+	0.009557982	0.990442

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7806_7806_1_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367813_RCSD1_chr1_167653136_ENST00000367854_length(amino acids)=625AA_BP=211
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDP
KSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLG
FKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLG
QNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGS
HLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRR
SPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEH

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>7806_7806_2_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367813_RCSD1_chr1_167653136_ENST00000537350_length(amino acids)=595AA_BP=211
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDP
KSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLG
FKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLIEKLQA
NLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDC
GELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEV
DGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDV

--------------------------------------------------------------

>7806_7806_3_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367815_RCSD1_chr1_167653136_ENST00000367854_length(amino acids)=630AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPP
KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQ
PPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEK
PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEE
VGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM

--------------------------------------------------------------

>7806_7806_4_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367815_RCSD1_chr1_167653136_ENST00000537350_length(amino acids)=600AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLI
EKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR
SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARR
SSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV

--------------------------------------------------------------

>7806_7806_5_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367816_RCSD1_chr1_167653136_ENST00000367854_length(amino acids)=630AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPP
KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQ
PPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEK
PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEE
VGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM

--------------------------------------------------------------

>7806_7806_6_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000367816_RCSD1_chr1_167653136_ENST00000537350_length(amino acids)=600AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLI
EKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR
SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARR
SSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV

--------------------------------------------------------------

>7806_7806_7_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000499679_RCSD1_chr1_167653136_ENST00000367854_length(amino acids)=585AA_BP=171
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKE
RGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNAN
VDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALL
PGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVE
SSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEV
PESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQ

--------------------------------------------------------------

>7806_7806_8_ATP1B1-RCSD1_ATP1B1_chr1_169099327_ENST00000499679_RCSD1_chr1_167653136_ENST00000537350_length(amino acids)=555AA_BP=171
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKE
RGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNAN
VDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVR
SRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSE
GAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEM
EKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPA

--------------------------------------------------------------

>7806_7806_9_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367813_RCSD1_chr1_167653137_ENST00000367854_length(amino acids)=625AA_BP=211
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDP
KSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLG
FKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLG
QNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGS
HLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRR
SPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEH

--------------------------------------------------------------

>7806_7806_10_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367813_RCSD1_chr1_167653137_ENST00000537350_length(amino acids)=595AA_BP=211
MLTMGKRKCSPASQSLFLFQFQKMELKFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDP
KSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLG
FKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLIEKLQA
NLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDC
GELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEV
DGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDV

--------------------------------------------------------------

>7806_7806_11_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367815_RCSD1_chr1_167653137_ENST00000367854_length(amino acids)=630AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPP
KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQ
PPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEK
PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEE
VGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM

--------------------------------------------------------------

>7806_7806_12_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367815_RCSD1_chr1_167653137_ENST00000537350_length(amino acids)=600AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLI
EKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR
SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARR
SSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV

--------------------------------------------------------------

>7806_7806_13_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367816_RCSD1_chr1_167653137_ENST00000367854_length(amino acids)=630AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPP
KVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQ
PPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEK
PPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEE
VGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPAVPKPEDDTPVQDTKM

--------------------------------------------------------------

>7806_7806_14_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000367816_RCSD1_chr1_167653137_ENST00000537350_length(amino acids)=600AA_BP=216
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISF
RPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNANVDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLI
EKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRR
SQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARR
SSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGV

--------------------------------------------------------------

>7806_7806_15_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000499679_RCSD1_chr1_167653137_ENST00000367854_length(amino acids)=585AA_BP=171
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKE
RGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNAN
VDNSASPSVAQLAGRFREQAAAAKETPASKPTRRKPPCSLPLFPPKVDLGQNGEEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALL
PGASPKSPGLKAMVSPFHSPPSTPSSPGVRSRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVE
SSQQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEV
PESPQTSGPEAENRCGSPREEKPAGEEAEMEKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQ

--------------------------------------------------------------

>7806_7806_16_ATP1B1-RCSD1_ATP1B1_chr1_169099328_ENST00000499679_RCSD1_chr1_167653137_ENST00000537350_length(amino acids)=555AA_BP=171
MAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKE
RGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKERPAETNAN
VDNSASPSVAQLAGRFREQAAAAKEKSPPNASHPPKFKVKSSPLIEKLQANLTFDPAALLPGASPKSPGLKAMVSPFHSPPSTPSSPGVR
SRPSEAEEVPVSFDQPPEGSHLPCYNKVRTRGSIKRRPPSRRFRRSQSDCGELGDFRAVESSQQNGAKEEDGDEVLPSKSKAPGSPLSSE
GAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNGEKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGEEAEM
EKATEVKGERVQNEEVGPEHDSQETKKLEEGAAVKETPHSPPGGVKGGDVPKQEKGKEKQQEGAVLEPGCSPQTGPAQLETSSEVQSEPA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:169099328/chr1:167653137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP1B1 P05026	.
FUNCTION: This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. {ECO:0000269\|PubMed:19694409}.; FUNCTION: Involved in cell adhesion and establishing epithelial cell polarity. {ECO:0000269\|PubMed:19694409}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367815

1_34

216.0

304.0

Topological domain

Cytoplasmic

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367816

1_34

216.0

304.0

Topological domain

Cytoplasmic

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367815

1_34

216.0

304.0

Topological domain

Cytoplasmic

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367816

1_34

216.0

304.0

Topological domain

Cytoplasmic

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367815

35_62

216.0

304.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367816

35_62

216.0

304.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367815

35_62

216.0

304.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367816

35_62

216.0

304.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RCSD1

chr1:169099327

chr1:167653136

ENST00000367854

227_330

2.0

417.0

Domain

Note=RCSD

Tgene

RCSD1

chr1:169099328

chr1:167653137

ENST00000367854

227_330

2.0

417.0

Domain

Note=RCSD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367815

191_303

216.0

304.0

Region

Note=immunoglobulin-like

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367816

191_303

216.0

304.0

Region

Note=immunoglobulin-like

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367815

191_303

216.0

304.0

Region

Note=immunoglobulin-like

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367816

191_303

216.0

304.0

Region

Note=immunoglobulin-like

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367815

63_303

216.0

304.0

Topological domain

Extracellular

Hgene

ATP1B1

chr1:169099327

chr1:167653136

ENST00000367816

63_303

216.0

304.0

Topological domain

Extracellular

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367815

63_303

216.0

304.0

Topological domain

Extracellular

Hgene

ATP1B1

chr1:169099328

chr1:167653137

ENST00000367816

63_303

216.0

304.0

Topological domain

Extracellular

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ATP1B1
RCSD1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ATP1B1-RCSD1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ATP1B1-RCSD1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source