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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RUNX1-CBFA2T2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RUNX1-CBFA2T2
FusionPDB ID: 78645
FusionGDB2.0 ID: 78645
HgeneTgene
Gene symbol

RUNX1

CBFA2T2

Gene ID

861

9139

Gene nameRUNX family transcription factor 1CBFA2/RUNX1 partner transcriptional co-repressor 2
SynonymsAML1|AML1-EVI-1|AMLCR1|CBF2alpha|CBFA2|EVI-1|PEBP2aB|PEBP2alphaEHT|MTGR1|ZMYND3|p85
Cytomap

21q22.12

20q11.21-q11.22

Type of geneprotein-codingprotein-coding
Descriptionrunt-related transcription factor 1AML1-EVI-1 fusion proteinPEA2-alpha BPEBP2-alpha BSL3-3 enhancer factor 1 alpha B subunitSL3/AKV core-binding factor alpha B subunitacute myeloid leukemia 1 proteincore-binding factor, runt domain, alpha subunit 2protein CBFA2T2CBFA2/RUNX1 translocation partner 2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-rela
Modification date2020032220200313
UniProtAcc

Q06455

O43439

Ensembl transtripts involved in fusion geneENST idsENST00000300305, ENST00000325074, 
ENST00000344691, ENST00000358356, 
ENST00000399240, ENST00000437180, 
ENST00000486278, ENST00000494829, 
ENST00000344201, ENST00000346541, 
ENST00000359606, ENST00000397798, 
ENST00000397800, ENST00000492345, 
ENST00000491618, ENST00000543126, 
ENST00000342704, ENST00000375279, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score46 X 68 X 13=4066417 X 18 X 9=2754
# samples 8925
** MAII scorelog2(89/40664*10)=-5.51380298959468
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2754*10)=-3.46152855947288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RUNX1 [Title/Abstract] AND CBFA2T2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RUNX1(36231874)-CBFA2T2(32194762), # samples:1
RUNX1(36231771)-CBFA2T2(32194762), # samples:1
RUNX1(36095625)-CBFA2T2(32161779), # samples:1
Anticipated loss of major functional domain due to fusion event.RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
RUNX1-CBFA2T2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRUNX1

GO:0030097

hemopoiesis

21873977

HgeneRUNX1

GO:0045893

positive regulation of transcription, DNA-templated

10207087|14970218

HgeneRUNX1

GO:0045944

positive regulation of transcription by RNA polymerase II

9199349|10207087|14970218|21873977

TgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

TgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453


check buttonFusion gene breakpoints across RUNX1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CBFA2T2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute myeloid leukemiaGU070940RUNX1chr21

36231874

CBFA2T2chr20

32194762
ChiTaRS5.0N/AGU070940RUNX1chr21

36231771

-CBFA2T2chr20

32194762

+
ChiTaRS5.0N/AGU086368RUNX1chr21

36095625

-CBFA2T2chr20

32161779

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000344691RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+4759211015783863761
ENST00000344691RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+9254211015783863761
ENST00000325074RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+322657702330776
ENST00000325074RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+772157702330776
ENST00000300305RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+370710584452811788
ENST00000300305RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+820210584452811788
ENST00000399240RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+3252603712356761
ENST00000399240RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+7747603712356761
ENST00000486278RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+34067571442510788
ENST00000486278RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+79017571442510788
ENST00000358356RUNX1chr2136231771-ENST00000342704CBFA2T2chr2032194762+4759211015783863761
ENST00000358356RUNX1chr2136231771-ENST00000375279CBFA2T2chr2032194762+9254211015783863761

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000344691ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0259299780.97407
ENST00000344691ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0105796090.9894204
ENST00000325074ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0346208330.9653791
ENST00000325074ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0101531350.9898469
ENST00000300305ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0305812250.9694188
ENST00000300305ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0094578690.9905421
ENST00000399240ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.031948370.9680517
ENST00000399240ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0123885220.9876115
ENST00000486278ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.032791860.96720815
ENST00000486278ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0101443550.98985565
ENST00000358356ENST00000342704RUNX1chr2136231771-CBFA2T2chr2032194762+0.0259299780.97407
ENST00000358356ENST00000375279RUNX1chr2136231771-CBFA2T2chr2032194762+0.0105796090.9894204

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>78645_78645_1_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

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>78645_78645_2_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000300305_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

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>78645_78645_3_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=776AA_BP=193
MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL
PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA
IKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASST
SSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRE
LLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLM
NPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRS
MAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQK
AVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLH

--------------------------------------------------------------

>78645_78645_4_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000325074_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=776AA_BP=193
MPAAPRGPAQGEAAARTRSRDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVL
PTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRA
IKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASST
SSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRE
LLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLM
NPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRS
MAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQK
AVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLH

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>78645_78645_5_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

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>78645_78645_6_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000344691_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------

>78645_78645_7_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------

>78645_78645_8_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000358356_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

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>78645_78645_9_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------

>78645_78645_10_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000399240_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=761AA_BP=178
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFK
VVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRIGP
EKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGA
RQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQY
LAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQH
YTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREEL
NYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIAT
ERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQNLHGQSPHGQGRPLLPVG

--------------------------------------------------------------

>78645_78645_11_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000342704_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------

>78645_78645_12_RUNX1-CBFA2T2_RUNX1_chr21_36231771_ENST00000486278_CBFA2T2_chr20_32194762_ENST00000375279_length(amino acids)=788AA_BP=205
MASDSIFESFPSYPQCFMRECILGMNPSRDVHDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELV
RTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVF
TNPPQVATYHRAIKITVDGPREPRIGPEKRVPAMPGSPVEVKIQSRSSPPTMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSP
PQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIP
FLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERREENSFDRDTIAPEPPAKRVCTISPA
PRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRDRHHSLGLNGGYQDELVDHRLTEREWADEWKHLDHALN
CIMEMVEKTRRSMAVLRRCQESDREELNYWKRRYNENTELRKTGTELVSRQHSPGSADSLSNDSQREFNSRPGTGYVPVEFWKKTEEAVN
KVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDW

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:36231874/chr20:32194762)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RUNX1

Q06455

CBFA2T2

O43439

FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199, PubMed:10688654). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588). {ECO:0000250|UniProtKB:Q61909, ECO:0000269|PubMed:10688654, ECO:0000269|PubMed:10973986, ECO:0000269|PubMed:16803958, ECO:0000269|PubMed:23251453, ECO:0000269|PubMed:23812588, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-5850_178204.33333333333334481.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-4750_178192.33333333333334469.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-3650_178177.33333333333334454.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-3550_178177.33333333333334251.0DomainRunt
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-6950_178204.33333333333334481.0DomainRunt
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011451_49111.333333333333334596.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112451_49120.333333333333332605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011451_49130.333333333333332615.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112451_49120.333333333333332605.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817451_4910264.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011451_4910576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213451_4910576.0Coiled coilOntology_term=ECO:0000255
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034270401133_9711.333333333333334596.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST000003442010633_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034654111233_9720.333333333333332605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000035960601133_9730.333333333333332615.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000037527911233_9720.333333333333332605.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST000003977981733_970264.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039780001133_970576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000049234521333_970576.0Compositional biasNote=Pro-rich
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011113_20811.333333333333334596.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106113_2080264.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112113_20820.333333333333332605.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011113_20830.333333333333332615.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112113_20820.333333333333332605.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817113_2080264.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011113_2080576.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213113_2080576.0DomainTAFH
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011331_37711.333333333333334596.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011435_48411.333333333333334596.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112331_37720.333333333333332605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112435_48420.333333333333332605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011331_37730.333333333333332615.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011435_48430.333333333333332615.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112331_37720.333333333333332605.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112435_48420.333333333333332605.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817331_3770264.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817435_4840264.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011331_3770576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011435_4840576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213331_3770576.0RegionNervy homology region 2 (NHR2)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213435_4840576.0RegionNervy homology region 3 (NHR3)
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000342704011517_55311.333333333333334596.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000034420106517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000346541112517_55320.333333333333332605.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000359606011517_55330.333333333333332615.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000375279112517_55320.333333333333332605.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST0000039779817517_5530264.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000397800011517_5530576.0Zinc fingerMYND-type
TgeneCBFA2T2chr21:36231771chr20:32194762ENST00000492345213517_5530576.0Zinc fingerMYND-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58187_453204.33333333333334481.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47187_453192.33333333333334469.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36187_453177.33333333333334454.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35187_453177.33333333333334251.0Compositional biasNote=Pro/Ser/Thr-rich
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69187_453204.33333333333334481.0Compositional biasNote=Pro/Ser/Thr-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
RUNX1SUV39H1, KAT6B, CBFB, AES, PAX5, YAP1, JUN, FOS, SMAD3, SMAD1, SMAD2, SMAD5, VDR, ELF4, ELF2, CEBPB, TLE1, CBFA2T2, TRAF6, FHL2, MYOD1, HIPK2, EP300, HDAC1, HDAC3, KAT6A, tat, TCF12, TCF3, RUNX1T1, NCOR1, SIAH1, UBE2L6, RUNX1, PML, RARA, HDAC2, SIN3A, NR4A2, TRIM33, STUB1, Vdr, SMARCA4, SMARCB1, SMARCC1, CDK1, TAL1, COPRS, KMT2A, RBM14, SPEN, DNMT1, ELAVL1, CBFA2T3, PRMT1, HLA-DMA, CREBBP, UXT, CTBP2, NOTCH1, MYC, NCOR2, FOXP3, SOX2, CTBP1, HDAC11, RAG1, SPI1, ELF1, Cep72, CDK6, vif, KLF6, NFATC1, NFATC2, ZNF131, BRCA1, CDK9, FANCD2, Cbfb, CTNNB1, WWP1, RNF38, RNF44, DTX2, TRIM5, UHRF2, DZIP3, NEDD4, NKX2-1, HIF1A, ACTB, ARID1A, ARID3A, ASH2L, ACTL6A, BRD9, C2orf44, CCNK, CDC16, CDKN2AIP, CLTC, NELFB, CPSF3, CPSF6, CSTF2, CSTF2T, CTPS1, DDX1, DDX17, DDX21, DDX3X, DDX41, DDX5, DHX15, DHX36, DHX9, DPF2, EEF1A1, EEF1A2, EWSR1, EZR, FAF1, FERMT3, FIP1L1, FUBP1, FUS, GATAD2A, GATAD2B, GMPS, HIC2, HNRNPH1, HNRNPM, HNRNPR, HNRNPU, HSPA1A, HSPA2, HSPA5, HSPA8, HSPA9, IGF2BP1, INTS10, INTS9, KHSRP, KIF2B, LARP7, LCP1, LMNA, LMNB1, LRRC40, LRWD1, MED1, MED12, MED16, MED17, MED26, MEN1, MLLT1, MTA2, NDC80, NOP56, NONO, NUP85, ORC2, PABPC1, PABPC4, PAXIP1, PRMT5, PSIP1, PSPC1, RAD18, RANGAP1, RARS, RBBP5, RBM39, RPA1, RPAP2, SF1, SF3B2, SF3B3, SFPQ, SMARCC2, SMARCD1, SNRNP70, SNRPD1, SNX9, U2SURP, SRP68, SYNCRIP, TAF15, TFRC, TKT, TRAP1, TRIM25, TUBA1B, TUBB2A, UBP1, USP39, WDR76, XRCC6, XRN2, ZNF326, DMBT1, DNAJA3, DNAJB11, DPYSL2, DYNLL1, EIF3A, EIF3G, EIF4A2, EMG1, DCPS, IKZF3, IKZF1, MAD2L2, KIAA1429, Hipk2, HIST1H4A, ORF3b, MAPK1, TEAD2, SNRPC, BAG3, TEKT5, BAG4, NFKBID, VPS37C, FAM222B, OLIG3, GCC1, HGS, TEAD4, FBXO17, CIC, GSK3A, ATG7, FBXW12, RUNX2, FOXF2, NAAA, GPR55, BTF3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RUNX1all structure
CBFA2T2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58362_402204.33333333333334481.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47362_402192.33333333333334469.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36362_402177.33333333333334454.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35362_402177.33333333333334251.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69362_402204.33333333333334481.0FOXP3
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58291_371204.33333333333334481.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47291_371192.33333333333334469.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36291_371177.33333333333334454.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35291_371177.33333333333334251.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69291_371204.33333333333334481.0KAT6A
HgeneRUNX1chr21:36231771chr20:32194762ENST00000300305-58307_400204.33333333333334481.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000325074-47307_400192.33333333333334469.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000344691-36307_400177.33333333333334454.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000358356-35307_400177.33333333333334251.0KAT6B
HgeneRUNX1chr21:36231771chr20:32194762ENST00000437180-69307_400204.33333333333334481.0KAT6B


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Related Drugs to RUNX1-CBFA2T2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RUNX1-CBFA2T2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRUNX1C1832388Platelet Disorder, Familial, with Associated Myeloid Malignancy11CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRUNX1C0023467Leukemia, Myelocytic, Acute4CGI;CTD_human;GENOMICS_ENGLAND
HgeneRUNX1C0026998Acute Myeloid Leukemia, M13CTD_human
HgeneRUNX1C1879321Acute Myeloid Leukemia (AML-M2)3CTD_human
HgeneRUNX1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma2CTD_human
HgeneRUNX1C0003873Rheumatoid Arthritis1CTD_human
HgeneRUNX1C0006413Burkitt Lymphoma1ORPHANET
HgeneRUNX1C0017636Glioblastoma1CTD_human
HgeneRUNX1C0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneRUNX1C0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneRUNX1C0023473Myeloid Leukemia, Chronic1ORPHANET
HgeneRUNX1C0033578Prostatic Neoplasms1CTD_human
HgeneRUNX1C0040034Thrombocytopenia1GENOMICS_ENGLAND
HgeneRUNX1C0334588Giant Cell Glioblastoma1CTD_human
HgeneRUNX1C0349639Juvenile Myelomonocytic Leukemia1CTD_human
HgeneRUNX1C0376358Malignant neoplasm of prostate1CTD_human
HgeneRUNX1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneRUNX1C1621958Glioblastoma Multiforme1CTD_human
HgeneRUNX1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneRUNX1C2713368Hematopoetic Myelodysplasia1CTD_human
HgeneRUNX1C3463824MYELODYSPLASTIC SYNDROME1CTD_human