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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SCYL1-ASNA1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SCYL1-ASNA1
	FusionPDB ID: 79767
	FusionGDB2.0 ID: 79767
		Hgene	Tgene
	Gene symbol	SCYL1	ASNA1
	Gene ID	57410	439
	Gene name	SCY1 like pseudokinase 1	guided entry of tail-anchored proteins factor 3, ATPase
	Synonyms	GKLP\|HT019\|NKTL\|NTKL\|P105\|SCAR21\|TAPK\|TEIF\|TRAP	ARSA-I\|ARSA1\|ASNA-I\|ASNA1\|TRC40
	Cytomap	11q13.1	19p13.13
	Type of gene	protein-coding	protein-coding
	Description	N-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-int	ATPase ASNA1arsA arsenite transporter, ATP-binding, homolog 1golgi to ER traffic 3 homologtransmembrane domain recognition complex 40 kDa ATPase subunit
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000270176, ENST00000279270, ENST00000420247, ENST00000524944, ENST00000525364, ENST00000527009, ENST00000533862, ENST00000534462,	ENST00000357332, ENST00000591090,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 8 X 7=448	8 X 8 X 4=256
	# samples	14	10
	** MAII score	log2(14/448*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SCYL1 [Title/Abstract] AND ASNA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SCYL1(65299154)-ASNA1(12856190), # samples:1
Anticipated loss of major functional domain due to fusion event.	SCYL1-ASNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SCYL1-ASNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SCYL1-ASNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SCYL1-ASNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SCYL1	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER	18556652
Tgene	ASNA1	GO:0071816	tail-anchored membrane protein insertion into ER membrane	25535373

Fusion gene breakpoints across SCYL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ASNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0801	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000525364	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2150	1193	77	1930	617
ENST00000525364	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2150	1193	77	1930	617
ENST00000270176	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2150	1193	77	1930	617
ENST00000270176	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2150	1193	77	1930	617
ENST00000420247	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2142	1185	69	1922	617
ENST00000420247	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2142	1185	69	1922	617
ENST00000533862	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2115	1158	42	1895	617
ENST00000533862	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2115	1158	42	1895	617
ENST00000279270	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2114	1157	41	1894	617
ENST00000279270	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2114	1157	41	1894	617
ENST00000524944	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2106	1149	33	1886	617
ENST00000524944	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2106	1149	33	1886	617
ENST00000527009	SCYL1	chr11	65299154	+	ENST00000591090	ASNA1	chr19	12856190	+	2123	1166	278	1903	541
ENST00000527009	SCYL1	chr11	65299154	+	ENST00000357332	ASNA1	chr19	12856190	+	2123	1166	278	1903	541

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000525364	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.01145062	0.9885494
ENST00000525364	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.01145062	0.9885494
ENST00000270176	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.01145062	0.9885494
ENST00000270176	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.01145062	0.9885494
ENST00000420247	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011278546	0.98872143
ENST00000420247	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011278546	0.98872143
ENST00000533862	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011236977	0.98876303
ENST00000533862	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011236977	0.98876303
ENST00000279270	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011311387	0.98868865
ENST00000279270	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011311387	0.98868865
ENST00000524944	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011244512	0.9887554
ENST00000524944	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.011244512	0.9887554
ENST00000527009	ENST00000591090	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.012783952	0.98721606
ENST00000527009	ENST00000357332	SCYL1	chr11	65299154	+	ASNA1	chr19	12856190	+	0.012783952	0.98721606

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79767_79767_1_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000270176_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_2_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000270176_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

--------------------------------------------------------------

>79767_79767_3_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000279270_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_4_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000279270_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_5_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000420247_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_6_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000420247_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

--------------------------------------------------------------

>79767_79767_7_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000524944_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

--------------------------------------------------------------

>79767_79767_8_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000524944_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

--------------------------------------------------------------

>79767_79767_9_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000525364_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_10_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000525364_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

--------------------------------------------------------------

>79767_79767_11_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000527009_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=541AA_BP=295
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEY
QQKIIPVVVKMFSSTDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDT
APTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYE
TERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSA

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>79767_79767_12_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000527009_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=541AA_BP=295
MAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSA
QGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPAR
FLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEY
QQKIIPVVVKMFSSTDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDT
APTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYE
TERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSA

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>79767_79767_13_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000533862_ASNA1_chr19_12856190_ENST00000357332_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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>79767_79767_14_SCYL1-ASNA1_SCYL1_chr11_65299154_ENST00000533862_ASNA1_chr19_12856190_ENST00000591090_length(amino acids)=617AA_BP=371
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLH
VVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPE
LEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSN
RFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSS
TDRAMRIRLLQQEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPT
IVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKID

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65299154/chr19:12856190)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

14_314

372.0

809.0

Domain

Protein kinase

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

14_314

372.0

782.0

Domain

Protein kinase

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

14_314

372.0

792.0

Domain

Protein kinase

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

14_314

372.0

788.0

Domain

Protein kinase

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

761_797

372.0

809.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

761_797

372.0

782.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

761_797

372.0

792.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

761_797

372.0

788.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

589_619

372.0

809.0

Compositional bias

Note=Pro-rich

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

589_619

372.0

782.0

Compositional bias

Note=Pro-rich

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

589_619

372.0

792.0

Compositional bias

Note=Pro-rich

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

589_619

372.0

788.0

Compositional bias

Note=Pro-rich

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

350_388

372.0

809.0

Repeat

Note=HEAT 1

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

389_427

372.0

809.0

Repeat

Note=HEAT 2

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000270176

507_545

372.0

809.0

Repeat

Note=HEAT 3

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

350_388

372.0

782.0

Repeat

Note=HEAT 1

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

389_427

372.0

782.0

Repeat

Note=HEAT 2

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000279270

507_545

372.0

782.0

Repeat

Note=HEAT 3

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

350_388

372.0

792.0

Repeat

Note=HEAT 1

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

389_427

372.0

792.0

Repeat

Note=HEAT 2

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000420247

507_545

372.0

792.0

Repeat

Note=HEAT 3

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

350_388

372.0

788.0

Repeat

Note=HEAT 1

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

389_427

372.0

788.0

Repeat

Note=HEAT 2

Hgene

SCYL1

chr11:65299154

chr19:12856190

ENST00000533862

507_545

372.0

788.0

Repeat

Note=HEAT 3

Tgene

ASNA1

chr11:65299154

chr19:12856190

ENST00000357332

45_52

103.0

349.0

Nucleotide binding

ATP

Tgene

ASNA1

chr11:65299154

chr19:12856190

ENST00000591090

45_52

103.0

349.0

Nucleotide binding

ATP

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SCYL1
ASNA1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SCYL1	chr11:65299154	chr19:12856190	ENST00000270176	+	8	18	793_808	372.0	809.0	COPB1
Hgene	SCYL1	chr11:65299154	chr19:12856190	ENST00000279270	+	8	17	793_808	372.0	782.0	COPB1
Hgene	SCYL1	chr11:65299154	chr19:12856190	ENST00000420247	+	8	18	793_808	372.0	792.0	COPB1
Hgene	SCYL1	chr11:65299154	chr19:12856190	ENST00000533862	+	8	18	793_808	372.0	788.0	COPB1

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Related Drugs to SCYL1-ASNA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SCYL1-ASNA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source