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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP6V1G1-TNC

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP6V1G1-TNC
FusionPDB ID: 8200
FusionGDB2.0 ID: 8200
HgeneTgene
Gene symbol

ATP6V1G1

TNC

Gene ID

9550

7134

Gene nameATPase H+ transporting V1 subunit G1troponin C1, slow skeletal and cardiac type
SynonymsATP6G|ATP6G1|ATP6GL|ATP6J|Vma10CMD1Z|CMH13|TN-C|TNC|TNNC
Cytomap

9q32

3p21.1

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase subunit G 1ATPase, H+ transporting, lysosomal (vacuolar proton pump), member JATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1V-ATPase 13 kDa subunit 1V-ATPase subunit G 1vacuolar ATP synthase subunit M16vacuolar H(+)-ATPtroponin C, slow skeletal and cardiac musclescardiac troponin Cslow twitch skeletal/cardiac muscle troponin Ctroponin C type 1 (slow)
Modification date2020031320200313
UniProtAcc

O75348

.
Ensembl transtripts involved in fusion geneENST idsENST00000473413, ENST00000374050, 
ENST00000340094, ENST00000341037, 
ENST00000345230, ENST00000346706, 
ENST00000350763, ENST00000423613, 
ENST00000535648, ENST00000537320, 
ENST00000542877, ENST00000481475, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 3=1268 X 8 X 4=256
# samples 711
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/256*10)=-1.21864028647534
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP6V1G1 [Title/Abstract] AND TNC [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP6V1G1(117350200)-TNC(117783546), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ATP6V1G1-TNC seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTNC

GO:0006937

regulation of muscle contraction

18092822

TgeneTNC

GO:0060048

cardiac muscle contraction

25771144


check buttonFusion gene breakpoints across ATP6V1G1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A0JE-01AATP6V1G1chr9

117350200

+TNCchr9

117783546

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374050ATP6V1G1chr9117350200+ENST00000423613TNCchr9117783546-4971757028571

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374050ENST00000423613ATP6V1G1chr9117350200+TNCchr9117783546-0.437742650.5622574

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8200_8200_1_ATP6V1G1-TNC_ATP6V1G1_chr9_117350200_ENST00000374050_TNC_chr9_117783546_ENST00000423613_length(amino acids)=71AA_BP=35

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:117350200/chr9:117783546)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP6V1G1

O75348

.
FUNCTION: Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:28296633}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241802_18881801.01838.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241889_19771801.01838.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241975_21901801.01838.0DomainFibrinogen C-terminal
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211533_16211528.01565.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211622_17111528.01565.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211712_18011528.01565.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211802_18881528.01565.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211889_19771528.01565.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211975_21901528.01565.0DomainFibrinogen C-terminal
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221622_17111619.01656.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221712_18011619.01656.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221802_18881619.01656.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221889_19771619.01656.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221975_21901619.01656.0DomainFibrinogen C-terminal
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231712_18011710.01747.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231802_18881710.01747.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231889_19771710.01747.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231975_21901710.01747.0DomainFibrinogen C-terminal
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201533_16211528.01565.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201622_17111528.01565.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201712_18011528.01565.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201802_18881528.01565.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201889_19771528.01565.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201975_21901528.01565.0DomainFibrinogen C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224118_1451801.01838.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921118_1451528.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022118_1451619.01656.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628118_1452165.02202.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123118_1451710.01747.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820118_1451528.01565.0Coiled coilOntology_term=ECO:0000255
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241076_11651801.01838.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241167_12561801.01838.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241258_13501801.01838.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241351_14391801.01838.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241440_15311801.01838.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241533_16211801.01838.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241622_17111801.01838.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST0000034009422241712_18011801.01838.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224174_1861801.01838.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224186_2171801.01838.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224217_2481801.01838.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224248_2801801.01838.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224280_3111801.01838.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224311_3421801.01838.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224342_3731801.01838.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224373_4041801.01838.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224404_4351801.01838.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224435_4661801.01838.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224466_4971801.01838.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224497_5281801.01838.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224528_5591801.01838.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224559_5901801.01838.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224590_6211801.01838.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224625_7151801.01838.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224716_8041801.01838.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224805_8941801.01838.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224895_9901801.01838.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000003400942224991_10751801.01838.0DomainFibronectin type-III 5
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211076_11651528.01565.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211167_12561528.01565.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211258_13501528.01565.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211351_14391528.01565.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000034523019211440_15311528.01565.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921174_1861528.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921186_2171528.01565.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921217_2481528.01565.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921248_2801528.01565.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921280_3111528.01565.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921311_3421528.01565.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921342_3731528.01565.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921373_4041528.01565.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921404_4351528.01565.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921435_4661528.01565.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921466_4971528.01565.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921497_5281528.01565.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921528_5591528.01565.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921559_5901528.01565.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921590_6211528.01565.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921625_7151528.01565.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921716_8041528.01565.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921805_8941528.01565.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921895_9901528.01565.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000003452301921991_10751528.01565.0DomainFibronectin type-III 5
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221076_11651619.01656.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221167_12561619.01656.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221258_13501619.01656.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221351_14391619.01656.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221440_15311619.01656.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST0000034670620221533_16211619.01656.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022174_1861619.01656.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022186_2171619.01656.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022217_2481619.01656.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022248_2801619.01656.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022280_3111619.01656.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022311_3421619.01656.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022342_3731619.01656.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022373_4041619.01656.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022404_4351619.01656.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022435_4661619.01656.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022466_4971619.01656.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022497_5281619.01656.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022528_5591619.01656.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022559_5901619.01656.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022590_6211619.01656.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022625_7151619.01656.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022716_8041619.01656.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022805_8941619.01656.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022895_9901619.01656.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000003467062022991_10751619.01656.0DomainFibronectin type-III 5
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281076_11652165.02202.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281167_12562165.02202.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281258_13502165.02202.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281351_14392165.02202.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281440_15312165.02202.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281533_16212165.02202.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281622_17112165.02202.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281712_18012165.02202.0DomainFibronectin type-III 13
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628174_1862165.02202.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281802_18882165.02202.0DomainFibronectin type-III 14
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628186_2172165.02202.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281889_19772165.02202.0DomainFibronectin type-III 15
TgeneTNCchr9:117350200chr9:117783546ENST0000035076326281975_21902165.02202.0DomainFibrinogen C-terminal
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628217_2482165.02202.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628248_2802165.02202.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628280_3112165.02202.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628311_3422165.02202.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628342_3732165.02202.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628373_4042165.02202.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628404_4352165.02202.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628435_4662165.02202.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628466_4972165.02202.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628497_5282165.02202.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628528_5592165.02202.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628559_5902165.02202.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628590_6212165.02202.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628625_7152165.02202.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628716_8042165.02202.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628805_8942165.02202.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628895_9902165.02202.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000003507632628991_10752165.02202.0DomainFibronectin type-III 5
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231076_11651710.01747.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231167_12561710.01747.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231258_13501710.01747.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231351_14391710.01747.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231440_15311710.01747.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231533_16211710.01747.0DomainFibronectin type-III 11
TgeneTNCchr9:117350200chr9:117783546ENST0000053564821231622_17111710.01747.0DomainFibronectin type-III 12
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123174_1861710.01747.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123186_2171710.01747.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123217_2481710.01747.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123248_2801710.01747.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123280_3111710.01747.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123311_3421710.01747.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123342_3731710.01747.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123373_4041710.01747.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123404_4351710.01747.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123435_4661710.01747.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123466_4971710.01747.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123497_5281710.01747.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123528_5591710.01747.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123559_5901710.01747.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123590_6211710.01747.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123625_7151710.01747.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123716_8041710.01747.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123805_8941710.01747.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123895_9901710.01747.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000005356482123991_10751710.01747.0DomainFibronectin type-III 5
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201076_11651528.01565.0DomainFibronectin type-III 6
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201167_12561528.01565.0DomainFibronectin type-III 7
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201258_13501528.01565.0DomainFibronectin type-III 8
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201351_14391528.01565.0DomainFibronectin type-III 9
TgeneTNCchr9:117350200chr9:117783546ENST0000053732018201440_15311528.01565.0DomainFibronectin type-III 10
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820174_1861528.01565.0DomainEGF-like 1%3B incomplete
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820186_2171528.01565.0DomainEGF-like 2
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820217_2481528.01565.0DomainEGF-like 3
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820248_2801528.01565.0DomainEGF-like 4
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820280_3111528.01565.0DomainEGF-like 5
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820311_3421528.01565.0DomainEGF-like 6
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820342_3731528.01565.0DomainEGF-like 7
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820373_4041528.01565.0DomainEGF-like 8
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820404_4351528.01565.0DomainEGF-like 9
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820435_4661528.01565.0DomainEGF-like 10
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820466_4971528.01565.0DomainEGF-like 11
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820497_5281528.01565.0DomainEGF-like 12
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820528_5591528.01565.0DomainEGF-like 13
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820559_5901528.01565.0DomainEGF-like 14
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820590_6211528.01565.0DomainEGF-like 15
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820625_7151528.01565.0DomainFibronectin type-III 1
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820716_8041528.01565.0DomainFibronectin type-III 2
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820805_8941528.01565.0DomainFibronectin type-III 3
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820895_9901528.01565.0DomainFibronectin type-III 4
TgeneTNCchr9:117350200chr9:117783546ENST000005373201820991_10751528.01565.0DomainFibronectin type-III 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP6V1G1
TNC


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP6V1G1-TNC


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP6V1G1-TNC


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource