UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SLIT2-PACRGL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLIT2-PACRGL
FusionPDB ID: 83669
FusionGDB2.0 ID: 83669
HgeneTgene
Gene symbol

SLIT2

PACRGL

Gene ID

9353

133015

Gene nameslit guidance ligand 2parkin coregulated like
SynonymsSLIL3|Slit-2C4orf28
Cytomap

4p15.31

4p15.31

Type of geneprotein-codingprotein-coding
Descriptionslit homolog 2 proteinPACRG-like proteinPARK2 co-regulated likePARK2 coregulated like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000273739, ENST00000503823, 
ENST00000503837, ENST00000504154, 
ENST00000509394, 		ENST00000507634, 
ENST00000295290, ENST00000360916, 
ENST00000444671, ENST00000502374, 
ENST00000502938, ENST00000503585, 
ENST00000508753, ENST00000513459, 
ENST00000538990, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 2=504 X 6 X 2=48
# samples 65
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLIT2 [Title/Abstract] AND PACRGL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLIT2(20270504)-PACRGL(20728908), # samples:2
Anticipated loss of major functional domain due to fusion event.SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLIT2-PACRGL seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLIT2

GO:0001933

negative regulation of protein phosphorylation

18345009

HgeneSLIT2

GO:0002689

negative regulation of leukocyte chemotaxis

11309622

HgeneSLIT2

GO:0007411

axon guidance

11748139

HgeneSLIT2

GO:0008045

motor neuron axon guidance

10102268

HgeneSLIT2

GO:0010593

negative regulation of lamellipodium assembly

16439689

HgeneSLIT2

GO:0010596

negative regulation of endothelial cell migration

18345009

HgeneSLIT2

GO:0014912

negative regulation of smooth muscle cell migration

16439689

HgeneSLIT2

GO:0021834

chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

11748139

HgeneSLIT2

GO:0021836

chemorepulsion involved in postnatal olfactory bulb interneuron migration

15207848

HgeneSLIT2

GO:0030336

negative regulation of cell migration

19005219

HgeneSLIT2

GO:0030837

negative regulation of actin filament polymerization

19759280

HgeneSLIT2

GO:0031290

retinal ganglion cell axon guidance

10864954|19498462

HgeneSLIT2

GO:0043116

negative regulation of vascular permeability

18345009

HgeneSLIT2

GO:0048754

branching morphogenesis of an epithelial tube

18345009

HgeneSLIT2

GO:0048846

axon extension involved in axon guidance

16840550

HgeneSLIT2

GO:0050919

negative chemotaxis

11748139

HgeneSLIT2

GO:0050929

induction of negative chemotaxis

10197527

HgeneSLIT2

GO:0051058

negative regulation of small GTPase mediated signal transduction

16439689

HgeneSLIT2

GO:0071504

cellular response to heparin

17062560

HgeneSLIT2

GO:0071672

negative regulation of smooth muscle cell chemotaxis

16439689

HgeneSLIT2

GO:0071676

negative regulation of mononuclear cell migration

16439689

HgeneSLIT2

GO:0090024

negative regulation of neutrophil chemotaxis

19759280

HgeneSLIT2

GO:0090260

negative regulation of retinal ganglion cell axon guidance

17062560

HgeneSLIT2

GO:0090288

negative regulation of cellular response to growth factor stimulus

16439689


check buttonFusion gene breakpoints across SLIT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PACRGL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AP-A052-01ASLIT2chr4

20555591

+PACRGLchr4

20754188

+
ChimerDB4UCECTCGA-AP-A052-01ASLIT2chr4

20555591

+PACRGLchr4

20754250

+
ChimerDB4UCECTCGA-KP-A3VZ-01ASLIT2chr4

20270504

+PACRGLchr4

20728908

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000503823SLIT2chr420270504+ENST00000538990PACRGLchr420728908+14569514691122217
ENST00000504154SLIT2chr420270504+ENST00000538990PACRGLchr420728908+1152647165818217
ENST00000273739SLIT2chr420270504+ENST00000538990PACRGLchr420728908+1126621139792217
ENST00000503837SLIT2chr420270504+ENST00000538990PACRGLchr420728908+9003950566188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000503823ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0389025250.9610975
ENST00000504154ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0260364410.97396356
ENST00000273739ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0282525660.97174746
ENST00000503837ENST00000538990SLIT2chr420270504+PACRGLchr420728908+0.0226513170.9773487

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83669_83669_1_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000273739_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------

>83669_83669_2_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503823_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------

>83669_83669_3_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000503837_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=188AA_BP=0
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENK
ISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVEEGSQQKLFFLPVDVSSTNCGYSFILFFCK

--------------------------------------------------------------

>83669_83669_4_SLIT2-PACRGL_SLIT2_chr4_20270504_ENST00000504154_PACRGL_chr4_20728908_ENST00000538990_length(amino acids)=217AA_BP=1
MGLRHCAVPSEQQAKESPQCRRGRRRRGKMRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLD
LNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLGALASSNLKFQHTAPYAVE

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:20270504/chr4:20728908)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43631_55131.666666666666661522.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43731_55131.666666666666661526.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43731_55131.666666666666661530.0DomainNote=LRRNT
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436104_125131.666666666666661522.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43656_77131.666666666666661522.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+43680_101131.666666666666661522.0RepeatNote=LRR 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437104_125131.666666666666661526.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43756_77131.666666666666661526.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+43780_101131.666666666666661526.0RepeatNote=LRR 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437104_125131.666666666666661530.0RepeatNote=LRR 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43756_77131.666666666666661530.0RepeatNote=LRR 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+43780_101131.666666666666661530.0RepeatNote=LRR 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361036_1074131.666666666666661522.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361076_1112131.666666666666661522.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361121_1157131.666666666666661522.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361160_1333131.666666666666661522.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361332_1368131.666666666666661522.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+4361453_1528131.666666666666661522.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436209_259131.666666666666661522.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436264_300131.666666666666661522.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436430_480131.666666666666661522.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436497_533131.666666666666661522.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436664_714131.666666666666661522.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436718_754131.666666666666661522.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436859_909131.666666666666661522.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436918_955131.666666666666661522.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436957_996131.666666666666661522.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436998_1034131.666666666666661522.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371036_1074131.666666666666661526.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371076_1112131.666666666666661526.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371121_1157131.666666666666661526.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371160_1333131.666666666666661526.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371332_1368131.666666666666661526.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+4371453_1528131.666666666666661526.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437209_259131.666666666666661526.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437264_300131.666666666666661526.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437430_480131.666666666666661526.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437497_533131.666666666666661526.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437664_714131.666666666666661526.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437718_754131.666666666666661526.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437859_909131.666666666666661526.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437918_955131.666666666666661526.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437957_996131.666666666666661526.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437998_1034131.666666666666661526.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371036_1074131.666666666666661530.0DomainEGF-like 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371076_1112131.666666666666661530.0DomainEGF-like 5%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371121_1157131.666666666666661530.0DomainEGF-like 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371160_1333131.666666666666661530.0DomainLaminin G-like
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371332_1368131.666666666666661530.0DomainEGF-like 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+4371453_1528131.666666666666661530.0DomainCTCK
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437209_259131.666666666666661530.0DomainNote=LRRCT 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437264_300131.666666666666661530.0DomainNote=LRRNT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437430_480131.666666666666661530.0DomainNote=LRRCT 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437497_533131.666666666666661530.0DomainNote=LRRNT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437664_714131.666666666666661530.0DomainNote=LRRCT 3
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437718_754131.666666666666661530.0DomainNote=LRRNT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437859_909131.666666666666661530.0DomainNote=LRRCT 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437918_955131.666666666666661530.0DomainEGF-like 1
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437957_996131.666666666666661530.0DomainEGF-like 2
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437998_1034131.666666666666661530.0DomainEGF-like 3%3B calcium-binding
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436128_149131.666666666666661522.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436152_173131.666666666666661522.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436176_197131.666666666666661522.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436301_322131.666666666666661522.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436325_346131.666666666666661522.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436349_370131.666666666666661522.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436373_394131.666666666666661522.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436397_418131.666666666666661522.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436534_555131.666666666666661522.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436559_580131.666666666666661522.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436583_604131.666666666666661522.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436607_628131.666666666666661522.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436631_652131.666666666666661522.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436755_777131.666666666666661522.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436778_799131.666666666666661522.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436802_823131.666666666666661522.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503823+436826_847131.666666666666661522.0RepeatNote=LRR 20
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437128_149131.666666666666661526.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437152_173131.666666666666661526.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437176_197131.666666666666661526.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437301_322131.666666666666661526.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437325_346131.666666666666661526.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437349_370131.666666666666661526.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437373_394131.666666666666661526.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437397_418131.666666666666661526.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437534_555131.666666666666661526.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437559_580131.666666666666661526.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437583_604131.666666666666661526.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437607_628131.666666666666661526.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437631_652131.666666666666661526.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437755_777131.666666666666661526.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437778_799131.666666666666661526.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437802_823131.666666666666661526.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000503837+437826_847131.666666666666661526.0RepeatNote=LRR 20
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437128_149131.666666666666661530.0RepeatNote=LRR 4
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437152_173131.666666666666661530.0RepeatNote=LRR 5
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437176_197131.666666666666661530.0RepeatNote=LRR 6
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437301_322131.666666666666661530.0RepeatNote=LRR 7
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437325_346131.666666666666661530.0RepeatNote=LRR 8
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437349_370131.666666666666661530.0RepeatNote=LRR 9
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437373_394131.666666666666661530.0RepeatNote=LRR 10
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437397_418131.666666666666661530.0RepeatNote=LRR 11
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437534_555131.666666666666661530.0RepeatNote=LRR 12
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437559_580131.666666666666661530.0RepeatNote=LRR 13
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437583_604131.666666666666661530.0RepeatNote=LRR 14
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437607_628131.666666666666661530.0RepeatNote=LRR 15
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437631_652131.666666666666661530.0RepeatNote=LRR 16
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437755_777131.666666666666661530.0RepeatNote=LRR 17
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437778_799131.666666666666661530.0RepeatNote=LRR 18
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437802_823131.666666666666661530.0RepeatNote=LRR 19
HgeneSLIT2chr4:20270504chr4:20728908ENST00000504154+437826_847131.666666666666661530.0RepeatNote=LRR 20


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLIT2
PACRGL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to SLIT2-PACRGL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SLIT2-PACRGL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource