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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SPAG9-BRIP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SPAG9-BRIP1
FusionPDB ID: 85454
FusionGDB2.0 ID: 85454
HgeneTgene
Gene symbol

SPAG9

BRIP1

Gene ID

9043

83990

Gene namesperm associated antigen 9BRCA1 interacting protein C-terminal helicase 1
SynonymsCT89|HLC-6|HLC4|HLC6|JIP-4|JIP4|JLP|PHET|PIG6BACH1|FANCJ|OF
Cytomap

17q21.33

17q23.2

Type of geneprotein-codingprotein-coding
DescriptionC-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancerFanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1
Modification date2020031520200315
UniProtAcc.

Q9BX63

Ensembl transtripts involved in fusion geneENST idsENST00000262013, ENST00000357122, 
ENST00000505279, ENST00000509724, 
ENST00000510283, 		ENST00000583837, 
ENST00000259008, ENST00000577598, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 21 X 10=420012 X 15 X 7=1260
# samples 2513
** MAII scorelog2(25/4200*10)=-4.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1260*10)=-3.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SPAG9 [Title/Abstract] AND BRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BRIP1(59934419)-SPAG9(49157065), # samples:2
SPAG9(49133773)-BRIP1(59924581), # samples:2
Anticipated loss of major functional domain due to fusion event.BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BRIP1-SPAG9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SPAG9-BRIP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPAG9

GO:0042147

retrograde transport, endosome to Golgi

19056739

TgeneBRIP1

GO:0006357

regulation of transcription by RNA polymerase II

14504288


check buttonFusion gene breakpoints across SPAG9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A0TQ-01ASPAG9chr17

49133773

-BRIP1chr17

59924581

-
ChimerDB4BRCATCGA-AR-A0TQ-01ASPAG9chr17

49133773

-BRIP1chr17

59926617

-
ChimerDB4BRCATCGA-AR-A0TQSPAG9chr17

49133772

-BRIP1chr17

59924581

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262013SPAG9chr1749133773-ENST00000259008BRIP1chr1759924581-597770420939461245
ENST00000262013SPAG9chr1749133773-ENST00000577598BRIP1chr1759924581-41667042093181990
ENST00000505279SPAG9chr1749133773-ENST00000259008BRIP1chr1759924581-58465737838151245
ENST00000505279SPAG9chr1749133773-ENST00000577598BRIP1chr1759924581-4035573783050990
ENST00000357122SPAG9chr1749133773-ENST00000259008BRIP1chr1759924581-597770420939461245
ENST00000357122SPAG9chr1749133773-ENST00000577598BRIP1chr1759924581-41667042093181990
ENST00000262013SPAG9chr1749133772-ENST00000259008BRIP1chr1759924581-597770420939461245
ENST00000262013SPAG9chr1749133772-ENST00000577598BRIP1chr1759924581-41667042093181990
ENST00000505279SPAG9chr1749133772-ENST00000259008BRIP1chr1759924581-58465737838151245
ENST00000505279SPAG9chr1749133772-ENST00000577598BRIP1chr1759924581-4035573783050990
ENST00000357122SPAG9chr1749133772-ENST00000259008BRIP1chr1759924581-597770420939461245
ENST00000357122SPAG9chr1749133772-ENST00000577598BRIP1chr1759924581-41667042093181990

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262013ENST00000259008SPAG9chr1749133773-BRIP1chr1759924581-0.0001051770.99989486
ENST00000262013ENST00000577598SPAG9chr1749133773-BRIP1chr1759924581-0.000210280.9997898
ENST00000505279ENST00000259008SPAG9chr1749133773-BRIP1chr1759924581-9.10E-050.99990904
ENST00000505279ENST00000577598SPAG9chr1749133773-BRIP1chr1759924581-0.0001880470.99981195
ENST00000357122ENST00000259008SPAG9chr1749133773-BRIP1chr1759924581-0.0001051770.99989486
ENST00000357122ENST00000577598SPAG9chr1749133773-BRIP1chr1759924581-0.000210280.9997898
ENST00000262013ENST00000259008SPAG9chr1749133772-BRIP1chr1759924581-0.0001051770.99989486
ENST00000262013ENST00000577598SPAG9chr1749133772-BRIP1chr1759924581-0.000210280.9997898
ENST00000505279ENST00000259008SPAG9chr1749133772-BRIP1chr1759924581-9.10E-050.99990904
ENST00000505279ENST00000577598SPAG9chr1749133772-BRIP1chr1759924581-0.0001880470.99981195
ENST00000357122ENST00000259008SPAG9chr1749133772-BRIP1chr1759924581-0.0001051770.99989486
ENST00000357122ENST00000577598SPAG9chr1749133772-BRIP1chr1759924581-0.000210280.9997898

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85454_85454_1_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000262013_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_2_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000262013_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

>85454_85454_3_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000357122_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_4_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000357122_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

>85454_85454_5_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000505279_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_6_SPAG9-BRIP1_SPAG9_chr17_49133772_ENST00000505279_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

>85454_85454_7_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000262013_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_8_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000262013_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

>85454_85454_9_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000357122_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_10_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000357122_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

>85454_85454_11_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000505279_BRIP1_chr17_59924581_ENST00000259008_length(amino acids)=1245AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFN
KQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLT
RKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIR

--------------------------------------------------------------

>85454_85454_12_SPAG9-BRIP1_SPAG9_chr17_49133773_ENST00000505279_BRIP1_chr17_59924581_ENST00000577598_length(amino acids)=990AA_BP=165
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE
REKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEIRKRHCFGTEVHNLD
AKVDSGKTVKLNSPLEKINSFSPQKPPGHCSRCCCSTKQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMT
ILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADI
IFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAE
YLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRF
ADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQ
LEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVI
VEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRGLLPGR
QWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQD
NESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKSMKSSSHLPLIEKSFIIFSEMIFIWV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:59934419/chr17:49157065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRIP1

Q9BX63

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269|PubMed:11301010, ECO:0000269|PubMed:14983014, ECO:0000269|PubMed:16116421, ECO:0000269|PubMed:16153896}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG9chr17:49133772chr17:59924581ENST00000262013-33066_166165.01322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000357122-32966_166165.01308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000505279-33066_166165.01312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000262013-33066_166165.01322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000357122-32966_166165.01308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000505279-33066_166165.01312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000262013-3307_95165.01322.0DomainRH1
HgeneSPAG9chr17:49133772chr17:59924581ENST00000357122-3297_95165.01308.0DomainRH1
HgeneSPAG9chr17:49133772chr17:59924581ENST00000505279-3307_95165.01312.0DomainRH1
HgeneSPAG9chr17:49133773chr17:59924581ENST00000262013-3307_95165.01322.0DomainRH1
HgeneSPAG9chr17:49133773chr17:59924581ENST00000357122-3297_95165.01308.0DomainRH1
HgeneSPAG9chr17:49133773chr17:59924581ENST00000505279-3307_95165.01312.0DomainRH1
TgeneBRIP1chr17:49133772chr17:59924581ENST00000259008420393_396169.01250.0MotifNote=DEAH box
TgeneBRIP1chr17:49133773chr17:59924581ENST00000259008420393_396169.01250.0MotifNote=DEAH box
TgeneBRIP1chr17:49133772chr17:59924581ENST00000259008420185_192169.01250.0Nucleotide bindingATP
TgeneBRIP1chr17:49133773chr17:59924581ENST00000259008420185_192169.01250.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPAG9chr17:49133772chr17:59924581ENST00000262013-330408_534165.01322.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133772chr17:59924581ENST00000262013-330724_758165.01322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000357122-329408_534165.01308.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133772chr17:59924581ENST00000357122-329724_758165.01308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000505279-330408_534165.01312.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133772chr17:59924581ENST00000505279-330724_758165.01312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000510283-127408_53401178.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133772chr17:59924581ENST00000510283-12766_16601178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000510283-127724_75801178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000262013-330408_534165.01322.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133773chr17:59924581ENST00000262013-330724_758165.01322.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000357122-329408_534165.01308.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133773chr17:59924581ENST00000357122-329724_758165.01308.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000505279-330408_534165.01312.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133773chr17:59924581ENST00000505279-330724_758165.01312.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000510283-127408_53401178.0Coiled coilOntology_term=ECO:0000269
HgeneSPAG9chr17:49133773chr17:59924581ENST00000510283-12766_16601178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133773chr17:59924581ENST00000510283-127724_75801178.0Coiled coilOntology_term=ECO:0000255
HgeneSPAG9chr17:49133772chr17:59924581ENST00000262013-330500_571165.01322.0DomainRH2
HgeneSPAG9chr17:49133772chr17:59924581ENST00000357122-329500_571165.01308.0DomainRH2
HgeneSPAG9chr17:49133772chr17:59924581ENST00000505279-330500_571165.01312.0DomainRH2
HgeneSPAG9chr17:49133772chr17:59924581ENST00000510283-127500_57101178.0DomainRH2
HgeneSPAG9chr17:49133772chr17:59924581ENST00000510283-1277_9501178.0DomainRH1
HgeneSPAG9chr17:49133773chr17:59924581ENST00000262013-330500_571165.01322.0DomainRH2
HgeneSPAG9chr17:49133773chr17:59924581ENST00000357122-329500_571165.01308.0DomainRH2
HgeneSPAG9chr17:49133773chr17:59924581ENST00000505279-330500_571165.01312.0DomainRH2
HgeneSPAG9chr17:49133773chr17:59924581ENST00000510283-127500_57101178.0DomainRH2
HgeneSPAG9chr17:49133773chr17:59924581ENST00000510283-1277_9501178.0DomainRH1
TgeneBRIP1chr17:49133772chr17:59924581ENST0000025900842011_442169.01250.0DomainHelicase ATP-binding
TgeneBRIP1chr17:49133773chr17:59924581ENST0000025900842011_442169.01250.0DomainHelicase ATP-binding
TgeneBRIP1chr17:49133772chr17:59924581ENST00000259008420158_175169.01250.0MotifNuclear localization signal
TgeneBRIP1chr17:49133773chr17:59924581ENST00000259008420158_175169.01250.0MotifNuclear localization signal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SPAG9
BRIP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SPAG9-BRIP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SPAG9-BRIP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource