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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AXIN1-DNMT3A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AXIN1-DNMT3A
FusionPDB ID: 8555
FusionGDB2.0 ID: 8555
HgeneTgene
Gene symbol

AXIN1

DNMT3A

Gene ID

8312

1788

Gene nameaxin 1DNA methyltransferase 3 alpha
SynonymsAXIN|PPP1R49DNMT3A2|HESJAS|M.HsaIIIA|TBRS
Cytomap

16p13.3

2p23.3

Type of geneprotein-codingprotein-coding
Descriptionaxin-1axis inhibition protein 1axis inhibitor 1fused, mouse, homolog ofprotein phosphatase 1, regulatory subunit 49DNA (cytosine-5)-methyltransferase 3ADNA (cytosine-5-)-methyltransferase 3 alphaDNA MTase HsaIIIADNA cytosine methyltransferase 3A2
Modification date2020032220200322
UniProtAcc

O15169

Q9Y6K1

Ensembl transtripts involved in fusion geneENST idsENST00000262320, ENST00000354866, 
ENST00000481769, 		ENST00000380746, 
ENST00000402667, ENST00000474887, 
ENST00000264709, ENST00000321117, 
ENST00000406659, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 10 X 9=14404 X 4 X 3=48
# samples 234
** MAII scorelog2(23/1440*10)=-2.6463630453853
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AXIN1 [Title/Abstract] AND DNMT3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AXIN1(354303)-DNMT3A(25523112), # samples:1
Anticipated loss of major functional domain due to fusion event.AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AXIN1-DNMT3A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAXIN1

GO:0001934

positive regulation of protein phosphorylation

9601641

HgeneAXIN1

GO:0032147

activation of protein kinase activity

9601641

HgeneAXIN1

GO:0034622

cellular protein-containing complex assembly

16601693

HgeneAXIN1

GO:0045732

positive regulation of protein catabolic process

9601641

HgeneAXIN1

GO:0090090

negative regulation of canonical Wnt signaling pathway

10644691

TgeneDNMT3A

GO:0006306

DNA methylation

12138111|19786833|23042785


check buttonFusion gene breakpoints across AXIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNMT3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8686AXIN1chr16

354303

-DNMT3Achr2

25523112

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262320AXIN1chr16354303-ENST00000321117DNMT3Achr225523112-559616262142921423
ENST00000262320AXIN1chr16354303-ENST00000264709DNMT3Achr225523112-559616262142921423
ENST00000262320AXIN1chr16354303-ENST00000406659DNMT3Achr225523112-29911626212054677
ENST00000354866AXIN1chr16354303-ENST00000321117DNMT3Achr225523112-538614161540821355
ENST00000354866AXIN1chr16354303-ENST00000264709DNMT3Achr225523112-538614161540821355
ENST00000354866AXIN1chr16354303-ENST00000406659DNMT3Achr225523112-27811416151844609

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262320ENST00000321117AXIN1chr16354303-DNMT3Achr225523112-0.0008805620.99911946
ENST00000262320ENST00000264709AXIN1chr16354303-DNMT3Achr225523112-0.0008805620.99911946
ENST00000262320ENST00000406659AXIN1chr16354303-DNMT3Achr225523112-0.0084652350.99153477
ENST00000354866ENST00000321117AXIN1chr16354303-DNMT3Achr225523112-0.0006311290.99936885
ENST00000354866ENST00000264709AXIN1chr16354303-DNMT3Achr225523112-0.0006311290.99936885
ENST00000354866ENST00000406659AXIN1chr16354303-DNMT3Achr225523112-0.0068640310.9931359

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8555_8555_1_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1423AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE
GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR
WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK
LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD
SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL
VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP
GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR
YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR
PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS

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>8555_8555_2_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1423AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE
GAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPRLTFQAGDPYYISKRKRDEWLAR
WKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKAGDDEPEYEDGRGFGIGELVWGK
LRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRKAIYEVLQVASSRAGKLFPVCHD
SDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKPRKSTAEKPKVKEIIDERTRERL
VYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVLMCGNNNCCRCFCVECVDLLVGP
GAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDR
YIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGTGRLFFEFYRLLHDARPKEGDDR
PFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKFSKVRTITTRSNS

--------------------------------------------------------------

>8555_8555_3_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000262320_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=677AA_BP=535
MPPPEPAGVGPEPRPRGAGGWELAAGPLRRPRGLPRVRLRAAEPQPPRWGPPRAAPPPGPARRAAAERMGPDRAAPLREPGPGSRHHRAR
DRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPASYSFCSGKGVGIKGETSTATPRR
SDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCDSNEEKRLKLARAIYRKYILDNN
GIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVCSDQSSGSGTGKGISGYLPTLNE
DEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYALAPATSANDSEQQSLSSDADTL
SLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQRTREAEEKLEERLKRVRMDGEEQ
EEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRSEPQPEEGSPAGGQKGGAPAEGE

--------------------------------------------------------------

>8555_8555_4_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000264709_length(amino acids)=1355AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS
EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR
LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA
GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK
AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP
RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL
MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL
SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE
CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE

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>8555_8555_5_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000321117_length(amino acids)=1355AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS
EPQPEEGSPAGGQKGGAPAEGEGAAETLPEASRAVENGCCTPKEGRGAPAEAGKEQKETNIESMKMEGSRGRLRGGLGWESSLRQRPMPR
LTFQAGDPYYISKRKRDEWLARWKREAEKKAKVIAGMNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTPEPVGSDAGDKNATKA
GDDEPEYEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGTRWVMWFGDGKFSVVCVEKLMPLSSFCSAFHQATYNKQPMYRK
AIYEVLQVASSRAGKLFPVCHDSDESDTAKAVEVQNKPMIEWALGGFQPSGPKGLEPPEEEKNPYKEVYTDMWVEPEAAAYAPPPPAKKP
RKSTAEKPKVKEIIDERTRERLVYEVRQKCRNIEDICISCGSLNVTLEHPLFVGGMCQNCKNCFLECAYQYDDDGYQSYCTICCGGREVL
MCGNNNCCRCFCVECVDLLVGPGAAQAAIKEDPWNCYMCGHKGTYGLLRRREDWPSRLQMFFANNHDQEFDPPKVYPPVPAEKRKPIRVL
SLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRHQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNPVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQE
CLEHGRIAKFSKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLGRSWSVPVIRHLFAPLKE

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>8555_8555_6_AXIN1-DNMT3A_AXIN1_chr16_354303_ENST00000354866_DNMT3A_chr2_25523112_ENST00000406659_length(amino acids)=609AA_BP=467
MGPDRAAPLREPGPGSRHHRARDRLIHFGAVSTDVLGCSAHCSLTQSPKMNIQEQGFPLDLGASFTEDAPRPPVPGEEGELVSTDPRPAS
YSFCSGKGVGIKGETSTATPRRSDLDLGYEPEGSASPTPPYLKWAESLHSLLDDQDGISLFRTFLKQEGCADLLDFWFACTGFRKLEPCD
SNEEKRLKLARAIYRKYILDNNGIVSRQTKPATKSFIKGCIMKQLIDPAMFDQAQTEIQATMEENTYPSFLKSDIYLEYTRTGSESPKVC
SDQSSGSGTGKGISGYLPTLNEDEEWKCDQDMDEDDGRDAAPPGRLPQKLLLETAAPRVSSSRRYSEGREFRYGSWREPVNPYYVNAGYA
LAPATSANDSEQQSLSSDADTLSLTDSSVDGIPPYRIRKQHRREMQESVQVNGRVPLPHIPRTYRVPKEVRVEPQKFAEELIHRLEAVQR
TREAEEKLEERLKRVRMDGEEQEEPRGKEERQEPSTTARKVGRPGRKRKHPPVESGDTPKDPAVISKSPSMAQDSGASELLPNGDLEKRS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:354303/chr2:25523112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AXIN1

O15169

DNMT3A

Q9Y6K1

FUNCTION: Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (PubMed:12192039, PubMed:27098453). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway (PubMed:12192039). In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B (PubMed:12192039). Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (PubMed:16601693). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development (PubMed:17210684). Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation (PubMed:17210684). {ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17210684, ECO:0000269|PubMed:27098453}.FUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. {ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:30478443}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-51188_211418.0863.0DomainRGS
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-51088_211418.0827.0DomainRGS
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-51120_29418.0863.0MotifNote=Tankyrase-binding motif
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-51020_29418.0827.0MotifNote=Tankyrase-binding motif
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123292_35024.0913.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123482_61424.0913.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123634_91224.0913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123292_35024.0913.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123482_61424.0913.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123634_91224.0913.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019292_3500724.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019482_6140724.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019634_9120724.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018292_3500690.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018482_6140690.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018634_9120690.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914292_35024.0167.0DomainPWWP
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914482_61424.0167.0DomainADD
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914634_91224.0167.0DomainSAM-dependent MTase C5-type
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123641_64524.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123686_68824.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123891_89324.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123641_64524.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123686_68824.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123891_89324.0913.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019641_6450724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019686_6880724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019891_8930724.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018641_6450690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018686_6880690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018891_8930690.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914641_64524.0167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914686_68824.0167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914891_89324.0167.0RegionS-adenosyl-L-methionine binding
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123493_52324.0913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000264709123534_59024.0913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123493_52324.0913.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000321117123534_59024.0913.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019493_5230724.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000380746019534_5900724.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018493_5230690.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST00000402667018534_5900690.0Zinc fingerPHD-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914493_52324.0167.0Zinc fingerGATA-type%3B atypical
TgeneDNMT3Achr16:354303chr2:25523112ENST0000040665914534_59024.0167.0Zinc fingerPHD-type%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511780_862418.0863.0DomainDIX
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510780_862418.0827.0DomainDIX


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AXIN1
DNMT3A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511434_502418.0863.0CTNNB1
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510434_502418.0827.0CTNNB1
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511348_433418.0863.0GSK3B
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510348_433418.0827.0GSK3B
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511677_752418.0863.0HIPK2
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510677_752418.0827.0HIPK2
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511575_789418.0863.0PPP2CA
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510575_789418.0827.0PPP2CA
HgeneAXIN1chr16:354303chr2:25523112ENST00000262320-511507_757418.0863.0RNF111
HgeneAXIN1chr16:354303chr2:25523112ENST00000354866-510507_757418.0827.0RNF111


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Related Drugs to AXIN1-DNMT3A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AXIN1-DNMT3A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource