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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SUPT5H-EGLN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SUPT5H-EGLN2
FusionPDB ID: 88152
FusionGDB2.0 ID: 88152
HgeneTgene
Gene symbol

SUPT5H

EGLN2

Gene ID

6829

100529264

Gene nameSPT5 homolog, DSIF elongation factor subunitRAB4B-EGLN2 readthrough (NMD candidate)
SynonymsSPT5|SPT5H|Tat-CT1EGLN2|EIT-6|EIT6|HIF-PH1|HPH-1|HPH-3|PHD1|RERT-lncRNA
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingncRNA
Descriptiontranscription elongation factor SPT5DRB sensitivity-inducing factor 160 kDa subunitDRB sensitivity-inducing factor large subunitDSIF large subunitDSIF p160Tat-cotransactivator 1 proteinhSPT5suppressor of Ty 5 homologEgl nine homolog 2Estrogen-induced tag 6HIF-prolyl hydroxylase 1Hypoxia-inducible factor prolyl hydroxylase 1Prolyl hydroxylase domain-containing protein 1RAB4B-EGLN2 readthrough (non-protein coding)RAB4B-EGLN2 readthrough long non-coding RNA
Modification date2020031320200313
UniProtAcc.

Q96KS0

Ensembl transtripts involved in fusion geneENST idsENST00000359191, ENST00000402194, 
ENST00000432763, ENST00000598725, 
ENST00000599117, 		ENST00000303961, 
ENST00000406058, ENST00000594140, 
ENST00000593726, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 13 X 9=19892 X 2 X 2=8
# samples 192
** MAII scorelog2(19/1989*10)=-3.3879719525028
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: SUPT5H [Title/Abstract] AND EGLN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SUPT5H(39948380)-EGLN2(41313714), # samples:1
Anticipated loss of major functional domain due to fusion event.SUPT5H-EGLN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUPT5H-EGLN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SUPT5H-EGLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SUPT5H-EGLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SUPT5H-EGLN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SUPT5H-EGLN2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUPT5H

GO:0000122

negative regulation of transcription by RNA polymerase II

9450929

HgeneSUPT5H

GO:0006368

transcription elongation from RNA polymerase II promoter

9450929

HgeneSUPT5H

GO:0032785

negative regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0032786

positive regulation of DNA-templated transcription, elongation

9450929

HgeneSUPT5H

GO:0045944

positive regulation of transcription by RNA polymerase II

9450929


check buttonFusion gene breakpoints across SUPT5H (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EGLN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0787-01ASUPT5Hchr19

39948380

+EGLN2chr19

41313714

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000599117SUPT5Hchr1939948380+ENST00000593726EGLN2chr1941313714+1299674136729197
ENST00000432763SUPT5Hchr1939948380+ENST00000593726EGLN2chr1941313714+111148647428148
ENST00000402194SUPT5Hchr1939948380+ENST00000593726EGLN2chr1941313714+111148647428148
ENST00000359191SUPT5Hchr1939948380+ENST00000593726EGLN2chr1941313714+1179554542138134
ENST00000598725SUPT5Hchr1939948380+ENST00000593726EGLN2chr1941313714+113951450298134

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000599117ENST00000593726SUPT5Hchr1939948380+EGLN2chr1941313714+0.0018563590.9981437
ENST00000432763ENST00000593726SUPT5Hchr1939948380+EGLN2chr1941313714+0.0014042280.9985958
ENST00000402194ENST00000593726SUPT5Hchr1939948380+EGLN2chr1941313714+0.0014042280.9985958
ENST00000359191ENST00000593726SUPT5Hchr1939948380+EGLN2chr1941313714+0.0025625160.9974375
ENST00000598725ENST00000593726SUPT5Hchr1939948380+EGLN2chr1941313714+0.002386850.9976132

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88152_88152_1_SUPT5H-EGLN2_SUPT5H_chr19_39948380_ENST00000359191_EGLN2_chr19_41313714_ENST00000593726_length(amino acids)=134AA_BP=4
MSSAPSSHWSSSSYSSSTSASSRMKPPWRGFLGGRSSSSSSSSSSYSSSSSSSSSSSGSSSFSLPAALRRSSSTSASSPSLLRSLSSSSE

--------------------------------------------------------------

>88152_88152_2_SUPT5H-EGLN2_SUPT5H_chr19_39948380_ENST00000402194_EGLN2_chr19_41313714_ENST00000593726_length(amino acids)=148AA_BP=4
MSSAPSSHWSSSSYSSSTSASSRMKPPWRGFLGGRSSSSSSSSSSYSSSSSSSSSSSGSSSFSLPAALRRSSSTSASSPSLLRSLSSSSE

--------------------------------------------------------------

>88152_88152_3_SUPT5H-EGLN2_SUPT5H_chr19_39948380_ENST00000432763_EGLN2_chr19_41313714_ENST00000593726_length(amino acids)=148AA_BP=4
MSSAPSSHWSSSSYSSSTSASSRMKPPWRGFLGGRSSSSSSSSSSYSSSSSSSSSSSGSSSFSLPAALRRSSSTSASSPSLLRSLSSSSE

--------------------------------------------------------------

>88152_88152_4_SUPT5H-EGLN2_SUPT5H_chr19_39948380_ENST00000598725_EGLN2_chr19_41313714_ENST00000593726_length(amino acids)=134AA_BP=4
MSSAPSSHWSSSSYSSSTSASSRMKPPWRGFLGGRSSSSSSSSSSYSSSSSSSSSSSGSSSFSLPAALRRSSSTSASSPSLLRSLSSSSE

--------------------------------------------------------------

>88152_88152_5_SUPT5H-EGLN2_SUPT5H_chr19_39948380_ENST00000599117_EGLN2_chr19_41313714_ENST00000593726_length(amino acids)=197AA_BP=179
MEVRRPCQPRKSRVRRGQRVGSRERTRQPQSGVVRTAAGTEGGGGAREGTSGETEARGGAQDCGTRQGCCLSQQQRKMSDSEDSNFSEEE
DSERSSDGEEAEVDEERRSAAGSEKEEEPEDEEEEEEEEEYDEEEEEEDDDRPPKKPRHGGFILDEADVDDEYEDEDQWEDGAEDILEKA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:39948380/chr19:41313714)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EGLN2

Q96KS0

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A (PubMed:11595184, PubMed:12039559, PubMed:15925519, PubMed:16509823, PubMed:17114296, PubMed:23932902). Target proteins are preferentially recognized via a LXXLAP motif (PubMed:11595184, PubMed:12039559, PubMed:15925519). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519, PubMed:19339211). Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A (PubMed:11595184, PubMed:12039559, PubMed:12181324, PubMed:15925519). Also hydroxylates HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Has a preference for the CODD site for both HIF1A and HIF2A (PubMed:11595184, PubMed:12039559, PubMed:15925519). Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:11595184, PubMed:12039559, PubMed:15925519). Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes (PubMed:11595184, PubMed:12039559, PubMed:15925519). EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle (PubMed:11595184, PubMed:12039559, PubMed:15925519). Also regulates susceptibility to normoxic oxidative neuronal death (PubMed:11595184, PubMed:12039559, PubMed:15925519). Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation (PubMed:23932902). Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions (PubMed:17114296). Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity). {ECO:0000250|UniProtKB:Q91YE2, ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12039559, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:15925519, ECO:0000269|PubMed:16509823, ECO:0000269|PubMed:17114296, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:23932902}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEGLN2chr19:39948380chr19:41313714ENST0000059414035278_376107.33333333333333126.0DomainFe2OG dioxygenase
TgeneEGLN2chr19:39948380chr19:41313714ENST0000059414035225_235107.33333333333333126.0RegionBeta(2)beta(3) 'finger-like' loop

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+32811_106102.333333333333331084.0Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328844_968102.333333333333331084.0Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+42911_106102.333333333333331084.0Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429844_968102.333333333333331084.0Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+43011_106102.333333333333331088.0Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430844_968102.333333333333331088.0Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+32911_106102.333333333333331088.0Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329844_968102.333333333333331088.0Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+53111_106102.333333333333331088.0Compositional biasNote=Glu-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531844_968102.333333333333331088.0Compositional biasNote=Pro-rich
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328273_306102.333333333333331084.0DomainNote=KOW 1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328420_451102.333333333333331084.0DomainNote=KOW 2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328472_503102.333333333333331084.0DomainNote=KOW 3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328594_627102.333333333333331084.0DomainNote=KOW 4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328704_737102.333333333333331084.0DomainNote=KOW 5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429273_306102.333333333333331084.0DomainNote=KOW 1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429420_451102.333333333333331084.0DomainNote=KOW 2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429472_503102.333333333333331084.0DomainNote=KOW 3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429594_627102.333333333333331084.0DomainNote=KOW 4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429704_737102.333333333333331084.0DomainNote=KOW 5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430273_306102.333333333333331088.0DomainNote=KOW 1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430420_451102.333333333333331088.0DomainNote=KOW 2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430472_503102.333333333333331088.0DomainNote=KOW 3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430594_627102.333333333333331088.0DomainNote=KOW 4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430704_737102.333333333333331088.0DomainNote=KOW 5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329273_306102.333333333333331088.0DomainNote=KOW 1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329420_451102.333333333333331088.0DomainNote=KOW 2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329472_503102.333333333333331088.0DomainNote=KOW 3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329594_627102.333333333333331088.0DomainNote=KOW 4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329704_737102.333333333333331088.0DomainNote=KOW 5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531273_306102.333333333333331088.0DomainNote=KOW 1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531420_451102.333333333333331088.0DomainNote=KOW 2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531472_503102.333333333333331088.0DomainNote=KOW 3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531594_627102.333333333333331088.0DomainNote=KOW 4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531704_737102.333333333333331088.0DomainNote=KOW 5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328754_817102.333333333333331084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328844_950102.333333333333331084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429754_817102.333333333333331084.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429844_950102.333333333333331084.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430754_817102.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430844_950102.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329754_817102.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329844_950102.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531754_817102.333333333333331088.0RegionNote=9 X 7 AA approximate tandem repeats of G-S-[QR]-T-P-X-[YQ]%2C motif CTR1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531844_950102.333333333333331088.0RegionNote=10 X 8 AA approximate tandem repeats of P-[TS]-P-S-P-[QA]-[SG]-Y%2C motif CTR2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328754_759102.333333333333331084.0RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328760_765102.333333333333331084.0RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328766_771102.333333333333331084.0RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328772_778102.333333333333331084.0RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328781_787102.333333333333331084.0RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328788_794102.333333333333331084.0RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328796_802102.333333333333331084.0RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328803_809102.333333333333331084.0RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328811_817102.333333333333331084.0RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328844_851102.333333333333331084.0RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328854_862102.333333333333331084.0RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328863_869102.333333333333331084.0RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328881_885102.333333333333331084.0RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328896_902102.333333333333331084.0RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328904_911102.333333333333331084.0RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328916_921102.333333333333331084.0RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328924_930102.333333333333331084.0RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328932_939102.333333333333331084.0RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328943_950102.333333333333331084.0RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429754_759102.333333333333331084.0RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429760_765102.333333333333331084.0RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429766_771102.333333333333331084.0RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429772_778102.333333333333331084.0RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429781_787102.333333333333331084.0RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429788_794102.333333333333331084.0RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429796_802102.333333333333331084.0RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429803_809102.333333333333331084.0RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429811_817102.333333333333331084.0RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429844_851102.333333333333331084.0RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429854_862102.333333333333331084.0RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429863_869102.333333333333331084.0RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429881_885102.333333333333331084.0RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429896_902102.333333333333331084.0RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429904_911102.333333333333331084.0RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429916_921102.333333333333331084.0RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429924_930102.333333333333331084.0RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429932_939102.333333333333331084.0RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429943_950102.333333333333331084.0RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430754_759102.333333333333331088.0RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430760_765102.333333333333331088.0RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430766_771102.333333333333331088.0RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430772_778102.333333333333331088.0RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430781_787102.333333333333331088.0RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430788_794102.333333333333331088.0RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430796_802102.333333333333331088.0RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430803_809102.333333333333331088.0RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430811_817102.333333333333331088.0RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430844_851102.333333333333331088.0RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430854_862102.333333333333331088.0RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430863_869102.333333333333331088.0RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430881_885102.333333333333331088.0RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430896_902102.333333333333331088.0RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430904_911102.333333333333331088.0RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430916_921102.333333333333331088.0RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430924_930102.333333333333331088.0RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430932_939102.333333333333331088.0RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430943_950102.333333333333331088.0RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329754_759102.333333333333331088.0RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329760_765102.333333333333331088.0RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329766_771102.333333333333331088.0RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329772_778102.333333333333331088.0RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329781_787102.333333333333331088.0RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329788_794102.333333333333331088.0RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329796_802102.333333333333331088.0RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329803_809102.333333333333331088.0RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329811_817102.333333333333331088.0RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329844_851102.333333333333331088.0RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329854_862102.333333333333331088.0RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329863_869102.333333333333331088.0RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329881_885102.333333333333331088.0RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329896_902102.333333333333331088.0RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329904_911102.333333333333331088.0RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329916_921102.333333333333331088.0RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329924_930102.333333333333331088.0RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329932_939102.333333333333331088.0RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329943_950102.333333333333331088.0RepeatNote=CTR2-10
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531754_759102.333333333333331088.0RepeatNote=CTR1-1%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531760_765102.333333333333331088.0RepeatNote=CTR1-2
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531766_771102.333333333333331088.0RepeatNote=CTR1-3
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531772_778102.333333333333331088.0RepeatNote=CTR1-4
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531781_787102.333333333333331088.0RepeatNote=CTR1-5
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531788_794102.333333333333331088.0RepeatNote=CTR1-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531796_802102.333333333333331088.0RepeatNote=CTR1-7
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531803_809102.333333333333331088.0RepeatNote=CTR1-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531811_817102.333333333333331088.0RepeatNote=CTR1-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531844_851102.333333333333331088.0RepeatNote=CTR2-1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531854_862102.333333333333331088.0RepeatNote=CTR2-2%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531863_869102.333333333333331088.0RepeatNote=CTR2-3%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531881_885102.333333333333331088.0RepeatNote=CTR2-4%3B half-length
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531896_902102.333333333333331088.0RepeatNote=CTR2-5%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531904_911102.333333333333331088.0RepeatNote=CTR2-6
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531916_921102.333333333333331088.0RepeatNote=CTR2-7%3B approximate
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531924_930102.333333333333331088.0RepeatNote=CTR2-8
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531932_939102.333333333333331088.0RepeatNote=CTR2-9
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531943_950102.333333333333331088.0RepeatNote=CTR2-10
TgeneEGLN2chr19:39948380chr19:41313714ENST0000030396146278_376389.3333333333333408.0DomainFe2OG dioxygenase
TgeneEGLN2chr19:39948380chr19:41313714ENST0000040605846278_376389.3333333333333408.0DomainFe2OG dioxygenase
TgeneEGLN2chr19:39948380chr19:41313714ENST0000059372635278_376389.3333333333333408.0DomainFe2OG dioxygenase
TgeneEGLN2chr19:39948380chr19:41313714ENST000003039614689_134389.3333333333333408.0MotifBipartite nuclear localization signal
TgeneEGLN2chr19:39948380chr19:41313714ENST000004060584689_134389.3333333333333408.0MotifBipartite nuclear localization signal
TgeneEGLN2chr19:39948380chr19:41313714ENST000005937263589_134389.3333333333333408.0MotifBipartite nuclear localization signal
TgeneEGLN2chr19:39948380chr19:41313714ENST000005941403589_134107.33333333333333126.0MotifBipartite nuclear localization signal
TgeneEGLN2chr19:39948380chr19:41313714ENST0000030396146225_235389.3333333333333408.0RegionBeta(2)beta(3) 'finger-like' loop
TgeneEGLN2chr19:39948380chr19:41313714ENST0000040605846225_235389.3333333333333408.0RegionBeta(2)beta(3) 'finger-like' loop
TgeneEGLN2chr19:39948380chr19:41313714ENST0000059372635225_235389.3333333333333408.0RegionBeta(2)beta(3) 'finger-like' loop


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SUPT5H
EGLN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328313_420102.333333333333331084.0RNA polymerase II
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429313_420102.333333333333331084.0RNA polymerase II
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430313_420102.333333333333331088.0RNA polymerase II
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329313_420102.333333333333331088.0RNA polymerase II
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531313_420102.333333333333331088.0RNA polymerase II
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000359191+328176_270102.333333333333331084.0SUPT4H1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000402194+429176_270102.333333333333331084.0SUPT4H1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000432763+430176_270102.333333333333331088.0SUPT4H1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000598725+329176_270102.333333333333331088.0SUPT4H1
HgeneSUPT5Hchr19:39948380chr19:41313714ENST00000599117+531176_270102.333333333333331088.0SUPT4H1


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Related Drugs to SUPT5H-EGLN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SUPT5H-EGLN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource