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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SYNRG-CCR7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SYNRG-CCR7
FusionPDB ID: 88499
FusionGDB2.0 ID: 88499
HgeneTgene
Gene symbol

SYNRG

CCR7

Gene ID

11276

1236

Gene namesynergin gammaC-C motif chemokine receptor 7
SynonymsAP1GBP1|SYNGBLR2|CC-CKR-7|CCR-7|CD197|CDw197|CMKBR7|EBI1
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionsynergin gammaAP1 gamma subunit binding protein 1AP1 subunit gamma-binding protein 1adaptor-related protein complex 1 gamma subunit-binding protein 1gamma-synerginC-C chemokine receptor type 7Bukitt's lymphoma receptor 2CC chemokine receptor 7EBV-induced G protein-coupled receptor 1Epstein-Barr virus induced gene 1Epstein-Barr virus-induced G-protein coupled receptor 1MIP-3 beta receptorchemokine (C-C motif)
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000339208, ENST00000345615, 
ENST00000346661, ENST00000394378, 
ENST00000502449, ENST00000585472, 
ENST00000591288, ENST00000588194, 
ENST00000579344, ENST00000246657, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 26 X 10=54607 X 2 X 7=98
# samples 219
** MAII scorelog2(21/5460*10)=-4.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/98*10)=-0.122856747785533
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SYNRG [Title/Abstract] AND CCR7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SYNRG(35921297)-CCR7(38715194), # samples:3
Anticipated loss of major functional domain due to fusion event.SYNRG-CCR7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYNRG-CCR7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYNRG-CCR7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYNRG-CCR7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCR7

GO:0002408

myeloid dendritic cell chemotaxis

11602640

TgeneCCR7

GO:0071345

cellular response to cytokine stimulus

11602640

TgeneCCR7

GO:0090023

positive regulation of neutrophil chemotaxis

21051556


check buttonFusion gene breakpoints across SYNRG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCR7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0BZ-01ASYNRGchr17

35921297

-CCR7chr17

38715194

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339208SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-39041804932930945
ENST00000346661SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-38461746352872945
ENST00000345615SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-3585148582611867
ENST00000502449SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35601460312586851
ENST00000591288SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-33061206262332768
ENST00000394378SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35551455262581851
ENST00000585472SYNRGchr1735921297-ENST00000246657CCR7chr1738715194-35521452262578850

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339208ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.000871940.99912804
ENST00000346661ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0009497830.9990502
ENST00000345615ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020885210.9979115
ENST00000502449ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0021116820.99788827
ENST00000591288ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0026100510.99739
ENST00000394378ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020987560.9979012
ENST00000585472ENST00000246657SYNRGchr1735921297-CCR7chr1738715194-0.0020819850.99791807

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88499_88499_1_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000339208_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=945AA_BP=568
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVS
GTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANR
TTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAA
AQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADK
SSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPI
MYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISID
RYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCY
LVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKF

--------------------------------------------------------------

>88499_88499_2_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000345615_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=867AA_BP=490
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPR
ETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVM
GINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMD
KYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKK
DVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFF
SGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIG
FLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCV

--------------------------------------------------------------

>88499_88499_3_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000346661_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=945AA_BP=568
MLIRWRRRRQRQVGSKMALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQ
GPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKS
RDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVS
GTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANR
TTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAA
AQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADK
SSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPI
MYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISID
RYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCY
LVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKF

--------------------------------------------------------------

>88499_88499_4_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000394378_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=851AA_BP=474
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQAS
SGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSEN
TVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSI
ICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVA
IVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVII
RTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDL

--------------------------------------------------------------

>88499_88499_5_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000502449_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=851AA_BP=474
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQAS
SGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSEN
TVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSI
ICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVA
IVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVII
RTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDL

--------------------------------------------------------------

>88499_88499_6_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000585472_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=850AA_BP=473
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAA
GMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSR
DAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGK
LTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASS
GFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENT
VPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSII
CFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAI
VQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIR
TLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLF

--------------------------------------------------------------

>88499_88499_7_SYNRG-CCR7_SYNRG_chr17_35921297_ENST00000591288_CCR7_chr17_38715194_ENST00000246657_length(amino acids)=768AA_BP=391
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPA
AGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFS
RDAKMHPTPASHPKKPGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPG
KLTKEELYTVLAMIAVTQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIA
ADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWF
LPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCI
SIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMS
FCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35921297/chr17:38715194)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322115_155554.33333333333341315.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220115_155476.33333333333331225.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321115_155554.33333333333341303.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221115_155475.33333333333331236.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120115_155393.33333333333331109.0Coiled coilOntology_term=ECO:0000255
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322295_388554.33333333333341315.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220295_388476.33333333333331225.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321295_388554.33333333333341303.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221295_388475.33333333333331236.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120295_388393.33333333333331109.0DomainEH
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322457_461554.33333333333341315.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220457_461476.33333333333331225.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321457_461554.33333333333341303.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221457_461475.33333333333331236.0MotifNote=DFXDF motif 1
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703117_1303.3333333333333335379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703153_1703.3333333333333335379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703192_2193.3333333333333335379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703248_2633.3333333333333335379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570325_593.3333333333333335379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703290_3133.3333333333333335379.0Topological domainExtracellular
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703332_3783.3333333333333335379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570387_953.3333333333333335379.0Topological domainCytoplasmic
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703131_1523.3333333333333335379.0TransmembraneHelical%3B Name%3D3
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703171_1913.3333333333333335379.0TransmembraneHelical%3B Name%3D4
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703220_2473.3333333333333335379.0TransmembraneHelical%3B Name%3D5
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703264_2893.3333333333333335379.0TransmembraneHelical%3B Name%3D6
TgeneCCR7chr17:35921297chr17:38715194ENST0000024665703314_3313.3333333333333335379.0TransmembraneHelical%3B Name%3D7
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570360_863.3333333333333335379.0TransmembraneHelical%3B Name%3D1
TgeneCCR7chr17:35921297chr17:38715194ENST000002466570396_1163.3333333333333335379.0TransmembraneHelical%3B Name%3D2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322690_694554.33333333333341315.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322775_779554.33333333333341315.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220690_694476.33333333333331225.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220775_779476.33333333333331225.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321690_694554.33333333333341303.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321775_779554.33333333333341303.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221690_694475.33333333333331236.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221775_779475.33333333333331236.0MotifNote=DFXDF motif 3
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120457_461393.33333333333331109.0MotifNote=DFXDF motif 1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120690_694393.33333333333331109.0MotifNote=DFXDF motif 2
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120775_779393.33333333333331109.0MotifNote=DFXDF motif 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SYNRG
CCR7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322666_678554.33333333333341315.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220666_678476.33333333333331225.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321666_678554.33333333333341303.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221666_678475.33333333333331236.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120666_678393.33333333333331109.0AP1G1%2C AP1G2 and GGA1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000339208-1322518_786554.33333333333341315.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000345615-1220518_786476.33333333333331225.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000346661-1321518_786554.33333333333341303.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000585472-1221518_786475.33333333333331236.0AP1G1
HgeneSYNRGchr17:35921297chr17:38715194ENST00000591288-1120518_786393.33333333333331109.0AP1G1


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Related Drugs to SYNRG-CCR7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SYNRG-CCR7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource