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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SYTL2-EED

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SYTL2-EED
FusionPDB ID: 88580
FusionGDB2.0 ID: 88580
HgeneTgene
Gene symbol

SYTL2

EED

Gene ID

54843

8726

Gene namesynaptotagmin like 2embryonic ectoderm development
SynonymsCHR11SYT|EXO4|PPP1R151|SGA72M|SLP2|SLP2ACOGIS|HEED|WAIT1
Cytomap

11q14.1

11q14.2

Type of geneprotein-codingprotein-coding
Descriptionsynaptotagmin-like protein 2breast cancer-associated antigen SGA-72Mchromosome 11 synaptotagminexophilin-4protein phosphatase 1, regulatory subunit 151polycomb protein EEDWD protein associating with integrin cytoplasmic tails 1embryonic ectoderm development protein
Modification date2020032020200313
UniProtAcc.

O75530

Ensembl transtripts involved in fusion geneENST idsENST00000316356, ENST00000354566, 
ENST00000359152, ENST00000389958, 
ENST00000389960, ENST00000524452, 
ENST00000525423, ENST00000527523, 
ENST00000528231, ENST00000528566, 
ENST00000529581, ENST00000533892, 
ENST00000525702, 		ENST00000527888, 
ENST00000263360, ENST00000327320, 
ENST00000351625, ENST00000528180, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 5=28010 X 8 X 5=400
# samples 913
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/400*10)=-1.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SYTL2 [Title/Abstract] AND EED [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SYTL2(85429833)-EED(85988022), # samples:1
Anticipated loss of major functional domain due to fusion event.SYTL2-EED seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYTL2-EED seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SYTL2-EED seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYTL2-EED seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SYTL2-EED seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYTL2

GO:0006887

exocytosis

18812475

HgeneSYTL2

GO:0006904

vesicle docking involved in exocytosis

18812475

HgeneSYTL2

GO:0010923

negative regulation of phosphatase activity

19389623


check buttonFusion gene breakpoints across SYTL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EED (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J5-01ASYTL2chr11

85429833

-EEDchr11

85988022

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000527523SYTL2chr1185429833-ENST00000263360EEDchr1185988022+227317021921709505
ENST00000527523SYTL2chr1185429833-ENST00000528180EEDchr1185988022+224417021921709505
ENST00000527523SYTL2chr1185429833-ENST00000327320EEDchr1185988022+267917021921709505
ENST00000527523SYTL2chr1185429833-ENST00000351625EEDchr1185988022+235017021921709505
ENST00000389958SYTL2chr1185429833-ENST00000263360EEDchr1185988022+950379370738122
ENST00000389958SYTL2chr1185429833-ENST00000528180EEDchr1185988022+921379370738122
ENST00000389958SYTL2chr1185429833-ENST00000327320EEDchr1185988022+135637955830783
ENST00000389958SYTL2chr1185429833-ENST00000351625EEDchr1185988022+1027379370738122

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000527523ENST00000263360SYTL2chr1185429833-EEDchr1185988022+0.0035390290.996461
ENST00000527523ENST00000528180SYTL2chr1185429833-EEDchr1185988022+0.0039742550.9960258
ENST00000527523ENST00000327320SYTL2chr1185429833-EEDchr1185988022+0.001901570.99809843
ENST00000527523ENST00000351625SYTL2chr1185429833-EEDchr1185988022+0.0029146330.9970854
ENST00000389958ENST00000263360SYTL2chr1185429833-EEDchr1185988022+0.095720780.90427923
ENST00000389958ENST00000528180SYTL2chr1185429833-EEDchr1185988022+0.074620690.92537934
ENST00000389958ENST00000327320SYTL2chr1185429833-EEDchr1185988022+0.200635980.7993641
ENST00000389958ENST00000351625SYTL2chr1185429833-EEDchr1185988022+0.1039218750.89607817

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>88580_88580_1_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000263360_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------

>88580_88580_2_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000327320_length(amino acids)=83AA_BP=1

--------------------------------------------------------------

>88580_88580_3_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000351625_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------

>88580_88580_4_SYTL2-EED_SYTL2_chr11_85429833_ENST00000389958_EED_chr11_85988022_ENST00000528180_length(amino acids)=122AA_BP=3
MKMSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKC

--------------------------------------------------------------

>88580_88580_5_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000263360_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------

>88580_88580_6_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000327320_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------

>88580_88580_7_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000351625_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------

>88580_88580_8_SYTL2-EED_SYTL2_chr11_85429833_ENST00000527523_EED_chr11_85988022_ENST00000528180_length(amino acids)=505AA_BP=
MPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAA
PASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLE
KSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLT
IHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQS
TSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:85429833/chr11:85988022)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EED

O75530

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313579_619860.33333333333341273.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312579_619860.33333333333341257.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-10191_57539.3333333333334936.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-3131_57860.33333333333341273.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313628_753860.33333333333341273.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-10191_57538.3333333333334911.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-9181_57538.3333333333334911.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-3121_57860.33333333333341257.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312628_753860.33333333333341257.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-9191_57490.3333333333333903.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-9181_57538.3333333333334935.0DomainRabBD
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812359_399322.0442.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812408_441322.0442.0RepeatNote=WD 7
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811359_399322.0401.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811408_441322.0401.0RepeatNote=WD 7
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913359_399347.0467.0RepeatNote=WD 6
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913408_441347.0467.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019579_619539.3333333333334936.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19579_6191.0366.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019579_619538.3333333333334911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918579_619538.3333333333334911.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919579_619490.3333333333333903.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918579_619538.3333333333334935.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212579_6190377.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211579_6190337.0Compositional biasNote=Ser-rich
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019628_753539.3333333333334936.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000316356-1019768_897539.3333333333334936.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000354566-313768_897860.33333333333341273.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-191_571.0366.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19628_7531.0366.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389958-19768_8971.0366.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019628_753538.3333333333334911.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000389960-1019768_897538.3333333333334911.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918628_753538.3333333333334911.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000524452-918768_897538.3333333333334911.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525423-312768_897860.33333333333341257.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-191_570377.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19628_7530377.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000525702-19768_8970377.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919628_753490.3333333333333903.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000527523-919768_897490.3333333333333903.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918628_753538.3333333333334935.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000528231-918768_897538.3333333333334935.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-2121_570377.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212628_7530377.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000529581-212768_8970377.0DomainC2 2
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-2111_570337.0DomainRabBD
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211628_7530337.0DomainC2 1
HgeneSYTL2chr11:85429833chr11:85988022ENST00000533892-211768_8970337.0DomainC2 2
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812142_185322.0442.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812188_228322.0442.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812234_275322.0442.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000263360812304_341322.0442.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000026336081291_134322.0442.0RepeatNote=WD 1
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811142_185322.0401.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811188_228322.0401.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811234_275322.0401.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000327320811304_341322.0401.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000032732081191_134322.0401.0RepeatNote=WD 1
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913142_185347.0467.0RepeatNote=WD 2
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913188_228347.0467.0RepeatNote=WD 3
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913234_275347.0467.0RepeatNote=WD 4
TgeneEEDchr11:85429833chr11:85988022ENST00000351625913304_341347.0467.0RepeatNote=WD 5
TgeneEEDchr11:85429833chr11:85988022ENST0000035162591391_134347.0467.0RepeatNote=WD 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SYTL2
EED


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEEDchr11:85429833chr11:85988022ENST0000026336081281_441322.0442.0EZH2
TgeneEEDchr11:85429833chr11:85988022ENST0000032732081181_441322.0401.0EZH2
TgeneEEDchr11:85429833chr11:85988022ENST0000035162591381_441347.0467.0EZH2


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Related Drugs to SYTL2-EED


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SYTL2-EED


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource